Journal of nuclear biology and medicine (Turin, Italy : 1991)最新文献_第8页

Fourier amplitude image circumferential profile analysis in the evaluation of the dipyridamole test. 傅立叶振幅图像周向剖面分析在双嘧达莫试验评价中的应用。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

A Bestetti, A Lomuscio, M Castellani, L Giovanella, L Pedrazzini, A Chiti, G L Tarolo

{"title":"Fourier amplitude image circumferential profile analysis in the evaluation of the dipyridamole test.","authors":"A Bestetti, A Lomuscio, M Castellani, L Giovanella, L Pedrazzini, A Chiti, G L Tarolo","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to evaluate a circumferential profile method of analysis (CPA) of the Fourier image of amplitude (FA), obtained by equilibrium gated radionuclide angiocardiography (EGRA) in the assessment of the response to the dipyridamole (DIP) test in patients with previous myocardial infarction. The changes in regional wall motion (RWM) induced by DIP in a group of 29 patients with previous MI were compared with those of a ten-patient control group. On the basis of SPECT thallium-201 standard stress-rest scintigraphy the infarcted patients were divided into 9 patients with fixed perfusion defects at four hours and 20 patients with both fixed and reversible perfusion defects. The quantitative CPA was carried out on the FA image normalized by the mean amplitude calculated for the left ventricle (LV) area. A circular ROI was drawn around the FA left ventricle image and two curves (basal and post-DIP) with 60 points were obtained. We compared this method with a five-sector method of analysis applied to the same FA images. An increase of 2 or more SD in the basal post-DIP ratio curve, compared with the average of the ratios in the control group, was found in 16 of 20 patients with reversible perfusion defects (sensitivity: 80%) and an increase in the same ratio was found in 2 of 9 MI patients with fixed perfusion defects (specificity: 78%). A sensitivity and specificity of 60% and 78% respectively were found using sectorial analysis.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"185-90"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19163055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallium-67 scintigraphy in an AIDS patients presenting tuberculous pericarditis. 1例艾滋病结核性心包炎的镓-67显像。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

P Bertolaccini, M Chimenti, S Bianchi, G Manfredini, G Barattini, A Maneschi

引用次数: 0

Radioimmunoscintigraphy with 99mTc-225.28S-F(ab')2 in cutaneous and ocular melanomas: cases of particular clinical interest. 99mTc-225.28S-F(ab’)2放射免疫显像在皮肤和眼部黑色素瘤中的应用:具有特殊临床意义的病例

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

F Salzillo, M Mele, T Lombardo, N Delle Noci, C Minervini, A D'Addabbo

{"title":"Radioimmunoscintigraphy with 99mTc-225.28S-F(ab')2 in cutaneous and ocular melanomas: cases of particular clinical interest.","authors":"F Salzillo, M Mele, T Lombardo, N Delle Noci, C Minervini, A D'Addabbo","doi":"","DOIUrl":"","url":null,"abstract":"In the attempt to contribute to a correct and early diagnosis of melanoma, this paper critically evaluates, in 40 patients with cutaneous localization and 20 with ocular localization, the results of immunoscintigraphy with 99mTc-225.28S-F(ab')2 and the clinical, instrumental and biopsy findings. While the cutaneous melanoma group is mainly composed of patients subjected to surgical exeresis of the lesion before radioimmunoscintigraphy (RIS), the ocular melanoma group is composed of patients with the primary lesion in situ or previously treated with contact radiotherapy. In the cutaneous melanoma group 5 cases presented falsely positive immunoscintigraphic findings, and only 2 falsely negative. In the ocular melanomas, the percentage of false negatives was higher (n = 7). This is probably attributable to the antigenic expressivity, higher in the metastases than in the primary melanomas. The cases of particular interest are discussed in relation to the clinical picture, to the instrumental examinations and to the histological findings. The work made it possible to contribute to a more correct interpretation of the RIS findings in the staging and follow-up of cutaneous and ocular melanomas.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"191-7"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19163056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Captopril renal scintigraphy: a viewpoint. 卡托普利肾显像:一个观点。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

M Dondi, S Fanti, N Monetti

引用次数: 0

Thallium-201 lung uptake: comparison of an automatic and a manual method of ROI drawing. 铊-201肺摄取:自动和手动ROI绘制方法的比较。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

