Acta paediatrica Japonica : Overseas edition最新文献

{"title":"Transient extreme spindles in a case of subacute Mycoplasma pneumoniae encephalitis.","authors":"S Akaboshi,&nbsp;T Koeda,&nbsp;S Houdou","doi":"10.1111/j.1442-200x.1998.tb01973.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01973.x","url":null,"abstract":"<p><p>We describe a 4-year-old boy with delirium including somnolence, irritability, agitation and visual hallucination, associated with Mycoplasma pneumoniae (MP) encephalitis. The MP encephalitis was diagnosed from increased MP-antibody (> 1:1280). Electroencephalography during sleep revealed continuous 9 Hz fast wave activity over the bilateral frontocentral regions, which was thought to represent extreme spindles. These extreme spindles were in parallel with the degree of delirium. Transient extreme spindles have not previously been reported in MP or other encephalitis.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"479-82"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01973.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celiac disease in Turkish short-statured children and the value of antigliadin antibody in diagnosis.","authors":"B Altuntaş,&nbsp;A Kansu,&nbsp;A Ensari,&nbsp;N Girgin","doi":"10.1111/j.1442-200x.1998.tb01968.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01968.x","url":null,"abstract":"<p><strong>Background: </strong>It is generally accepted that celiac disease (CD) must always be taken into consideration when dealing with children manifesting growth failure. It is, therefore, important to have laboratory tests capable of detecting patients who should undergo intestinal biopsy. In this study, we have prospectively evaluated clinical characteristics, gliadin antibody measurements and duodenal biopsies in 47 children with short stature and without gastrointestinal symptoms, in order to determine the incidence of CD and the diagnostic value of immunoglobulin (Ig)A and IgG antigliadin antibodies (AGA) for CD.</p><p><strong>Methods: </strong>Anthropometric parameters and IgA- and IgG AGA were evaluated in 47 children with short stature. Antigliadin antibodies were measured by enzyme-linked immunosorbent assay (Euroimmun kit). Endoscopic intestinal biopsies were taken from all children.</p><p><strong>Results: </strong>On the basis of intestinal biopsy, 26 (55.3%) patients were found to be probable CD. Sensitivity, specificity, positive predictive (PPV) and negative predictive value (NPV) for IgA AGA was found to be 23, 90, 75 and 48%, respectively. Sensitivity, specificity and PPV for IgG AGA was 100, 0 and 55%, respectively. The NPV for IgG AGA was not determined.</p><p><strong>Conclusions: </strong>The results of our study demonstrated that because of their incomplete sensitivity, specificity, PPV and NPV, intestinal biopsy can not be replaced by these tests.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"457-60"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01968.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-acquired severe staphylococcal septicemia in children: the relationship with blunt trauma.","authors":"N Güler,&nbsp;U Oneş,&nbsp;M Yazicioĝlu,&nbsp;I Yalçin,&nbsp;N Salman,&nbsp;A Somer","doi":"10.1111/j.1442-200x.1998.tb01965.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01965.x","url":null,"abstract":"<p><strong>Background: </strong>With the aim of establishing the role of blunt trauma, a trauma without any fracture or obvious wound, as a risk factor in children who were admitted for community-acquired severe staphylococcal septicemia with various organ involvement, 63 patients were investigated during a seven-year study period. All children were previously healthy.</p><p><strong>Results: </strong>Blunt trauma was present in 12 (46%) of 26 septicemic patients in whom skeletal infections were diagnosed and the relative risk of trauma was high (odds ratio 15.0; confidence interval 2.9-75.8, P < 0.001) in these children. Patients with multiple organ involvement and with multifocal skeletal infections were more frequent among traumatized patients. Children with skeletal involvement were significantly older than others (P < 0.001). The period between the first symptom of infection and the diagnosis was shorter in traumatized children (P < 0.001). None of the children with staphylococcal pulmonary or soft tissue infection had any history of trauma. We conclude that blunt trauma is one of the important risk factors for skeletal involvement in staphylococcal septicemia. Its immunosuppressive nature, especially in local damage of the skin barrier, may be the cause of seeding and multifocal infection.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"441-5"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01965.