J J Sandstede, C Lipke, W Kenn, M Beer, T Pabst, D Hahn
{"title":"Cine MR imaging after myocardial infarction--assessment and follow-up of regional and global left ventricular function.","authors":"J J Sandstede, C Lipke, W Kenn, M Beer, T Pabst, D Hahn","doi":"10.1023/a:1006342810026","DOIUrl":"https://doi.org/10.1023/a:1006342810026","url":null,"abstract":"<p><p>Myocardial infarction often leads to regional wall motion defects and in case of large defects to remodeling of the left ventricle. With this study, changes in regional and global myocardial function of 12 patients 3 weeks after myocardial infarction and after revascularization therapy were determined using MRI. Cine MRI was performed at study entry at rest and during low-dose dobutamine stimulation. All patients were re-examined at rest 3 and 6 months after the revascularization, including analysis of wall thickening and of left ventricular end-diastolic volume index (LVEDVI), end-systolic volume index (LVESVI), ejection fraction (LVEF), and mass index. After revascularization. 6 patients with stress-induced improvement of regional wall thickening recovered, 4 patients without improvement did not, but 2 patients without stress-induced improvement of wall thickening also recovered. Concerning global cardiac function, patients with mainly improved regional wall motion also showed a lower LVESVI and a higher LVEF than patients without improvement of regional contractility 6 months after revascularization in comparison to study entry. In conclusion, improvement of global myocardial function after revascularization is higher in patients with improved contractility in the infarcted region. The extent of the response of regions with wall motion defects to dobutamine stress correlates with the actual improvement after revascularization, and, therefore, dobutamine stress MRI may be helpful in selecting patients that will have a higher benefit from a revascularization therapy.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"435-40"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006342810026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Jerosch-Herold, N Wilke, Y Wang, G R Gong, A M Mansoor, H Huang, S Gurchumelidze, A E Stillman
{"title":"Direct comparison of an intravascular and an extracellular contrast agent for quantification of myocardial perfusion. Cardiac MRI Group.","authors":"M Jerosch-Herold, N Wilke, Y Wang, G R Gong, A M Mansoor, H Huang, S Gurchumelidze, A E Stillman","doi":"10.1023/a:1006368619112","DOIUrl":"https://doi.org/10.1023/a:1006368619112","url":null,"abstract":"<p><p>A direct comparison of extracellular and intravascular contrast agents for the assessment of myocardial perfusion was carried out in a porcine model (N = 5) with a flow-limiting occluder on the left anterior descending coronary artery. Rapid imaging during the first pass of an extracellular or intravascular contrast agent with a saturation-recovery-prepared TurboFLASH sequence showed comparable peak contrast-to-noise enhancements in myocardial tissue regions with flows averaging 1.1 +/- 0.2 at baseline to 4.8 +/- 0.6 ml/min/g during hyperemia. The coefficient of variation between the MR estimates of blood flow with Gadomer-17 and the microsphere blood flow measurements was 11 +/- 11%, while the corresponding co-efficient of variation for blood flow estimates with the extracellular CA was 23 +/- 11%. Blood volume differences between rest and hyperemia observed with the intravascular tracer were significant (Vvasc(rest) = 0.078 +/- 0.013 ml/g, versus Vvasc(hyperemia) = 0.102 +/- 0.019 ml/g; p < 0.05). The effects of water exchange were minimized through the choice of pulse sequence parameters to provide blood volume estimates consistent with the changes expected between rest and hyperemia. This study represents the first application of multiple indicators in first pass imaging studies for the assessment of myocardial perfusion. The use of an intravascular instead of an extracellular contrast agent allows a reduction of the degrees of freedom for modeling tissue residue curves and results in improved accuracy of blood flow estimates.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"453-64"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006368619112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Ichida, I Hashimoto, S Tsubata, Y Hamamichi, K Uese, A Murakami, R Futatsuya, T Miyawaki
