Alexandria Dental Journal最新文献

{"title":"Microleakage Assessment Using Different Composite Application Techniques in Primary Molars. An In-Vitro Comparative Study","authors":"Sherif Darwish, Moustafa Matar, Mohamed Bayoumi","doi":"10.21608/adjalexu.2024.273938.1479","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.273938.1479","url":null,"abstract":"INTRODUCTION: Resin-based materials are being used in restorative dentistry on a large scale. Since their introduction, they have replaced amalgam restorations due to their esthetics and ongoing improved physical properties. However, microleakage which results from polymerization shrinkage remains to be the main problem of resin restorations. AIM: To assess the microleakage in primary molars after composite application with different layering techniques. MATERIALS AND METHODS : Standardized class I cavities were done in 40 primary extracted molars, filled with composite, placed in 0.5% basic fuchsin solution, and assessed for microleakage using stereomicroscope. RESULTS: Composite filling using the Hot-Dog technique showed the least microleakage when assessed under the stereomicroscope. CONCLUSION: Restoring primary teeth with composite restoration using the Hot-Dog application technique exhibits less marginal leakage with statistically significant differences when compared with the horizontal placement technique, the split horizontal placement technique, and the succussive cusp build-up technique.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"111 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141820587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“THERAPEUTIC EFFECT OF FLAXSEEDS ON OSTEOPOROSIS IN ALVEOLAR BONE OF RATS”","authors":"Sally Samir Sakr, S. Abdelmajeed, Mounir El-Adway, Dina A. Nagui","doi":"10.21608/adjalexu.2023.240759.1418","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.240759.1418","url":null,"abstract":"BACKGROUND: Osteoporosis is a bone disorder, occurs due to disruption of bone remodeling. Primary osteoporosis is observed in post-menopausal women and aging population. Glucocorticoids are implicated as a main cause for secondary osteoporosis. Pharmacological treatments for osteoporosis cause adverse effects thus using natural herbs is preferable. Flaxseeds may has a key role in enhancing bone mass. OBJECTIVES: To assess the therapeutic efficacy of flaxseeds against glucocorticoids induced osteoporosis in alveolar bone of rats. MATERIALS AND METHODS: A total of 45 adult albino female rats were divided into three equal groups, Control group I, Glucocorticoid group II and Flaxseed treated group III. All rats will be fed on basal diet (BD). Rats in group II and III received Methylprednisolone 5 mg/kg 5 days per week by subcutaneous injection for 4 weeks. After induction of osteoporosis, rats in group III were fed with BD supplemented with 7% flaxseeds daily for 8 weeks. After 12 weeks, rats were euthanized. The mandible was dissected and prepared for scanning electron microscope (SEM) and energy dispersive x-ray microanalysis (EDX). RESULTS: It was found that the alveolar bone in the control group had normal ultrastructural traits. There were alterations to the ultrastructure of the cortical bone surface in the glucocorticoid group. The trabecular bone also had wide marrow spaces and poorly developed trabeculae. Compared to group II, group III had a more regular cortical bone surface with well architecture trabeculae and narrow marrow spaces. CONCLUSION : Flaxseeds is suggested as a therapeutic approach for alveolar bone osteoporosis","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"64 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141652416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KIAA0101 IMMUNOHISTOCHEMICAL EXPRESSION IN DIAGNOSTIC DILEMMA BETWEEN AMELOBLASTOMA AND AMELOBLASTIC CARCINOMA (IN VITRO STUDY)","authors":"Ahlaam Hosny Nassef, Hamed Mohamed Anwar Fouad, H. Raslan, A. M. Zahran, Ahmed Mohammad Hussein","doi":"10.21608/adjalexu.2023.244645.1427","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.244645.1427","url":null,"abstract":"INTRODUCTION: Odontogenic tumors are a variety of oral lesions with clinical and histological variability. Some are benign, while others, like ameloblastoma, show infiltrative behavior. The most aggressive destructive odontogenic tumor is ameloblastic carcinoma. Diagnostic challenges arise in differentiating a malignant type from a classic benign ameloblastoma due to overlapping clinicopathologic features, prompting the use of immunohistochemical methods. KIAA0101, a nucleoprotein, is crucial for cell proliferation regulation, and its expression as a prognostic marker is being extensively researched in various human tumor sorts. However, its role in odontogenic tumors still needs more diagnostic research to be approved. Aim of the study: Evaluation of KIAA0101 