Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology最新文献_第9页

Solubility of inert gases in PFC blood substitute, blood plasma, and mixtures. 惰性气体在PFC血液代用品、血浆和混合物中的溶解度。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119768

G L Pollack, R P Kennan, G T Holm

引用次数: 10

Fluosol and hyperbaric oxygen as an adjunct to radiation therapy in the treatment of malignant gliomas: a pilot study. 氟雾剂和高压氧辅助放射治疗恶性胶质瘤的初步研究。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119738

S Dowling, J J Fischer, S Rockwell

{"title":"Fluosol and hyperbaric oxygen as an adjunct to radiation therapy in the treatment of malignant gliomas: a pilot study.","authors":"S Dowling, J J Fischer, S Rockwell","doi":"10.3109/10731199209119738","DOIUrl":"https://doi.org/10.3109/10731199209119738","url":null,"abstract":"Several clinical trials have been reported using Fluosol and oxygen breathing as an adjunct to radiation. Theoretical considerations and animal experiments, however, indicate that a combination of perfluorochemicals and hyperbaric oxygen (HBO) increases tumor oxygenation and radiation response to a greater extent than is seen either with a perfluorochemical and normobaric oxygen or with HBO alone. This is the first report of a pilot study of the use of Fluosol and HBO with radiation in humans. Twenty patients with anaplastic astrocytoma or glioblastoma multiforme were treated in a phase I trial of radiation with Fluosol and HBO at three atmospheres. Total Fluosol dose was escalated from 42 ml/kg in six courses to 80 ml/kg in four courses. Patients were irradiated in an HBO chamber with 600 cGy weekly fractions following Fluosol administration. Sixteen patients completed treatment; no interruption was necessitated by treatment toxicity. The addition of Fluosol/HBO did not increase the incidence of HBO related toxicities. No significant chronic toxicities were seen. This pilot study demonstrates that Fluosol and HBO can safely be used as an adjunct to radiation in the treatment of human tumors.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"903-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12500874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

A nonlinear analysis of pulsatile blood flow applied to investigate shear stress in arterial prostheses. 脉冲血流的非线性分析应用于研究动脉假体的剪切应力。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209117854

J Charara, G Beaudoin, R Guidoin

{"title":"A nonlinear analysis of pulsatile blood flow applied to investigate shear stress in arterial prostheses.","authors":"J Charara, G Beaudoin, R Guidoin","doi":"10.3109/10731199209117854","DOIUrl":"https://doi.org/10.3109/10731199209117854","url":null,"abstract":"Although the main function of an arterial graft is to restore distal blood flow, there is evidence that certain local parameters of blood flow, particularly wall shear stresses, are important in determining the graft's long-term patency. Wall shear stresses were associated with intimal hyperplasia, intimal proliferation, and endothelial cell development, morphology, and attachment. Here we present a detailed method which permits the investigation of the wall shear stress acting on arteries and prostheses in dogs. The theory takes into account the nonlinear terms of the Navier-Stokes equations as well as the nonlinear behaviour and large deformation of the arterial wall. It is based on the numerical resolution of the nonlinear equations by the Crank-Nicolson method which was selected for its unconditional stability. Through the locally measured values of the pressure, pressure gradient, radius and flow rate, the velocity distribution and wall shear stress at a given location along the artery or the prosthesis, can be determined. Complete results on the same dog are presented for the distal aorta and for the middle of a chemically processed prosthesis, implanted as substitute in the thoracic aorta.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209117854","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12784518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Rheology of concentrated perfluorocarbon emulsions. 浓全氟碳乳液的流变学研究。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119733