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, clinical characteristics and natural history of vertically transmitted human immunodeficiency virus-1 infection in Japan.","authors":"K Akagi","doi":"10.1111/j.1442-200x.1998.tb01979.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01979.x","url":null,"abstract":"<p><strong>Background: </strong>According to the Ministry of Health and Welfare AIDS Surveillance Committee's report on vertically transmitted human immunodeficiency virus (HIV) infection, there have been eight children with acquired immune deficiency syndrome (AIDS) and 18 children with HIV infection in Japan, totalling 26 in all as of February 1997. A search of the literature fails to reveal any report that deals with many cases of vertically transmitted HIV infection in Japan.</p><p><strong>Methods: </strong>A primary questionnaire survey was taken of the main medical institutions across the country, followed by a secondary questionnaire survey of physicians and pediatricians who treated the disease. A clinical review was made of 19 children with vertically transmitted HIV infection (including eight AIDS children) according to the 1994 Revised Classification System for HIV Infection in Children.</p><p><strong>Results: </strong>The mean age at diagnosis was 14.5 months and the diagnosis was made at less than 18 months of life in approximately 70% of infected children. In the mean observation period of 16 months, six of eight AIDS children (75%), and one child of group B died. The mean period of observation for the seven dead children was 7 months, and six of seven children died by 36 months of life. The survival period after the diagnosis of AIDS was 15 months. The diagnosis of HIV infection was made based on the clinical symptoms of all children with AIDS. Of 11 children, six (45%) presented with symptoms of HIV infection by 6 months of life, and 10 of 11 children (91%) presented with symptoms by 26 months of life. The noteworthy clinical findings included hepatomegaly, splenomegaly, recurrent respiratory tract infection, lymph node swelling, oral candidiasis, hepatitis, wasting syndrome, HIV encephalopathy and severe pneumonia. The favored age for the start of complications and the magnitude of decrease in the HIV helper cell count varied with each case of complications of HIV infection (wasting syndrome, HIV encephalopathy) or opportunistic infections (cytomegalovirus infection, Mycobacterium avium complex infection). Anti-HIV drugs (mainly zidovudine) had been used in five of eight children with AIDS and were effective in two long survivors alone.</p><p><strong>Conclusions: </strong>Children who are diagnosed with HIV infection, based on their clinical symptoms, carry a poor prognosis. In this respect, early diagnosis and progress in anti-HIV therapy are necessary.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"496-502"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01979.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encephalopathy and cytomegalovirus colitis in an AIDS child.","authors":"M Togawa,&nbsp;M Shiomi,&nbsp;K Okawa,&nbsp;Y Kobayashi,&nbsp;K Fujita,&nbsp;R Murata","doi":"10.1111/j.1442-200x.1998.tb01982.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01982.x","url":null,"abstract":"<p><p>A 2-year-old girl, who had prolonged thrush and spastic diplegia, was found to have a mother-to-child vertical transmission of human immunodeficiency virus type-1 (HIV). A brain computed tomography scan revealed a symmetrical calcification on the bilateral basal ganglia and periventricular white matter. She had an acquired immune deficiency syndrome (AIDS) encephalopathy of pure dominant pyramidal tract disorder without an intellectual deficit. Helper cell lymphocyte count (CD4) increased with the beginning of zidovudine (ZDV, also known as AZT) monotherapy but began to decrease after the 4th week to reach the baseline at 20th week. Zidovudine plus didanosine combination therapy was started at the 68th week, but because of intolerance, the combination was changed to ZDV plus lamivudine at the 98th week. By the 80th week, neither severe opportunistic infection nor deterioration of the neurological status was recognized, but chronic diarrhea appeared. The diarrhea advanced to the wasting syndrome at the age of 4 years and cytomegalovirus genome was confirmed in a biopsied specimen of the colon. Ganciclovir treatment was effective in stopping the diarrhea and increasing her bodyweight, but after the age of 5, resumption of diarrhea was followed by progressive emaciation and weakness. This work may provide some clues in treating children's AIDS.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"515-22"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01982.