International journal of cardiac imaging最新文献

{"title":"Fusion imaging: combined visualization of 3D reconstructed coronary artery tree and 3D myocardial scintigraphic image in coronary artery disease.","authors":"T H Schindler,&nbsp;N Magosaki,&nbsp;M Jeserich,&nbsp;U Oser,&nbsp;T Krause,&nbsp;R Fischer,&nbsp;E Moser,&nbsp;E Nitzsche,&nbsp;M Zehender,&nbsp;H Just,&nbsp;U Solzbach","doi":"10.1023/a:1006232407637","DOIUrl":"https://doi.org/10.1023/a:1006232407637","url":null,"abstract":"<p><strong>Background: </strong>In patients with coronary artery disease, coronary angiography is performed for assessment of epicardial coronary artery stenoses. In addition, myocardial scintigraphy is commonly used to evaluate regional myocardial perfusion. These two-dimensional (2D) imaging modalities are typically reviewed through a subjective, visual observation by a physician. Even though on the analysis of 2D display scintigraphic myocardial perfusion segments are arbitrarily assigned to three major coronary artery systems, the standard myocardial distribution territories of the coronary tree correspond only in 50-60% of patients. On the other hand, the mental integration of both 2D images of coronary angiography and myocardial scintigraphy does not allow an accurate assignment of particular myocardial perfusion regions to the corresponding vessels. To achieve an objective assignment of each vessel segment of the coronary artery tree to the corresponding myocardial regions, we have developed a 3D 'fusion image' technique and applied it to patients with coronary artery disease. The morphological data (coronary angiography) and perfusion data (myocardial scintigraphy) are displayed in a 3D format, and these two 3D data sets are merged into one 3D image.</p><p><strong>Results: </strong>Seventy-eight patients with coronary artery disease were studied with this new 3D fusion technique. Of 162 significant coronary lesions, 120 (74%) showed good coincidence with regional myocardial perfusion abnormality on 3D fusion image. No regional myocardial perfusion abnormality was found in 44 (26%) lesions. Furthermore, the 3D fusion image revealed 24 ischemic myocardial regions that could not be related to angiographically significant coronary artery lesions.</p><p><strong>Conclusion: </strong>The results of this study demonstrate that our newly developed 3D fusion technique is useful for an accurate assignment of coronary vessel segments to the corresponding myocardial perfusion regions, and suggest that it may be helpful to improve the interpretative and decision-making process in the treatment of patients with coronary artery disease.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"357-68; discussion 369-70"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006232407637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21451978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue Doppler imaging (TDI) for on-line detection of regional early diastolic ventricular asynchrony in patients with coronary artery disease.","authors":"C Bruch,&nbsp;A Schmermund,&nbsp;T Bartel,&nbsp;J Schaar,&nbsp;R Erbel","doi":"10.1023/a:1006255329288","DOIUrl":"https://doi.org/10.1023/a:1006255329288","url":null,"abstract":"<p><p>Diastolic filling of the left ventricle is often impaired in patients with coronary artery disease (CAD) in the absence of systolic wall motion abnormalities or previous myocardial infarction. The current study was designed to assess the ability of tissue Doppler imaging (TDI) for on-line detection of regional diastolic wall motion abnormalities to identify CAD in patients with preserved systolic function. 20 normal subjects (age 51 +/- 13 years) and 17 CAD patients with normal systolic function and > or = 70% luminal narrowing of the LAD (age 56 +/- 11 years) were included. Coronary anatomy was unknown to the echocardiographer. In the parasternal short axis and the apical 4-chamber-view, peak tissue velocities of the anterior/inferior and the midseptal/midlateral LV segments during rapid ejection (RE), isovolumic relaxation (IR), rapid filling (RF) and atrial contraction (AC) were analyzed by color-M-Mode-TDI. In the apical view, in 13 of 35 (37%) patients with adequate recordings, myocardial asynchrony was detected during IR: while the septum was moving inwards (red color-coding), the lateral wall was moving outwards (blue/green coding). In the remaining 22 patients (63%) a slow, synchronous outward motion of septum and lateral wall with homogeneous color-coding (blue/green) was seen. Unblinding of the coronary status revealed a critical LAD stenosis in all 13 patients (100%) with myocardial asynchrony. Analysis of midseptal peak velocities during IR revealed positive velocities (1.22 +/- 1.64 cm/s) in CAD patients and negative velocities (-1.39 +/- 0.81 cm/s) in normal subjects. Thus, TDI allowed for the on-line detection of early diastolic asynchrony in 13 of 16 (82%) patients with critical LAD-narrowing. Due to the rapid assessment of regional wall motion abnormalities, TDI might help to identify CAD in patients with normal systolic function.