Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology最新文献_第8页

Systemic hemodynamic and renal effects of unmodified human SFHS in dogs. 未经修饰的人SFHS对狗的全身血流动力学和肾脏影响。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119709

J Ning, L M Peterson, P J Anderson, G P Biro

{"title":"Systemic hemodynamic and renal effects of unmodified human SFHS in dogs.","authors":"J Ning, L M Peterson, P J Anderson, G P Biro","doi":"10.3109/10731199209119709","DOIUrl":"https://doi.org/10.3109/10731199209119709","url":null,"abstract":"Isovolumic exchange transfusion (25% of total estimated blood volume) was carried out in the anesthetized dogs using 9 g/dl of unmodified human stroma-free hemoglobin solution (SFHS). The objective was to determine the systemic hemodynamic, blood distribution and renal effects of SFHS over a 2-3 hour period post-exchange. At 30 minutes after the exchange, blood pressure rose from 114 +/- 117 to 133 +/- 22 mmHg, but this rise was not sustained thereafter. Mean pulmonary arterial blood pressure rose from 8 +/- 3 to 13 +/- 2 mmHg, and remained above the pre-exchange level up to 3 hours post-exchange. Cardiac output remained within normal limits. Significant flow-increments were seen at 30 minutes in heart, brain, liver, gut, and kidney, but these were also not sustained. A fall in glomerular filtration rate (GFR) occurred after the exchange and remained below the pre-exchange level. A reduction in urine flow at 150 minutes post-exchange was observed and was accompanied by a reduction in urinary electrolyte excretion. The findings suggest that the initial effects of the administration of unmodified stroma-free hemoglobin solution are those of peripheral vasoconstriction which does not appear to significantly restrict flow to the vital organs, such as heart and brain. Unmodified hemoglobin was found to cause a decrease in renal function.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"723-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12564537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Extracorporeal elimination of carbamazepine by haemoperfusion. 卡马西平血液灌流体外消除。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209117344

U Kuhlmann, R Becker, H Ebel, A Gressner, H Lange

{"title":"Extracorporeal elimination of carbamazepine by haemoperfusion.","authors":"U Kuhlmann, R Becker, H Ebel, A Gressner, H Lange","doi":"10.3109/10731199209117344","DOIUrl":"https://doi.org/10.3109/10731199209117344","url":null,"abstract":"The clearance of the haemoperfusion cartridge H 200 C Tekin was determined in vitro for blood dissolved carbamazepine to test the efficiency of haemoperfusion treatment. In the first hour of in vitro haemoperfusion test of pig blood (concentration of carbamazepine 1084 mg/l) a clearance of 190 ml/min was obtained, which declined slightly to 150 ml/min after 4 hours. In a second test the elimination of carbamazepine from albumin solution was proven to be more than 1000 mg of carbamazepine after a four hour perfusion period using teflon coated charcoal. These results are in accordance with the clinical course of a 30 years old male patient who presented with severe hypoxaemia due to acute intoxication by 6 g carbamazepine. The carbamazepine blood level was 33.7 mg/l. Charcoal haemoperfusion was started immediately. A dramatic improvement of clinical symptoms was already observed during haemoperfusion. The carbamazepine serum level was 18.6 mg/l after 4 hours of haemoperfusion.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 5","pages":"1171-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209117344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12627636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Treatment of uraemic hyperphosphatemia with calcium acetate: a safe alternative to calcium carbonate. 醋酸钙治疗尿毒性高磷血症:碳酸钙的安全替代品。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209117346

M Biagini, M Malaguti, R Sicoli, R Capece, A Friggi, G Ciaffi, R Bargagna

{"title":"Treatment of uraemic hyperphosphatemia with calcium acetate: a safe alternative to calcium carbonate.","authors":"M Biagini, M Malaguti, R Sicoli, R Capece, A Friggi, G Ciaffi, R Bargagna","doi":"10.3109/10731199209117346","DOIUrl":"https://doi.org/10.3109/10731199209117346","url":null,"abstract":"Clinical usefulness of calcium acetate (CAA) as phosphorus binder was assessed in 19 stable hemodialysis patients with persistent hyperphosphatemia. All were dialysed thrice weekly with a constant dialytic schedule and a dialysate calcium of 3.5 mEq/l. One month prior the study beginning all patients stopped assumption of Ca and vitamin D supplements. In the first period of the study CAA (mean daily doses 2.2 g) was administered for one month followed by 15 days of withdrawal. The mean serum phosphorus decreased from 7.6 +/- 1.4 to 5.8 +/- 0.8 mg% (p < 0.005). After 15 days of withdrawal mean serum phosphorus reached the pretreatment value. Then the patients entered a long term study with personalized doses of CAA (between 1 and 4 g/day) and administration in 8 of them of alpha-calcidol. After a mean follow-up period of 5.4 +/- 1.5 months serum phosphorus was reduced from 7.5 +/- 1.1 to 5.6 +/- 1.1 mg% (p < 0.0005) while calcemia increased from 9.0 +/- 0.7 to 9.6 +/- 0.6 mg% (p < 0.005). Only one patient developed mild hypercalcemia. We concluded that CAA is a safe alternative to calcium carbonate for the control of hyperphosphatemia of uraemic patients for the most efficient phosphorus binding and the lesser absorption of calcium.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 5","pages":"1193-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209117346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12627638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up. 通过血液透析和血液过滤去除β 2微球蛋白:四年随访。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209117348