immunoexpression in ameloblastoma and ameloblastic carcinoma. MATERIAL AND METHODS: Sixty blocks of human odontogenic tissues, divided equally into enamel organs (serving as a normal control), ameloblastoma, and ameloblastic carcinoma, were included in the study. Sections were stained with hematoxylin and eosin to determine an accurate histopathological diagnosis. Immunohistochemical analysis using the KIAA0101 antibody was performed using universal immunostaining techniques. RESULTS: Different immunoexpression of KIAA0101 were expressed in enamel organs, ameloblastoma, and ameloblastic carcinoma. The enamel organs showed the lowest expression levels, while the highest were detected in ameloblastic carcinoma. CONCLUSION : KIAA0101 produced a valuable indicator for tissue proliferation in ameloblastoma and ameloblastic carcinoma","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"122 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TARGETING WNT PATHWAY THROUGH miR-142-3P AS A POTENTIAL THERAPEUTIC APPROACH IN ORAL SQUAMOUS CELL CARCINOMA (IN VITRO STUDY)","authors":"Yara Moustafa Eldahshan, Sahar E. Riad, Hagar Ramadan Elkafrawy, E. Magdy, Mai Mahmoud Saleh","doi":"10.21608/adjalexu.2024.245158.1428","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.245158.1428","url":null,"abstract":"INTRODUCTION: Oral squamous cell carcinoma (OSCC) accounts for 95% of oral cancers and is associated with a low 5-year survival rate using the conventional treatments methods. Advancements in oncological research require understanding the molecular mechanisms driving OSCC occurrence and progression to devise more effective therapeutic approaches and improving prognostic outcomes. Among these mechanisms, the WNT/β -catenin signaling pathway is recognized for its contribution in promoting tumorigenesis, cancer progression, and metastasis, making it a potential target for unconventional cancer therapies. MicroRNA-142-3p (miR-142-3p), a constituent of the miR-142 family, has demonstrated tumor-suppressive properties in certain malignancies. It was proposed that miR-142-3p positively modulates WNT signaling by directly targeting the adenomatous polyposis coli (APC) gene. This targeting destabilizes β -catenin, resulting in suppression of WNT pathway activity. OBJECTIVES: In this current investigation, the aim was to explore the capabilities of miR-142-3p in modulating the WNT pathway and evaluating its impact on the proliferation, migration, and apoptosis of OSCC-4 cells. METHODOLOGY: MiR-142-3p was transfected into OSCC-4 cell line. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was employed to determine cytotoxicity, while the impact on cell migration was evaluated through scratch wound healing test. Apoptotic effects were evaluated using Annexin-V, while cell proliferation was measured through Ki-67 staining, both analyzed by flow cytometry. RESULTS: The results indicated that miR-142-3p suppressed OSCC-4 proliferation and migration, demonstrating its anti-proliferative potential. It didn't induce early apoptosis however, it enhanced late-stage apoptosis in a dose-dependent manner. CONCLUSIONS: miR-142-3p exhibits a promise as a potential therapeutic option for OSCCs.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":" 1054","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological and Mechanical Evaluation of Integrated Nano-Hydroxyapatite in 3D-Printed Polylactic Acid Scaffold","authors":"Mai M Eldokmak, Marwa Essawy, Sally Abdelkader, Salma Abolgheit","doi":"10.21608/adjalexu.2024.243326.1425","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.243326.1425","url":null,"abstract":"INTRODUCTION: Tissue engineering is a technique for simulating nature. It involves the development of artificial substitutes to restore the functions of damaged tissues. It includes the usage of porous matrix to allow its loading with cells to produce a regenerative construct. Most synthetic polymers including polylactic acid used in 3D printing are not designed to act as a scaffold to promote cellular adhesion and has limited bioactivity, so they need modification to increase bioactivity, promote cellular adhesion and then tissue regeneration. OBJECTIVE: Our purpose was to study the bioactivity, compressive strength, elastic modulus and toughness of 3D-printed PLA scaffold modified with 5% nano-hydroxyapatite (nano-HA) versus PLA scaffold. METHODS: The fused deposition modeling method was used to print PLA, and PLA with embedded 5% nano-HA particles in the matrix. The chemical composition and surface properties of scaffolds were characterized by Energy Dispersive X-ray Analysis and Scanning Electron Microscope, the mechanical properties of scaffolds were tested using universal testing machine testing. The scaffold bioactivity was determined by monitoring the deposition of calcium phosphate compounds after simulated body fluid immersion. RESULTS: The nano-HA loaded PLA scaffold showed decreasing compressive strength and toughness which recorded 16.02 MPa and 226.82 J respectively compared to blank PLA scaffold which recorded 27.87 MPa and 1026.7 J, but it showed increasing calcium phosphate crystals deposition. CONCLUSIONS: This study explored the efficacy of modifying PLA scaffold with inductive nano-HA incorporated in the matrix, which improved its bioactivity without interfering with the compressive strength of PLA material significantly.