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"379-90"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006255329288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21454576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial volumes assessed by three- and two-dimensional echocardiography compared to MRI estimates.","authors":"O Rodevan,&nbsp;R Bjornerheim,&nbsp;M Ljosland,&nbsp;J Maehle,&nbsp;H J Smith,&nbsp;H Ihlen","doi":"10.1023/a:1006276513186","DOIUrl":"https://doi.org/10.1023/a:1006276513186","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to establish the accuracy and reproducibility of left atrial volume measurements by three-dimensional (3D) echocardiography compared to 2D biplane and monoplane measurements.</p><p><strong>Background: </strong>No echocardiographic technique is generally accepted as optimal for estimation of left atrial size.</p><p><strong>Methods: </strong>Left atrial volumes of 18 unselected cardiac patients were obtained with magnetic resonance imaging (MRI) (volumes 145 +/- 58 ml). These volumes were compared with those obtained with different echocardiographic methods: a multiplane 3D method based on 90 images acquired by apical probe rotation, a simplified 3D method using only the three standard apical views, and 2D biplane and monoplane methods based on area-length, disc summation and spherical formulas.</p><p><strong>Results: </strong>The echocardiographic methods significantly underestimated maximum left atrial volumes as obtained by MRI by 14-37% (p < 0.001). Accuracy, expressed as 1 SD of individual estimates around this systematic underestimation, was 25 to 27% for all methods, except for the 2D 2-chamber monoplane method (37%). Interobserver coefficient of variation was between 14 and 20% for all methods (n.s.).</p><p><strong>Conclusion: </strong>All echocardiographic methods significantly underestimated left atrial volumes as obtained by MRI. A minor non-significant improvement in individual echocardiographic estimates by the 3D methods was obtained at the cost of more time consumption. In unselected patients ultrasound image quality precludes significant improvement of left atrial volume measurements by the applied 3D methods.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"397-410"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006276513186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21454578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest-redistribution thallium-201 myocardial scintigraphic study in cardiac amyloidosis.","authors":"K Kodama,&nbsp;M Hamada,&nbsp;T Kuwahara,&nbsp;M Nakamura,&nbsp;Y Shigematsu,&nbsp;K Hiwada,&nbsp;T Iwata,&nbsp;Y Hoshii,&nbsp;T Ishihara","doi":"10.1023/a:1006210913708","DOIUrl":"https://doi.org/10.1023/a:1006210913708","url":null,"abstract":"<p><strong>Background: </strong>Histopathological study in amyloid heart demonstrates that myocyte destructed by the extracellular deposition of amyloid protein together with viable myocyte is present. We hypothesized that rapid thallium washout may be found in amyloid heart as in regions which have a mixture of viable myocyte and scar tissue in patients with myocardial infarction. Thus, the purpose of this study was to evaluate the extent and severity of myocardial damage due to amyloid deposits using the washout rate of the tracer on rest-redistribution thallium-201 (201Tl) myocardial scans in cardiac amyloidosis patients.</p><p><strong>Methods: </strong>Rest-redistribution 201Tl myocardial scintigraphy was performed in 5 patients with biopsy-proved systemic amyloidosis with cardiac involvement (amyloidosis group). The initial and delayed images were obtained 15 min and 4 h, respectively, after intravenous injection of the tracer of 111 MBq. Washout rate of the tracer was calculated. Twelve patients with no apparent heart disease served as controls (control group).</p><p><strong>Results: </strong>Mean washout rate of the whole heart was higher in the amyloidosis group than in the control group (56 +/- 9% vs 36 +/- 6%, p < 0.001). Particularly, 4 of the 5 patients in the amyloidosis group presented a very high rate of thallium clearance which ranged from 57 to 61%, and died in less than a year. In the remaining 1 patient who had a normal washout rate of the tracer in the first study, it changed from 40 to 53% during the 5-year follow-up period.</p><p><strong>Conclusions: </strong>Washout rate in the setting of rest and delayed 201Tl images may represent the severity of amyloid depositions in the myocardium and may provide prognostic information.