FEMS microbiology immunology最新文献

Macrophage-neoplastic cell interactions: implications for neoplastic cell growth. 巨噬细胞-肿瘤细胞相互作用:对肿瘤细胞生长的影响。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05914.x

R G Pugh-Humphreys

{"title":"Macrophage-neoplastic cell interactions: implications for neoplastic cell growth.","authors":"R G Pugh-Humphreys","doi":"10.1111/j.1574-6968.1992.tb05914.x","DOIUrl":"https://doi.org/10.1111/j.1574-6968.1992.tb05914.x","url":null,"abstract":"Subcutaneous transplantation of EL4 lymphoma cells within C57BL10 mice evoked an oedematous inflammatory response involving increased leukopoiesis within the bone marrow, a blood leukocytosis, an influx of leukocytes into the transplants and surrounding host connective tissues, and extensive remodelling of surrounding host connective tissues involving fibroplasia and angiogenesis. Dexamethasone not only significantly reduced the numbers of circulating blood leukocytes within C57BL10 mice bearing the subcutaneous EL4 lymphoma transplants, but also reduced the oedematous inflammatory response to the transplants. The decreased influx of inflammatory leukocytes into the site of EL4 lymphoma cell transplantation within the dexamethasone-treated mice, was accompanied by reduced growth of the transplants. Although the EL4 lymphoma cells produce factors with Colony Stimulating Factor activity and with chemotactic activity for cells of the monocyte-macrophage lineage, they do not appear to produce fibroblast growth factors directly but can induce (or stimulate) macrophages to generate fibroblast growth factors in vitro. While not directly inhibiting the growth of subcutaneous fibroblasts in vitro, dexamethasone does suppress the production and/or activity of fibroblast growth factors generated through macrophage-EL4 cell interactions in vitro. The inhibitory effects of dexamethasone on macrophage influx, fibroplasia and angiogenesis within the connective tissue surrounding the EL4 lymphoma transplants appear to be casually related events and would account for the inhibitory effect of dexamethasone on the growth of the lymphoma transplants.","PeriodicalId":77129,"journal":{"name":"FEMS microbiology immunology","volume":"5 5-6","pages":"289-308"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05914.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12456282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Tumour cell inhibition of macrophage cytokine activity. 肿瘤细胞抑制巨噬细胞细胞因子活性。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05913.x

B M Hannigan, O R McNally, O Kirrane, S J Eason

引用次数: 5

The role of inositol lipids in the activation of monocytes by interleukin-1 and bacterial endotoxin. 肌醇脂在白细胞介素-1和细菌内毒素激活单核细胞中的作用。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05909.x

D Rotondo, C R Earl, G McIntosh, F S McIntosh, A Hepburn, A S Milton, J Davidson

{"title":"The role of inositol lipids in the activation of monocytes by interleukin-1 and bacterial endotoxin.","authors":"D Rotondo, C R Earl, G McIntosh, F S McIntosh, A Hepburn, A S Milton, J Davidson","doi":"10.1111/j.1574-6968.1992.tb05909.x","DOIUrl":"https://doi.org/10.1111/j.1574-6968.1992.tb05909.x","url":null,"abstract":"The effect of interleukin-1 (IL-1) and bacterial endotoxin (lipopolysaccharide, LPS) on the activation of phosphoinositidase C (PIC) and on prostaglandin E2 release was studied in monocytes (M phi). Both IL-1 alpha and IL-1 beta increased the release of PGE2 in a concentration-dependent manner, with EC50s of 0.48 nM and 0.12 nM, respectively. Intact M phi were prelabelled with [3H]inositol and the formation of inositol phosphates (IPs) was estimated by ion exchange chromatography. PIC activity was estimated directly by measuring the conversion of [3H]phosphatidylinositol-4,5-bisphosphate to aqueous soluble radioactivity by M phi homogenates. IL-1 alpha (5.8 nM) increased the accumulation of IPs within 1-4 minutes and increases in IP3 and IP4 occurred before the increase in IP1+2 whereas LPS only increased the IPs level after at least 30 min. IL-1 alpha increased PIC activity in M phi homogenates within 15 min with an EC50 of 0.58 nM and IL-1 beta (0.1 nM) also increased activity. Neither IL-1 alpha nor IL-1 beta affected the PIC activity of membrane or cytosolic fractions. LPS decreased activity in all fractions. These data indicate that IL-1, but not LPS, can directly lead to an increased activity of PIC which may be involved in eicosanoid formation in M phi.","PeriodicalId":77129,"journal":{"name":"FEMS microbiology immunology","volume":"5 5-6","pages":"249-59"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05909.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12508473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Phagocyte activation in coronary artery disease. 冠状动脉疾病中的吞噬细胞活化。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05911.x

G Ricevuti, A Mazzone, I Mazzucchelli, G Fossati, D Pasotti, P Cavigliano, L Rolandi, G Viarengo, M Rossi, A Notario

