Journal of nuclear biology and medicine (Turin, Italy : 1991)最新文献_第10页

Amino-dextran-deferoxamine: a potential polymeric heterobifunctional agent for high-level 111In-labeling of anti-melanoma monoclonal antibody TP41.2. 氨基右旋-去铁胺:抗黑色素瘤单克隆抗体TP41.2高水平111in标记的潜在多聚异功能剂

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-06-01

T S Wang, R A Fawwaz, R L Van Heertum

{"title":"Amino-dextran-deferoxamine: a potential polymeric heterobifunctional agent for high-level 111In-labeling of anti-melanoma monoclonal antibody TP41.2.","authors":"T S Wang, R A Fawwaz, R L Van Heertum","doi":"","DOIUrl":"","url":null,"abstract":"Amino-dextran-10 (ADX-10) was partially oxidized to polyaldehyde-ADX which was then reacted with deferoxamine (DFO) to form a Schiff's base and converted into a secondary amine, ADX-DFO (I) with ten moles of DFO per mole of ADX. ADX-DFO was chelated with Indium or 111In to yield ten moles of In or 111In per mole of ADX-DFO. A selective maleimide derivatization of (I) with sulfosuccinimidyl-4-(p-maleimidophenyl) butyrate yielded (II), which contained 3 moles of maleimide groups per mole of (II). The sulfhydryl-amidinium derivatization of the monoclonal antibody (MoAb) TP41.2 with 2-IT produced (III). Compounds (II) and (III) were combined to form the thioether space-arm linkage of (IV), which was subsequently radiolabeled with 111In to yield (V). MoAb-DFO-111In, (VI), was also prepared for a control study. Direct cell binding revealed the immunoreactivity of (V) to be 79.7% and that of (VI) to be 60.3%. The in vitro stability of (V) at 4, 24, and 48 hours resulted in 1.7%, 7.0% and 16.0% hydrolysis respectively, as compared with 2.1%, 8.7% and 18.5% hydrolysis of the control (VI), at the same time intervals. In a biodistribution study in non-tumor rats at 4, 24, and 48 hours post-injection, the liver concentration at 48 hours was 2.97% (ID/g) for (V) and 4.84% (ID/g) for (VI). This novel technique for radiolabeling antibodies allows for a high level of radiometallic labeling, preservation of immunoreactivity, and reduction of uptake by the liver.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 2","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19359854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum 25-hydroxyvitamin D levels in normal subjects: seasonal variations and relationships with parathyroid hormone and osteocalcin. 正常人血清25-羟基维生素D水平:季节性变化及其与甲状旁腺激素和骨钙素的关系

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-06-01

A Benucci, M Tommasi, B Fantappié, S Scardigli, S Ottanelli, E Pratesi, S Romano

引用次数: 0

Detection of abnormal esophageal motility and gastroesophageal reflux in patients with angina-like chest pain by a radionuclide esophageal transit test. 放射性核素食管透射试验检测心绞痛样胸痛患者食管运动异常和胃食管反流。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-06-01

C H Kao, K Y Wang, S J Wang, Y T Chen, S H Yeh

{"title":"Detection of abnormal esophageal motility and gastroesophageal reflux in patients with angina-like chest pain by a radionuclide esophageal transit test.","authors":"C H Kao, K Y Wang, S J Wang, Y T Chen, S H Yeh","doi":"","DOIUrl":"","url":null,"abstract":"A modified radionuclide esophageal transit test including the esophageal mean transit time (MTT), residual fraction (RF) and retrograde index (RI), was carried out to evaluate esophageal motility and to detect gastroesophageal reflux in three groups: (A) 25 patients (13 males, 12 females, age: 45-65 years) with angina-like chest pain but normal coronary angiogram; (B) 31 patients (14 males, 17 females, age: 42-63 years) with coronary artery disease (CAD) demonstrated by abnormal coronary angiographic findings and intractable angina-like chest pain even after treatment; and (C) 25 normal volunteers (10 males, 15 females, age: 39-67 years). In groups A and B abnormal results were found in 60% (15/25) and 39% (12/31) for MTT; in 28% (7/25) and 39% (12/31) for RF and in 36% (9/25) and 58% (18/31) for RI (i.e., higher than the mean +/- 2 SD of normal values; MTT: 5.72 +/- SD 0.91, RF: 0.129 +/- SD 0.057, RI: 0.055 +/- SD 0.054), respectively. We conclude that the causes of non-cardiac chest pain in group A patients with normal coronary arteries were primarily esophageal dysmotility or spasm (prolonged MTT). However, in group B patients decreased pressure of the lower esophageal sphincter due to the side effects of anti-angina drugs induced delayed cleaning of the esophagus (higher RF) or gastroesophageal reflux (higher RI).","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 2","pages":"53-6"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19359847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TSH-receptor antibody (TSH-R Ab) variations in patients undergoing subtotal thyroidectomy for Graves' disease: a prospective study. 格雷夫斯病甲状腺次全切除术患者tsh受体抗体(TSH-R Ab)变化:一项前瞻性研究