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"371-8"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006210913708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21451980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an accurate method for three-dimensional reconstruction and quantitative assessment of volumes, lengths and diameters of coronary vascular branches and segments from biplane angiographic projections.","authors":"E Wellnhofer,&nbsp;A Wahle,&nbsp;I Mugaragu,&nbsp;J Gross,&nbsp;H Oswald,&nbsp;E Fleck","doi":"10.1023/a:1006322609072","DOIUrl":"https://doi.org/10.1023/a:1006322609072","url":null,"abstract":"<p><strong>Unlabelled: </strong>The goal of the study was the validation of an accurate method for three-dimensional reconstruction and quantitative assessment of volumes, lengths and diameters of coronary vascular branches and segments from biplane angiographic projections.</p><p><strong>Methods: </strong>The accuracy was tested in a complex phantom. In vivo, inter- and intraobserver agreement were assessed by analysis of routine angiograms. The sensitivity was evaluated using angiograms of patients having diagnostic vasoactive pharmacological intervention. Two-dimensional quantitative coronary angiography (2-D QCA) and 3-D QCA were compared concerning the accuracy of diameter evaluation.</p><p><strong>Results: </strong>3-D QCA yields accurate results (< 3% error) even based on nonorthogonal views, provided that projections parallel to the object are avoided. The inter- and intraobserver variability is < or = 5%. Significant (p < 0.01) changes of the volume (36-39%) and the diameter (19-21%) are detected following pharmacological intervention. 2-D QCA and 3-D QCA agree in short matched segments without foreshortening. 2-D QCA is rather sensitive to foreshortening and not suitable for evaluation of diameters of longer branches or total coronaries.</p><p><strong>Conclusion: </strong>3-D QCA permits an accurate, reproducible and sensitive comprehensive three-dimensional geometric analysis of the coronaries and is superior to 2-D QCA with respect to extended diameter evaluation.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"339-53; discussion 355-6"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006322609072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21451979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic tissue characterization in patients with dilated cardiomyopathy: comparison with findings from right ventricular endomyocardial biopsy.","authors":"S Fujimoto,&nbsp;R Mizuno,&nbsp;Y Nakagawa,&nbsp;A Kimura,&nbsp;K Yamaji,&nbsp;C Yutani,&nbsp;K Dohi,&nbsp;H Nakano","doi":"10.1023/a:1006272919061","DOIUrl":"https://doi.org/10.1023/a:1006272919061","url":null,"abstract":"<p><strong>Aim: </strong>The clinical usefulness of integrated backscatter (IB) imaging was compared with right ventricular endomyocardial biopsy for assessing myocardial damage in patients with dilated cardiomyopathy (DCM).</p><p><strong>Methods: </strong>We examined 15 patients with DCM and 20 healthy controls. In addition to the conventional M-mode echocardiographic parameters, we determined the cyclic variation in IB values (CV-IB) obtained from parasternal short axis views of the left ventricle just under the transducer for both the interventricular septum (IVS) and the left ventricular posterior wall (PW). The per cent fibrosis area (%) and the transverse diameter of myocytes (microm) were measured in right ventricular endomyocardial biopsy specimens by computer image analysis. To analyze the relationship between pathological findings and CV-IB, we divided patients into four subgroups on the basis of the pathological characteristics of endomyocardial biopsy specimens as follows: degeneration dominant group (n = 5), fibrosis dominant group (n = 5), dilated phase hypertrophic cardiomyopathy (n = 2), and mixed type (n = 3).</p><p><strong>Results: </strong>CV-IB in the IVS and the PW was lower in patients with DCM (8.8 +/- 2.9, 8.3 +/- 2.7 dB, respectively) than in normal subjects (14.4 +/- 2.9, 13.6 +/- 2.6 dB, respectively). Biopsy findings showed a mean per cent fibrosis area of 24.0 +/- 12.3%, and a mean myocyte diameter of 14.3 +/- 2.9 microm in patients with DCM. CV-IB was correlated with both of these findings: per cent fibrosis area (r = -0.56 in IVS, r = -0.56 in PW) and myocyte diameter (r = 0.67 in IVS, r = 0.71 in PW). CV-IB was decreased in all DCM subgroups compared with normal subjects, but there was no significant difference between subgroups.</p><p><strong>Conclusions: </strong>CV-IB was correlated with both the extent of fibrosis in myocardial tissue and the myocyte diameter. These findings suggest that ultrasonic tissue characterization is a good indicator of the severity of fibrosis and myocyte atrophy in patients with DCM.