Y Huang, Y J Lee, M R Chen, C H Hsu, S P Lin, T C Sung, S C Chang, J G Chang
{"title":"MICA基因跨膜区多态性与川崎病的关系。","authors":"Y Huang, Y J Lee, M R Chen, C H Hsu, S P Lin, T C Sung, S C Chang, J G Chang","doi":"10.1159/000019132","DOIUrl":null,"url":null,"abstract":"<p><p>Kawasaki disease is a febrile disease of children complicated with vasculitis of the coronary arteries and potential aneurysm formation. It has been recognized worldwide and appears to be increasing in frequency. Studies have found that Kawasaki disease is associated with major histocompatibility complex (MHC) class I B antigens. The MHC-class-I-chain-related gene A (MICA) is located near HLA-B. It has a triplet repeat microsatellite polymorphism in the transmembrane region. We investigated the microsatellite polymorphism in children with Kawasaki disease and controls. Seventy children (46 boys), age at diagnosis 1.68 +/- 1.69 years, with Kawasaki who were treated with aspirin as well as intravenous gamma-globulin were enrolled. Control subjects consisted of 154 children (87 boys), age 2.81 +/- 2.12 years. Phenotype frequency of allele A4 in patients with aneurysm formation was significantly lower than in patients without aneurysms [relative risk (RR) = 0.06, 95% confidence interval (CI) = 0.01-0.48, p = 0.00469, pc = 0.0232] and showed a similar tendency when compared with controls. Gene frequency of allele A4 was also significantly lower in patients who developed aneurysms than in patients who did not (RR = 0.07, 95% CI = 0.01-0.57, p = 0.0057, pc = 0.0282). Gene frequency of allele A5 showed a tendency to be higher in patients who developed aneurysms than in controls (RR = 2.35, 95% CI = 0.98-5.63, p = 0.0486, pc = 0. 220). Allele A5.1 tended to be negatively associated with Kawasaki disease (RR = 0.57, 95% CI = 0.35-0.93, p = 0.022, pc = 0.105). Our study showed that allele A4 was negatively associated with coronary aneurysm formation in Kawasaki disease. This suggests that allele A4 protects the children with Kawasaki disease from developing coronary aneurysms after aspirin and gamma globulin therapy.</p>","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000019132","citationCount":"46","resultStr":"{\"title\":\"Polymorphism of transmembrane region of MICA gene and Kawasaki disease.\",\"authors\":\"Y Huang, Y J Lee, M R Chen, C H Hsu, S P Lin, T C Sung, S C Chang, J G Chang\",\"doi\":\"10.1159/000019132\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Kawasaki disease is a febrile disease of children complicated with vasculitis of the coronary arteries and potential aneurysm formation. It has been recognized worldwide and appears to be increasing in frequency. Studies have found that Kawasaki disease is associated with major histocompatibility complex (MHC) class I B antigens. The MHC-class-I-chain-related gene A (MICA) is located near HLA-B. It has a triplet repeat microsatellite polymorphism in the transmembrane region. We investigated the microsatellite polymorphism in children with Kawasaki disease and controls. Seventy children (46 boys), age at diagnosis 1.68 +/- 1.69 years, with Kawasaki who were treated with aspirin as well as intravenous gamma-globulin were enrolled. Control subjects consisted of 154 children (87 boys), age 2.81 +/- 2.12 years. Phenotype frequency of allele A4 in patients with aneurysm formation was significantly lower than in patients without