Biotherapy (Dordrecht, Netherlands)最新文献_第2页

Diets, food components and human cancer. 饮食，食物成分和人类癌症。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1007915103561

D McGregor

引用次数: 7

Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. 姬松茸肽-葡聚糖制剂在小鼠双移植肿瘤系统中的抗肿瘤作用。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1008054111445

T Ebina, Y Fujimiya

{"title":"Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice.","authors":"T Ebina, Y Fujimiya","doi":"10.1023/a:1008054111445","DOIUrl":"https://doi.org/10.1023/a:1008054111445","url":null,"abstract":"The antitumor effect of extracts obtained from the fruit body of Agaricus blazei Murill was examined in a double-grafted tumor system, in which BALB/c mice received simultaneous intradermal injections of Meth-A tumor cells in both the right (10(6) cells) and left flank (2 x 10(5) cells), and were then injected with 5 mg of extracts of A. blazei in the right tumor on days 3, 4 and 5. Intratumoral administration of ethanol-soluble (Fraction 1), water-ethanol-soluble (Fraction 2), ammonium oxalate-soluble (Fraction 3) and ammonium oxalate-insoluble (Fraction 4) fractions resulted in inhibition of tumor growth, with Fraction 3 showing the most tumoricidal activity, producing regression of the right tumor and inhibition of growth of the left, non-injected tumor. The maximum effect was obtained using 0.5 mg of Fraction 3 and this amount was used in subsequent experiments. The antitumor effect of intratumorally administered Fraction 3 was enhanced by oral ad lib administration of feed containing 0.083% of Fraction 3. When immunized spleen cells from mice that had been cured by intratumoral administration of 0.5 mg of Fraction 3 were directly injected (2 x 10(7) cells/mouse) into the Meth-A tumor, tumor growth was inhibited. The tumor cells on day 7 from the Fraction 3-treated right tumor and from the left tumor were cultured for 24 h and their culture supernatants were assayed for neutrophil or macrophage chemotactic activity. Significant macrophage chemotactic factor activity was detected in the culture media from the left tumor tissue. Serum levels of immunosuppressive acidic protein (IAP), produced by activated macrophages and neutrophils, increased transiently soon after intradermal injection of 0.5 mg of Fraction 3. These results suggest that regression of the left non-injected tumor was due to an immune reaction, involving induction of cytotoxic cells in the spleen, and the release of chemotactic factors in the distant tumor.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"11 4","pages":"259-65"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1008054111445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20855794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 111

Hodgkin's disease: a disorder of dysregulated cellular cross-talk. 何杰金氏病:一种细胞串扰失调的疾病。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1007/BF02678551

A Pinto, V Gattei, V Zagonel, D Aldinucci, M Degan, A De Iuliis, F M Rossi, F Tassan Mazzocco, C Godeas, M Rupolo, D Poletto, A Gloghini, A Carbone, H J Gruss

{"title":"Hodgkin's disease: a disorder of dysregulated cellular cross-talk.","authors":"A Pinto, V Gattei, V Zagonel, D Aldinucci, M Degan, A De Iuliis, F M Rossi, F Tassan Mazzocco, C Godeas, M Rupolo, D Poletto, A Gloghini, A Carbone, H J Gruss","doi":"10.1007/BF02678551","DOIUrl":"https://doi.org/10.1007/BF02678551","url":null,"abstract":"Hodgkin's disease (HD) is a peculiar type of human malignant lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells-derived cytokines. H-RS cells can be functionally regarded as antigen-presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B-cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the treatment of HD patients.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"10 4","pages":"309-20"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02678551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20511641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Effectiveness of weekly subcutaneous recombinant human erythropoietin administration for chemotherapy-induced anemia. 重组人红细胞生成素每周一次皮下注射治疗化疗性贫血的疗效。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1007951530405

M Tsukuda, S Yuyama, H Kohno, K Itoh, T Kokatsu, S Kawai

{"title":"Effectiveness of weekly subcutaneous recombinant human erythropoietin administration for chemotherapy-induced anemia.","authors":"M Tsukuda, S Yuyama, H Kohno, K Itoh, T Kokatsu, S Kawai","doi":"10.1023/a:1007951530405","DOIUrl":"https://doi.org/10.1023/a:1007951530405","url":null,"abstract":"The effects of weekly subcutaneous recombinant human erythropoietin (r-hEPO) administration on anemia during chemotherapy including cisplatin and 5-fluorouracil in patients with head and neck carcinomas were examined. Weekly subcutaneous r-hEPO administration in cancer patients has not been investigated previously. Patients were treated with r-hEPO 100 IU/kg (2 patients), 200 IU/kg (6 patients), or 400 IU/kg (5 patients), or placebo, and effectiveness was evaluated by monitoring hemoglobin concentration changes after administration for 8 weeks. Hemoglobin concentrations in all 3 r-hEPO dosage groups were higher than that in the control group during chemotherapy. All r-hEPO doses produced improvements in the anemia induced by chemotherapy; however, the 400 IU/kg dose was most effective. The requirement for blood transfusions decreased in patients receiving r-hEPO therapy, and no significant side-effects were associated with r-hEPO administration. These results suggest that chemotherapy-induced anemia can be prevented by weekly subcutaneous r-hEPO administration.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"11 1","pages":"21-5"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1007951530405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20537045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Mutagenic chemicals: their significance. 致突变化学物质:它们的意义。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1007906901743