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"391-6"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006272919061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21454577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-derived left ventricular function parameters and mass in healthy young adults: relation with gender and body size.","authors":"J T Marcus,&nbsp;L K DeWaal,&nbsp;M J Götte,&nbsp;R J van der Geest,&nbsp;R M Heethaar,&nbsp;A C Van Rossum","doi":"10.1023/a:1006268405585","DOIUrl":"https://doi.org/10.1023/a:1006268405585","url":null,"abstract":"<p><strong>Purpose: </strong>To obtain normal values of left ventricular (LV) end-diastolic volume (EDV), stroke volume (SV), cardiac output (CO) and LV mass, in relation to gender, weight (W), length (L) and body surface area (BSA).</p><p><strong>Methods: </strong>Sixty-one healthy volunteers (32 male, 22.4 +/- 2.2 years) were examined, weight was 70.9 +/- 12.2 kg, length was 1.78 +/- 0.09 m, BSA was 1.88 +/- 0.19 m2. Segmented k-space breathhold cine MRI was used to obtain a stack of parallel short-axis images, from which LV volumes and end-diastolic mass were derived by slice summation. Four different body size indices were studied: W, L, L2 and BSA.</p><p><strong>Results: </strong>After indexing for L, L2 and BSA, the gender differences in all LV parameters are still persisting. After indexing for W, gender differences persist for EDV and EDM, but are no longer observed for SV and CO. Separate regression analyses for males and females were performed. EDV, SV, CO and EDM correlated significantly with each body size index, both in males and in females. L or BSA were in general better predictors for LV parameters than W. Linear regression equations of EDV (ml) vs. L(m) were for males: EDV = 275 x L - 359 and for females: EDV = 190 x L - 215. Equations of SV(ml) vs. L were for males: SV = 186 x L - 237 and for females: SV = 118 x L - 121. Equations of LV mass(g) vs. L were for males: Mass = 175 x L - 179 and for females: Mass = 65.8 x L - 10.9.</p><p><strong>Conclusion: </strong>Most gender differences in LV parameters remain even after correction for body size indices. Normal reference values for LV parameters are given in relation to body size indices, by calculating regression coefficients separately for males and females. These normal values serve to obtain more accurate reference values for a patient with given gender, weight and length, and thus to improve the differentiation between normal and abnormal LV parameters.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 5","pages":"411-9"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006268405585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21454579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a Fourier-based program for three-dimensional reconstruction of the mitral annulus on application to sparse, noisy data.","authors":"S Ratanasopa,&nbsp;E L Bolson,&nbsp;F H Sheehan,&nbsp;J A McDonald,&nbsp;G Bashein","doi":"10.1023/a:1006184726733","DOIUrl":"https://doi.org/10.1023/a:1006184726733","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the accuracy of mitral annular reconstruction from noisy, sparse data typical of three-dimensional (3D) transthoracic echocardiograms.</p><p><strong>Background: </strong>Our Fourier-based method for reconstructing the annulus from dense, accurate 3D transesophageal echo (TEE) data has been validated in vitro with four harmonics in the x, y, and z coordinates (4,4,4).</p><p><strong>Methods: </strong>Thirteen mitral annuli were reconstructed from 'complete' 3D TEE data using four harmonics (4,4,4) and used to measure area, eccentricity. height, perimeter, and interpeak and intervalley distances; these were the 'true values'. To simulate transthoracic echo data, the TEE data sets were reduced evenly and unevenly (randomly). The complete and reduced data sets were used to reconstruct the annuli using three sets of fitting parameters: (4,4,4), (1,1,3), and (1,1,4). The resulting size and shape measurements were compared with true values.</p><p><strong>Results: </strong>Regardless of the fitting parameters used, area, 2D perimeter, and 3D perimeter measurements were more accurate using reconstructions from evenly-reduced than randomly-reduced data sets (p < 0.006), and depended significantly on both data density (p < 0.015 for all) and data distribution (p < 0.02 for all). Perimeter, height, and eccentricity of the reconstructed annuli were more accurately measured using four harmonics (4,4,4).</p><p><strong>Conclusions: </strong>Mitral annuli can be reconstructed from sparse, noisy data using the (4,4,4) fit if at least 25 points are obtained from evenly distributed imaging planes. These results suggest that detailed analysis of mitral annular size and shape can be made accurately from 3D transthoracic echocardiograms.