{"title":"A novel technique using biplane cine magnetic resonance imaging to evaluate left ventricular volume in children.","authors":"F Ichida, I Hashimoto, S Tsubata, Y Hamamichi, K Uese, A Murakami, R Futatsuya, T Miyawaki","doi":"10.1023/a:1006352217295","DOIUrl":"https://doi.org/10.1023/a:1006352217295","url":null,"abstract":"<p><p>The purpose of the study is to determine the feasibility of a novel simplified technique using cine magnetic resonance imaging (MRI) to assess left ventricular (LV) volume and ejection fraction (EF) validated by comparison with biplane LV angiography. Previous MRI studies to assess LV volumes have used multiple axial planes, which are compromised by partial volume effects and are time consuming to acquire and analyze. Accordingly, we developed a simplified imaging approach using biplane cine MRI and imaging planes aligned with the intrinsic cardiac axes of the LV. We studied 20 children (aged 4 months to 10 years) with various heart diseases. The accuracy of cine MRI was compared with that of LV angiography in all patients. LV volumes were calculated using Simpson's rule algorithm, for both MRI and LV angiography. LV volumes determined from MRI were slightly underestimated but correlated reasonably well with angiographic volumes (LVEDV: Y = 0.88X + 1.58, r = 0.99, LVESV: Y = 0.73X + 1.03, r = 0.98). Most importantly, even in patients who had abnormal ventricular curvature such as in tetralogy of Fallot, MRI determined LV volumes correlated well with angiographic values. The MR study was completed within 35 min in all patients. In conclusion, simplified biplane cine MRI, using the intrinsic LV axis planes, permits noninvasive assessment of LV volumes in views comparable to standard angiographic projections and appears practical for clinical use in childhood heart disease since the scan and analysis times are relatively short.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"465-71"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006352217295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Usefulness of coronary MR angiography prior to angioplasty.","authors":"A J Duerinckx, D Laughrun, B S Lewis","doi":"10.1023/a:1006331628682","DOIUrl":"https://doi.org/10.1023/a:1006331628682","url":null,"abstract":"<p><p>The range of indications for percutaneous transluminal coronary angioplasty (PTCA) has increased greatly since the procedure was initially introduced. The success rate depends on the anatomy and length of the occlusion and on the state of the distal vessel. We present a case where the use of magnetic resonance angiography (MRA) allowed to evaluate the length of a subtotal occlusion prior to PTCA, and thus could have had an impact on therapeutic decisions. Coronary MR angiography is one of the many applications of breathhold MRI, where breathholding and segmented k-space acquisition are combined to provide anatomical images of coronary vessels. Coronary MR angiography allows reproducible visualization of coronary vessels. Even under adverse circumstances (poor cardiac triggering) the images are sometimes of sufficient quality to help make a diagnosis. This capability may increase the as yet limited clinical use of MR technology in the practice of cardiology.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"533-40"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006331628682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K R Hoffmann, A Wahle, C Pellot-Barakat, J Sklansky, M Sonka
{"title":"Biplane X-ray angiograms, intravascular ultrasound, and 3D visualization of coronary vessels.","authors":"K R Hoffmann, A Wahle, C Pellot-Barakat, J Sklansky, M Sonka","doi":"10.1023/a:1006372704091","DOIUrl":"https://doi.org/10.1023/a:1006372704091","url":null,"abstract":"<p><p>The technology for determination of the 3D vascular tree and quantitative characterization of the vessel lumen and vessel wall has become available. With this technology, cardiologists will no longer rely primarily on visual inspection of coronary angiograms but use sophisticated modeling techniques combining images from various modalities for the evaluation of coronary artery disease and the effects of treatment. Techniques have been developed which allow the calculation of the imaging geometry and the 3D position of the vessel centerlines of the vascular tree from biplane views without a calibration object, i.e., from the images themselves, removing the awkwardness of moving the patient to obtain 3D information. With the geometry and positional information, techniques for reconstructing the vessel lumen can now be applied that provide more accurate estimates of the area and shape of the vessel lumen. In conjunction with these developments, techniques have been developed for combining information from intravascular ultrasound images with the information obtained from angiography. The combination of these technologies will yield a more comprehensive characterization and understanding of coronary artery disease and should lead to improved and perhaps less invasive patient care.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"495-512"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006372704091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Markl, B Schneider, J Hennig, S Peschl, J Winterer, T Krause, J Laubenberger
