Infectious agents and disease最新文献_第6页

Development of a meningococcal vaccine. 研制脑膜炎球菌疫苗。

Infectious agents and disease Pub Date : 1995-03-01

J T Poolman

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Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections. 次黄嘌呤-鸟嘌呤磷酸核糖基转移酶作为治疗原虫感染的靶点。

Infectious agents and disease Pub Date : 1995-03-01

B Ullman, D Carter

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Aleutian mink disease: puzzles and paradigms. 阿留申水貂疾病:谜题和范例。

Infectious agents and disease Pub Date : 1994-12-01

M E Bloom, H Kanno, S Mori, J B Wolfinbarger

{"title":"Aleutian mink disease: puzzles and paradigms.","authors":"M E Bloom, H Kanno, S Mori, J B Wolfinbarger","doi":"","DOIUrl":"","url":null,"abstract":"Aleutian mink disease (AD) is a naturally occurring persistent virus infection of mink caused by the Aleutian mink disease parvovirus (ADV). The classical form of AD, which occurs in adult mink, is notable for high titers of antiviral antibodies, hypergammaglobulinemia, plasmacytosis, and immune complex disease. In addition, there is a progressive renal disease characterized by mesangial proliferative glomerulonephritis and severe interstitial nephritis. Development of AD depends on both host and viral factors, and mink of certain genotypes fail to develop progressive disease when inoculated with low-virulence strains of virus. In newborn mink kits, ADV causes a fatal, acute interstitial pneumonitis associated with permissive viral replication in alveolar type 2 cells, but treatment of newborn kits with anti-viral antibody aborts the acute disease and converts into one resembling the persistent infection observed in adults. In infected adult mink, ADV is sequestered as immune complexes in lymphoid organs, but actual viral replication is restricted at the level of the individual cell and can be detected in only a small population of macrophages and follicular dendritic cells. ADV infection of mink primary macrophages and the human macrophage cell line U937 is antibody dependent and leads to the production of the cytokine interleukin-6. Furthermore, levels of interleukin-6 are increased in lymph node culture supernatants from infected mink. Chronic production of interleukin-6 may promote development of the immune disorder characteristic of AD.","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"3 6","pages":"279-301"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18887050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The optimum microbiological food safety program. 最佳微生物食品安全方案。

Infectious agents and disease Pub Date : 1994-12-01

L M Crawford

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Is there a role for non-nucleoside reverse transcriptase inhibitors in the treatment of HIV infection? 非核苷类逆转录酶抑制剂在治疗HIV感染中是否有作用?

Infectious agents and disease Pub Date : 1994-12-01

J M Kilby, M S Saag

引用次数: 0

"Teaching microbiology" vs. "learning microbiology". “微生物学教学”vs。“学习微生物学”。

Infectious agents and disease Pub Date : 1994-12-01

V S Hinshaw

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Variant subpopulations of Staphylococcus aureus as cause of persistent and recurrent infections. 不同亚群的金黄色葡萄球菌作为持续和反复感染的原因。

Infectious agents and disease Pub Date : 1994-12-01

R A Proctor, J M Balwit, O Vesga

引用次数: 0

Etiology and epidemiology of the Four Corners hantavirus outbreak. 四角汉坦病毒爆发的病原学和流行病学。

Infectious agents and disease Pub Date : 1994-10-01

L E Chapman, R F Khabbaz

{"title":"Etiology and epidemiology of the Four Corners hantavirus outbreak.","authors":"L E Chapman, R F Khabbaz","doi":"","DOIUrl":"","url":null,"abstract":"In May and June 1993, a handful of previously healthy residents of rural areas in the Four Corners region of the southwestern United States died of acute unexplained respiratory distress, later diagnosed as hantavirus pulmonary syndrome. Their illnesses were characterized most prominently by a prodrome of fever and myalgias, followed by thrombocytopenia, the presence of immature white blood cells on the peripheral smear, and catastrophic respiratory decline associated with the sudden onset of noncardiogenic pulmonary edema and hypotensive shock. Although the primary care doctors who treated these patients were spread over a relatively wide rural geographic area, this cluster was recognized in large part because these patients belonged to a defined cohort receiving medical care from a unified system of interconsulting physicians, the Indian Health Service. By just over 2 weeks after receiving laboratory diagnostic specimens, Public Health Service scientists had identified a newly recognized hantavirus as the cause of this disease cluster and Peromyscus maniculatus (the deer mouse) as the rodent reservoir for this zoonotic virus. The oral history of local American Indian healers describes clusters of similar deaths occurring over three cycles during the twentieth century in association with identifiable ecological markers. The abrupt introduction to Western medical practitioners of a disease long recognized by indigenous healers through illness occurring among a cohort of patients seeking care from medical officers of the U.S. Uniformed Services parallels the initial Western medical recognition of previous human illnesses associated with hantaviral infections through disease outbreaks among military troops. The remarkable speed with which the etiology of this disease was elucidated is attributable to both the power of modern genetic investigational techniques and the scientific groundwork laid by nearly half a century of systematic research on hantaviruses.","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"3 5","pages":"234-44"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18864855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlamydia trachomatis antigens: role in immunity and pathogenesis. 沙眼衣原体抗原:在免疫和发病中的作用。

Infectious agents and disease Pub Date : 1994-10-01

R C Brunham, R W Peeling

{"title":"Chlamydia trachomatis antigens: role in immunity and pathogenesis.","authors":"R C Brunham, R W Peeling","doi":"","DOIUrl":"","url":null,"abstract":"As an intracellular bacteria, Chlamydia trachomatis is an extraordinarily successful pathogen. Chlamydial infections are among the most common of all human infections. Chlamydial disease is less common than infection and is attributed to immune responses to specific antigens of the organism. A major variant surface protein, major outer membrane protein (MOMP), is the principal target of neutralizing antibodies and may be the target of protective immunity. The detailed genetic and immunochemical knowledge of MOMP has stimulated multiple attempts to design an oligopeptide vaccine. Success has been limited in part because of the antigenic variation that the protein exhibits and in part because of the absence of knowledge regarding the three-dimensional structure of the protein. Individuals with severe forms of chlamydial disease often display immune responses to a common chlamydial heat shock protein 60 (hsp60) antigen. Because the protein shares nearly 50% sequence identity with the human homolog, it is speculated that molecular mimacy may result in autoimmune inflammatory damage that in turn causes chlamydial disease sequelae. Because hsp60 immune responses are genetically determined, susceptibility genes for chlamydial disease may also exist. A detailed understanding of the immunobiology of C. trachomatis infection may result from molecular study of chlamydial antigens and the precise nature of immune responses they elicit. Nevertheless, even with the rapid progress that has been made in uncovering the major chlamydial antigens, more remains hidden than revealed. As demonstrated by their successful ecology, chlamydiae remain several stops ahead of even their most ardent pursuers.","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"3 5","pages":"218-33"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18864854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-resistant tuberculosis in adults: implications for the health care worker. 成人耐药结核病:对卫生保健工作者的启示

Infectious agents and disease Pub Date : 1994-10-01

N E Dunlap, M E Kimerling

引用次数: 0