D McGregor

引用次数: 2

Heat shock proteins as potential targets in the therapy of inflammatory arthritis. 热休克蛋白作为炎症性关节炎治疗的潜在靶点。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1007/BF02678297

J S Gaston

{"title":"Heat shock proteins as potential targets in the therapy of inflammatory arthritis.","authors":"J S Gaston","doi":"10.1007/BF02678297","DOIUrl":"https://doi.org/10.1007/BF02678297","url":null,"abstract":"Whether heat shock proteins (hsp) will be therapeutic targets in arthritis depends on their role in pathogenesis. In this article, three possibilities are considered. Firstly, an excessive immune response to bacterial hsp could be arthritogenic - as may occur in reactive arthritis. In these circumstances therapy would be directed to down-regulating this immune response, or altering the nature of the immune response e.g. by changing cytokine production from interferon-g to IL-4. However this approach depends on the immune response to bacterial hsp not being critical for control of the bacterial infection. Secondly, an immune response to bacterial hsp may induce autoimmunity by cross-reactivity, e.g. with the homologous human. This could also be modulated in the same way with a lower likelihood of interfering with control of the infectious agent, since only a component of the immune response against the bacterial hsp will be cross-reactive with self. Thirdly, recent experiments raise the possibility that joint inflammation might be controlled by T cells which recognizes self hsp, particularly hsp60. Therapies might enhance this response; protection from experimental arthritis by prior immunization with hsp60 is well established. Whether similar approaches will be viable after arthritis is established remains to be seen.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"10 3","pages":"197-203"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02678297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20481105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Hematopoietic growth factors in autologous transplantation. 造血生长因子在自体移植中的应用。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1007/BF02678550

G C Avanzi, M Gallicchio, G Saglio

引用次数: 8

Oral cavity gate of an entry into the communication network. 口腔门的一种进入通讯网络的入口。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1007901223254

J A Georgiades

引用次数: 1

Contribution of cytokines on the suppression of lung metastasis. 细胞因子在抑制肺转移中的作用。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1008070025561

Y Ishihara, H Iijima, K Matsunaga

{"title":"Contribution of cytokines on the suppression of lung metastasis.","authors":"Y Ishihara, H Iijima, K Matsunaga","doi":"10.1023/a:1008070025561","DOIUrl":"https://doi.org/10.1023/a:1008070025561","url":null,"abstract":"Weekly injection of a protein-bound polysaccharide PSK in mice with Lewis Lung Cancer (LLC) significantly decreased the number of lung metastatic foci concomitant with enhancement of cytostatic activity in the bronchoalveolar lavage (BAL) cells. These effects were more marked when the agent was given intratracheally, inducing a larger number of pulmonary macrophages, lymphocytes and neutrophils concomitant with increases in BAL tumor necrosis factor-alpha (TNF-alpha), mouse inflammatory protein-alpha (MIP-1alpha), mouse inflammatory protein-beta (MIP-1beta), interleukin-1alpha (IL-1alpha) and interleukin-6 (IL-6), but not interleukin-2 (IL-2) and interleukin-4 (IL-4). Pre-treatment with anti TNF-alpha antibody reduced these effects. The time course and production of PSK-induced cytokines were similar between the tumor-bearing mice and control mice. BAL neutrophils in mice with LLC showed a tendency toward acceleration of O2- production compared with circulating neutrophils. Pulmonary macrophage phagocytosis was also significantly higher in the LLC mice. These results suggest that enhancement of cytostasis appears to be induced by activation and/or improvement of function in inflammatory and immune cells through cytokines under immunomodulator treatment in lung metastasis, possibly via a TNF-alpha-dependent mechanism.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"11 4","pages":"267-75"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1023/a:1008070025561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20855795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Oxidative stress and cancer: the role of redox regulation. 氧化应激与癌症:氧化还原调节的作用。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1998-01-01 DOI: 10.1023/a:1007934229968

S Toyokuni

引用次数: 81