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Developmental anatomy of craniofacial sutures. 颅面缝合线的发育解剖学。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115028
D. Rice
{"title":"Developmental anatomy of craniofacial sutures.","authors":"D. Rice","doi":"10.1159/0000115028","DOIUrl":"https://doi.org/10.1159/0000115028","url":null,"abstract":"Sutures are fibrous joints in the vertebrate skull. They consist of two bone ends and intervening fibrous tissue which differentiates from embryonic mesenchyme. Sutures are not merely articulations between bones they are primary sites of osteogenesis mediating much of the growth of the face and skull vault. In this chapter the development of sutures will be described including the origin of sutural tissues, the determinants of suture location, and suture morphology. Also, the main functions of sutures will be explained.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64393764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 91
Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts. FGFR2和twist在人类颅缝闭合中的作用:来自颅骨成骨细胞基因突变的见解。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115036
P. Marie, K. Kaabeche, Hind Guénou
{"title":"Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts.","authors":"P. Marie, K. Kaabeche, Hind Guénou","doi":"10.1159/0000115036","DOIUrl":"https://doi.org/10.1159/0000115036","url":null,"abstract":"Recent advances in molecular genetics have led to a better understanding of the role of specific genes such as fibroblast growth factor receptor (FGFR) and Twist in cranial bone formation. Specifically, the analysis of osteoblast abnormalities induced by FGFR2 and Twist genetic mutations inducing craniosynostosis in humans has provided some insights into the role of these genes in the premature cranial suture formation in syndromic craniosynostosis. This also led to a better understanding of the cellular and molecular mechanisms that control osteoblast biology and pathology in humans. In this review paper, we summarize the effects of FGFR2 and Twist genetic mutations resulting in altered osteoblast phenotype and premature cranial fusion based on our analysis in human syndromic craniosynostosis.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"144-59"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64393673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Single suture craniosynostosis: diagnosis and imaging. 单缝线颅缝闭锁:诊断与影像学。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115033
J. Hukki, P. Saarinen, M. Kangasniemi
{"title":"Single suture craniosynostosis: diagnosis and imaging.","authors":"J. Hukki, P. Saarinen, M. Kangasniemi","doi":"10.1159/0000115033","DOIUrl":"https://doi.org/10.1159/0000115033","url":null,"abstract":"Craniosynostosis, premature suture fusion, is one of the most common craniofacial anomalies affecting approximately 1 in 2,500 live births. Craniosynostosis is most commonly an isolated (nonsyndromic) condition with the sagittal suture being the most commonly affected suture. In this review we describe the range of isolated synostoses and show how these can lead to a variety of different morphological and functional abnormalities.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64393942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Suture neontology and paleontology: the bases for where, when and how boundaries between bones have been established and have evolved. 缝合线新学和古生物学:骨头之间的界限在何时、何地以及如何建立和进化的基础。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115032
M. Depew, C. Compagnucci, J. Griffin
{"title":"Suture neontology and paleontology: the bases for where, when and how boundaries between bones have been established and have evolved.","authors":"M. Depew, C. Compagnucci, J. Griffin","doi":"10.1159/0000115032","DOIUrl":"https://doi.org/10.1159/0000115032","url":null,"abstract":"Much of what has been written about sutures has either focused on the genetic and biologic etiologies of specific sutural development, maintenance, and pathogenesis or on the utilization of sutures as character states in vertebrate cladistic analyses. There is a much more modest literature explicitly concerned with the evolution of sutures. We provide a small bridge of these literatures by presenting a discussion of the evolutionary biologic bases for the patterns of where, when, and how sutural boundaries between skeletal and dental elements have been established and have evolved. As sutural boundaries do not exist in the absence of the nucleation events that initiate the generation of skeletal elements, we explore historic models seeking to identify the inductive events dictating the specific times and places where a cranial skeletal element forms, the elaboration of its sutural boundaries, and the mechanisms whereby subsequent phyletic changes may be manifested and recognized.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"57-78"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64393633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Current treatment of craniosynostosis and future therapeutic directions. 颅缝闭锁的治疗现状及未来治疗方向。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115043
D. Wan, Matthew D. Kwan, H. Lorenz, M. Longaker
