Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology最新文献

Bleomycin: effect on satellite DNA in mouse fibroblasts. 博来霉素对小鼠成纤维细胞卫星DNA的影响。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461654

H Madreiter, R Osieka, C Wittekind, P Kaden, C Mittermayer

引用次数: 2

[Change of toxicity and carcinogenicity of n-methyl-n-nitrosobenzylamine in rats by methylsubstitution at the c-atoms adjacent to nitrogen (author's transl)]. [n-甲基-n-亚硝基苄胺对大鼠的毒性和致癌性的变化通过在氮附近的c原子甲基取代(作者译)]。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461646

F Schweinsberg, M Kouros, K Manncke, K Rieth

引用次数: 0

The fine structure of monoclonal Hodgkin cells cultured in diffusion chambers. 单克隆霍奇金细胞在扩散室培养的精细结构。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461647

E N Schmid, W R Boecker, K G Lickfeld

{"title":"The fine structure of monoclonal Hodgkin cells cultured in diffusion chambers.","authors":"E N Schmid, W R Boecker, K G Lickfeld","doi":"10.1007/BF00461647","DOIUrl":"https://doi.org/10.1007/BF00461647","url":null,"abstract":"Pleural effusion cells from two patients with stage IV Hodgkin's disease have been cultured continuously in diffusion chambers in mice and studied by electron microscopy after a culture period exceeding 100 days. Cell identity and monoclonal growth in culture has been documented by marker chromosomes (Hossfeld and Schmidt, 1978). These cultured cells grow in close connection, projecting pseudopode-like processes into the intercellular spaces. Most nuclei are lobulated. They always are of low electron density with a norrow rim of condensed chromatin confined to the nuclear membrane. One large prominent nucleolus and up to four smaller nucleoli are found. Nuclear pockets in case 1 and deep cytoplasmic invaginations into the nuclear area in both cases frequently occur. In the cytoplasm, besides microtubuli and fibrils, the Golgi apparatus and mitochondria are the predominant organelles. Most mitochondria appear to be dilated containing fragmented cristae. Free ribosomes and polysomal aggregates are randomly distributed. The ratio nucleoplasm:cytoplasm, on the average, is 0.7 in both cases and the cell diameters lie distinctly above those of lymphocytes. At the electron microscope level these cultured monoclonal cells of Hodgkin's disease are not distinguishable from those described in genuine Hodgkin material. Their probable origin and apparent relation to true histiocytic lymphoma cells will be discussed.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"92 3","pages":"243-54"},"PeriodicalIF":0.0,"publicationDate":"1978-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00461647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11371542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephroblastoma and neuroblastoma--histology and prognosis. 肾母细胞瘤和神经母细胞瘤的组织学和预后。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461655

P Meister, M Middeke, H K Selbmann

引用次数: 0

In vitro studies of human breast carcinoma cells obtained by aspiration biopsy. 人乳腺癌细胞抽吸活检的体外研究。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461653

M Volk, H Schöndorf, H Naujoks

引用次数: 1

The change in carcinogenic effectiveness of some cyclic nitrosamines at different doses. 某些环亚硝胺在不同剂量下致癌性的变化。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461644

W Lijinsky, H W Taylor

{"title":"The change in carcinogenic effectiveness of some cyclic nitrosamines at different doses.","authors":"W Lijinsky, H W Taylor","doi":"10.1007/BF00461644","DOIUrl":"https://doi.org/10.1007/BF00461644","url":null,"abstract":"The carcinogenic effectiveness in rats of three cyclic nitrosamines administered at two doses separated by a factor of five has been studied. All three compounds showed a response at the lower dose quite different from that at the higher dose. One, 2,6-dimethyl-dinitrosopiperazine, was only a little less effective at the lower dose than at the higher dose, giving 100% nasal turbinate tumors, but only 33% esophageal tumors, compared with 100% esophageal tumors at the higher dose. 3,4-Dichloronitrosopiperidine gave 100% incidence of esophageal tumors at the higher dose. At the lower dose, survival of the rats was very much better, some living 80 weeks, and, in addition to the esophagus, there were tumors of several organs including forestomach, tongue, and nasal turbinates. On the other hand, 2,6-dimethylnitrosomorpholine was a very much weaker carcinogen at the lower than at the higher dose, only six animals dying with tumors, compared with 100% incidence at the higher dose. However, the pattern of mortality of rats given the lower dose of dimethylnitrosomorpholine was similar to that of rats given the lower dose of dichloronitrosopiperidine.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"92 3","pages":"221-5"},"PeriodicalIF":0.0,"publicationDate":"1978-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00461644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11371717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Nitrate nitrogen levels in drinking water of urban areas with high- and low-risk populations for stomach cancer: an environmental epidemiology study. 胃癌高、低危人群城市地区饮用水硝酸盐氮水平:环境流行病学研究。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461645