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 4","pages":"301-7"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006184726733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21378950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke volume changes during dobutamine-atropine stress echocardiography: the influence of heart rate and ischaemia.","authors":"D Poldermans,&nbsp;R Rambaldi,&nbsp;E Boersma,&nbsp;W Vletter,&nbsp;S Carlier,&nbsp;A Elhendy,&nbsp;J J Bax,&nbsp;A J Man in 't Veld,&nbsp;J R Roelandt","doi":"10.1023/a:1006182227351","DOIUrl":"https://doi.org/10.1023/a:1006182227351","url":null,"abstract":"<p><strong>Background: </strong>A decrease in stroke volume during dobutamine-atropine stress echocardiography heralds ischaemia and possible hypotension. Hypotension results from worsening of LV-function (as a result of ischaemia) left ventricular outflow tract obstruction or hypovolemia, while an increase of stroke volume indicates the preservation of myocardial contractile reserve.</p><p><strong>Objective: </strong>To assess stroke volume changes during dobutamine stress echocardiography in relation to heart rate and occurrence of ischaemia and to validate a new automated cardiac output measurement device.</p><p><strong>Methods: </strong>In fifty patients, the stroke volume was assessed using the echocardiographic biplane discs method during a stress echocardiography. These data were reference values for the validation of a new automated cardiac output measurement using the first method as a reference.</p><p><strong>Results: </strong>Stroke volume measured by the biplane discs method and automated cardiac output device decreased from rest to peak stress, respectively, from 54+/-16 to 34+/-9 (63%) ml and 63+/-17 to 38+/-15 (60%) ml (p < 0.001). Stroke volume decreased with increased heart rate and stress-induced ischaemia when assessed by the biplane discs method, but with the automated device it decreased only with increased heart rate.</p><p><strong>Conclusions: </strong>Both increased heart rate and myocardial ischaemia during dobutamine stress echocardiography cause a reduction of stroke volume. However, the automated device did not detect the effects of stress-induced ischaemia on stroke volume. It appears that the biplane discs method is more sensitive for evaluating the effect of ischaemia.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 4","pages":"263-9"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006182227351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21379663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does remodeling occur in the diseased human saphenous vein bypass grafts? An intravascular ultrasound study.","authors":"J Ge,&nbsp;F Liu,&nbsp;R Bhate,&nbsp;M Haude,&nbsp;G Görge,&nbsp;D Baumgart,&nbsp;S Sack,&nbsp;R Erbel","doi":"10.1023/a:1006125205217","DOIUrl":"https://doi.org/10.1023/a:1006125205217","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery remodeling is a common phenomenon in human atherosclerotic arteries. Controversies exist concerning the presence of absence of the remodeling process in diseased human coronary saphenous vein bypass grafts. The purpose of the study was to observe the vessel and lumen dimensions in patients who had undergone saphenous vein grafting with intravascular ultrasound to find out whether the remodeling process exists in the diseased human saphenous vein bypass grafts.</p><p><strong>Methods: </strong>A total of 43 saphenous vein bypass grafts from 43 patients (39 males, 4 females, mean age 63+/-8 years); 1-16 years (mean 9.3+/-4.0 years) after grafting, who had not undergone previous catheter intervention, were studied using intravascular ultrasound. The vessel, lumen and plaque area were measured at the lesion segment as well as in the proximal and distal reference segments. The percent stenosis was calculated.</p><p><strong>Results: </strong>In 43 bypass grafts having severe stenosis before intervention, plaque was eccentric in 69.4% and concentric in 30.6%. No calcification was detected in 75% cases and 25% cases has mild-moderate intimal calcification. The vessel area in the lesion segment was 19.0+/-9.7 mm2, significantly larger than the proximal reference segment 12.8+/-4.0 min2 as well as the distal reference segment 12.9+/-3.6 mm2 (p < 0.001). It was also larger than that of the average area of the proximal and distal reference segments (p < 0.001). The vessel area increased in accordance with plaque area (p < 0.001). A weak relationship existed between vessel area and percent stenosis (r = 0.37, p = 0.04).</p><p><strong>Conclusion: </strong>In contrary to previous findings, diseased human saphenous vein bypass grafts undergo focal compensatory enlargement (remodeling) in the presence of plaque formation. The underlying mechanism is probably similar to that in de novo atherosclerosis.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 4","pages":"295-300"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006125205217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21378949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}