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-06-01

D Rubello, D Casara, M R Pelizzo, M E Girelli, A Piotto, M Piccolo, B Busnardo

{"title":"TSH-receptor antibody (TSH-R Ab) variations in patients undergoing subtotal thyroidectomy for Graves' disease: a prospective study.","authors":"D Rubello, D Casara, M R Pelizzo, M E Girelli, A Piotto, M Piccolo, B Busnardo","doi":"","DOIUrl":"","url":null,"abstract":"Variations in circulating TSH-R Ab were correlated to the thyroid function outcome in a group of 43 patients who received subtotal thyroidectomy for Graves' disease. There were 36 females and 7 males, ranging in age from 18 to 63 years (mean +/- SD = 41.3 +/- 9.5 years). All patients were operated on by the same surgeon, with the same surgical technique, leaving a remnant of 4-5 grams of thyroid. When a condition of subclinical hypothyroidism was found after surgery, thyroid function was tested again within 2-3 months. Thus, in cases with persisting elevated TSH levels, L-thyroxine was administered. During follow-up a progressive decrease in the prevalence of euthyroid patients was documented (51.2% at 3 months, 30.2% at 2 years, 28% at 4 years), with a parallel increase in cases of subclinical and overt hypothyroidism. Two patients with persisting detectable TSH-R Abs showed recurrent disease within 2 years after surgery. No case of relapse was observed among patients who became TSH-R Ab negative. TSH-R Abs remained detectable in 68% of euthyroid and in 63.6% of subclinical hypothyroid patients before L-thyroxine administration, whereas TSH-R Abs remained positive in only 30% of patients with overt hypothyroidism, and became undetectable in most patients with subclinical hypothyroidism after L-thyroxine was begun. The persistence of TSH-R Abs in patients who have undergone surgery for Graves' disease should be considered a risk condition for relapse. These patients must be carefully followed-up.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 2","pages":"73-6"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19359850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

99mTc-MAG3 and 99mTc-DMSA in the detection and assessment of pyelonephritis. 99mTc-MAG3、99mTc-DMSA对肾盂肾炎的检测与评价。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-06-01

F Tamgac, J L Moretti, J M Rocchisani, G Baillet, P Weinmann

引用次数: 0

Semiquantitative evaluation of regional cerebral flow by means of SPECT with 99mTc-hexamethyl-propylene amine oxime in hypertensive patients under treatment. 用99mtc -六甲基丙烯胺肟SPECT半定量评价高血压治疗患者脑血流。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-03-01

F Claudiani, P Stimamiglio, C Castello, G Villavecchia, M Cabria, L Bertolazzi

{"title":"Semiquantitative evaluation of regional cerebral flow by means of SPECT with 99mTc-hexamethyl-propylene amine oxime in hypertensive patients under treatment.","authors":"F Claudiani, P Stimamiglio, C Castello, G Villavecchia, M Cabria, L Bertolazzi","doi":"","DOIUrl":"","url":null,"abstract":"Cerebral SPECT with 99mTc-HM-PAO allows a semiquantitative evaluation of regional cerebral blood flow (rCBF). Using this method we studied 25 patients affected by slight-to-moderate degree hypertension, in effective pharmacological treatment, and a control group of normotensives. On the cross-sections symmetrical ROIs were traced at the level of the cerebral lobes and the cerebellum. From the counts obtained on the ROIs the rCBF values were calculated in percentage units with Lassen's algorithm. We found no significant differences between the rCBF values of the two groups. In 5 hypertensive patients, however, focal areas of hypoperfusion were evidenced. These patients did not differ from the other hypertensives by pressure levels or other risk factors. Neurological, tomographic and flowmeter examinations of the supraaortic arteries proved to be normal. It is possible that SPECT with 99mTc-HM-PAO identifies a subgroup of hypertensives at risk of future cerebrovascular pathology despite the setting up of an effective antihypertensive therapy.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19316742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[123I]IBZM uptake in metastatic melanoma. [1231]刘建平。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-03-01