H Schiffl, B D'Agostini, E Held

{"title":"Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up.","authors":"H Schiffl, B D'Agostini, E Held","doi":"10.3109/10731199209117348","DOIUrl":"https://doi.org/10.3109/10731199209117348","url":null,"abstract":"Efficient removal of total body burden beta 2-Microglobulin (beta 2-M) in uremia is a continuing challenge, as dialysis-related amyloidosis represents a major complication of chronic renal replacement therapy. To investigate long-term beta 2-M removal we studied 3 groups of stable end-staged renal failure patients over a period of 4 years; we compared low flux (cuprophane) hemodialysis (n = 12), high flux (polysulfone) hemodialysis (n = 12) and hemofiltration using high flux polysulfone (n = 8). In contrast to the cuprophane membrane, the polysulfone membrane eliminated considerable amounts of beta 2-M. This was associated with a sustained reduction of predialysis serum beta 2-M-levels (by 20%). Compared with high flux hemodialysis, hemofiltration provided a 50% higher elimination of beta 2-M. Thus, our long-term evaluation of beta 2-M removal suggests that hemofiltration rather than hemodialysis may be the treatment of choice for delaying the incidence of dialysis-related amyloidosis.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 5","pages":"1223-32"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209117348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12627640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Modified hemoglobin solution as possible perfusate relevant to organ transplantation. 修饰血红蛋白溶液尽可能灌注与器官移植相关的血液。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119680

T Agishi, K Sonda, I Nakajima, S Fuchinoue, H Honda, H Suga, H Liu, S Teraoka, K Ota

{"title":"Modified hemoglobin solution as possible perfusate relevant to organ transplantation.","authors":"T Agishi, K Sonda, I Nakajima, S Fuchinoue, H Honda, H Suga, H Liu, S Teraoka, K Ota","doi":"10.3109/10731199209119680","DOIUrl":"https://doi.org/10.3109/10731199209119680","url":null,"abstract":"A modified hemoglobin solution (<pyridoxylated hemoglobin>-<polyoxyethylene> conjugate solution, PHP solution) has very interesting characteristics such as oxygen-carrying property without corpuscular components. Experimental use of the PHP solution has shown promising possibilities as a perfusate relevant to organ transplantations. 1) Elongation of warm ischemic time in canine kidneys: Dogs survived even with the unilateral kidneys which had been exposed up to 4.5 hour warm ischemia and, thereafter, perfused with the PHP solution. 2) Elongation of perfusion preservation period of canine livers: Dogs survived with the transplanted livers which had been perfused for 48 hours with the PHP solution. 3) Successful perfusion of rat small intestine: Lewis rat intestines perfused and preserved for 12 hours with the PHP solution showed a higher survival rate compared with those with Collins or UW solution. 4) Removal of antibodies: By exchange transfusion with a total of 30-60 ml of the PHP solution, a Lewis rat hematocrit lowered to 5% while IgG went down to nil from 8970 mg/dl, IgA to 28 mg/dl from 118 mg/dl and IgM to 190 mg/dl from 897 mg/dl. This technique is expected to be applicable for removal of the naturally existing antibodies in xenotransplantation.","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"539-44"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12562863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Lymphoid tissue responses to concentrated perfluorochemical emulsions in rats. 大鼠淋巴组织对浓全氟化学乳剂的反应。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119759

P K Bentley, O L Johnson, C Washington, K C Lowe

引用次数: 5

Protective effects of a novel perfluorochemical emulsion in photodynamic therapy. 新型全氟化学乳剂在光动力治疗中的保护作用。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119743

K C Lowe, S L Akande, R Bonnett, R D White, M C Berenbaum

引用次数: 8

Development of highly fluid, concentrated and stable fluorocarbon emulsions for diagnosis and therapy. 用于诊断和治疗的高流动性、浓缩和稳定的氟碳乳剂的开发。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119726

J G Riess, J L Dalfors, G K Hanna, D H Klein, M P Krafft, T J Pelura, E G Schutt

引用次数: 43

Terminal sterilization of perfluorocarbon (PFC) emulsions: difficulties and possible solutions. 全氟碳(PFC)乳剂的末端灭菌:困难和可能的解决方案。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119730

J L Dalfors, C A Espinosa

引用次数: 3

Blood substitutes based on modified hemoglobin prepared by encapsulation or crosslinking: an overview. 以包封或交联制备的改良血红蛋白为基础的血液替代品:综述。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI: 10.3109/10731199209119634

T M Chang

引用次数: 41