American Journal of Biomedical Sciences最新文献

Comparative analysis of ELISA, FEIA and CLIA techniques in diagnostic immunoassays for thyroid stimulating hormone: A cross-sectional study form Morang, Nepal ELISA、FEIA和CLIA技术在促甲状腺激素诊断免疫分析中的比较分析:来自尼泊尔Morang的横断面研究

American Journal of Biomedical Sciences Pub Date : 2023-07-27 DOI: 10.3126/jbs.v10i1.57050

R. L. Mallick, C. P. Gaire

{"title":"Comparative analysis of ELISA, FEIA and CLIA techniques in diagnostic immunoassays for thyroid stimulating hormone: A cross-sectional study form Morang, Nepal","authors":"R. L. Mallick, C. P. Gaire","doi":"10.3126/jbs.v10i1.57050","DOIUrl":"https://doi.org/10.3126/jbs.v10i1.57050","url":null,"abstract":"Background: TSH and circulating thyroid hormones are measured in serum as part of a thyroid function test (TFT), which evaluates the thyroid gland's ability to produce and regulate thyroid hormones. The objective of the current study was to compare the technical performance between ELISA, FEIA and the currently marketed automated CLIA for measuring the TSH level. \u0000Material and methods: A total of 1,200 participants were enrolled in the study. Subjects were chosen randomly, either OPD patients or inpatients of Birat Medical College Teaching Hospital. Chemiluminescence Immunoassay (CLIA), Enzyme-linked Immunoassay (ELISA) and Fluorometric Enzyme Immunoassay (FEIA) technologies were performed. \u0000Results: The total number of patients (1200) was categorized into group I, normal TSH (n = 680); group II, elevated TSH (n = 300); and group III, decreased TSH (n = 220). CLIA and FEIA based results were significantly more sensitive compared to ELISA results for TSH detection. \u0000Conclusion: Chemiluminescence assay system, when compared to FEIA and ELISA, is far superior in terms of accuracy and sensitivity for reporting both subnormal and above normal TSH levels and can be helpful in the detection of subclinical thyroid dysfunction (SCTD) and in the screening of thyroid diseases.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86040194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of mid-trimester maternal serum β-hCG and AFP as markers of preterm and term adverse pregnancy outcomes form a tertiary care hospital, Morang, Nepal 尼泊尔莫朗一家三级医院妊娠中期孕妇血清β-hCG和AFP作为早产和足月不良妊娠结局标志物的分析

American Journal of Biomedical Sciences Pub Date : 2023-06-26 DOI: 10.3126/jbs.v10i1.56077

R. L. Mallick, C. P. Gaire, P. Dahal, N. Kafle

{"title":"Analysis of mid-trimester maternal serum β-hCG and AFP as markers of preterm and term adverse pregnancy outcomes form a tertiary care hospital, Morang, Nepal","authors":"R. L. Mallick, C. P. Gaire, P. Dahal, N. Kafle","doi":"10.3126/jbs.v10i1.56077","DOIUrl":"https://doi.org/10.3126/jbs.v10i1.56077","url":null,"abstract":"Background: Mid-trimester maternal serum markers have been used for prenatal aneuploidy screening for a long time. The aim of the study was to assess the mid-term serum levels of β-human chorionic gonadotropin and alpha-fetoproteins for placenta-mediated adverse pregnancy outcomes (PMAPOs) in preterm and term pregnancies. \u0000Material and methods: A prospective cohort study involving nulliparous women with singletons without aneuploidy or fatal fetal abnormalities was carried out a tertiary care hospital, Morang, Nepal. AFP and β-hCG levels were estimated between 13 and 17 weeks of gestation in the mother's serum. All values were in multiples of the median (MoM) and compared between women with PMAPOs. \u0000Results: The serum levels of AFP and β-hCG were obtained in 176 out of 300 nulliparous women. The MoM of serum β-hCG (1.3 vs 1.1) and AFP (1.4 vs 1.1) were higher in PMAPOs-affected women than in controls. \u0000Conclusion:Preterm PMAPOs, but not term PMAPOs, are more likely in the present study when maternal serum AFP or β -hCG levels are more significant than 2.0 MoM. If fetal growth is within the normal range at 37 weeks of gestation, it is advisable that women with increased serum β-hCG or AFP receive regular prenatal care.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88778061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marburg virus disease: In a nutshell 马尔堡病毒病:简而言之

American Journal of Biomedical Sciences Pub Date : 2023-06-26 DOI: 10.3126/jbs.v10i1.56075

B. Roy

引用次数: 0

American Journal of Biomedical Sciences Pub Date : 2023-06-26 DOI: 10.3126/jbs.v10i1.56076