{"title":"Cardiac phase contrast gradient echo MRI: measurement of myocardial wall motion in healthy volunteers and patients.","authors":"M Markl, B Schneider, J Hennig, S Peschl, J Winterer, T Krause, J Laubenberger","doi":"10.1023/a:1006355106334","DOIUrl":"https://doi.org/10.1023/a:1006355106334","url":null,"abstract":"<p><p>A number of methods have been proposed for the noninvasive measurement of myocardial wall motion. The paper describes a strategy for assessing myocardial motion based on the sensitivity of the phase of the MR-signal to motion using a breath-hold phase contrast technique. A motion-sensitized and a motion-compensated MR-signal are measured during successive scans. The difference between the two MR-signals is used to calculate myocardial velocity in all three spatial dimensions. Postprocessing includes the transformation of the measured velocities into an internal coordinate system of the left ventricle. Also various presentation modes and further processing of the received velocity information are provided including calculation of global motion parameters. We examined 20 patients suffering from myocardial infarction. The overall left ventricular motion can be characterized by appropriate parameters describing the rotation and contraction or expansion, respectively. Regional motional disturbances are visualized using parametric images. Contrary to the highly consistent interindividual data in normal volunteers, patients showed significant localized motion deficits.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"441-52"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006355106334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative measurements in IVUS images.","authors":"J Dijkstra, G Koning, J H Reiber","doi":"10.1023/a:1006334517720","DOIUrl":"https://doi.org/10.1023/a:1006334517720","url":null,"abstract":"<p><p>IntraVascular UltraSound (IVUS) is a catheter-based technique which provides real-time high resolution tomographic images of both the lumen and arterial wall of a coronary segment, this in contrast to X-ray arteriography that provides a shadow image (luminogram) of the entire lumen. Nowadays the lumen and vessel parameters are measured manually, which is very time consuming and suffers from high inter- and intra-obser variability. With the continuing improvement in IVUS imaging, it is now feasible to develop and clinically apply automated methods of three-dimensional quantitative analysis of the coronary vessel morphology in an objective and reproducible way with automated contour detection techniques (QCU). Quantification, in 2D and 3D, as well as volume rendering for visualization of the IVUS images requires segmentation of the images (contour detection). The 3D contour detection system described in this article is based on the combination of contour detection in the transversal and sagital view. This article provides some of the basic principles of IVUS, the IVUS image quantification, the three-dimensional reconstruction and the contour detection and quantification in three-dimensional IVUS images.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"513-22"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006334517720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Ichida, I Hashimoto, S Tsubata, Y Hamamichi, K Uese, A Murakami, T Miyawaki
{"title":"Evaluation of pulmonary blood supply by multiplanar cine magnetic resonance imaging in patients with pulmonary atresia and severe pulmonary stenosis.","authors":"F Ichida, I Hashimoto, S Tsubata, Y Hamamichi, K Uese, A Murakami, T Miyawaki","doi":"10.1023/a:1006391814569","DOIUrl":"https://doi.org/10.1023/a:1006391814569","url":null,"abstract":"<p><p>The purpose of this study was to assess the capability of multiplanar cine magnetic resonance imaging (MRI) for evaluating pre- and post-operative pulmonary circulation in patients with pulmonary atresia and severe pulmonary stenosis. Seventy-three multiplanar cine MRIs were performed in 30 patients, aged 1 month to 7 years (mean age, 27 months). The morphology and size of the central pulmonary arteries (PA), source of the major aortopulmonary collateral arteries (MAPCA), patency of Blalock-Taussig (BT) shunt vessels, and the post-operative pulmonary circulation were assessed. The accuracy of cine MRI was compared with that of angiography in all patients. The PA was visualized to the first hilar branch in 21 patients, but not in 8 patients in whom the central PA was absent. On follow-up MRI, PA growth was measured, and the results showed excellent correlation with the results obtained by angiography. In 17 patients who had undergone 23 BT shunt operations, cine MRI correctly demonstrated all patient shunts and 5 of 6 stenotic lesions. Multiplanar cine MRI provided excellent detail of the peripheral PA in all patients, 7 of 8 peripheral pulmonary stenoses, 3 of 4 nonconfluent pulmonary arteries, and 2 of 3 PA obstructions. Although the sources of MAPCA were identified in 7 of 9 patients, the distal connection of the MAPCA was not detected in all patients. Seven patients were reexamined after pulmonary plasty; they exhibited normal pulmonary flow patterns. Multiplanar cine MRI provides high-resolution imaging of PA with dynamic visualization of flow and is an effective noninvasive technique for evaluating pre- and post-operative patients with pulmonary atresia and severe pulmonary stenosis.