Y Ni, D H Klein, T J Pelura

{"title":"Rheology of concentrated perfluorocarbon emulsions.","authors":"Y Ni, D H Klein, T J Pelura","doi":"10.3109/10731199209119733","DOIUrl":"https://doi.org/10.3109/10731199209119733","url":null,"abstract":"Oil-in-water emulsions conthing perfluomtylbromide (perflubron; PFOB) at up to about 50 vol.% and stabilized with egg yolk pbospbolipid (EYP) have been prepared and their rheology bas been studied. The emulsions are non-Newtonian, and their viscosities are strongly dependent on the volume fnction of pertlubron. as well as on pmcessing and formulation. Using a controlled-stress rbeometer with double-gap geometry, the viscosity at shear rates less hn 0. I sec-1 an be measured. Tbe viscoelastic properties of the emulsions have been explored using oscilhtion and stress-sweep techniques and an be used for the prediction of emulsion stability. MatPrbls and Metbods Pertluhn and naturnl egg yolk phospholipid were used as purchased without further purification. Bohlin CS (controlled-suess) rheMneter with C25 (concentric cylinder, 12ml sample) or DG (double gap, 30 ml sample) meauring geometry was used for dynamic (stress-sweep and oscillation) and smtic (viscosity, etc.) measurements. BrooWield dplate viscometer (Iml sample) was also used for routine viscosity measurements. Results and Discussion","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"869-71"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12562350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Enhancement by perflusion emulsion (Oxygent) and carbogen breathing of the tumor growth delay of the FSaIIC fibrosarcoma after treatment with antitumor alkylating agents. 抗肿瘤烷化剂治疗FSaIIC纤维肉瘤后，灌注乳剂(氧)和碳呼吸对肿瘤生长延迟的增强作用。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119736

S A Holden, B A Teicher, C Ha, G Ara, T S Herman

{"title":"Enhancement by perflusion emulsion (Oxygent) and carbogen breathing of the tumor growth delay of the FSaIIC fibrosarcoma after treatment with antitumor alkylating agents.","authors":"S A Holden, B A Teicher, C Ha, G Ara, T S Herman","doi":"10.3109/10731199209119736","DOIUrl":"https://doi.org/10.3109/10731199209119736","url":null,"abstract":"Many anticancer drugs require oxygen to be cytotoxic, or are selectively cytotoxic toward cells under oxygenated conditions. The effects of the dilute perfluorochemical emulsion Fluosol-DA with a wide variety of chemotherapeutic agents have been explored; however, it has not been possible to determine the optimal level of circulating perfluorochemical emulsion with anticancer drugs because the volume of Fluosol that may be administered in limited. Using a concentrated 90% Perflubron emulsion, Oxygent, a wide range of perfluorochemical emulsion doses have been examined in combination with melphalan, cyclophosphamide and BCNU in a murine solid tumor model. When Oxygent was administered by injection i.v. just prior to the injection of melphalan (10 mg/kg), the greatest tumor growth delays were obtained with Oxygent levels between 4 and 12 g PFC/kg. With each of these drugs the greatest tumor growth delays were obtained when the drug was prepared in the emulsion and the combination injected i.v. In each case, each dose of drug was followed by 6 h. of breathing carbogen.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"895-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12562353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Effect of emulsion concentration on biodistribution of perflubron in tumor-bearing mice. 乳剂浓度对全氟隆在荷瘤小鼠体内生物分布的影响。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119739

D M Long, B L Witt, J A Escobar, R A Long

引用次数: 1

Resuscitation of bled dogs with pyridoxalated-polymerized hemoglobin solution. 吡哆酸聚合血红蛋白溶液对出血犬的复苏作用。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119678

J Ning, P J Anderson, G P Biro

{"title":"Resuscitation of bled dogs with pyridoxalated-polymerized hemoglobin solution.","authors":"J Ning, P J Anderson, G P Biro","doi":"10.3109/10731199209119678","DOIUrl":"https://doi.org/10.3109/10731199209119678","url":null,"abstract":"We bled 25% of estimated total blood volume, then infused pyridoxalated polymerized human stroma-free hemoglobin solution (PP-SFH) (10 g/dl) to dogs under anesthesia in a volume equal to the blood removed. Central hemodynamics, blood flow distribution to organs, and renal function were studied up to 2-3 hours following the infusion. Mean arterial pressure was reduced from 120 +/- 3 to 86 +/- 7 mmHg at the end of the 30-minute hypovolumic period and the cardiac output was reduced by 27%. Immediately following the PP-SFH infusion we observed a further fall in blood pressure (43%) caused by a fall in cardiac output which lasted for 10 minutes. Blood pressure was restored gradually with the continuation of the infusion and the cardiac output was restored and maintained well. During the hypovolumic period, blood flow to the heart, renal cortex, and liver were reduced, whereas normal flow to the renal medulla and brain were maintained. After the resuscitation, blood flow to the heart, brain, liver, and renal medulla significantly exceeded the normal range, but remained subnormal in the renal cortex. Glomerular filtration rate (GFR), urine flow, and electrolyte excretion were all reduced during the hypovolumic period and were not restored to the pre-bleed levels after the infusion.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"525-30"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12562861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Study of effect of the newly developed artificial blood "Neo Red Cells (NRC)" on hemodynamics and blood gas transport in canine hemorrhagic shock. 新研制的人造血液“新红血球”(NRC)对犬失血性休克血流动力学和血气输送影响的研究。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119679

