International journal of cardiac imaging最新文献_第8页

BMIPP imaging to assess functional outcome in patients with acute and chronic left ventricular dysfunction. BMIPP成像评估急性和慢性左心室功能不全患者的功能结局。

International journal of cardiac imaging Pub Date : 1999-02-01 DOI: 10.1023/a:1006128116056

P R Franken, A S Hambÿe, F W De Geeter

引用次数: 5

beta-Methyl-p-(123I)-iodophenyl pentadecanoic acid single-photon emission computed tomography in cardiomyopathy. -甲基-p-(123I)-碘苯五酸单光子发射计算机断层扫描在心肌病中的应用。

International journal of cardiac imaging Pub Date : 1999-02-01 DOI: 10.1023/a:1006188301035

T Nishimura

{"title":"beta-Methyl-p-(123I)-iodophenyl pentadecanoic acid single-photon emission computed tomography in cardiomyopathy.","authors":"T Nishimura","doi":"10.1023/a:1006188301035","DOIUrl":"https://doi.org/10.1023/a:1006188301035","url":null,"abstract":"beta-Methyl-p-(123I)-iodophenyl pentadecanoic acid (BMIPP) is one of the branched-chain free fatty acids, which has suitable characteristics for myocardial SPECT because of higher uptake and longer retention in the myocardium. Recent advances of BMIPP myocardial SPECT for evaluating cardiomyopathy were reviewed. BMIPP defects were observed in 80% patients with hypertrophic cardiomyopathy (HCM). Moreover, BMIPP uptake was reduced at sites that corresponded with hypertrophic areas, where thallium uptake was increased. The correlations between severity score and septal wall thickness and LV function were better with BMIPP SPECT, suggesting that BMIPP is more suitable for the assessment of myocardial integrity in HCM. The dissociation between BMIPP and thallium defects was not observed frequently in dilated cardiomyopathy (DCM). We carried out BMIPP myocardial SPECT to evaluate the therapeutic effects of co-enzyme Q10 on DCM patients. Hearts to the mediastinum ratio and BMIPP defect scores were significantly decreased after co-enzyme Q10 treatment. BMIPP myocardial SPECT was confirmed to be sensitive in evaluating the therapeutic effect for the perspective of metabolic SPECT imaging. Recently, a lack of myocardial uptake of BMIPP has been found in a small subset of patients (0.3%-1.2%). Cardiac radionuclide imaging using BMIPP and 18F-FDG were performed on patients with type I CD36 deficiency. The percent dose uptake of 18F-FDG was significantly higher than in normal controls. CD functions as a major myocardial long-chain fatty acid transporter and its absence may lead to a compensatory upregulation of myocardial glucose uptake. An increased frequency of CD36 deficiency was demonstrated in cardiomyopathy. Therefore, fatty acid transport proteins and their related gene defects in relation to BMIPP uptake may become an important issue in the future.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 1","pages":"41-8"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006188301035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21317819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

BMIPP compared with PET metabolism. BMIPP与PET代谢比较。

International journal of cardiac imaging Pub Date : 1999-02-01 DOI: 10.1023/a:1006148619691

E Tadamura, N Tamaki, T Kudoh, N Hattori, J Konishi

引用次数: 5

Myocardial imaging with 123I-BMIPP in patients with congestive heart failure. 充血性心力衰竭患者心肌显像123I-BMIPP。

International journal of cardiac imaging Pub Date : 1999-02-01 DOI: 10.1023/a:1006152804670