R Zaldívar, W H Wetterstrand

{"title":"Nitrate nitrogen levels in drinking water of urban areas with high- and low-risk populations for stomach cancer: an environmental epidemiology study.","authors":"R Zaldívar, W H Wetterstrand","doi":"10.1007/BF00461645","DOIUrl":"https://doi.org/10.1007/BF00461645","url":null,"abstract":"A correlation study between mean nitrate nitrogen levels (ppm) in drinking water samples (N = 1389) of Chilean urban areas and age-adjusted death rates per 100 000 population from stomach cancer, by province or region and sex, was made. Drinking water samples from all provinces (N = 25) had a weighed mean of 1.446 ppm (S.E.M. 0.068) with a range of 0.00--30.00 ppm. Nitrate nigrogen levels showed a positive but not significant association with male death rates. The correlation coefficient was +0.0335. Similarly, such levels did exhibit a positive but not significant correlation with female death rates (r = +0.0486). When NO3-N levels and male (r = +0.1367) or female (r = +0.1143) death rates were studied, by region, positive but insignificant correlations were detected. Using Cochran's approximation, mean nitrate nitrogen levels in drinking water samples from six provinces with 50% of the Chilean population (period 1953--55 versus 1973--75), showed a decrease from 1.835 to 1.291 ppm, but there was no significant difference (t = 1.32) between the two values, except in samples from Santiago Province (t = 2.11, P less than 0.05). Provinces (south central area) showing the highest gastric cancer mortality rates in the world for females (up to 40.8/100,000), and ranking second for males (up to 84.1/100,000), exhibited a very low mean level (0.825 ppm).","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"92 3","pages":"227-34"},"PeriodicalIF":0.0,"publicationDate":"1978-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00461645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11371718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma. 脾切除术对B淋巴细胞和t淋巴细胞及苯并芘诱导的小鼠肉瘤的影响。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461649

C Witting, E Hultsch

引用次数: 1

Effect of generalized graft-versus-host-reaction on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma. 移植物抗宿主反应对B淋巴细胞和t淋巴细胞及苯并芘诱导的小鼠肉瘤的影响。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461648

C Witting, E Hultsch

{"title":"Effect of generalized graft-versus-host-reaction on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.","authors":"C Witting, E Hultsch","doi":"10.1007/BF00461648","DOIUrl":"https://doi.org/10.1007/BF00461648","url":null,"abstract":"Unlabelled: The investigations of 400 adult hybrids from A/Jax fem. BALB/c male were aimed at answering the following questions: 1. What is the influence of a generalized graft-versus-host-reaction (GVHR) on the induction and growth of benzpyren-induced sarcoma? 2. What is the behavior of B- and T-lymphocytes during GVHR, and during induction and growth of benzpyren-induced sarcoma? 3. Which are the deductions to be drawn with regard to the effect of B- and T-lymphocytes during tumorigenesis and tumor growth?Results: 1. The number of tumors was significantly greater in the GVHR animals (74.5%) than in the controls (49.5%). 2. A significant decrease of T-lymphocytes and increase of B-lymphocytes during GVHR were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a marked decrease of the total round cell count and the T cells, while the count of B-lymphocytes remained uninfluenced. These results are discussed and compared with results of other authors.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"92 3","pages":"255-65"},"PeriodicalIF":0.0,"publicationDate":"1978-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00461648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11255070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Release of glycolytic enzymes from cultivated tumor cells. 培养肿瘤细胞中糖酵解酶的释放。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1978-10-30 DOI: 10.1007/BF00461650

K Keller, H Kolbe, K Lange, B Zimmermann

{"title":"Release of glycolytic enzymes from cultivated tumor cells.","authors":"K Keller, H Kolbe, K Lange, B Zimmermann","doi":"10.1007/BF00461650","DOIUrl":"https://doi.org/10.1007/BF00461650","url":null,"abstract":"Several types of cultured cells release glycolytic enzymes into their suspending medium. This effect is most obvious with tumor cells, especially with their ascites forms. Erythrocytes do not release glycolytic enzymes. The total extracellular phosphoglucose isomerase activity consists of two components. One part is dissolved in the medium, the other one is sedimentable at 150 X g together with the cells. The latter seems to be localized at the cell surface. At densities of about 10(6) cells/ml maximum activity in the medium is reached within 5--10 min. After that no further release of enzyme activity can be observed. Serum reduces the rate of enzyme release considerably. This effect can be reversed by washing with protein free media. Treatment with trypsin leads to high extracellular phosphoglucose isomerase activities of the cells which originally show low external enzyme activity. Erythrocytes do not show any effect with trypsin, ascites tumor cells do not alter their high extracellular enzyme activity. At a density of 10(5) cells/ml, Yoshida acites tumor cells, cultured in vitro, release about 12% of originally intracellular phosphoglucose isomerase activity by 5 elutions with fresh medium. The process of enzyme release shows a certain selectivity in respect to different glycolytic enzymes. Aldolase exhibits the highest activity in the medium in relation to its homogenate activity.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"92 3","pages":"275-86"},"PeriodicalIF":0.0,"publicationDate":"1978-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00461650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11371544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0