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"118 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE USE OF MAGNETIC MALLET FOR DELAYED IMPLANT PLACEMENT IN POSTERIOR MANDIBLE (RANDOMIZED CONTROLED CLINICAL TRIAL)","authors":"moataz fawzi abdelaziz, S. Osman, Mohamed Shokry","doi":"10.21608/adjalexu.2024.251045.1450","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.251045.1450","url":null,"abstract":"BACKGROUND: Instead of using drills for implant bone site preparation, new tools have been developed to decrease surgical stress, gain more control over the incision, boost primary stability, and shorten recovery and morbidity periods. A novel apparatus that utilises magneto-dynamic technology has been suggested for use in bone surgical procedures, such as the preparation of dental implant sites. AIM OF THE STUDY: Evaluation of the use of magnetic mallet versus conventional drill system for delayed implant placement in posterior mandible. MATERIALS AND METHODS: A randomized, controlled, clinical trial was carried out in patients requiring dental implants to replace their extracted tooth in posterior mandible. Patients who met the inclusion criteria was randomly divided in to two groups: study group (osteotomy with magnetic mallet) and controlled group (osteotomy with conventional drill system) and this was clinically evaluated (primary and secondary stability evaluation ) and radiographically evaluated (bone density evaluation). RESULTS: Implants done with magnetic mallet had a statistically significant higher primary stability than Implants done with drill system and Secondary stability was statistically significant higher in study group than Implants done in control group while Both methods are comparable regarding the bone density . CONCLUSION: Magnetic mallet show better significant primary stability, and secondary stability than the conventional drill system. Both methods are comparable regarding the bone density. RUNNING TITLE:","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"8 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Using the Magnetic Mallet for Ridge Splitting of the Narrow Posterior Mandibular Ridge with Simultaneous Implant Placement (A Clinical Trial)","authors":"Mohamed Hisham Salama, N. Mohamed, Marwa G. Noureldin","doi":"10.21608/adjalexu.2024.238963.1422","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.238963.1422","url":null,"abstract":"INTRODUCTION: Implant placement in the posterior mandible is sometimes problematic due to loss of horizontal bone width after extraction of posterior teeth. With simultaneous implant placement, the Magnetic Mallet can be used in horizontal bone compaction and expansion. OBJECTIVES: To clinically and radiographically evaluate bone width change using the magnetic mallet for ridge splitting of the narrow posterior mandibular ridge. The secondary aim was to radiographically evaluate bone density change using the magnetic mallet for ridge splitting of the narrow posterior mandibular ridge and the implant stability. MATERIALS AND METHODS: Ten patients with narrow posterior mandibular edentulous ridges underwent ridge splitting using the magnetic mallet and osseodensification with simultaneous implant placement. The assessment comprised a cone beam computed tomography analysis of bone width and bone density change at two weeks, 4, and 6 months postoperatively. Furthermore, implant stability was measured using Osstell. RESULTS: The mean bone density preoperatively (480.73±119.38 HU) increased significantly six months after ridge splitting and osseodensification (697.89±86.90 HU). Implant stability also significantly increased at four months postoperatively (62.50±2.64) than immediate postoperative (52.40±3.63) ( p <.001). Bone width showed a significant increase at six months postoperatively (10.34±0.78 mm) when compared with preoperative (8.45±0.84 mm) ( p <.001). CONCLUSION: The magnetic mallet is an effective and minimally invasive method for ridge splitting of the narrow posterior mandibular ridge with simultaneous implant placement for horizontal bone augmentation. A significant increase in bone width, bone density, good implant stability, and minimal postoperative pain evidence this. Furthermore, the technique is believed to be safe and less time-consuming, eliminating the costs and need for bone grafting and saving time, since no need for a second surgery.