Y Ishida, Y Yasumura, N Nagaya, K Fukuchi, K Komamura, M Takamiya, K Miyatake

{"title":"Myocardial imaging with 123I-BMIPP in patients with congestive heart failure.","authors":"Y Ishida, Y Yasumura, N Nagaya, K Fukuchi, K Komamura, M Takamiya, K Miyatake","doi":"10.1023/a:1006152804670","DOIUrl":"https://doi.org/10.1023/a:1006152804670","url":null,"abstract":"First, we studied the diagnostic utility of myocardial imaging with 123I-BMIPP (BMIPP), a 3-methyl-branched fatty acid analog, in patients with various types of cardiomyopathy and left ventricular dysfunction (ejection fraction below 40%) by comparing with myocardial flow tracer imaging. The incidence of a dissociation between myocardial BMIPP and 201Tl distributions (BMIPP < 201Tl) as a marker of metabolic abnormality in viable tissue varied considerably among various heart diseases. Patients with ischemic cardiomyopathy and the dilated form of hypertrophic cardiomyopathy had a higher incidence while those with idiopathic dilated, alcoholic and hypertensive cardiomyopathy had a lower incidence. These results suggest that the marked difference between ischemic and idiopathic dilated cardiomyopathies may contribute to the differential diagnosis between these two diseases which are main basic abnormalities in congestive heart failure. Second, we investigated the relationship between myocardial BMIPP uptake and ventricular stress in patients with right ventricular pressure overload due to pulmonary hypertension. Myocardial BMIPP uptake in the right ventricle estimated by referring to uptake in the left ventricle showed a significant correlation with mean pulmonary artery pressure (mPAP) and no significant difference with myocardial 99mTc-sestamibi uptake in the 15-81 mmHg mPAP range. These results suggest that myocardial utilization of free fatty acid may be preserved in the presence of higher ventricular wall stress.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 1","pages":"71-7"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006152804670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21317822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

BMIPP-design and development. bmipp -设计和开发。

International journal of cardiac imaging Pub Date : 1999-02-01 DOI: 10.1023/a:1006147228352

F F Knapp, J Kropp

{"title":"BMIPP-design and development.","authors":"F F Knapp, J Kropp","doi":"10.1023/a:1006147228352","DOIUrl":"https://doi.org/10.1023/a:1006147228352","url":null,"abstract":"In the early 1980s a major obstacle for myocardial SPECT using iodine-123-labeled fatty acids and imaging technology available at that time was the rapid metabolism and myocardial washout of activity. Development of the 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) fatty acid analogue was based on the established effects of methyl-branching in delineating the enzymatic aberration in Refum's disease and our early studies with the tellurium (Te)-substituted fatty acid analogues. Extensive animal studies with the Te-fatty acids demonstrated that this major structural alteration did not affect initial myocardial extraction, but could successfully inhibit subsequent metabolism and significantly delay washout. Tracer kinetic evaluation and metabolic studies on experimental animals and Langendorff-perfused rat hearts clearly demonstrated that introduction of methyl-branching is an effective approach which alters tracer kinetics by delaying myocardial washout of radioiodinated fatty acids by increasing myocardial retention. Although irreversible retention of iodine-123 BMIPP is not observed, subsequent extensive human studies have clearly substantiated the delayed myocardial washout of BMIPP in comparison with the p-IPPA straight chain analogue. Although contemporary SPECT capabilities allow much more rapid acquisition periods, the delayed washout is still a practical benefit in relation to the use of BMIPP. Most important, the unexpected mis-match which has been widely observed between perfusion tracer distribution and the regional BMIPP distribution (i.e. BMIPP < flow tracer) has been linked to the identification of jeopardized, but viable myocardial regions. In this paper the development of BMIPP is discussed and the results of recent studies focusing on evaluating the effects of the absolute configuration of the branched methyl group using the 3(R)-BMIPP and 3(S)-BMIPP are described.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006147228352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21318580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Calculation of left ventricular outflow tract area using three-dimensional echocardiography. Influence on quantification of aortic valve stenosis. 三维超声心动图计算左室流出道面积。对主动脉瓣狭窄量化的影响。

International journal of cardiac imaging Pub Date : 1998-12-01 DOI: 10.1023/a:1006045303442

