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American Journal of Advanced Drug Delivery最新文献

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Logarithmic Partition Coefficient ComparisonStudy and Molecular Weight of SynthesizedProdrugs of Ibuprofen+Paracetamol, DiclofenacSodium+Paracetamol and Ibuprofen+DiclofenacSodium 布洛芬+扑热息痛、双氯芬那钠+扑热息痛、布洛芬+双氯芬那钠合成前药的对数分配系数比较及分子量研究
American Journal of Advanced Drug Delivery Pub Date : 2016-01-01 DOI: 10.21767/2321-547X.1000003
D. Sen, Jalpa Patel
{"title":"Logarithmic Partition Coefficient ComparisonStudy and Molecular Weight of SynthesizedProdrugs of Ibuprofen+Paracetamol, DiclofenacSodium+Paracetamol and Ibuprofen+DiclofenacSodium","authors":"D. Sen, Jalpa Patel","doi":"10.21767/2321-547X.1000003","DOIUrl":"https://doi.org/10.21767/2321-547X.1000003","url":null,"abstract":"Prodrug is a substance which after administration is metabolized into a pharmacologically active drug. Actually prodrug has least medicinal value in in-vitro/in-vivo but after biotransformation by metabolism in invivo it releases the active medicament. A drug is a substance which is a chemical entity, has definite structural skeleton, obtained by natural or synthetic or semisynthetic source, which can fit on bioreceptor platform having controlling capacity to control over the biochemical malfunction. Every drug is xenobiotic because it is coming from outer source (xeno) and active in biological unit (biotic). Prodrug is the precursor of drug which is made by derivatization of the same to enhance the bioavailability by pharmacokinetics, lipid solubility by partition coefficient and increase the physicochemical and biochemical parameters by pharmacodynamics. Ibuprofen, Diclofenac and Paracetamol have been taken as NSAID (Non-Steroidal Anti Inflammatory Drug) and three prodrugs have been synthesized by reacting with acid chloride of ibuprofen and diclofenac with paracetamol to get prodrug of ester linkage and acid chloride of ibuprofen has been reacted with diclofenac to get prodrug of amide linkage. All three prodrugs showed different logP values and molecular weights according to the solubility parameters and electronegativity: logP profile: Prodrug-C>Prodrug-B>prodrug-A; molecular weight profile: Prodrug-C>Prodrug-B>prodrug-A.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91538058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Formulation And Evaluation Of Acyclovir Sodium Solid Lipid Microparticles 阿昔洛韦钠固体脂质微粒的制备及评价
American Journal of Advanced Drug Delivery Pub Date : 2016-01-01 DOI: 10.21767/2321-547X.1000005
A. Nagappa, G. Agarwal, Vinuth Chikkamath, S. Agarwal, R. Rani, P. K. Karar
{"title":"Formulation And Evaluation Of Acyclovir Sodium Solid Lipid Microparticles","authors":"A. Nagappa, G. Agarwal, Vinuth Chikkamath, S. Agarwal, R. Rani, P. K. Karar","doi":"10.21767/2321-547X.1000005","DOIUrl":"https://doi.org/10.21767/2321-547X.1000005","url":null,"abstract":"Acyclovir sodium is an antiviral drug used to treat herpes, chicken pox and herpes skin infections. Acyclovir sodium potential as an antiviral drug is limited by its low oral bioavailability (20-30%) with short half life (2-3hours) with poor plasma protein binding. There is an opportunity to utilize Acyclovir sodium as an antiviral drug by enhancing the bioavailability by formulation technology. In this paper solid microparticle (o/w) of Acyclovir was prepared by melt dispersion technique. The characterization of drug using scanning electron microscopy, FT-IR, particle size, percentage yield, drug loading capacity, hausner’s ratio and carr’s index, bulk density and tapped density. In vitro drug release studies using phosphate buffer has shown as formulation F5 sustained release for 17hrs.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83613603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Review on Polymorphism PerpetuatesPharmaceuticals 多态性使药物永久存在的研究进展
American Journal of Advanced Drug Delivery Pub Date : 2016-01-01 DOI: 10.21767/2321-547X.1000002
N. L. Prasanthi, M. Sudhir, N. Jyothi, V. S. Vajrapriya
{"title":"A Review on Polymorphism PerpetuatesPharmaceuticals","authors":"N. L. Prasanthi, M. Sudhir, N. Jyothi, V. S. Vajrapriya","doi":"10.21767/2321-547X.1000002","DOIUrl":"https://doi.org/10.21767/2321-547X.1000002","url":null,"abstract":"The investigation of drug polymorphism is an essential step in any formulation. While formulating a drug product physiochemical stability, solubility and bioavailability of active ingredient are prominent are factors. The Study of polymorphism is necessarily predominant acquire comprehensive knowledge on rapid absorption of low solubility drugs in systemic circulation. In order to increase the effective surface area of the drug substances by turning them into different shapes, the empowerment of dissolution rate and bioavailability by employing recrystallization technique is very important. Since most of the drugs are examined through oral route practice, the size and shape of the crystal play a key note is their dissolution rate, as proved by Noyes Whitney, through his equation. In this an crystal view point the writer makes an effort to prove the importance of polymorphism in pharmaceuticals and how it shows its impact on pharmaceutical properties like solubility, dissolution rate, bioavailability, etc. of drug substances.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88697545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
