Biotherapy (Dordrecht, Netherlands)最新文献_第10页

Transfer factor in chronic mucocutaneous candidiasis. 慢性黏液皮肤念珠菌病的转移因子。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02628665

M Masi, C De Vinci, O R Baricordi

{"title":"Transfer factor in chronic mucocutaneous candidiasis.","authors":"M Masi, C De Vinci, O R Baricordi","doi":"10.1007/BF02628665","DOIUrl":"https://doi.org/10.1007/BF02628665","url":null,"abstract":"Fifteen patients suffering from chronic mucocutaneous candidiasis were treated with an in vitro produced TF specific for Candida albicans antigens and/or with TF extracted from pooled buffy coats of blood donors. CMI of the patients was assessed using the LMT and the LST in presence of candidine. The aim of the study was the clinical evaluation of TF treatment and the incidence of positive tests before, during, and after therapy. Immunological data were matched using the Chi square test. 87 LMT were performed for each antigen dose and at the dilution of 1/50, 58.9% (33/56) tests were positive during non-treatment or non-specific TF treatment. On the contrary 83.9% (26/31) were positive during specific TF treatment (P < 0.05). In the LST, a significant decrease of thymidine uptake in the control cultures in presence of autologous or AB serum was observed when patients were matched according to non-treatment, and both non specific (P < 0.05) and specific TF treatment (P < 0.01). Only during specific TF treatment was a significant increase of reactivity against the Candida antigen at the highest concentration noticed, when compared with the period of non specific treatment (P < 0.01). Clinical observations were encouraging: all but one patient experienced significant improvement during treatment with specific TF. These data confirm that orally administered specific TF, extracted from induced lymphoblastoid cell-lines, increases the incidence of reactivity against Candida antigens in the LMT. LST reactivity appeared not significantly increased with respect to the periods of non treatment, but was significantly increased when it was compared to the non-specific TF treatment periods. At the same time, a clinical improvement was noticed.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"9 1-3","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02628665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19953891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

A preliminary report on the use of transfer factor for treating stage D3 hormone-unresponsive metastatic prostate cancer. 转移因子用于治疗D3期激素无反应性转移性前列腺癌的初步报道。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02628669

G Pizza, C De Vinci, D Cuzzocrea, D Menniti, E Aiello, P Maver, G Corrado, P Romagnoli, E Dragoni, G LoConte, U Riolo, A Palareti, P Zucchelli, V Fornarola, D Viza

引用次数: 21

List of contributors 贡献者名单

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF01877211

A. Sensi, K. Ghosh, A. Sonnino, O. Brandenberg

引用次数: 0

Interferon receptors. 干扰素受体。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF01877201

J Langer, G Garotta, S Pestka

引用次数: 12

The use of transfer factors in chronic fatigue syndrome: prospects and problems. 转移因子在慢性疲劳综合征中的应用:展望与问题。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02628661

P H Levine

{"title":"The use of transfer factors in chronic fatigue syndrome: prospects and problems.","authors":"P H Levine","doi":"10.1007/BF02628661","DOIUrl":"https://doi.org/10.1007/BF02628661","url":null,"abstract":"Chronic fatigue syndrome (CFS) is a heterogeneous disorder characterized by severe prolonged unexplained fatigue and a variety of associated symptoms such as arthralgias, myalgias, cognitive dysfunction, and severe sleep disturbances. Many patients initially present with an acute onset of apparent infectious origin with either an upper respiratory or gastrointestinal illness, fever, chills, tender lymphadenopathy, and malaise suggestive of a flu-like illness. In some cases, specific viral infections can be identified at the outset, particularly herpes viruses such as Epstein-Barr virus (EBV), human herpes virus-6 (HHV-6), and cytomegalovirus (CMV). Transfer factors (TF) with specific activity against these herpes viruses has been documented. With some studies suggesting that persistent viral activity may play a role in perpetuation of CFS symptoms, there appears to be a rationale for the use of TF in patients with CFS and recent reports have suggested that transfer factor may play a beneficial role in this disorder. This report focuses on the heterogeneity of CFS, the necessity for randomized coded studies, the importance of patient selection and sub-classification in clinical trials, and the need to utilize specific end-points for determining efficacy of treatment.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"9 1-3","pages":"77-9"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02628661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Transfer Factor in the Era of AIDS. Proceedings of the Xth International Symposium on Transfer Factor. Bologna, Italy, 22-24 June 1995. 艾滋病时代的传递因子。第十届转移因子国际学术研讨会论文集。1995年6月22日至24日，意大利博洛尼亚。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01

引用次数: 0

Augmentation of antitumor effect by combined administration with interleukin-2 and sizofiran, a single glucan, on murine EL-4 lymphoma. 白细胞介素-2和西佐非兰(单一葡聚糖)联合给药增强小鼠EL-4淋巴瘤的抗肿瘤作用。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02620737