A Usuba, R Motoki, K Suzuki, K Sakaguchi, A Takahashi

{"title":"Study of effect of the newly developed artificial blood \"Neo Red Cells (NRC)\" on hemodynamics and blood gas transport in canine hemorrhagic shock.","authors":"A Usuba, R Motoki, K Suzuki, K Sakaguchi, A Takahashi","doi":"10.3109/10731199209119679","DOIUrl":"https://doi.org/10.3109/10731199209119679","url":null,"abstract":"The purpose of this study is to evaluate the newly developed liposome-encapsulated hemoglobin, named Neo Red Cells (NRC), in the treatment of hemorrhagic shock. The particle size of NRC is 180 +/- 88 nm, the hemoglobin concentration is 5.6 g/dl, the viscosity is 2 cp and P50 is 49.5 mmHg. The experiment was carried out on six mongrel dogs suffering hemorrhagic shock. Blood was extracted from the femoral artery and blood pressure became lower than 60 mmHg. NRC in amount equal to the amount of blood extracted was transfused immediately. Inhalating normal room air, the above manipulation was repeated 3-5 times. After 59% to 88% blood exchange using NRC, the total peripheral vascular resistance index (TPRI) was reduced and the cardiac index (CI) was increased, thereby alleviating the burden on the heart. The reduction of TPRI in the presence of hemorrhagic shock is presumed to be due to the small size of the NRC granules and their low viscosity. As the exchange rate increased, the oxygen consumption (VO2) increased remarkably, presumably due to the increase of CI and A-V difference of oxygen content. The conclusion of the study is that NRC is more suitable than natural blood for the treatment of hemorrhagic shock.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"531-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12562862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Retention of perfluorochemicals in rat liver and spleen. 全氟化学物质在大鼠肝脏和脾脏中的滞留。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119758

K C Lowe, P K Bentley

引用次数: 7

Acute effects of moderate Fluosol-DA hemodilution on hepatic microsomal and nonmicrosomal metabolism in rats. 中度氟索- da血液稀释对大鼠肝微粒体和非微粒体代谢的急性影响。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119760

R P Shrewsbury

{"title":"Acute effects of moderate Fluosol-DA hemodilution on hepatic microsomal and nonmicrosomal metabolism in rats.","authors":"R P Shrewsbury","doi":"10.3109/10731199209119760","DOIUrl":"https://doi.org/10.3109/10731199209119760","url":null,"abstract":"Fluosol has been shown to alter the disposition of several drugs immediately after its administration. Investigations in this laboratory established that the disposition of several drug markers requiring the hepatic microsomal cytochrome P-450 isoenzymes was time dependent for 72 hours. It was an additional purpose of the research to determine if the nonmicrosomal sulfation and acetylation pathways were also influenced by Fluosol hemodilution in a time dependent manner. Rats were moderately hemodiluted with Fluosol and received an intravenous dose of a drug marker 24, 48, or 72 hours after hemodilution. The formation clearance (ClF) of specific metabolites was used as the pharmacokinetic measure of a specific enzymatic activity. 3-Hydroxymethyl antipyrine ClF (phenobarbital inducible microsomal cytochrome P-450 isoenzymes) increased 300% only at 48 hours. Acetylsulfamethazine ClF (nonmicrosomal acetylation) increased 287% and 162% at 24 and 48 hours, respectively. Acetaminophen sulfate ClF (nonmicrosomal sulfation) decreased 30% only at 48 hours. Substantial evidence shows that cytochrome P-450 content is induced at 72 hours and remains induced for an unprecedented length of time by the PFCs in Fluosol. Therefore, it was unexpected that 3-hydroxymethyl antipyrine ClF was not increased at 72 hours. Several possible explanations are discussed for the unexpected findings.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"1037-43"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119760","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12563285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4