M. Hoque, Nasreen Nahar, M. S. Mahbub, Jesmine Akter, Begum Rowshan Ara

{"title":"Factors related to delay in cervical cancer diagnosis and treatment among women in Bangladesh: A cross-sectional study","authors":"M. Hoque, Nasreen Nahar, M. S. Mahbub, Jesmine Akter, Begum Rowshan Ara","doi":"10.3126/jbs.v10i1.56076","DOIUrl":"https://doi.org/10.3126/jbs.v10i1.56076","url":null,"abstract":"Background: Bangladesh has a large proportion of women at risk of developing cervical cancer. Though it is considered preventable, it is the second commonest cancer of women in Bangladesh. This study explored the factors influencing the delays in seeking cervical cancer care. \u0000Material and methods: Three hundred and ninety nine (399) randomly selected women with cervical cancer attending clinical care in a tertiary hospital were enrolled. Both quantitative and qualitative methods were followed. Face-to-face interviews using a semi-structured and in-depth questionnaire were carried out. The univariate analysis measured the association with statistical significance set at p<0.05. Content and context analyses were performed for a qualitative segment of the study. \u0000Results: The mean age of the respondent was 54.3 years (Mean ± SD, 54.3±11.7). The median duration of primary, secondary and tertiary delays was 45, 45 and 60, respectively. The association between primary delay and personal factors, e.g., lack of knowledge, was statistically significant (p<0.05). Economic factors were closely associated with secondary delay (p=0.000). Issues like healthcare facilities were significant for tertiary delay (p=0.000). \u0000Conclusion: This study identified multiple factors that can be addressed to reduce delays regarding cervical cancer diagnosis and treatment. Steps to reduce these delays can be expected to improve clinical care and the outcome of this cancer in women in Bangladesh.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89438141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging outbreak of XBB, and BA.5: An insight into Omicron subvariants XBB和BA.5的爆发:对欧米克隆亚变体的洞察

American Journal of Biomedical Sciences Pub Date : 2022-12-31 DOI: 10.3126/jbs.v9i2.52047

B. Roy

引用次数: 0

D-Dimer as a biomarker for COVID-19 patients' illness severity and mortality: A hospital-based study from eastern Nepal d -二聚体作为COVID-19患者疾病严重程度和死亡率的生物标志物:来自尼泊尔东部的一项基于医院的研究

American Journal of Biomedical Sciences Pub Date : 2022-12-31 DOI: 10.3126/jbs.v9i2.52048

A. Mittal, M. Farooqui

{"title":"D-Dimer as a biomarker for COVID-19 patients' illness severity and mortality: A hospital-based study from eastern Nepal","authors":"A. Mittal, M. Farooqui","doi":"10.3126/jbs.v9i2.52048","DOIUrl":"https://doi.org/10.3126/jbs.v9i2.52048","url":null,"abstract":"Background: The biomarker D-dimer, produced when fibrin breaks down, is frequently used to diagnose thrombotic diseases. D-dimer has been recognized as a potential indication of the prognosis for COVID-19 patients since the inception of the COVID-19 pandemic. We collected and compared the demographic, clinical, and liver function data of patients with confirmed COVID-19 at admission between those with elevated and those with normal D- dimer levels in our hospital-based study. \u0000Material and methods: A hospital-based study that used data from the biochemistry laboratory at Birat Medical College Teaching Hospital in Biratnagar, Nepal, was conducted between July 31 and December 31, 2021. Measurements included age, gender, D- Dimer, procalcitonin, C- Reactive Protein (CRP), aspartate transaminase, and alanine transaminase. \u0000Results: In COVID-19 patients with normal D-dimer levels, the mean age was 55 years (CI, 43-67), while in those with increased levels, it was 66 years (CI, 52-80). In the increased group of the D- dimer, almost 20% had diabetes mellitus, and 8% had chronic obstructive pulmonary disease. Compared to the normal group, the mean values of D- Dimer, procalcitonin, C- Reactive Protein (CRP), aspartate transaminase, and alanine transaminase, alkaline phosphate in the raised group were noticeably higher. \u0000Conclusion: In conclusion, SARS-CoV-2-infected individuals frequently have high D-dimer levels. Critically sick patients had much greater levels, which can be utilized as a predictive indicator for in-hospital mortality.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83611219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monkeypox outbreak: Must know for the clinicians 猴痘爆发:临床医生必须知道

American Journal of Biomedical Sciences Pub Date : 2022-12-12 DOI: 10.3126/jbs.v9i1.50096

B. Roy

引用次数: 0

Dengue outbreak in Bangladesh 孟加拉国爆发登革热疫情

American Journal of Biomedical Sciences Pub Date : 2022-12-12 DOI: 10.3126/jbs.v9i1.50098

F. Khatun

引用次数: 3

Digito-palmar Dermatoglyphics Patterns May Predict the Risk of Hypertension among Nigerians 尼日利亚人的指掌皮肤纹样可以预测高血压的风险

American Journal of Biomedical Sciences Pub Date : 2022-10-01 DOI: 10.5099/aj220400146

Timothy Oluwarotimi Folorunso, B. K. Akinola, Grace Edose Kadiri, G. Oladipo

引用次数: 0

Chemoprevention of 1,2 Dimethyl Hydrazine-Induced Colon Tumor in Albino Rat by Meloxicam and its Correlation with Immunoassay of Serum CEA 美洛昔康对1,2 -二甲基肼诱导的白化大鼠结肠肿瘤的化学预防作用及其与血清CEA免疫测定的相关性

American Journal of Biomedical Sciences Pub Date : 2022-10-01 DOI: 10.5099/aj220400154

SaeedSamah Mohamed, A. M. Amin, S. Skander, T. Hewala, Eithar Omer Mohamed Saleh, A. salih, Sabah Ali Mugahed Al-Qadasi, M. M. Badawi, M. A. Hamed

引用次数: 0