Epilepsy research. Supplement最新文献

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Financial aspects of introduction and application of new drugs and technologies. 引进和应用新药物和新技术的财务方面。
Epilepsy research. Supplement Pub Date : 1996-01-01
B G Vickrey, R J Gumnit
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引用次数: 0
Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances. 大鼠杏仁核点燃过程中阿片肽释放和mu受体结合:区域不一致。
Epilepsy research. Supplement Pub Date : 1996-01-01
L Rocha, N T Maidment, C J Evans, R F Ackermann, J Engel
{"title":"Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances.","authors":"L Rocha, N T Maidment, C J Evans, R F Ackermann, J Engel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"215-28"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20241939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-NMDA receptor antagonists and the development of amygdala kindling. 非nmda受体拮抗剂与杏仁核点燃的发展。
Epilepsy research. Supplement Pub Date : 1996-01-01
B S Meldrum, N Dürmüller
{"title":"Non-NMDA receptor antagonists and the development of amygdala kindling.","authors":"B S Meldrum, N Dürmüller","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"283-91"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20241946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic epileptic foci induced by intracranial tetanus toxin. 颅内破伤风毒素致慢性癫痫灶。
Epilepsy research. Supplement Pub Date : 1996-01-01
J G Jefferys
{"title":"Chronic epileptic foci induced by intracranial tetanus toxin.","authors":"J G Jefferys","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"111-7"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20244078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of potential positive drug interactions. 预测潜在的积极药物相互作用。
Epilepsy research. Supplement Pub Date : 1996-01-01
R E Nemire, A Wauquier
{"title":"Prediction of potential positive drug interactions.","authors":"R E Nemire, A Wauquier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"11 ","pages":"245-52"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20234876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rational polypharmacy in the bipolar affective disorders. 双相情感障碍的合理多药治疗。
Epilepsy research. Supplement Pub Date : 1996-01-01
R M Post, T A Ketter, P J Pazzaglia, K Denicoff, M S George, A Callahan, G Leverich, M Frye
{"title":"Rational polypharmacy in the bipolar affective disorders.","authors":"R M Post,&nbsp;T A Ketter,&nbsp;P J Pazzaglia,&nbsp;K Denicoff,&nbsp;M S George,&nbsp;A Callahan,&nbsp;G Leverich,&nbsp;M Frye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bipolar affective illness represents a syndrome not readily treated by single agents. Approximately 50% of patients are inadequately responsive to lithium and the majority of patients require supplemental antidepressants, antimanic, antipsychotic or hypnotic medications. These traditional adjunctive medications are associated with potential problems. Antidepressants may precipitate mania (at a rate about double that of placebo) or cause cycle acceleration. Neuroleptics may be associated with either more profound or longer depressive phases, and clearly increase the risk of tardive dyskinesia, to which bipolar patients appear particularly predisposed. Moreover, there are subgroups of patients who are known to be poorly responsive to lithium. These include patients with rapid cycling, dysphoric mania, co-morbid drug or alcohol abuse, a pattern of depression-mania-well interval (D-M-I as opposed to the M-D-I pattern), and patients without a family history of bipolar illness in first-degree relatives. There is increasing recognition that the anticonvulsants carbamazepine and valproate are effective alternatives or adjuncts to lithium in the acute and long-term treatment of bipolar illness. Ideally, one would want to assess whether patients who were unresponsive to lithium were responsive to an anticonvulsant alone prior to utilizing lithium in addition to anticonvulsant combination therapy. However, from the clinical perspective, it is often more expedient to use an anticonvulsant adjunctively to lithium to assess the efficacy of this combination and establish mood stabilization. When lithium is not discontinued, the increased morbidity during lithium withdrawal also would not occur and would not confound the evaluation of the new agent. We suggest the initial use of acute adjuncts to lithium with the anticonvulsants carbamazepine or valproate (instead of neuroleptics) so that their efficacy can be assessed in the individual's acute episode, with the likelihood of a positive response in longer-term prophylaxis. Hypnotic benzodiazepines with anticonvulsant properties, such as clonazepam or lorazepam, are often used to help to induce sleep in escalating bipolar patients, and may be useful adjuncts as well. Patients who were inadequately responsive to either carbamazepine or valproate alone may be responsive to the anticonvulsant combination. In a similar fashion, one can also utilize several mood-stabilizing drugs (lithium and an anticonvulsant such as carbamazepine or valproate) in the treatment of depressive breakthroughs, and then augment this combination (if necessary) with a catecholamine-active antidepressant such as bupropion or a serotonin-selective reuptake inhibitor (SSRI) such as fluoxetine, paroxetine, sertraline or if necessary a monoamine oxidase inhibitor (MAOI). Once the patient has responded to a combination of drugs, it becomes problematic to decide whether the last agent added was the crucial ingredient in helping the patient a","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"11 ","pages":"153-80"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20236366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of newer diagnostic techniques in patient management. 在病人管理中使用新的诊断技术。
Epilepsy research. Supplement Pub Date : 1996-01-01
H Stefan
{"title":"Use of newer diagnostic techniques in patient management.","authors":"H Stefan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"11 ","pages":"199-209"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20236368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total number of neurons in the ventro-lateral/posterior thalamic nuclei in a genetic petit mal-like rat strain. 遗传小雄样大鼠品系丘脑腹外侧/后核神经元总数。
Epilepsy research. Supplement Pub Date : 1996-01-01
A Mouritzen-Dam, A Møller, J Scheel-Krüger, L H Jensen, C Marescaux, M Vergnes
{"title":"Total number of neurons in the ventro-lateral/posterior thalamic nuclei in a genetic petit mal-like rat strain.","authors":"A Mouritzen-Dam,&nbsp;A Møller,&nbsp;J Scheel-Krüger,&nbsp;L H Jensen,&nbsp;C Marescaux,&nbsp;M Vergnes","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"303-7"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20241948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological properties of immature neocortical neurons relevant to pathophysiology of infantile epileptic encephalopathies. 未成熟新皮层神经元的生理特性与婴儿癫痫性脑病的病理生理相关。
Epilepsy research. Supplement Pub Date : 1996-01-01
G Avanzini, S Franceschetti, G Sancini
{"title":"Physiological properties of immature neocortical neurons relevant to pathophysiology of infantile epileptic encephalopathies.","authors":"G Avanzini,&nbsp;S Franceschetti,&nbsp;G Sancini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20244072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective vulnerability to perforant path stimulation: role of NMDA and non-NMDA receptors. 穿透路径刺激的选择性易感性:NMDA和非NMDA受体的作用。
Epilepsy research. Supplement Pub Date : 1996-01-01
L P Penix, K W Thompson, C G Wasterlain
{"title":"Selective vulnerability to perforant path stimulation: role of NMDA and non-NMDA receptors.","authors":"L P Penix,&nbsp;K W Thompson,&nbsp;C G Wasterlain","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"12 ","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20244073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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