Epilepsy research. Supplement最新文献

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Active role of cortical inhibition in the development of generalized epilepsy with spike-and-wave discharges: evidence from electrophysiological, microiontophoretic and simulation studies. 皮层抑制在伴随峰波放电的全身性癫痫发展中的积极作用:来自电生理、微离子电泳和模拟研究的证据。
Epilepsy research. Supplement Pub Date : 1992-01-01 DOI: 10.1016/b978-0-444-89710-7.50021-5
G Kostopoulos, G Antoniadis
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引用次数: 7
The role of NMDA receptors in in vitro epileptogenesis. NMDA受体在体外癫痫发生中的作用。
Epilepsy research. Supplement Pub Date : 1992-01-01 DOI: 10.1016/b978-0-444-89710-7.50025-2
W A Wilson, S Stasheff, S Swartzwelder, S Clark, W W Anderson
{"title":"The role of NMDA receptors in in vitro epileptogenesis.","authors":"W A Wilson, S Stasheff, S Swartzwelder, S Clark, W W Anderson","doi":"10.1016/b978-0-444-89710-7.50025-2","DOIUrl":"https://doi.org/10.1016/b978-0-444-89710-7.50025-2","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"8 ","pages":"157-65; discussion 165-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12503667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Granule cell inhibition and the activity of hilar neurons. 颗粒细胞的抑制作用与肺门神经元的活性。
Epilepsy research. Supplement Pub Date : 1992-01-01
U Misgeld, M Bijak, H Brunner
{"title":"Granule cell inhibition and the activity of hilar neurons.","authors":"U Misgeld,&nbsp;M Bijak,&nbsp;H Brunner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electrophysiological data from guinea pig hippocampal slices together with available morphological information about the dentate granule cell--hilar neuron circuitry strongly suggest that hilar neurons largely contribute to postsynaptic inhibition of granule cells. As in hippocampal pyramidal cells, inhibitory postsynaptic potentials in granule cells are either due to an increase in Cl-conductance or to an increase in K-conductance. It is therefore further suggested that hilar neurons inhibiting granule cells belong to at least two functionally distinct groups, those generating Cl-dependent and those generating K-dependent IPSPs. The presumed inhibitory action of hilar neurons is underlined by experiments applying pharmacological tools to suppress or enhance hilar neuron activity. Hyperpolarization of hilar neurons by the presumed GABAB-agonist (-)baclofen is associated with disinhibition of granule cells. If hilar neurons are activated by 4-amino-pyridine or picrotoxin to discharge in repetitive bursts, granule cells display repetitively occurring inhibitory postsynaptic potentials.</p>","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"7 ","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12508700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synaptic plasticity and activity-induced gene expression: will molecular neurobiology provide all the answers? 突触可塑性和活动诱导的基因表达:分子神经生物学能提供所有答案吗?
Epilepsy research. Supplement Pub Date : 1992-01-01
A J Tobin
{"title":"Synaptic plasticity and activity-induced gene expression: will molecular neurobiology provide all the answers?","authors":"A J Tobin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"9 ","pages":"385-94; discussion 394-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12511543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benign Localized and Generalized Epilepsies of Early Childhood. Symposium proceedings. Bad Kreuznach, Germany, September 1990. 幼儿良性局部和全身性癫痫。研讨会论文集。1990年9月,德国Bad Kreuznach。
Epilepsy research. Supplement Pub Date : 1992-01-01
{"title":"Benign Localized and Generalized Epilepsies of Early Childhood. Symposium proceedings. Bad Kreuznach, Germany, September 1990.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"6 ","pages":"1-230"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12530972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions. 在与惊厥相关的各种情况下,完整和去皮大鼠新纹状体中谷氨酸和相关氨基酸水平的变化。
Epilepsy research. Supplement Pub Date : 1992-01-01 DOI: 10.1016/b978-0-444-89710-7.50032-x
B A Engelsen, F Fonnum, K Furset
{"title":"Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions.","authors":"B A Engelsen,&nbsp;F Fonnum,&nbsp;K Furset","doi":"10.1016/b978-0-444-89710-7.50032-x","DOIUrl":"https://doi.org/10.1016/b978-0-444-89710-7.50032-x","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"8 ","pages":"211-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12530979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny 'fast-spiking' cells. 大鼠齿状神经元海马切片形态学和电生理分化:颗粒细胞、棘门细胞和棘突“快速尖峰”细胞。
Epilepsy research. Supplement Pub Date : 1992-01-01
H E Scharfman