T Menzel, S Mohr-Kahaly, S Wagner, T Fischer, A Brückner, J Meyer

{"title":"Calculation of left ventricular outflow tract area using three-dimensional echocardiography. Influence on quantification of aortic valve stenosis.","authors":"T Menzel, S Mohr-Kahaly, S Wagner, T Fischer, A Brückner, J Meyer","doi":"10.1023/a:1006045303442","DOIUrl":"https://doi.org/10.1023/a:1006045303442","url":null,"abstract":"In 23 patients with aortic valve stenosis (14 male, 9 female, mean age 66 +/- 21.5 years) left ventricular outflow tract cross-sectional area was determined in planimetric fashion using three-dimensional echocardiography. The 3-D data-set for each patient had been acquired in the course of a multiplane transesophageal examination. Aortic valve area was determined using the continuity equation. Results obtained were compared to those calculated by continuity equation using to the conventionally determined LVOT area (a = pi [d/2]2). As reference method the results were compared to invasive measurements. 3-D planimetric determination of LVOT cross-sectional area was possible in 20 of 23 patients. In three patients, this method failed due to artefacts. The mean difference to the conventionally calculated LVOT area amounted to 0.18 cm2 (SD = 0.46). The comparison of AVA determined by continuity equation and by invasive measurement showed a mean difference of -0.074 cm2 (SD = 0.21) for the conventionally calculated LVOT area; for the planimetrically determined LVOT area the mean difference of AVA amounted to -0.03 cm2 (SD = 0.14) (p < 0.05). Planimetric determination of LVOT area using 3-D echocardiography improves the agreement of the continuity equation with invasive measurement.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"14 6","pages":"373-9"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006045303442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21319237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Assessment of the normal adult right ventricular diastolic function using M-mode echocardiographic measurement of tricuspid ring motion. 用m型超声心动图测量三尖瓣环运动评价正常成人右心室舒张功能。

International journal of cardiac imaging Pub Date : 1998-12-01 DOI: 10.1023/a:1006127128984

Y Nakagawa, S Fujimoto, R Mizuno, A Kimura, T Hashimoto, H Nakano, K Dohi

{"title":"Assessment of the normal adult right ventricular diastolic function using M-mode echocardiographic measurement of tricuspid ring motion.","authors":"Y Nakagawa, S Fujimoto, R Mizuno, A Kimura, T Hashimoto, H Nakano, K Dohi","doi":"10.1023/a:1006127128984","DOIUrl":"https://doi.org/10.1023/a:1006127128984","url":null,"abstract":"Right ventricular function can be evaluated echocardiographically by assessing the longitudinal motion of the tricuspid ring recorded in the apical four chamber view. In this study, we applied this technique to assess the right ventricular diastolic function in 10 healthy Japanese men (mean age: 28 +/- 6 years; age range: 20-43 years). Echocardiographic studies were performed with a phased-array imaging system using a 2.5 MHz probe. Tricuspid ring motion was measured by two-dimensional echo guided M-mode echocardiogram of the right lateral tricuspid ring. The excursion of the tricuspid ring during early diastole (DS; mm) and the peak rate of change of the excursion (dS/dt; mm/sec) were measured. We also assessed the right ventricular function by cine magnetic resonance imaging (MRI). Cine gradient echo images were obtained along the short axis of the right ventricle. The right ventricular volume at each phase of the cardiac cycle was calculated by Simpson's method and time-volume curves were constructed. The peak filling rate (dV/dt; ml/s) was determined from these time-volume curves. The dS was 12.8 +/- 2.5 mm, dS/dt was 132 +/- 27 mm/sec and dV/dt was 269 +/- 66 ml/s. There were significant positive correlations between dS and dV/dt (r = 0.80, P < 0.01), and between dS/dt and dV/dt (r = 0.45, P < 0.05). Based on our results, M-mode echocardiographic measurements of tricuspid ring motion may be used to assess the right ventricular diastolic function.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"14 6","pages":"391-5"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006127128984","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21318577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Time-course of dobutamine-induced wall motion abnormalities in the infarct area following thrombolytic therapy. 溶栓治疗后多巴酚丁胺诱导梗死区壁运动异常的时间过程。

International journal of cardiac imaging Pub Date : 1998-12-01 DOI: 10.1023/a:1006028526024

