Experimental and clinical immunogenetics最新文献_第4页

The Mouse (Mus musculus) T Cell Receptor Delta Variable (TRDV), Diversity (TRDD) and Joining (TRDJ) Genes 小鼠(小家鼠)T细胞受体δ变量(TRDV)、多样性(TRDD)和连接(TRDJ)基因

Experimental and clinical immunogenetics Pub Date : 2000-11-29 DOI: 10.1159/000049087

N. Bosc, V. Contet, M. Lefranc

引用次数: 30

Subject Index Vol. 17, 2000 主题索引第17卷，2000年

Experimental and clinical immunogenetics Pub Date : 2000-11-01 DOI: 10.1159/000019143

引用次数: 0

Author Index Vol. 17, 2000 作者索引第17卷，2000年

Experimental and clinical immunogenetics Pub Date : 2000-11-01 DOI: 10.1159/000019142

引用次数: 0

Contents Vol. 17, 2000 目录2000年第17卷

Experimental and clinical immunogenetics Pub Date : 2000-11-01 DOI: 10.1159/000019144

F. Nakao, K. Ihara, Saifuddin Ahmed, Yuka Sasaki, K. Kusuhara, A. Takabayashi, S. Nishima, T. Hara, Jianming Tang, E. Naik, Caroline Costello, E. Karita, Charles A. Rivers, S. Allen, R. Kaslow, A. Fraile, M. D. Collado, L. Matarán, J. W. Martin, Antonio Nieto, N. Bosc, M. Lefranc, H. Kaneko, T. Fukao, R. Inoue, K. Kasahara, E. Matsui, N. Kondo, G. Folch, Dominique Scaviner, V. Contet

引用次数: 0

TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis. 西班牙强直性脊柱炎患者的TAP1和TAP2多态性。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019139

A Fraile, M D Collado, L Matarán, J Martín, A Nieto

{"title":"TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis.","authors":"A Fraile, M D Collado, L Matarán, J Martín, A Nieto","doi":"10.1159/000019139","DOIUrl":"https://doi.org/10.1159/000019139","url":null,"abstract":"Objective: HLA-B27 is strongly associated with ankylosing spondylitis (AS); however, the association is not absolute and additional susceptibility factors in the MHC region could play a role. We studied the influence of polymorphism in the transporter associated with antigen processing (TAP) genes, including point mutations not previously analyzed.Methods: HLA-B*27 typing and subtyping as well as TAP1 and TAP2 typing were performed by PCR-RFLP. Forty-four AS individuals were compared to 61 ethnically matched random individuals and 35 B*27-positive healthy unrelated individuals as controls.Results: The frequency of the TAP1B allele was significantly greater in the patient group compared with the random controls (corrected p value (p(c)) = 0.035; odds ratio = 15.8, p = 0.01). A greater frequency was also evident when B*27-positive patients and B*27- positive healthy controls were compared, although it did not reach statistical significance. No differences were observed in TAP2 alleles between the groups studied.Discussion: We did not find a primary association between TAP2 polymorphism and AS susceptibility. Formal confirmation of a linkage between the TAP and HLA-B loci would probably require family studies.","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":"17 4","pages":"199-204"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000019139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21920518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Polymorphism of transmembrane region of MICA gene and Kawasaki disease. MICA基因跨膜区多态性与川崎病的关系。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019132

Y Huang, Y J Lee, M R Chen, C H Hsu, S P Lin, T C Sung, S C Chang, J G Chang

{"title":"Polymorphism of transmembrane region of MICA gene and Kawasaki disease.","authors":"Y Huang, Y J Lee, M R Chen, C H Hsu, S P Lin, T C Sung, S C Chang, J G Chang","doi":"10.1159/000019132","DOIUrl":"https://doi.org/10.1159/000019132","url":null,"abstract":"Kawasaki disease is a febrile disease of children complicated with vasculitis of the coronary arteries and potential aneurysm formation. It has been recognized worldwide and appears to be increasing in frequency. Studies have found that Kawasaki disease is associated with major histocompatibility complex (MHC) class I B antigens. The MHC-class-I-chain-related gene A (MICA) is located near HLA-B. It has a triplet repeat microsatellite polymorphism in the transmembrane region. We investigated the microsatellite polymorphism in children with Kawasaki disease and controls. Seventy children (46 boys), age at diagnosis 1.68 +/- 1.69 years, with Kawasaki who were treated with aspirin as well as intravenous gamma-globulin were enrolled. Control subjects consisted of 154 children (87 boys), age 2.81 +/- 2.12 years. Phenotype frequency of allele A4 in patients with aneurysm formation was significantly lower than in patients without aneurysms [relative risk (RR) = 0.06, 95% confidence interval (CI) = 0.01-0.48, p = 0.00469, pc = 0.0232] and showed a similar tendency when compared with controls. Gene frequency of allele A4 was also significantly lower in patients who developed aneurysms than in patients who did not (RR = 0.07, 95% CI = 0.01-0.57, p = 0.0057, pc = 0.0282). Gene frequency of allele A5 showed a tendency to be higher in patients who developed aneurysms than in controls (RR = 2.35, 95% CI = 0.98-5.63, p = 0.0486, pc = 0. 220). Allele A5.1 tended to be negatively associated with Kawasaki disease (RR = 0.57, 95% CI = 0.35-0.93, p = 0.022, pc = 0.105). Our study showed that allele A4 was negatively associated with coronary aneurysm formation in Kawasaki disease. This suggests that allele A4 protects the children with Kawasaki disease from developing coronary aneurysms after aspirin and gamma globulin therapy.","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":"17 3","pages":"130-7"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000019132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21740635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Conservation of plasma regulatory proteins of the complement system in evolution: humans and fish. 补体系统血浆调节蛋白在进化中的保护:人类和鱼类。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019124

C Kemper, I Gigli, P F Zipfel

引用次数: 14

The mouse (Mus musculus) T cell receptor beta variable (TRBV), diversity (TRBD) and joining (TRBJ) genes. 小鼠(小家鼠)T细胞受体β变量(TRBV)、多样性(TRBD)和连接(TRBJ)基因。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019141

N Bosc, M P Lefranc

引用次数: 35

Complement component C6 polymorphism: novel protein-typing technique and distribution of allotypes in Germany. 补体成分C6多态性:新的蛋白质分型技术和德国同种异体的分布。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019121

B Schwarzenholz, A Correns, H Schröder, G Geserick

引用次数: 0

Cells and cytokines in the pathogenesis of inflammatory bowel disease: new insights from mouse T cell transfer models. 炎症性肠病发病机制中的细胞和细胞因子:来自小鼠T细胞转移模型的新见解

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019131

S Bregenholt

引用次数: 14