New developments in topical antifungal therapy 局部抗真菌治疗的新进展
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00006
M. Robert, Y. Kalia
{"title":"New developments in topical antifungal therapy","authors":"M. Robert, Y. Kalia","doi":"10.2165/00137696-200604040-00006","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00006","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"29 1","pages":"231-247"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74139212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Solid lipid nanoparticles for topical drug delivery 用于局部药物递送的固体脂质纳米颗粒
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00004
Jin Zhang, Carryn H. Purdon, Eric W. Smith
{"title":"Solid lipid nanoparticles for topical drug delivery","authors":"Jin Zhang, Carryn H. Purdon, Eric W. Smith","doi":"10.2165/00137696-200604040-00004","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00004","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"45 1","pages":"215-220"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77271914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Transdermal contraceptive patches 透皮避孕贴片
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00003
Senshang Lin, Y. Chien
{"title":"Transdermal contraceptive patches","authors":"Senshang Lin, Y. Chien","doi":"10.2165/00137696-200604040-00003","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00003","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"35 1 1","pages":"201-213"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90089575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Polymeric efflux pump inhibitors in oral drug delivery 聚合物外排泵抑制剂在口服给药中的应用
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00008
A. Bernkop‐Schnürch, V. Grabovac
{"title":"Polymeric efflux pump inhibitors in oral drug delivery","authors":"A. Bernkop‐Schnürch, V. Grabovac","doi":"10.2165/00137696-200604040-00008","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00008","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"64 1","pages":"263-272"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81192820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
New technologies to allow transdermal delivery of therapeutic proteins and small water-soluble drugs 新技术允许经皮输送治疗性蛋白质和小的水溶性药物
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00005
A. Banga
{"title":"New technologies to allow transdermal delivery of therapeutic proteins and small water-soluble drugs","authors":"A. Banga","doi":"10.2165/00137696-200604040-00005","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00005","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"26 1","pages":"221-230"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90532891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Differentiating factors between oral fast-dissolving technologies 口腔快速溶解技术之间的区别因素
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00007
G. Sandri, M. C. Bonferoni, F. Ferrari, S. Rossi, C. Caramella
{"title":"Differentiating factors between oral fast-dissolving technologies","authors":"G. Sandri, M. C. Bonferoni, F. Ferrari, S. Rossi, C. Caramella","doi":"10.2165/00137696-200604040-00007","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00007","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"1 1","pages":"249-262"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75881845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Extent of supercoiling in plasmid DNA vaccines 质粒DNA疫苗的超卷曲程度
American Journal of Advanced Drug Delivery Pub Date : 2006-12-01 DOI: 10.2165/00137696-200604040-00002
Manmohan J. Singh, M. Ugozzoli, Elawati Soenawan, A. Pannu, E. Pushnova, J. Allen, D. O’hagan
{"title":"Extent of supercoiling in plasmid DNA vaccines","authors":"Manmohan J. Singh, M. Ugozzoli, Elawati Soenawan, A. Pannu, E. Pushnova, J. Allen, D. O’hagan","doi":"10.2165/00137696-200604040-00002","DOIUrl":"https://doi.org/10.2165/00137696-200604040-00002","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"31 1","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73629313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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