R Bigi, G Curti, C Sponzilli, D Castini, G Occhi, C Fiorentini

{"title":"Time-course of dobutamine-induced wall motion abnormalities in the infarct area following thrombolytic therapy.","authors":"R Bigi, G Curti, C Sponzilli, D Castini, G Occhi, C Fiorentini","doi":"10.1023/a:1006028526024","DOIUrl":"https://doi.org/10.1023/a:1006028526024","url":null,"abstract":"Stress-induced asynergies in the infarct area following thrombolytic therapy are considered to reflect incomplete recanalization of the culprit vessel. However, reperfusion is a dynamic process with successive pathophysiological phases, so that the timing of assessment of residual ischemia may have relevant clinical implications. We studied the time-course of dobutamine-induced homozonal asynergies in 61 (group B) survivors of uncomplicated infarction as compared to 54 (group A) control subjects showing normal response to dobutamine stress echocardiography within 10 days of acute myocardial infarction. The 79 (43 of group A and 36 of group B) patients not presenting new cardiac events underwent further dobutamine stress echo within 90 +/- 17 days, which was positive in 20 and negative in 59. Persistence of test positivity was observed in just 17/36 (47%) patients, who showed significantly more extensive dobutamine-induced asynergies as compared to pre-discharge evaluation and less frequent (p < 0.01) evidence of viable myocardium. These results arise question about the decisional impact of stress-induced wall motion abnormalities in the culprit vessel area early after thrombolysis in low-risk patients and emphasize the need to further clarify the time factor role in this setting.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"14 6","pages":"381-4"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006028526024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21318574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracardiac echocardiography: computerized detection of left ventricular borders. 心内超声心动图:左心室边界的计算机检测。

International journal of cardiac imaging Pub Date : 1998-12-01 DOI: 10.1023/a:1006114907352

M Sonka, W Liang, P Kanani, J Allan, S DeJong, R Kerber, C McKay

引用次数: 18

Estimation of the right ventricular volume and ejection fraction by transthoracic three-dimensional echocardiography. A validation study using magnetic resonance imaging. 经胸三维超声心动图估计右心室容积和射血分数。磁共振成像验证研究。

International journal of cardiac imaging Pub Date : 1998-12-01 DOI: 10.1023/a:1006117321095

S Fujimoto, R Mizuno, Y Nakagawa, K Dohi, H Nakano

{"title":"Estimation of the right ventricular volume and ejection fraction by transthoracic three-dimensional echocardiography. A validation study using magnetic resonance imaging.","authors":"S Fujimoto, R Mizuno, Y Nakagawa, K Dohi, H Nakano","doi":"10.1023/a:1006117321095","DOIUrl":"https://doi.org/10.1023/a:1006117321095","url":null,"abstract":"Aims: To validate the use of three-dimensional transthoracic echocardiography compared with the magnetic resonance imaging for determination of right ventricular volume and ejection fraction.Methods and results: We recorded transthoracic echocardiographic images starting from the apical four-chamber view in which the RV is clearly visualized in 15 healthy volunteers. The scanning plane of the RV was obtained by the rotational scanning technique in 2 degree angular increments for three-dimensional reconstruction. The RV volumes in end-diastole and end-systole were calculated using a Tomtec three-dimensional reconstruction computer. We also assessed the RV by cine magnetic resonance imaging using the Siemens Magnetom Impact Expert (1.0 T). Cine gradient echo images were obtained in the short axis of the RV. The RV volume at each phase was calculated by Simpson's method. We also calculated the RV ejection fraction. The RV volumes in end-diastole and end-systole were 111 +/- 22 ml and 52 +/- 13 ml, respectively as determined by three-dimensional echo, and 115 +/- 18 ml and 55 +/- 14 ml determined by MRI. The right ventricular volumes at end-diastole and end-systole determined by three-dimensional echo were correlated with the volumes determined by MRI (r = 0.94 and 0.97, respectively, p < 0.001). The RV ejection fraction determined by three dimensional echo was also correlated with the ejection fraction determined by MRI (r = 0.90, p < 0.01).Conclusions: Three-dimensional transthoracic echocardiography provided reliable calculations of the right ventricular volume and ejection fraction.","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"14 6","pages":"385-90"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006117321095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21318575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62