M Castellani, A Chiti, L C Giovanella, A Bestetti, A Lomuscio, G L Tarolo

{"title":"Thallium-201 lung uptake: comparison of an automatic and a manual method of ROI drawing.","authors":"M Castellani, A Chiti, L C Giovanella, A Bestetti, A Lomuscio, G L Tarolo","doi":"","DOIUrl":"","url":null,"abstract":"An automatic method for ROI drawing to measure 201TI lung uptake after stress testing in planar and tomographic myocardial perfusion imaging, was compared with the more commonly used manual method. A linear correlation in the lung/heart ratio (LHR) and lung washout (LWO) data, obtained in planar and SPECT images with the two methods, was found. Pearson's correlation coefficient between the automatic and manual methods was highly significant both for LHR and for LWO. For LHR we found a high linear correlation between the two methods in the planar anterior (r = 0.71, p < 0.001), SPECT anterior (r = 0.84, p < 0.001), and SPECT LAO (r = 0.96, p < 0.001) views. The analysis of LWO data showed a good linear correlation for the planar anterior (r = 0.84, p < 0.001), SPECT anterior (r = 0.66, p < 0.005) and SPECT LAO (r = 0.79, p < 0.001) views. Furthermore, comparison by the student's t test of the averages of the LHR and LWO values obtained in the same views but with different methods was performed. The advantages and the critical issues associated with the automatic method are discussed; it appears to be quick and easy to perform and to be equivalent to the more time-consuming method based on a manual definition of left lung ROI.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"213-7"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19163625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Captopril scintigraphy: procedure, results, and theoretical evaluation of validity. 卡托普利显像:程序、结果和效度的理论评价。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

B Bubeck

引用次数: 0

Dual isotope myocardial perfusion SPECT in the detection of coronary artery disease: comparison of separate and simultaneous acquisition protocols. 双同位素心肌灌注SPECT在冠状动脉疾病检测中的应用:单独采集和同时采集方案的比较。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

M Unlu, S Gunaydin, N Ilgin, S Inanir, N Gokcora, L Gokgoz

{"title":"Dual isotope myocardial perfusion SPECT in the detection of coronary artery disease: comparison of separate and simultaneous acquisition protocols.","authors":"M Unlu, S Gunaydin, N Ilgin, S Inanir, N Gokcora, L Gokgoz","doi":"","DOIUrl":"","url":null,"abstract":"A time-saving dual isotope acquisition protocol was carried out for the simultaneous assessment of stress and rest myocardial perfusion, and the diagnostic value of the technique was evaluated using coronary angiography results as a reference. Fifty-five patients undergoing coronary angiography before surgery were included in the study. Stress tests were applied, either with a treadmill (25 patients) or dobutamine infusion (30 patients in 5-40 micrograms/kg/min doses). All patients received 3 mCi of thallium-201 at rest. Stress tests were applied 30 minutes later, and at peak stress 7 mCi of 99mTc-MIBI was administered. A dual isotope SPECT study was carried out one hour after the administration of 99mTc-MIBI. Tracer doses were optimised with phantom studies, and the down-scatter of each radioisotope on the other data was investigated. In 30 patients, 10 minutes after the 201Tl injection a separate rest 201Tl acquisition was also performed, to compare the data with dual acquisition. 201Tl rest imaging SPECT data was evaluated by segmental analysis according to coronary artery regions. In 55% of the segments stress defects were observed. Similar results were obtained for the detection of defect reversibility; i.e. stress MIBI/rest 201Tl (75%) and stress MIBI/simultaneous 201Tl (78%). The overall sensitivity and specificity of simultaneous dual isotope SPECT with respect to coronary angiography results were 88% and 84%, respectively. A good correlation and no significant difference was observed between the two acquisition methods. However, the simultaneous acquisition protocol has many advantages, i.e. halving the acquisition time, shortening the overall decision-making time, and decreasing unmatched stress-rest artifacts.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"233-7"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19163629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeatability of haemodynamic responses to cardiac stimulations by ambulatory monitoring of left ventricular function. 动态监测左心室功能对心脏刺激血流动力学反应的可重复性。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

