{"title":"巨噬细胞转铁蛋白合成:γ -干扰素上调及其对淋巴细胞增殖的影响。","authors":"A Djeha, J L Pérez-Arellano, S L Hayes, J H Brock","doi":"10.1111/j.1574-6968.1992.tb05912.x","DOIUrl":null,"url":null,"abstract":"<p><p>We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.</p>","PeriodicalId":77129,"journal":{"name":"FEMS microbiology immunology","volume":"5 5-6","pages":"279-82"},"PeriodicalIF":0.0000,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05912.x","citationCount":"17","resultStr":"{\"title\":\"Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation.\",\"authors\":\"A Djeha, J L Pérez-Arellano, S L Hayes, J H Brock\",\"doi\":\"10.1111/j.1574-6968.1992.tb05912.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.</p>\",\"PeriodicalId\":77129,\"journal\":{\"name\":\"FEMS microbiology immunology\",\"volume\":\"5 5-6\",\"pages\":\"279-82\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1574-6968.1992.tb05912.x\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FEMS microbiology immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/j.1574-6968.1992.tb05912.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEMS microbiology immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1574-6968.1992.tb05912.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation.
We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