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":" 1127","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF SHEAR BOND OF TWO PRESSABLE GLASS CERAMICS TO THEIR VENEERING MATERIALS (IN VITRO STUDY)","authors":"momen gamal elsoudany, Ihab Hammad, Islam M. Abdel Raheem","doi":"10.21608/adjalexu.2024.246600.1433","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.246600.1433","url":null,"abstract":"INTRODUCTION: The bond between the veneering ceramic and the substructure is important for the long-term survival of the restorations. However, the shear bond strength (SBS) of heat-pressed ceramic substructures to veneering ceramic materials remains unclear. AIM OF STUDY: This study aimed to evaluate the SBS and mode of failure of two heat-pressed glass ceramic substructures (lithium disilicate (LDS) and zirconia-reinforced lithium silicate (ZLS)) with their corresponding veneering ceramics. MATERIAL AND METHODS. Thirty glass ceramic disk-shaped specimens were fabricated from heat-pressed LDS and ZLS (n = 15) with a diameter of 10mm and a thickness of 3mm. LDS and ZLS specimens were veneered with fluorapatite glass ceramic (FLGC) and leucite-reinforced feldspathic porcelain (LFP), respectively. The veneering material was condensed in a mold and fired on the glass ceramic materials to form a disk with a diameter of 3mm and a thickness of 2mm. Specimens were subjected to shear force in a universal testing machine at a crosshead speed of 0.5 mm/minute until failure of the specimens. The failed specimens were examined under an optical microscope and a scanning electron microscope to analyze the mode of failure. Data were analyzed using independent t-test. RESULTS. LDS (29.75 MPa) showed a statistically significant higher shear bond strength than that ZLS (21.96 MPa) ( P value<.05). LDS group showed predominantly cohesive failure, while ZLS group showed mixed adhesive/cohesive failure. CONCLUSIONS. Zirconia-reinforced lithium silicate complex failed at lower load levels compared to the lithium disilicate complex. The predominantly cohesive failure mode in LDS specimens reflects the higher bond strength that surpassed the cohesive strength of the heat-pressed ceramic and the veneering material","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of The Efficiency of Custom-Made Three-Dimensional PEEK Plates in Mandibular Angle Fractures","authors":"Aliaa O. Kamal, A. Shaaban, Mohamed Shokry","doi":"10.21608/adjalexu.2023.247399.1441","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.247399.1441","url":null,"abstract":"","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF PIEZO-ASSISTED RIDGE SPLITTING USING OSSEODENSIFICATION DRILLS IN NARROW ANTERIOR MAXILLA WITH SIMULTANEOUS IMPLANT PLACEMENT (CLINICAL TRIAL)","authors":"Mahmoud Abdelfattah Moghazy Elbayaa, A. Shaaban, Mohamed Shokry","doi":"10.21608/adjalexu.2023.245469.1429","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.245469.1429","url":null,"abstract":"BACKGROUND: One of the most effective methods for horizontal bone augmentation, particularly in the maxilla, is the alveolar ridge splitting technique. But it is a highly sensitive technique that requires some experience, so using a piezoelectric device for ridge splitting provides high accuracy with fewer complications. AIM OF THE STUDY: This study aimed to assess maxillary anterior ridge splitting using piezotome and osseodensification drills with immediate implant placement. MATERIAL AND METHODS: Eight patients (12 dental implants) with a narrow anterior maxillary ridge without an undercut participated in this clinical study. They were given the assignment of ridge splitting in the anterior segment of the maxilla along with simultaneous implant insertion. Clinical evaluation was done to determine implant stability, postoperative edema and the incidence of intra-or postoperative complications. Radiographic evaluation (CBCT), which uses on-demand software to determine bone density surrounding the implant and bone width gain at the crest of the bone, was done. Clinical and radiographic follow up were done over 6 months. RESULTS: All patients had uneventful wound healing, with the exception of one who had a malformed split and another who had a slight infection that was treated conservatively. Six months postoperatively, bone width was 17.56±10.75% wider than preoperatively, with a statistically significant difference (P value = 0.007*). After six months, there was a 40.56±10.86% increase in bone density, with a statistically significant difference (P value = 0.013*). CONCLUSION: Alveolar ridge splitting using piezotome and osseodensification drills with immediate implant placement appears to be efficient in the treatment of narrow anterior maxillary ridges with less time-consuming.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"121 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}