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged suppressed thyroid-stimulating hormone levels in hyperthyroidism in a neonate born to a mother with Graves' disease.","authors":"M Hojo,&nbsp;N Momotani,&nbsp;N Ikeda,&nbsp;A Ueda,&nbsp;K Uno,&nbsp;T Ishikita,&nbsp;A Ishiguro,&nbsp;T Shimbo","doi":"10.1111/j.1442-200x.1998.tb01974.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01974.x","url":null,"abstract":"<p><p>We report here a case of neonatal hyperthyroidism born to a mother, whose pregnancy was complicated by poorly controlled Graves' disease. The patient demonstrated exophthalmos and marked goiter at birth, indicating the existence of thyrotoxicosis in utero. The mother's Graves' disease was well controlled in the third trimester, resulting in a slightly lower level of free thyroxine (FT4) in the umbilical cord blood serum; however, thyroid-stimulating hormone (TSH) was undetectable. Thyroid-stimulating hormone remained undetectable for 2 months, while FT4 levels varied in the course. This case suggests that severe and prolonged thyrotoxicosis in utero, due to poor control of pregnancy with Graves' disease, might induce unresponsiveness of the hypothalamo-pituitary system in the newborn.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"483-5"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01974.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of developmental changes in EEG-gamma band activity during childhood using the autoregressive model.","authors":"T Takano,&nbsp;T Ogawa","doi":"10.1111/j.1442-200x.1998.tb01966.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01966.x","url":null,"abstract":"<p><strong>Background: </strong>We characterized developmental changes in the EEG-gamma band during childhood using the autoregressive (AR) model, which was previously developed and described in our laboratory.</p><p><strong>Methods: </strong>The subjects comprised 707 healthy children ranging in age from 3 to 12 years. Electroencephalographs (EEG) were recorded from Fp1, Fp2, C3, C4, O1 and O2, monopolar leads referenced to the ear during quiet wakefulness (eyes closed). One 10 s artifact-free segment was selected from each record, digitized, then analyzed by AR and component analysis, which estimated the component wave and power spectrum.</p><p><strong>Results: </strong>Component waves obtained from all EEG leads were divided into eight groups, which comprised approximately 2, 5, 10, 17, 25, 30, 40 and 47 Hz peaks. The gamma band (peak wave 40 Hz; range 35-45 Hz) was a major EEG component throughout childhood. Different developmental characteristics of the gamma band power were exhibited in each lead. The power increased significantly (P < 0.01) between 3 and 4 years of age in all leads reaching a peak at 4-5 years of age, especially in the frontal region.</p><p><strong>Conclusions: </strong>These developmental characteristics might be related to the information processing and cognitive function, which is enhanced at 4-5 years of age, especially in the frontal region.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"446-52"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01966.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative microscopic anatomy, illustrated by its potential role in furthering understanding of the processes of structuring the developing human cerebral cortex.","authors":"B H Landing,&nbsp;W R Shankle,&nbsp;J P Boyd","doi":"10.1111/j.1442-200x.1998.tb01959.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01959.x","url":null,"abstract":"<p><p>In this study, we searched for patterns in selected, quantitative microscopic features of the developing postnatal human cortex for 35 cytoarchitectural areas at eight age points from birth to 72 months. These data come from the largest extant survey of the microscopic features of the developing postnatal human cerebral cortex (JL Conel, 1939-67). In contrast to Jacobson's proposal that cortical surface area increases in proportion to brain weight, Conel's data show that surface area increases as brain weight2/3, with the maximal rate of increase in both brain weight and cortical surface area occurring from 1 to 3 months. We computed the numbers of cortical neurons per cortical layer under 1 mm2 of cortical surface (neurons/layer per mm2 column) and divided these values by the total neuron number/mm2 column. For all areas, these data show plateaux in most of the layers for periods of months to years, often preceded and followed by changes in their neuron number in a sinusoidal fashion. The age points of the maxima and minima of such laminar values differ across the 35 cortical areas, indicating that their sinusoids are phase-shifted with respect to each other. Ranking the six layers in each area at each age point by their neuron number/layer per mm2 column shows that, by 72 months, the first areas to receive thalamic auditory