{"title":"Phagocyte activation in coronary artery disease.","authors":"G Ricevuti, A Mazzone, I Mazzucchelli, G Fossati, D Pasotti, P Cavigliano, L Rolandi, G Viarengo, M Rossi, A Notario","doi":"10.1111/j.1574-6968.1992.tb05911.x","DOIUrl":"https://doi.org/10.1111/j.1574-6968.1992.tb05911.x","url":null,"abstract":"Recent studies suggest that granulocytes (PMNs) play a role in the pathogenesis of acute and chronic myocardial ischemia and extension of myocardial injury. Granulocytes can release a variety of molecules mediating tissue injury which act synergistically with other molecules and cells. The aim of our investigation was to evaluate the granulocyte function in patients affected by coronary artery disease (CAD) and during coronary angioplasty (PTCA). We studied 20 patients suffering from CAD. The PMN's aggregating activity was greater in the coronary sinus than in the aorta (P < 0.01). The increase in aggregating activity was evident in patients who were smokers: their cells release significantly lower quantities of leukotriene C4 (P < 0.025). In the 20 patients who underwent coronary angioplasty we analyzed superoxide release after stimulation with phorbol-myristate-acetate (PMA). The results showed a greater decrease of PMN's superoxide production in the coronary sinus than in the aorta (P < 0.05). In all patients affected by CAD we evaluated the PMN's expression of CD11b/CD18 membrane integrins. In these patients the increase in expression of CD11b/CD18 was statistically significant in comparison with the controls (P < 0.01). This increase in expression correlates with a higher aggregation (r = 0.87, P < 0.001). The potential role of leukocytes, oxygen radicals, leukotrienes and granulocyte enzymes in the pathophysiology of myocardial injury due to regional ischemia and reperfusion is an area of intense investigation. This paper presents studies carried out in vivo which have been instrumental in demonstrating the role of granulocytes as mediators of myocardial ischemia.","PeriodicalId":77129,"journal":{"name":"FEMS microbiology immunology","volume":"5 5-6","pages":"271-8"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05911.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12534409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New pathways of phagocyte activation: the coupling of receptor-linked phospholipase D and the role of tyrosine kinase in primed neutrophils. 吞噬细胞活化的新途径:受体连接磷脂酶D的偶联和酪氨酸激酶在引物中性粒细胞中的作用。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05907.x

L G Garland

引用次数: 31

Sequential phospholipase activation in the stimulation of the neutrophil NADPH oxidase. 顺序磷脂酶激活刺激中性粒细胞NADPH氧化酶。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05908.x

F Watson, J J Robinson, S W Edwards

引用次数: 9

Pathways controlling the superoxide response during phagocyte differentiation: involvement of arachidonic acid and Ca2+ in the response to bacterial endotoxin. 在吞噬细胞分化过程中控制超氧化物反应的途径:花生四烯酸和Ca2+参与对细菌内毒素的反应。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05910.x

H A Leaver, S Janah, P L Yap, W B Ross, A Dhillon, L Turner

{"title":"Pathways controlling the superoxide response during phagocyte differentiation: involvement of arachidonic acid and Ca2+ in the response to bacterial endotoxin.","authors":"H A Leaver, S Janah, P L Yap, W B Ross, A Dhillon, L Turner","doi":"10.1111/j.1574-6968.1992.tb05910.x","DOIUrl":"https://doi.org/10.1111/j.1574-6968.1992.tb05910.x","url":null,"abstract":"In contrast to the phorbol ester oxidative response, which only develops during dimethylsulphoxide (DMSO)-induced differentiation of the human leukemic myeloblast HL-60 cell-line, the endotoxin response was observed in undifferentiated and differentiated cells. The Ca2+ response to endotoxin, detected in both differentiated and undifferentiated HL-60 cells, consisted of a transient 10-50 nM increase in intracellular Ca2+. A very slow, irreversible increase in intracellular Ca2+ was detected at high 1-100 micrograms/ml endotoxin concentrations, and this effect, and the inositol phosphate response, correlated with the surfactant activities of various endotoxins and Lipid A. Arachidonic acid and sodium arachidonate 1-50 microM stimulated a large 200-500 nM and transient Ca2+ response in undifferentiated HL-60 cells, which was significantly greater than that elicited by 1-50 microM eicosapentaenoic acid, and was not observed at similar concentrations of arachidonic acid methyl ester or myristic acid. These concentrations (1-50 microM) of arachidonic acid were observed to have surfactant activities on the plasma membrane. At lower arachidonic acid concentrations a marked potentiation of both Ca2+ and oxidative responses to the chemotactic peptide fMet-Leu-Phe was detected. It is possible that the arachidonic acid released during phospholipase A2 activation of neutrophils may be involved in cellular cross-talk and, at higher concentrations, in directly activating Ca2+ and superoxide production. It is also possible that previously reported effects of endotoxin at high concentrations are an in vitro artefact of surfactant properties of endotoxin.","PeriodicalId":77129,"journal":{"name":"FEMS microbiology immunology","volume":"5 5-6","pages":"261-70"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05910.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12508474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

New pathways of phagocyte activation: an overview. 吞噬细胞活化的新途径综述。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05906.x

H A Leaver, P L Yap, J Stewart

引用次数: 1

Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation. 巨噬细胞转铁蛋白合成:γ -干扰素上调及其对淋巴细胞增殖的影响。

FEMS microbiology immunology Pub Date : 1992-12-01 DOI: 10.1111/j.1574-6968.1992.tb05912.x

A Djeha, J L Pérez-Arellano, S L Hayes, J H Brock

引用次数: 17

The HlyB/HlyD-dependent secretion of toxins by gram-negative bacteria. 革兰氏阴性菌的HlyB/ hlyd依赖性毒素分泌。

FEMS microbiology immunology Pub Date : 1992-09-01

V Koronakis, P Stanley, E Koronakis, C Hughes

引用次数: 0