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"473-81"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006391814569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J J Westenberg, R J van der Geest, M N Wasser, J Doornbos, P M Pattynama, A de Roos, J Vanderschoot, J H Reiber
{"title":"Stenosis quantification from post-stenotic signal loss in phase-contrast MRA datasets of flow phantoms and renal arteries.","authors":"J J Westenberg, R J van der Geest, M N Wasser, J Doornbos, P M Pattynama, A de Roos, J Vanderschoot, J H Reiber","doi":"10.1023/a:1006329032742","DOIUrl":"https://doi.org/10.1023/a:1006329032742","url":null,"abstract":"<p><p>In this study a semi-automated and observer-independent algorithm for quantifying post-stenotic signal loss (PSL) in 3D phase-contrast (PC) magnetic resonance angiography (MRA) of patients with renal artery stenosis is presented. This algorithm was developed on MRA datasets of stenotic phantoms, which were included in a flow circuit with stationary flows. The length and the severity of the PSL (incorporating both length and degree of PSL) in the maximum intensity projections (MIPs) of MRA datasets were proposed for quantifying stenoses. The algorithm was tested in renal arteries of ten patients with renal artery stenosis and seven healthy volunteers. Digital subtraction angiography (DSA) was performed in the patients and served as the gold standard. Stenosis severity showed better correlation with the severity of the PSL than with the length, both for in vitro as in vivo. Spearman correlation coefficients (rS) showed statistically significant correlations between the severity of the PSL and parameters determined by DSA, i.e. percent diameter stenosis (rS = 0.90). The length of the PSL showed no correlation with the diameter stenosis (rS = 0.37).</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"483-93"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006329032742","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B J Wintersperger, H V Penzkofer, A Knez, J Weber, M F Reiser
{"title":"Multislice MR perfusion imaging and regional myocardial function analysis: complimentary findings in chronic myocardial ischemia.","authors":"B J Wintersperger, H V Penzkofer, A Knez, J Weber, M F Reiser","doi":"10.1023/a:1006390704517","DOIUrl":"https://doi.org/10.1023/a:1006390704517","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to assess the reliability of multislice MR perfusion imaging in comparison to regional wall function and nuclear medicine and to test different qualitative and quantitative parameters for perfusion assessment.</p><p><strong>Material and methods: </strong>15 patients with chronic myocardial ischemia underwent CINE and first-pass perfusion MR imaging. Functional myocardial imaging was performed using a segmented CINE FLASH sequence and systolic myocardial wall thickening was assessed after semiautomated segmentation. MR first-pass perfusion studies were performed using a multislice saturation recovery TurboFLASH sequence. Different parameters were calculated for assessment of hypoperfused segments and results of MR imaging compared to 99mTc-SestaMIBI SPECT.</p><p><strong>Results: </strong>MR perfusion imaging showed a sensitivity of 72% and a specificity of 98%. In combination with MR CINE imaging and wall thickening analysis we calculated a sensitivity of 100% and a specificity of 93%. Qualitative and quantitative perfusion parameter analysis showed significant differences between normal and hypoperfused segments for the signal intensity increase (p < 0.001), the signal intensity upslope (p < 0.001) as well as for the myocardial mean transit time (p < 0.001).</p><p><strong>Conclusion: </strong>The combination of systolic wall thickening analysis and myocardial perfusion can markedly improve the sensitivity of MRI in depiction of LV myocardial perfusion abnormalities. For assessment of hypoperfusion, different quantitative and qualitative parameters can be calculated showing significant differences between normal state and hypoperfusion.</p>","PeriodicalId":77179,"journal":{"name":"International journal of cardiac imaging","volume":"15 6","pages":"425-34"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1006390704517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21618144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}