L S Maffioli, L Mascheroni, C Clemente, M Baldini, M R Castellani

引用次数: 0

Comparison of pertechnetate and radioiodine thyroid scintiscans in thyroid disease. 高锝酸盐与放射性碘甲状腺扫描在甲状腺疾病中的比较。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-03-01

E Reschini, A Catania, C Ferrari, M Bergonzi, A Paracchi, P Raineri

引用次数: 0

Performance evaluation of a hand-held gamma detector probe used for radioimmunoguided surgery. 用于放射免疫引导手术的手持式伽玛探测器的性能评价。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-03-01

G Roncari, A Benevento, L Bianchi, L Ceriani, S Garancini, J Lovisolo, R Dionigi

{"title":"Performance evaluation of a hand-held gamma detector probe used for radioimmunoguided surgery.","authors":"G Roncari, A Benevento, L Bianchi, L Ceriani, S Garancini, J Lovisolo, R Dionigi","doi":"","DOIUrl":"","url":null,"abstract":"The success of radioimmunoguided surgery (RIGS) is dependent on the performance parameters of the apparatus, its correct handling, and the employment of a suitable radioactive compound. In the present study the authors examined the performance of the Neoprobe 1000 device with respect to the radioisotope 99mTc. Detecting efficiency was evaluated experimentally using a phantom containing a radioactive point source which could be moved both vertically and horizontally with respect to the central axis of the probe. In this way curves representing the variations in efficiency as a function of the vertical and horizontal distances of the source from the probe were constructed. Furthermore, values of minimum detectable activity as a function of source depth, counting time and background radioactivity were calculated. These results were compared to those previously obtained using 125I, the radioisotope most frequently employed in RIGS. The graphs and tables included could serve as a practical aid to help the operator obtain the best possible measuring conditions, thereby maximizing his/her results.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 1","pages":"21-5"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19315347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed effect of streptokinase on left ventricular function after acute myocardial infarction assessed by equilibrium gated radionuclide angiocardiography. 链激酶对急性心肌梗死后左心室功能的延迟影响。

Journal of nuclear biology and medicine (Turin, Italy : 1991) Pub Date : 1993-03-01

A Bestetti, A Lomuscio, A Chiti, L C Giovanella, M Castellani, G L Tarolo

{"title":"Delayed effect of streptokinase on left ventricular function after acute myocardial infarction assessed by equilibrium gated radionuclide angiocardiography.","authors":"A Bestetti, A Lomuscio, A Chiti, L C Giovanella, M Castellani, G L Tarolo","doi":"","DOIUrl":"","url":null,"abstract":"A blind comparative study was conducted on 80 consecutive patients who were given Streptokinase (SK) or placebo between 3 and 6 hours after the onset of acute myocardial infarction (AMI). Left ventricular ejection fraction (LVEF), peak ejection rate (PER), peak filling rate (PFR) and regional wall motion (RWM) were evaluated by equilibrium gated radionuclide angiocardiography (EGRA) at 3-5 weeks and 6 months after the onset of AMI. In the anterior AMI SK-group, the mean LVEF values rose from 0.37 at one month to 0.43 at six months, PER (end-diastolic volumes per second) from 1.76 to 2.00, and PFR (end-diastolic volumes per second) from 1.46 to 1.75 (p = 0.01, p < 0.05, and p < 0.05, respectively). In the anterior non-SK group no improvement was seen in any of the LV function parameters. Only a slight improvement was observed in the inferior AMI group, with no significant difference between the treated and non-treated patients. The regional wall motion analysis was in agreement with the global function data. In conclusion, SK treatment given between three and six hours after the onset of anterior AMI may result in some improvement in LV function, which becomes fully appreciable only after the complete resolution of stunning, i.e. after more than one month.","PeriodicalId":77217,"journal":{"name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","volume":"37 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19315350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0