Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology最新文献_第10页

Tumor frequency and characteristics after a single dose of dimethylnitrosamine or diethylnitrosamine in partially hepatectomized rats. 部分肝切除大鼠单剂量二甲基亚硝胺或二乙基亚硝胺后肿瘤发生频率和特征。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-10-01 DOI: 10.1007/BF00306018

A Fridman-Manduzio, R Gol-Winkler, E H Betz, R Goutier

引用次数: 0

Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram. 二硫仑对二乙基亚硝胺诱导的肝DNA链断裂的抑制作用。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-10-01 DOI: 10.1007/BF00306025

D Hadjiolov, N Frank, D Schmähl

引用次数: 5

[Mononuclear phagocytes in tumors: differentiation by a rosette technique (author's transl)]. [肿瘤中的单核吞噬细胞:玫瑰花结技术的分化]。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-10-01 DOI: 10.1007/BF00306026

G Bandlow

引用次数: 2

Immunhistochemical demonstration of different collagen types in the normal epiphyseal plate and in benign and malignant tumors of bone and cartilage. 正常骨骺板及骨、软骨良、恶性肿瘤中不同胶原类型的免疫组化证明。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-10-01 DOI: 10.1007/BF00306024

K Remberger, S Gay

引用次数: 7

Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice. 盐酸4-甲基苯肼对瑞士小鼠的致瘤作用。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-08-15 DOI: 10.1007/BF00283781

B Toth, A Tompa, K Patil

{"title":"Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice.","authors":"B Toth, A Tompa, K Patil","doi":"10.1007/BF00283781","DOIUrl":"https://doi.org/10.1007/BF00283781","url":null,"abstract":"4-Methylphenylhydrazine hydrochloride was administered as 10 weekly subcutaneous injections of 140 microgram/g body weight and as 7 weekly intragastric instillations of 250 microgram/g body weight in physiological saline to randomly bred Swiss mice. Treatments given subcutaneously resulted in induction of lung tumors in incidences of 36% in females and 44% in males, while intragastric treatment caused a 40% incidence in females. In addition, it gave rise to blood vessel tumors by intragastric route in incidences of 32% in females and 18% in males. In the two physiological saline-treated control groups, the lung tumor incidence (combined) was 20% in females and 21% in males, while the blood vessel tumor incidence (combined) was 7% in females and 6% in males. Histopathologically, the lesions were classified as adenomas and adenocarcinomas of the lungs, and angiomas and angiosarcomas of blood vessels. 4-Methylphenylhydrazine was postulated to be a metabolite of 4-hydroxymethylphenylhydrazine, an ingredient of the commonly eaten mushroom Agaricus bisporus. The implications are discussed with respect to the tumorigenesis data.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"89 3","pages":"245-52"},"PeriodicalIF":0.0,"publicationDate":"1977-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00283781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11362580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Comparative pathologic classification of malignant lymphomas. 恶性淋巴瘤的比较病理分类。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-08-15 DOI: 10.1007/BF00283782

G R Krueger

引用次数: 5

Combination chemotherapy with 1-methyl-1-nitrosourea (MNU) and cyclophosphamide in solid tumors. 1-甲基-1-亚硝基脲(MNU)联合环磷酰胺治疗实体瘤。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-08-15 DOI: 10.1007/BF00283785

K Kolarić

{"title":"Combination chemotherapy with 1-methyl-1-nitrosourea (MNU) and cyclophosphamide in solid tumors.","authors":"K Kolarić","doi":"10.1007/BF00283785","DOIUrl":"https://doi.org/10.1007/BF00283785","url":null,"abstract":"Twenty-four patients with far advanced malignant tumors, resistent to established chemotherapy,, were treated with the combination of MNU and Cyclophosphamide. The drugs were administered in six-day cycles sequentially. MNU in doses of 4 mg/kg body weight and Cyclophosphamide in doses of 8 mg/kg body weight were given. Results of treatment showed response (greater than 50% tumor regression) in 10 (42%) of the 24 treated patients. Seven remissions were complete and three partial. Patients with Hodgkin's disease, malignant melanoma and breast cancer responded to this combination chemotherapy. Objective remissions were obtained also in five of thirteen patients with primary or metastatic brain tumors and in five of nine patients with pulmonary metastases. Nausea and vomiting were the main toxic effects, especially after injections of MNU. Myelosuppression was noted in about 50% of treated patients. Since this combination of cytostatics showed significant antitumor activity, further investigations are necessary on a larger number of patients and in other types of malignant tumors.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"89 3","pages":"311-9"},"PeriodicalIF":0.0,"publicationDate":"1977-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00283785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11362583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Epidemiology of malignant bone tumours. 恶性骨肿瘤的流行病学。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-08-15 DOI: 10.1007/BF00283780

G Ott, G Wagner

引用次数: 1

On the function of hormone receptors in the action of steroidal alkylating agents. 激素受体在甾体烷化剂作用中的作用。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-08-15 DOI: 10.1007/BF00283786

G Trams, M v Urban

引用次数: 1

[Transplacental induction of neurogenic tumors in rabbits (author's transl)]. [经胎盘诱导兔神经源性肿瘤(作者译)]。

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology Pub Date : 1977-08-15 DOI: 10.1007/BF00283787

D Stavrou, E Dahme, B Schröder

{"title":"[Transplacental induction of neurogenic tumors in rabbits (author's transl)].","authors":"D Stavrou, E Dahme, B Schröder","doi":"10.1007/BF00283787","DOIUrl":"https://doi.org/10.1007/BF00283787","url":null,"abstract":"The oncogenic effect of ethylnitrosourea (ENU) on rabbits during the organogenesis was studied. ENU, dissolved in sodium phosphate (pH 6.0), was injected in a 50 mg/kg dosis intravenously in pregnant dams between the 8th and 10th day of gestation. From 12 offspring 8 grew up normally and appeared unremarkably until 30--36 months of age when neurologic signs first developed. Six rabbits showed one or more tumors along the peripheral nerves. Two rabbits were bearing brain gliomas in the vicinity of the 3rd ventricle. The tumors of the peripheral nervous system (PNS) were of variable size and soft consistency; they had a cut surface of spongy and even cystic appearance. Histologically, the PNS tumors resemble Schwannomas of the Antoni B type. An ultrastructural study of these neoplasms disclosed cells featuring a basal lamina type of lining characteristics of Schwann cells. These findings demonstrate that the exposure of rabbits to ENU during organogenesis results in the induction of neurogenic tumors which become clinically manifest late in life. It seems, therefore, that the selective oncogenic effect of ENU on the nervous tissues of the exposed animals depends exclusively on the stage of organogenesis at which the drug is brought to bear upon the target organ anlage.","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"89 3","pages":"331-9"},"PeriodicalIF":0.0,"publicationDate":"1977-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00283787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11414426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1