M Imbriaco, A Cuocolo, L Pace, A Nappi, E Nicolai, S Maurea, M Salvatore

{"title":"Repeatability of haemodynamic responses to cardiac stimulations by ambulatory monitoring of left ventricular function.","authors":"M Imbriaco, A Cuocolo, L Pace, A Nappi, E Nicolai, S Maurea, M Salvatore","doi":"","DOIUrl":"","url":null,"abstract":"Ambulatory monitoring (VEST) of left ventricular (LV) function has been shown to be accurate and repeatable. The aim of this study was to assess VEST repeatability in the evaluation of haemodynamic responses to different cardiac stimulations. Twelve patients (all men, mean age 59 +/- 8 years) underwent two separate VEST studies 5-day apart. In both studies, LV function was continuously monitored at rest and during different cardiac stimulations: 1) changing position from supine to upright (tilt); 2) sustained isometric exercise (handgrip); and 3) sublingual administration of 5 mg of nitroglycerin (NTG). Changes from baseline to peak response (delta) in the heart rate, ejection fraction, end-diastolic volume, end-systolic volume, stroke volume and cardiac output were evaluated. Reproducibility was assessed by computing, the coefficient of repeatability. In addition, the differences between the delta values obtained with the two VEST studies were plotted against their mean. This plot allowed us to detect whether there was any relationship between the error in the measurements and the best estimate of the \"true value\". No statistically significant differences between the two VEST studies were found in the haemodynamic changes in heart rate, ejection fraction, end-diastolic volume, end-systolic volume, stroke volume and cardiac output induced by handgrip, tilt and NTG. For each parameter the mean difference was not significantly different from zero and no significant relationship between the error and the \"true value\" was observed. Our results demonstrate that VEST has a good repeatability in measuring cardiac haemodynamic responses to different types of stimulations.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"238-44"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19163630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interference of specific autoantibodies in the assessment of serum thyroglobulin. 特异性自身抗体对血清甲状腺球蛋白测定的干扰。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

A Ligabue, M C Poggioli, A Zacchini

{"title":"Interference of specific autoantibodies in the assessment of serum thyroglobulin.","authors":"A Ligabue, M C Poggioli, A Zacchini","doi":"","DOIUrl":"","url":null,"abstract":"Prevalence of anti-thyroglobulin autoantibody (anti-TG Ab) above 120 IU/mL was 0.238 in 491 healthy and thyroid-disorder patients (80% female, mean overall age 50 +/- 15 years) presenting to the laboratory for contrastographic, endocrinologic, or general medical purposes. It is well known that anti-TG Ab (autoantibodies to thyroglobulin) can lead to the underestimation of serum thyroglobulin (TG). In this work, recovery (REC) of TG (thyroglobulin) added to the specimen was performed in all TG assays and low REC values were considered indicative of interference. The results show that REC = 70% is a very good cut-off value both for the anti-TG Ab prevalence found in our patients and in all prevalences below 0.6. However, we used an 80% cut-off which shows higher (+11%) sensitivity and in consequence improves the clinical decision. Only 60% of low REC values are directly attributable to high levels of anti-TG Ab. In the remaining 40%, low REC values are associated with low anti-TG Ab (< 120 IU/mL). These data indicate that anti-TG Ab concentrations are not always sufficient for evaluation of interference levels since they do not take account the actual effectiveness of anti-TG Ab. In fact, the same level of anti-TG Ab may reduce REC to different degrees (up to ten times) depending on the source serum. The practical consequence of this marked variability of autoantibody activity is that in the usual double Ab immunoassays REC must be determined for each sample to avoid unsuspected interference and negative influences on the clinical decision.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"273-9"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of silent left ventricular dysfunction during daily activities in coronary artery disease patients by the nuclear VEST. 核VEST检测冠心病患者日常活动中无症状左心室功能障碍

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-12-01

I V Vassiliadis, J Machac, S Sharma, S F Horowitz, S J Goldsmith

{"title":"Detection of silent left ventricular dysfunction during daily activities in coronary artery disease patients by the nuclear VEST.","authors":"I V Vassiliadis, J Machac, S Sharma, S F Horowitz, S J Goldsmith","doi":"","DOIUrl":"","url":null,"abstract":"Myocardial ischemia during routine daily activities was studied in patients with known coronary artery disease with an ambulatory radionuclide probe and recording device (VEST) and routine rest and exercise gated blood pool imaging. Seventeen patients were monitored for 60 minutes while sitting (baseline), standing in place, walking, eating (6 patients), and urinating (4 patients). Eleven of them (64%) failed to show an augmentation of at least 5% in the LVEF on an exercise gated blood pool imaging study (Group I) and 6 (36%) showed a normal response (Group II). Three patients (18%) in Group I experienced angina. Transient left ventricular dysfunction was detected by the VEST during walking, urinating or eating in 80% of the patients in Group I and 33% in Group II (p < 0.05). During walking, mean ejection fraction slightly decreased from 45 +/- 12% to 43 +/- 13% in Group I while the ejection fraction increased from 46 +/- 8% to 51 +/- 12% in Group II (p = 0.04 for the difference in responses). Standing in place and eating did not affect the mean ejection fraction. Urination in 4 patients in Group I caused a significant drop in ejection fraction in 3 patients for a mean change from 51 +/- 9% at rest to 42 +/- 15%. By contrast, none of the patients had angina or diagnostic ECG changes during the monitoring period.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 4","pages":"198-206"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19163057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0