Infectious agents and disease最新文献_第10页

Analysis of the epidemiology and pathogenesis of herpes simplex virus (HSV) infections in pregnant women and infants using the HSV-2 glycoprotein G antibody assay. 应用单纯疱疹病毒(HSV -2)糖蛋白G抗体试验分析孕妇和婴儿感染单纯疱疹病毒(HSV)的流行病学和发病机制。

Infectious agents and disease Pub Date : 1993-12-01

A M Arvin, C G Prober

引用次数: 0

Is chronic fatigue syndrome an infectious disease? 慢性疲劳综合症是一种传染病吗?

Infectious agents and disease Pub Date : 1993-10-01

A C Mawle, M Reyes, D S Schmid

引用次数: 0

Treatment research priorities for human immunodeficiency virus infection. 人类免疫缺陷病毒感染的治疗研究重点。

Infectious agents and disease Pub Date : 1993-10-01

C B Pettinelli, S M Schnittman

{"title":"Treatment research priorities for human immunodeficiency virus infection.","authors":"C B Pettinelli, S M Schnittman","doi":"","DOIUrl":"","url":null,"abstract":"Viral infections such as with the human immunodeficiency virus (HIV) present difficult challenges for the development of effective antiviral therapies. These viruses depend on the host cell machinery for their existence, and interference with these processes typically interferes with other important host physiology. HIV presents other challenges as well because of its inherent pathogenic destruction of the immune system. It is the goal of HIV therapeutics to attempt to cure HIV infection, or if that is not possible, to stop HIV disease progression while preserving a high quality of life for HIV-infected individuals. This may be achieved through an effective combination of interference with the viral life cycle and the pathogenic processes, and by slowing or reversing the immunologic dysfunction that leads to the complications of HIV infection. Unprecedented progress has been made in understanding the virus and HIV disease pathogenesis. This knowledge has led to the identification of viral features that have become targets for therapeutic intervention. This article reviews the most important priorities of HIV treatment research for adult HIV-infected patients for the immediate future. These priorities include the following: development of new antiretroviral compounds and their application as both monotherapies and in combination therapy approaches; immune-based therapeutic approaches; and research and treatment for acute or primary HIV infections.","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"2 5","pages":"291-303"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uses of CD4-lymphocyte count in AIDS treatment decisions. cd4淋巴细胞计数在艾滋病治疗决策中的应用。

Infectious agents and disease Pub Date : 1993-10-01

V De Gruttola, R Gelman, S Lagakos

引用次数: 0

Impact of Haemophilus influenzae type b vaccines on the epidemiology of bacterial meningitis. 乙型流感嗜血杆菌疫苗对细菌性脑膜炎流行病学的影响。

Infectious agents and disease Pub Date : 1993-10-01

J D Wenger

引用次数: 0

Mechanisms of processing and presentation of the antigens of Listeria monocytogenes. 单核增生李斯特菌抗原的加工和呈递机制。

Infectious agents and disease Pub Date : 1993-10-01

E M Hiltbold, H K Ziegler

{"title":"Mechanisms of processing and presentation of the antigens of Listeria monocytogenes.","authors":"E M Hiltbold, H K Ziegler","doi":"","DOIUrl":"","url":null,"abstract":"Antigen processing is the series of events through which protein antigens become degraded and are sent to the cell surface for recognition by T cells. These events within the cell have been studied extensively using the model system of infection with Listeria monocytogenes. This bacteria resides primarily intracellularly; immunity to it is mediated by cellular responses. Upon phagocytosis by a macrophage, engulfed Listeria express a hemolytic molecule, listeriolysin O (LLO), and can disrupt the membrane of the endosome and escape into the cellular cytoplasm. This allows the organism to escape the hostile environment of the endosome and also gives it access to the processing machinery of the cytoplasm. Therefore, Listeria monocytogenes can be processed within an endosome and be presented by class II MHC, or can escape into the cytoplasm and be processed there and presented by class I MHC. This LLO molecule is not only an important virulence factor, it is also a dominant antigen in the cellular immune response to Listeria. The outcome of antigen processing and presentation can be influenced by the expression of LLO, by the state of activation of the macrophage, and by the cytokines involved in the immune response.","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"2 5","pages":"314-23"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18520981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discussion of in vitro and in vivo assays for studying bacterial entry into and survival within eukaryotic cells. 探讨研究真核细胞内细菌进入和存活的体外和体内试验。

Infectious agents and disease Pub Date : 1993-08-01

J E Galán, V L Miller, D Portnoy

引用次数: 0

Nitric oxide mediates Bordetella pertussis tracheal cytotoxin damage to the respiratory epithelium. 一氧化氮介导百日咳杆菌气管细胞毒素对呼吸道上皮的损伤。

Infectious agents and disease Pub Date : 1993-08-01

L N Heiss, T A Flak, J R Lancaster, M L McDaniel, W E Goldman

引用次数: 0

Formation of the Legionella pneumophila replicative phagosome. 嗜肺军团菌复制吞噬体的形成。

Infectious agents and disease Pub Date : 1993-08-01

M S Swanson, R R Isberg