or visual input (primary sensory and unimodal association cortices) have the most neurons in layer 4 and in either layer 3 or 6. In contrast, by 72 months, other areas have the most neurons in layers 3 and 6, with the primary motor cortex reaching this ranking earlier than any other area. For temporal and parietal association areas, layers 2 (short cortico-cortical connections) and 4 (thalamo-cortical connections) have the most neurons from birth to 6 months, whereas layers 3 (long cortico-cortical connections) and 6 (cortico-thalamic connections) have the most neurons by 72 months. The quantitative, statistically non-random patterns demonstrated by our analyses suggest that hierarchical correlations between such structural changes and age-specific behavioral acquisitions exist during the first 72 months of postnatal development.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"400-18"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01959.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality among patients with a history of Kawasaki disease: the third look. The Kawasaki Disease Follow-up Group.","authors":"Y Nakamura,&nbsp;H Yanagawa,&nbsp;H Kato,&nbsp;K Harada,&nbsp;T Kawasaki","doi":"10.1111/j.1442-200x.1998.tb01960.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01960.x","url":null,"abstract":"<p><strong>Background: </strong>Long-term prognosis of Kawasaki disease is still unclear.</p><p><strong>Methods: </strong>In a cohort study, 6576 patients with Kawasaki disease were observed from their first medical encounter because of the disease through the end of 1994, or until death. Standardized mortality ratios (SMR) with 95% confidence intervals (CI) were calculated with vital statistics data of Japan used for the control.</p><p><strong>Results: </strong>Of 6576 patients who met the eligibility criteria, 6550 (99.6%) were followed through either the end of the study or the date of death. Twenty patients (14 male, 6 female subjects) died during the study period; an overall SMR of 1.35 (95% CI 0.82-2.08) was calculated. The SMR was 1.45 (95% CI 0.79-2.44) for male subjects and 1.15 (95% CI 0.42-2.52) for female subjects. During the acute phase of the disease (the first 2 months after the first visit to hospital), the SMR was higher, particularly in male subjects (SMR 10.13, 95% CI 3.72-22.08). After the acute phase, however, both boys and girls had low SMR. Nine of the 20 deaths were caused by Kawasaki disease; there were three deaths as a result of congenital heart diseases and two subjects died of malignant neoplasms of lymphatic or hematopoietic tissues.</p><p><strong>Conclusions: </strong>Although the mortality rate among those with a history of Kawasaki disease was elevated in Japan, many of the deaths that caused the elevation occurred during the acute phase of the disease. The mortality rate was not increased after the acute phase of the disease.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"419-23"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01960.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: is it an additional marker of perinatal asphyxia?","authors":"M Akisü,&nbsp;N Kültürsay,&nbsp;I Coker,&nbsp;A Hüseyinov","doi":"10.1111/j.1442-200x.1998.tb01962.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01962.x","url":null,"abstract":"<p><strong>Background: </strong>Hypoxic-ischemic encephalopathy (HIE) is still a very important cause of neonatal mortality and morbidity. Recently platelet-activating factor (PAF) has been accused of being responsible for the neuronal damage in hypoxic-ischemic brain.</p><p><strong>Methods: </strong>Therefore, we conducted a study in newborns with perinatal asphyxia to try to show the relationship between the clinical severity and plasma PAF levels.</p><p><strong>Results: </strong>Mean plasma levels of 19 asphyxiated infants (997.8 +/- 363.5 pg/mL) were significantly higher than that of 20 healthy infants (410.2 +/- 148.6 pg/mL, P < 0.0001). Patients with clinically severe HIE had significantly higher levels of PAF (1494.2 +/- 386.6 pg/mL) when compared with patients with mild HIE (815 +/- 114.5 pg/mL) and with moderate HIE (828.3 +/- 61.1 pg/mL). There was a significant correlation between plasma PAF concentration and arterial pH and base deficit, but no correlation with platelet and leukocyte counts.</p><p><strong>Conclusions: </strong>Plasma PAF levels correlating with the severity of HIE is interpreted to mean that high PAF levels may be an indicator of clinical severity and probably the poorer prognosis of patients with HIE.</p>","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"427-31"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01962.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20732148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}