American Journal of Biomedical Sciences最新文献_第10页

Genetic implications of viral hepatitis-associated hepatocellular carcinoma 病毒性肝炎相关肝细胞癌的遗传意义

American Journal of Biomedical Sciences Pub Date : 2018-12-27 DOI: 10.3126/JBS.V5I1.22117

M. Asim, B. Sathian

引用次数: 2

Effect of smoking on serum lipid profile amongst stroke patients: A descriptive study from Dhaka, Bangladesh 吸烟对中风患者血脂的影响:来自孟加拉国达卡的一项描述性研究

American Journal of Biomedical Sciences Pub Date : 2018-10-10 DOI: 10.3126/JBS.V4I2.21316

N. Habib, Mamunur Rashid, Farzana Afzal, B. Roy, Tahmina Afrose

引用次数: 0

Occurrence of Transfusion Transmissible Infections in Screened Blood with Rapid Diagnostic Kits in Comparison with ELISA Using Federal Medical Centre Owo as A Case Study 快速诊断试剂盒筛查血液中输血传播感染的发生率与ELISA的比较——以联邦医疗中心奥沃为例

American Journal of Biomedical Sciences Pub Date : 2018-10-01 DOI: 10.5099/aj180400211

J. Fapohunda, A. Atere, A. A. Adebisi

引用次数: 0

Stabilizing Ability and Anti-sickling Potentials of Ganoderma Lucidum Decoction Extract on Human HbS Erythrocytes Membrane 灵芝煎提物对人HbS红细胞膜的稳定能力及抗镰状细胞潜能

American Journal of Biomedical Sciences Pub Date : 2018-10-01 DOI: 10.5099/AJ180400202

R. Ohiri, E. Essien

引用次数: 0

Erythropoietin Protects Against Exertional Rhabdomyolysis-induced Acute Kidney Injury in Association with Preferential M2 Macrophage Polarization and Hemeoxygenase-1 Activation 促红细胞生成素与M2巨噬细胞优先极化和血红氧合酶-1激活有关，可预防运动性横纹肌溶解引起的急性肾损伤

American Journal of Biomedical Sciences Pub Date : 2018-10-01 DOI: 10.5099/aj180400223

M. Muhammad, A. M. A. Elhameed, Bakr Ahmed

{"title":"Erythropoietin Protects Against Exertional Rhabdomyolysis-induced Acute Kidney Injury in Association with Preferential M2 Macrophage Polarization and Hemeoxygenase-1 Activation","authors":"M. Muhammad, A. M. A. Elhameed, Bakr Ahmed","doi":"10.5099/aj180400223","DOIUrl":"https://doi.org/10.5099/aj180400223","url":null,"abstract":"Background: Exertional rhabdomyolysis (ER)-induced acute kidney injury (AKI) is a serious health threat associated with strenuous physical exercise. Erythropoietin (EPO) is a pleiotropic hormone with its immunomodulator function still unclear. We investigated the renoprotective effect of EPO in EXR-induced AKI, with an emphasis on macrophages phenotypic polarization and associated hemeoxygenase1 (HO1) bioactivity. Methods: Strenuous exercise was applied to rats, either or not preceded by EPO alone or combined with the HO1 enzyme blocker, Zinc protoporphyrins (Zn-PP). Serum levels of creatine phosphokinase, myoglobin, urea nitrogen, creatinine, and carboxyhemoglobin (COHb) % were estimated. In addition, we examined the inflammatory cytokines IL10 and TNFα , macrophages phenotypic markers, HO1 expression, and renal pathology. Results: EPO pre-treatment resulted in significant decreases in blood urea nitrogen, serum creatinine and myoglobin, tubular injury score, and intratubular cast % in addition to TNF-α decrease, IL10 increase with a preferential switching of macrophage polarization to the reparative M2 phenotype as antiinflammatory effect. Furthermore, EPO pre-treatment was associated with an increase in HO1 protein expression and COHb%. Such effects were significantly reversed when HO1 activity blocker, Zn-PP, was co-administered.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82373718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical skills and it’s importance in undergraduate medical curriculum 临床技能及其在本科医学课程中的重要性

American Journal of Biomedical Sciences Pub Date : 2018-07-16 DOI: 10.3126/JBS.V4I1.20570

B. Roy, Mamunur Rashid, B. Sathian, I. Banerjee

引用次数: 40

Anti-inflammatory properties of Dirinaria consimilis extracts in albino rats 白缕草提取物对白化大鼠的抗炎作用

American Journal of Biomedical Sciences Pub Date : 2018-07-16 DOI: 10.3126/JBS.V4I1.20572

