American Journal of Hematology最新文献

{"title":"Robustness of Hemophagocytic Lymphohistiocytosis Risk Estimates in CAR T-Cell Therapy.","authors":"Changhui Zhang, Hongyan Wu, Weilong Zhang","doi":"10.1002/ajh.70492","DOIUrl":"10.1002/ajh.70492","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":" ","pages":"2948-2951"},"PeriodicalIF":9.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Anemia Is Associated With Subclinical Myocardial Fibrosis in α-Τhalassemia Intermedia.","authors":"Karen S Kim, Saranya Veluswamy, John C Wood, Thomas D Coates, Christopher C Denton","doi":"10.1002/ajh.70473","DOIUrl":"10.1002/ajh.70473","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":" ","pages":"2944-2947"},"PeriodicalIF":9.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment, Depression and Cerebral Microbleeds in Immune Thrombocytopenia (ITP).","authors":"Camelia Vladescu, Rozanna Meijboom, Alice C J Hart, Deena Paul, Christine Ademokun, Ariam Teklemichael, Bridget Chivers, Anastasia Gontsarova, Richard Szydlo, Adam D Waldman, Nichola Cooper","doi":"10.1002/ajh.70462","DOIUrl":"10.1002/ajh.70462","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":" ","pages":"2934-2938"},"PeriodicalIF":9.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization and Outcomes of Hemodialysis and Peritoneal Dialysis in Sickle Cell–Attributed End‐Stage Kidney Disease","authors":"Miriam A. Osei, Mahyar Heydarpour, J. Kevin Tucker, Maureen Okam Achebe","doi":"10.1002/ajh.70530","DOIUrl":"https://doi.org/10.1002/ajh.70530","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"22 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Molecular Etiology of Paradoxical Hereditary Thrombocytosis Caused by Germline JAK2 Loss‐of‐Function","authors":"Guillaume Beziat, Elodie Rosa, Caroline Marty, Alyx Faurel, Hana Raslova, Lucie Rigolot, Christophe Marzac, Christine Bellanné‐Chantelot, William Vainchenker, Eric Delabesse, Véronique De Mas, Isabelle Plo","doi":"10.1002/ajh.70524","DOIUrl":"https://doi.org/10.1002/ajh.70524","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"48 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying Transfusion Endpoint and Safety Reporting in the Phase III rhTPO Trial","authors":"Jia Liu","doi":"10.1002/ajh.70527","DOIUrl":"https://doi.org/10.1002/ajh.70527","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"21 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rusfertide for Polycythemia Vera: Incremental Benefit Assessment","authors":"Ayalew Tefferi, Naseema Gangat, Paola Guglielmelli, Alessandro M. Vannucchi, Tiziano Barbui","doi":"10.1002/ajh.70528","DOIUrl":"https://doi.org/10.1002/ajh.70528","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"410 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Myeloma Masquerade: CCND3 ‐Rearranged Plasma Cell Myeloma Mimicking Lymphoplasmacytic Lymphoma","authors":"Stephen J. Babcock, Valentina Nardi","doi":"10.1002/ajh.70526","DOIUrl":"https://doi.org/10.1002/ajh.70526","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"46 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy of Vinblastine, Prednisolone, Methotrexate, and 6‐Mercaptopurine as a Front‐Line Therapy for Adult Patients With Langerhans Cell Histiocytosis","authors":"Aki Sato, Nozomi Yusa, Yukihisa Tanaka, Miho Ogawa, Eigo Shimizu, Koji Jimbo, Kazuaki Yokoyama, Masanori Nojima, Seiya Imoto, Arinobu Tojo, Yasuhito Nannya","doi":"10.1002/ajh.70523","DOIUrl":"https://doi.org/10.1002/ajh.70523","url":null,"abstract":"","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"29 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating HLA Disparity in AML Transplantation: Comparable Outcomes After Haploidentical and 9/10 Mismatched Unrelated Donor Transplantation With Treosulfan and PTCy","authors":"Daniele Avenoso,&nbsp;Mirko Farina,&nbsp;Michele Malagola,&nbsp;Yves Chalandon,&nbsp;Giorgia Saporiti,&nbsp;Annalisa Imovilli,&nbsp;Enrico Derenzini,&nbsp;Peter Remenyi,&nbsp;Massimo Martino,&nbsp;Maija Itala-Remes,&nbsp;Renato Fanin,&nbsp;Didier Blaise,&nbsp;Desiree Kunadt,&nbsp;Arancha Bermudez Rodriguez,&nbsp;Franca Fagioli,&nbsp;Thomas Schroeder,&nbsp;Irene Cavattoni,&nbsp;Maud Ngoya,&nbsp;Mohamed Houhou,&nbsp;Mohamad Mohty,&nbsp;Eolia Brissot,&nbsp;Fabio Ciceri","doi":"10.1002/ajh.70483","DOIUrl":"10.1002/ajh.70483","url":null,"abstract":"<p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative strategy for acute myeloid leukemia (AML), but the impact of HLA disparity in the era of posttransplant cyclophosphamide (PTCy) and reduced-toxicity conditioning remains unclear. We performed an EBMT registry study including 275 adult AML patients in first complete remission undergoing first allo-HSCT between 2012 and 2023 using a uniform platform of treosulfan-based conditioning and PTCy. Among them, 206 received haploidentical grafts and 69 underwent 9/10 mismatched unrelated donor (MMUD) transplantation. Median follow-up was 2.5 years. At 2 years, overall survival was 73.1% after haploidentical transplantation and 71.6% after MMUD transplantation (<i>p</i> = 0.96). Leukemia-free survival at 1 year was 66.3% and 65.2%, respectively (<i>p</i> = 0.76). Relapse incidence (17.1% vs. 18.7%, <i>p</i> = 0.84) and nonrelapse mortality (16.6% vs. 16.1%, <i>p</i> = 0.86) were comparable between groups. Rates of Grade II–IV and Grade III–IV acute GVHD were similar, whereas chronic GVHD was higher after haploidentical transplantation (36.4% vs. 12.7%, <i>p</i> = 0.001), without differences in extensive forms. In multivariable analyses, donor type was not associated with overall survival, leukemia-free survival, relapse incidence, or nonrelapse mortality. Increasing age adversely affected outcomes, while Karnofsky performance status ≥ 90 and reduced-intensity conditioning were associated with improved survival. These findings suggest that, within a treosulfan–PTCy platform, major transplant outcomes are comparable between donor types, although haploidentical transplantation was associated with a higher incidence of chronic GVHD.</p>","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"101 11","pages":"2736-2745"},"PeriodicalIF":9.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.70483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}