{"title":"Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny 'fast-spiking' cells.","authors":"H E Scharfman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intracellular recording and intracellular dye injection of single cells in the dentate region of rat hippocampal slices have been used to understand the different types of cells in the dentate and their possible functional organization. On the basis of combined electrophysiological and morphological data, the cells that have been sampled fall into three distinct groups: the granule cells, the spiny cells located in the hilus (the 'mossy' cell being the prototype), and the aspiny, 'fast-spiking' cells located throughout the region (many of which are likely to be GABAergic interneurons). Although there is some variability within each group, this variability is minor compared to the large differences between groups. To clarify these groups, each one is described first morphologically, at the level of the light microscope and histochemically, and then the three groups are described electrophysiologically, in terms of intrinsic electrophysiological characteristics, synaptic responses to perforant path stimulation, and possible roles in dentate circuitry. It is proposed that this apparent organization of neurons into three major classes be used as a starting point in our evolving understanding of the functional organization of the dentate region, and, in particular, the hilus. In addition, the possibility is raised that area CA3c cells of the hippocampus could be included in the dentate region as a fourth group. Together with the hilar cells, area CA3c could have the obviously important role of integrating the dentate circuitry with that of the hippocampus proper.</p>","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"7 ","pages":"93-109"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281805/pdf/nihms355578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12534400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depth electrodes. 深度电极。
Epilepsy research. Supplement Pub Date : 1992-01-01
S S Spencer
{"title":"Depth electrodes.","authors":"S S Spencer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"5 ","pages":"135-45"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12589155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subdural electrodes in the presurgical evaluation for surgery of epilepsy. 硬膜下电极在癫痫手术术前评价中的应用。
Epilepsy research. Supplement Pub Date : 1992-01-01
H Lüders, I Awad, R Burgess, E Wyllie, P Van Ness
{"title":"Subdural electrodes in the presurgical evaluation for surgery of epilepsy.","authors":"H Lüders,&nbsp;I Awad,&nbsp;R Burgess,&nbsp;E Wyllie,&nbsp;P Van Ness","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article gives first an overview of the advantages and disadvantages of electrodes of progressively greater invasiveness used in the evaluation of patients who are candidates for surgery of epilepsy. The following sections discuss the design of subdural electrodes, their clinical indications, and the relative advantages and disadvantages of subdural electrodes when compared with other invasive techniques.</p>","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"5 ","pages":"147-56"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12589156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different approaches to resective epilepsy surgery: standard and tailored. 不同的方法切除癫痫手术:标准和量身定制。
Epilepsy research. Supplement Pub Date : 1992-01-01
G A Ojemann
{"title":"Different approaches to resective epilepsy surgery: standard and tailored.","authors":"G A Ojemann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intra-operative approaches to resective surgery for medically intractable epilepsy, especially cases involving temporal lobes, vary from anatomically standardized operations to those tailored to the location of epileptogenic zones and eloquent areas in individual subjects. The choice of approaches seems to depend on different views of the variability in epileptogenic zones and eloquent areas and on the reliability of identifying these areas intraoperatively, including the value of interictal epileptic activity. Evidence relating to these issues is reviewed. Although the choice of an intra-operative approach has a major effect on the risks and costs of the evaluation for epilepsy surgery, with higher risks and costs for approaches using standard operations or extra-operative recording, no controlled study has compared the approaches. Indeed, the reported outcome for optimal candidates for each approach is nearly identical, providing little justification for use of approaches with higher risks and costs in all patients.</p>","PeriodicalId":77115,"journal":{"name":"Epilepsy research. Supplement","volume":"5 ","pages":"169-74"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12589158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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