V. B. Tatipamula, G. Vedula

{"title":"Anti-inflammatory properties of Dirinaria consimilis extracts in albino rats","authors":"V. B. Tatipamula, G. Vedula","doi":"10.3126/JBS.V4I1.20572","DOIUrl":"https://doi.org/10.3126/JBS.V4I1.20572","url":null,"abstract":"BackgroundEarlier, the lichens are used in traditional medicines by different cultures across the world. As the Dirinaria genus has been shown to be biologically active against inflammation in folklore, we assessed the in vitro and in vivo anti-inflammatory profile of Dirinaria consimilis.Material and methodsInitially, the hydroalcoholic extract of lichen, D. consimilis (Dc-HE) was prepared and re-extracted with n-hexane, chloroform, ethyl acetate, acetone and methanol. The resultant extracts were evaluated for their in vitro (protein denaturation method), acute toxicity and in vivo (formalin-induced rat paw oedema assay) anti-inflammatory studies.ResultsAmong all the tested extracts, the acetone and chloroform extract of D. consimilis depicted prominent anti-inflammatory activity in both the bioassays. The acetone extract inhibited protein denaturation with IC50 value of about 468 µg/mL while the standard (Indomethacin) with 120 µg/mL. Moreover, the Dc-HE was screened for acute toxicity studies in male albino rats up to 2000 mg/Kg b.w dosage. The in vivo anti-inflammatory analysis of acetone extract (200 mg/mL) showed potent reduction of rat paw oedema nearer to that of the standard, whereas chloroform extract depicted moderate depletion and the other extracts revealed mild inhibitory profile against inflammation.ConclusionThis study reveals that the lichen, D. consimilis might be a good source of anti-inflammatory agents.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78659772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Haptoglobin Phenotypes and Association with Vascular Complications in Nigerian Type 2 Diabetes Patients 尼日利亚2型糖尿病患者的联珠蛋白表型及其与血管并发症的关系

American Journal of Biomedical Sciences Pub Date : 2018-07-01 DOI: 10.5099/aj180300184

O. O. Olaniyan, H. Osadolor

引用次数: 0

Applied Fluid-Structure Interaction Technique to Initial Insight into the Effect of Exercise on the Aortic Valve Stroke Work 应用流固耦合技术初步了解运动对主动脉瓣卒中功的影响

American Journal of Biomedical Sciences Pub Date : 2018-07-01 DOI: 10.4172/2168-9873.1000295

Hamidreza Ghasemi Bahraseman, E. Languri, D. Espino, H. Shojaei, K. Hassani, Hossein Derakhshandeh

{"title":"Applied Fluid-Structure Interaction Technique to Initial Insight into the Effect of Exercise on the Aortic Valve Stroke Work","authors":"Hamidreza Ghasemi Bahraseman, E. Languri, D. Espino, H. Shojaei, K. Hassani, Hossein Derakhshandeh","doi":"10.4172/2168-9873.1000295","DOIUrl":"https://doi.org/10.4172/2168-9873.1000295","url":null,"abstract":"The left ventricular stroke work is a measure of the work done by the left ventricle during the ejection of blood throughout per cardiac cycle. The aim of this investigation was to propose a model to numerically evaluate the stroke work for a healthy subject by using a fluid-structure interaction (FSI) simulation during exercise protocol. Aortic valve dimensions were calculated using an imaging technique of echocardiography. An FSI simulation was performed using an Arbitrary Lagrangian-Eulerian (ALE) mesh. Boundary conditions were defined by pressure loads on ventricular and aortic sides. Stroke work was predicted to increase to 121% from 60 bpm to 125 bpm, and it did not increase much above 125 bpm. Based on derived regression equations of our FSI results for stroke work and comparing of them with clinical ones, numerically-predicted stroke work values are in good agreements with published clinical data. The slope of stroke work changes to mean arterial pressure, while exercise protocol, is 168.08 ml which is 12.2% less than the average slope of clinical data. The y-axis intercept of stroke work changes to mean arterial pressure, while exercise protocol, is -11186 mmHg.ml which is 15% less than the average y-axis intercept of clinical data. Our results for the specific patient show that numerical methods can be proposed to predict good estimates of patient specific stroke work at different heart rates.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76955800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Research and Design a Non- Invasive Blood Glucose Measuring Module 一种无创血糖测量模块的研究与设计

American Journal of Biomedical Sciences Pub Date : 2018-07-01 DOI: 10.5099/aj180300149

Duong Trong Luong, N. X. Huy, Dao Viet Hung, Nguyen Thai Ha, N. D. Thuan

引用次数: 3