Y Kano, H Kakuta, J Hashimoto

{"title":"Augmentation of antitumor effect by combined administration with interleukin-2 and sizofiran, a single glucan, on murine EL-4 lymphoma.","authors":"Y Kano, H Kakuta, J Hashimoto","doi":"10.1007/BF02620737","DOIUrl":"https://doi.org/10.1007/BF02620737","url":null,"abstract":"The antitumor effect of the combined administration with recombinant human interleukin-2 (rIL-2) and sizofiran (SPG), a single glucan of Shizophyllum commune Fries, was studied in vivo in C57BL/6 mice intraperitoneally inoculated with EL-4 lymphoma. The effect was evaluated by a) comparing the survival time of the mice, b) analysis of the intraperitoneal cell population in Giemsa-stained specimens, c) surface marker analysis of peritoneal exudative cells with flow cytometry, d) cytotoxic assay of cells against EL-4 and Yac-1 lymphoma, and e) elimination of some cell populations by monoclonal antibodies, to identify the antitumor-effector cells showing cytotoxic activity. The survival of mice given both rIL-2 and SPG was significantly longer than the control mice or those given SPG alone or rIL-2 alone. It was demonstrated that the administration of SPG and/or rIL-2 to the EL-4 lymphoma-bearing mice activated immune-response cells in the peritoneal cavity such as T lymphocytes, NK cells, or macrophages, which might be effective in reducing lymphoma cells. The combination of rIL-2 and SPG administration appears to activate the antitumor-immune response at the tumor site more effectively than when either agent was administered alone.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"9 4","pages":"241-7"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02620737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19973589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dialysable lymphocyte extract (DLyE) in infantile onset autism: a pilot study. 可透析淋巴细胞提取物(DLyE)在婴儿期自闭症中的应用:一项初步研究。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02628672

H H Fudenberg

引用次数: 37

Dialysable leucocyte extract (DLE) reduces lipopolysaccharide-induced tumour necrosis factor secretion in human leucocytes. 可透析白细胞提取物(DLE)减少人白细胞脂多糖诱导的肿瘤坏死因子分泌。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02628675

M Ojeda Ojeda, C B Fernandez Ortega, M J Araña Rosaínz

{"title":"Dialysable leucocyte extract (DLE) reduces lipopolysaccharide-induced tumour necrosis factor secretion in human leucocytes.","authors":"M Ojeda Ojeda, C B Fernandez Ortega, M J Araña Rosaínz","doi":"10.1007/BF02628675","DOIUrl":"https://doi.org/10.1007/BF02628675","url":null,"abstract":"Dialysable leucocyte extract (DLE), obtained from lysed leucocytes, provide clinical effectiveness in a broad spectrum of diseases. Tumour necrosis factor (TNF) is raised in AIDS patients leading to an increase in human immunodeficiency virus (HIV) replication in vitro [1,2], whereas progression to AIDS in asymptomatic HIV infected individuals is retarded under treatment with DLE. In the present study we tested the DLE effect in vitro on both TNF biological activity (cytotoxicity) in L929 cells and its induction by lipopolysaccharide (LPS) in human monocytes as well as in whole blood from healthy donors. When monocytic cells were simultaneously exposed to LPS and DLE during a period of 5 1/2 hours, the induction of TNF was strongly diminished. The same inhibitory effect of DLE on TNF induction was observed when LPS was added to the culture medium prior to DLE. No significant effect of DLE on TNF-mediated cytotoxicity, even in the presence of the highest concentrations of DLE tested, was detected. DLE treatment of whole human blood regulates responses to LPS: simultaneous in vitro exposure to endotoxin provokes a remarkable decrease (4- and 1.6-fold) of TNF release. In pre-incubation experiments, TNF production was largely reduced or completed abrogated. These results could, in part, explain the in vivo observed effect, when under treatment with this extract, the progression to AIDS of HIV-infected individuals was retarded. The results suggest that \"natural' substances like DLE may be important immunomodulators in inflammatory diseases.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"9 1-3","pages":"163-70"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02628675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19956573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

In vitro studies during long-term oral administration of specific transfer factor. 长期口服特定传递因子的体外研究。

Biotherapy (Dordrecht, Netherlands) Pub Date : 1996-01-01 DOI: 10.1007/BF02628677

G Pizza, C De Vinci, V Fornarola, A Palareti, O Baricordi, D Viza

{"title":"In vitro studies during long-term oral administration of specific transfer factor.","authors":"G Pizza, C De Vinci, V Fornarola, A Palareti, O Baricordi, D Viza","doi":"10.1007/BF02628677","DOIUrl":"https://doi.org/10.1007/BF02628677","url":null,"abstract":"153 patients suffering from recurrent pathologies, i.e. viral infections (keratitis, keratouveitis, genital and labial herpes) uveitis, cystitis, and candidiasis were treated with in vitro produced transfer factor (TF) specific for HSV-1/2, CMV and Candida albicans. The cell-mediated immunity of seropositive patients to HSV-1/2 and/or CMV viruses was assessed using the leucocyte migration inhibition test (LMT) and lymphocyte stimulation test (LST) in presence of the corresponding antigens, and the frequency of positive tests before, during and after TF administration was studied. The data were stratified per type of test, antigen and the recipients' pathology, and statistically evaluated. For the LMT, a total of 960 tests were carried out for each antigen dilution, 3 different antigen dilutions were used per test. 240/960 tests (25.4%) were found positive during non-treatment or treatment with unspecific TF, whereas 147/346 tests (42.5%) were found positive when the antigen corresponding to the specificity of the TF administered to the patient was used (P < 0.001). When the data were stratified following pathology, a significant increased incidence of positive tests during specific treatment was also observed (0.0001 < P < 0.05). In the LST (1174 tests), a significant increase of thymidine uptake was observed in the absence of antigen (control cultures), during treatment with both specific and unspecific TF, but also in the presence of antigen and/or autologous serum during specific TF administration (P < 0.0001). TF administration also significantly increased the soluble HLA class I antigens level in 40 patients studied to this effect.","PeriodicalId":77043,"journal":{"name":"Biotherapy (Dordrecht, Netherlands)","volume":"9 1-3","pages":"175-85"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02628677","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19956575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15