A Review on Polymorphism PerpetuatesPharmaceuticals

Abstract

The investigation of drug polymorphism is an essential step in any formulation. While formulating a drug product physiochemical stability, solubility and bioavailability of active ingredient are prominent are factors. The Study of polymorphism is necessarily predominant acquire comprehensive knowledge on rapid absorption of low solubility drugs in systemic circulation. In order to increase the effective surface area of the drug substances by turning them into different shapes, the empowerment of dissolution rate and bioavailability by employing recrystallization technique is very important. Since most of the drugs are examined through oral route practice, the size and shape of the crystal play a key note is their dissolution rate, as proved by Noyes Whitney, through his equation. In this an crystal view point the writer makes an effort to prove the importance of polymorphism in pharmaceuticals and how it shows its impact on pharmaceutical properties like solubility, dissolution rate, bioavailability, etc. of drug substances.