{"title":"Preclinical Drug Development","authors":"Krishna Tanneru","doi":"10.36648/2321-547X.21.9.53","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.53","url":null,"abstract":"Preclinical drug development incorporates the activities that link to the discovery of drug in the laboratory to human clinical trials. Before the clinical trials, tests and treatments are assessed in the research of preclinical. Preclinical research is not done with the persons. Preclinical studies also designed to identify the lead candidate from many hits; to develop the best procedure for new drug scale-up; to select the best formulation; to determine the route, frequency, and duration of exposure; and support the intended clinical trial design ultimately. The specifics of each preclinical development package may vary, but all have few common features.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80182820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Editorial Note on Journal Successful Journey-2020","authors":"Kaustuv Sahoo","doi":"10.36648/2321-547X.21.9.49","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.49","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"69 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91430882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Molecular Designing of Drugs","authors":"H. Gude","doi":"10.36648/2321-547X.21.9.50","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.50","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90852153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanical Dispersion Methods of Liposomes","authors":"O. Brown","doi":"10.36648/2321-547X.21.9.56","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.56","url":null,"abstract":"Sonication is potentially the most broadly utilized framework for the approach of SUV. Here, MLVs are sonicated either with a shower type sonicator or a test sonicator under a lethargic air. The critical loads of this strategy are low inside volume/representation adequacy, conceivable corruption of phospholipids and mixes to be embodied, finish of gigantic particles, metal pollution from test tip, and presence of MLV nearby SUV.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79564806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screening and Design for Drug Discovery","authors":"Adeola Sade","doi":"10.36648/2321-547X.21.9.33-34","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.33-34","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77407005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rajeev, D. Samuvel, P. Sathieshkumar, C. Thirumavalavan, S. Chitra, Y. R. Maneksha, Ramasamy
{"title":"SIDDHA MEDICAL MANAGEMENT ON COVID-19 POSITIVE CASE STUDY IN GSMCandH, TIRUNELVELI, TAMIL NADU,INDIA","authors":"S. Rajeev, D. Samuvel, P. Sathieshkumar, C. Thirumavalavan, S. Chitra, Y. R. Maneksha, Ramasamy","doi":"10.36648/2321-547X.21.9.58","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.58","url":null,"abstract":"The most recently discovered coronavirus causes coronavirus disease COVID-19. The common symptoms of COVID-19 are fever, dry cough, and tiredness. Siddha medicines which mainly focusses on enhancing the host immunity could play a major role in viral diseases. As per Siddha classical wisdom, improving immunity with immune boosters is one of the key approaches for prevention of disease and maintenance of health. The treatment protocol was fixed such as all the patients admitted in the ward were given kabasura kudineer as base medicine. In addition, other siddha medicines were given based on the associated symptoms. If fever was present Linga chendooram with thirikaduku chooranam, Brahmanantha Birava mathirai twice a day was given additionally. If cough was present Thalisadi vadagam, Adathodai manapagu was given additionally until the symptoms subsides. If anosmia was present Herbal Smolder, vasantha kusumahara mathirai, thalisadi vadagam and adathoda manapagu twice a day, if loose motion was present sundai vatral was given additionally. The treatment protocol and diet pattern was planned such that it balances the three humours, combats the diseases, improves general immunity with specific actions on the respiratory tract and provides adequate nutrition. Apart from this the entire In Patient (IP) block was disinfected using herbal fumigation. Further, a novel herbal air cleanser pouch was also provided to all patients which is to be kept inside the mask which would precisely filter the inhaling air & ward off the airborne microorganisms. The results and observations are encouraging. The combined therapy and procedure seemed to be very effective in the management of COVID-19 disease","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79175499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review on Molecular Nanotechnology","authors":"M. Liam","doi":"10.36648/2321-547X.21.9.31-32","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.31-32","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83862678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consequence of Remdesivir Drug on Covid Patients","authors":"M. Pravallika","doi":"10.36648/2321-547X.21.9.61","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.61","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84065276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications and Types of Targeted Drug Delivery","authors":"G. Atwal","doi":"10.36648/2321-547X.21.9.54","DOIUrl":"https://doi.org/10.36648/2321-547X.21.9.54","url":null,"abstract":"There are various sorts of medication conveyance vehicles, like polymeric micelles, liposomes, lipoprotein-based medication transporters, Nano-molecule drug transporters, dentrimers, and so forth. An ideal medication conveyance vehicle should be non-poisonous, biocompatible, nonimmunogenic, biodegradable and should maintain a strategic distance from acknowledgment by the host's safeguard systems [1].","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"18 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82342116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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