{"title":"Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation.","authors":"A Djeha, J L Pérez-Arellano, S L Hayes, J H Brock","doi":"10.1111/j.1574-6968.1992.tb05912.x","DOIUrl":null,"url":null,"abstract":"<p><p>We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.</p>","PeriodicalId":77129,"journal":{"name":"FEMS microbiology immunology","volume":"5 5-6","pages":"279-82"},"PeriodicalIF":0.0000,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05912.x","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEMS microbiology immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1574-6968.1992.tb05912.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
Abstract
We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.
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