{"title":"Current treatment of craniosynostosis and future therapeutic directions.","authors":"D. Wan, Matthew D. Kwan, H. Lorenz, M. Longaker","doi":"10.1159/0000115043","DOIUrl":"https://doi.org/10.1159/0000115043","url":null,"abstract":"Normal craniofacial development is contingent upon coordinated growth between the brain and overlying calvaria. Craniosynostosis, the premature fusion of one or more cranial sutures, perturbs this natural framework, resulting in dramatic dysmorphology of the skull and face along with a multitude of associated functional abnormalities. Traditional approaches to the treatment of craniosynostosis have employed complex surgical remodeling of the skull vault and facial deformities all aimed at increasing the amount of intracranial volume and restoring a more normal craniofacial appearance. Significant morbidity and mortality, however, have plagued these procedures, driving dramatic evolution in our approach towards the treatment of pathologically fused sutures. Recent clinical and genetic studies have identified multiple forms of human craniosynostosis, each associated with mutations within various cytokine signaling pathways. Knowledge garnered from these investigations bear promise for the future development of alternative strategies to enhance or perhaps even replace contemporary approaches for the treatment of craniosynostosis.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"209-30"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64394551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Clinical features of syndromic craniosynostosis. 综合征型颅缝闭闭的临床特点。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115034
D. Rice
{"title":"Clinical features of syndromic craniosynostosis.","authors":"D. Rice","doi":"10.1159/0000115034","DOIUrl":"https://doi.org/10.1159/0000115034","url":null,"abstract":"Disruption of normal suture development and function can result in premature suture fusion, craniosynostosis. This review focuses on syndromic forms of craniosynostosis. More than 100 syndromes in which craniosynostosis is a feature have been documented and here the most common conditions including Apert and Crouzon syndromes are described as well as other conditions with a particularly interesting molecular etiology, such as Saethre- Chotzen and craniofrontonasal syndrome.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"91-106"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64394041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Fibroblast growth factor signaling in cranial suture development and pathogenesis. 成纤维细胞生长因子信号在颅骨缝线发育和发病中的作用。
Frontiers of oral physiology Pub Date : 2008-01-01 DOI: 10.1159/0000115037
M. Hajihosseini
{"title":"Fibroblast growth factor signaling in cranial suture development and pathogenesis.","authors":"M. Hajihosseini","doi":"10.1159/0000115037","DOIUrl":"https://doi.org/10.1159/0000115037","url":null,"abstract":"Apert, Pfeiffer and Crouzon syndromes are congenital craniosynostosis syndromes caused by mutations that perturb the level of fibroblast growth factor receptor (FGFR) signaling. The cellular and molecular impact of these mutations have been studied in vitro and in animal models in vivo. Here, I highlight the complexity of the FGF/FGFR signaling system and review the candidate modifiers responsible for regulating the levels of FGF/FGFR signaling in tissues. I also review what we have learned from the phenotypic analysis of mice that model these craniosynostosis syndromes and discuss some in vivo strategies for further understanding as well as alleviating the associated craniofacial defects.","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"12 1","pages":"160-77"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64394100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
The functioning dentition. 有功能的牙齿。
Frontiers of oral physiology Pub Date : 1976-01-01 DOI: 10.1159/000393320
A W Haddad
{"title":"The functioning dentition.","authors":"A W Haddad","doi":"10.1159/000393320","DOIUrl":"https://doi.org/10.1159/000393320","url":null,"abstract":"","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"2 ","pages":"146-83"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000393320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12247899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Sensorimotor examination of the mouth and pharynx. 口腔和咽的感觉运动检查。
Frontiers of oral physiology Pub Date : 1976-01-01 DOI: 10.1159/000393317
J F Bosma
{"title":"Sensorimotor examination of the mouth and pharynx.","authors":"J F Bosma","doi":"10.1159/000393317","DOIUrl":"https://doi.org/10.1159/000393317","url":null,"abstract":"","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"2 ","pages":"78-107"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000393317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12247903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Dentinal and periodontal sensory mechanisms. 牙本质和牙周感觉机制。
Frontiers of oral physiology Pub Date : 1976-01-01 DOI: 10.1159/000393315
D J Anderson, B Matthews
{"title":"Dentinal and periodontal sensory mechanisms.","authors":"D J Anderson, B Matthews","doi":"10.1159/000393315","DOIUrl":"https://doi.org/10.1159/000393315","url":null,"abstract":"","PeriodicalId":77140,"journal":{"name":"Frontiers of oral physiology","volume":"2 ","pages":"38-50"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000393315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12247901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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