aneurysms [relative risk (RR) = 0.06, 95% confidence interval (CI) = 0.01-0.48, p = 0.00469, pc = 0.0232] and showed a similar tendency when compared with controls. Gene frequency of allele A4 was also significantly lower in patients who developed aneurysms than in patients who did not (RR = 0.07, 95% CI = 0.01-0.57, p = 0.0057, pc = 0.0282). Gene frequency of allele A5 showed a tendency to be higher in patients who developed aneurysms than in controls (RR = 2.35, 95% CI = 0.98-5.63, p = 0.0486, pc = 0. 220). Allele A5.1 tended to be negatively associated with Kawasaki disease (RR = 0.57, 95% CI = 0.35-0.93, p = 0.022, pc = 0.105). Our study showed that allele A4 was negatively associated with coronary aneurysm formation in Kawasaki disease. 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引用次数: 46
摘要
川崎病是一种儿童并发冠状动脉血管炎和潜在动脉瘤形成的发热性疾病。它已得到全世界的认可,而且似乎越来越频繁。研究发现川崎病与主要组织相容性复合体(MHC) I类B抗原有关。mhc - i类链相关基因A (MICA)位于HLA-B附近。它在跨膜区具有三联体重复微卫星多态性。我们研究了川崎病患儿和对照组的微卫星多态性。纳入70名儿童(46名男孩),诊断时年龄1.68±1.69岁,川崎患者接受阿司匹林和静脉注射γ -球蛋白治疗。对照组为154名儿童(男孩87名),年龄2.81±2.12岁。形成动脉瘤患者A4等位基因表型频率显著低于未形成动脉瘤患者[相对危险度(RR) = 0.06, 95%可信区间(CI) = 0.01 ~ 0.48, p = 0.00469, pc = 0.0232],且与对照组相似。A4等位基因的基因频率在发生动脉瘤的患者中也明显低于未发生动脉瘤的患者(RR = 0.07, 95% CI = 0.01 ~ 0.57, p = 0.0057, pc = 0.0282)。发生动脉瘤患者的A5等位基因频率有高于对照组的趋势(RR = 2.35, 95% CI = 0.98-5.63, p = 0.0486, pc = 0)。220)。等位基因A5.1与川崎病呈负相关(RR = 0.57, 95% CI = 0.35 ~ 0.93, p = 0.022, pc = 0.105)。我们的研究表明等位基因A4与川崎病冠状动脉瘤形成负相关。这表明等位基因A4保护患有川崎病的儿童在服用阿司匹林和丙种球蛋白治疗后不发生冠状动脉瘤。
Polymorphism of transmembrane region of MICA gene and Kawasaki disease.
Kawasaki disease is a febrile disease of children complicated with vasculitis of the coronary arteries and potential aneurysm formation. It has been recognized worldwide and appears to be increasing in frequency. Studies have found that Kawasaki disease is associated with major histocompatibility complex (MHC) class I B antigens. The MHC-class-I-chain-related gene A (MICA) is located near HLA-B. It has a triplet repeat microsatellite polymorphism in the transmembrane region. We investigated the microsatellite polymorphism in children with Kawasaki disease and controls. Seventy children (46 boys), age at diagnosis 1.68 +/- 1.69 years, with Kawasaki who were treated with aspirin as well as intravenous gamma-globulin were enrolled. Control subjects consisted of 154 children (87 boys), age 2.81 +/- 2.12 years. Phenotype frequency of allele A4 in patients with aneurysm formation was significantly lower than in patients without aneurysms [relative risk (RR) = 0.06, 95% confidence interval (CI) = 0.01-0.48, p = 0.00469, pc = 0.0232] and showed a similar tendency when compared with controls. Gene frequency of allele A4 was also significantly lower in patients who developed aneurysms than in patients who did not (RR = 0.07, 95% CI = 0.01-0.57, p = 0.0057, pc = 0.0282). Gene frequency of allele A5 showed a tendency to be higher in patients who developed aneurysms than in controls (RR = 2.35, 95% CI = 0.98-5.63, p = 0.0486, pc = 0. 220). Allele A5.1 tended to be negatively associated with Kawasaki disease (RR = 0.57, 95% CI = 0.35-0.93, p = 0.022, pc = 0.105). Our study showed that allele A4 was negatively associated with coronary aneurysm formation in Kawasaki disease. This suggests that allele A4 protects the children with Kawasaki disease from developing coronary aneurysms after aspirin and gamma globulin therapy.