{"title":"Intestinal absorption of amino acids and peptides.","authors":"D M Matthews","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 20","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11548733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Background to the therapeutic potential of essential amino acid analogues.","authors":"P Richards","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental investigation of the metabolic effects of essential amino acid analogues has to be critically assessed against a background of limited experimental techniques and very incomplete understanding of both protein metabolism and protein requirements. Although interest in the therapeutic use of these compounds initially centered on patients with chronic renal failure, their therapeutic potential is by no means confined to renal disease. The fact that metabolic effects of essential amino acid analogues cannot be explained simply in terms of their conversion to the essential amino acids raises the possibility that they may prove to be useful inducers of protein anabolism. Improvement in nitrogen balance may only be of the order of a few grams and measurable nitrogen balance is only a small proportion of total protein turnover, nevertheless, small changes may prove to be of considerable clinical significance.</p>","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 19","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1976-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12254890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beneficial effects of tube feedings with essential amino acids and adequate calories in uremic patients.","authors":"H C Meng","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 19","pages":"34-5"},"PeriodicalIF":0.0,"publicationDate":"1976-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12015577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effect of essential amino acids and their analogs in chronic kidney failure].","authors":"J Kult, A Heidland","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 19","pages":"36-42"},"PeriodicalIF":0.0,"publicationDate":"1976-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12254892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Walser, D G Sapir, W E Mitch, M Batshaw, S Brusilow, W C Maddrey
{"title":"Evidence for an anabolic action of essential amino acid analogues in uremia and starvation.","authors":"M Walser, D G Sapir, W E Mitch, M Batshaw, S Brusilow, W C Maddrey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nitrogen-free analogues of essential amino acids, when administered with those essential amino acids for which analogues are ineffective or unavailable, exert three actions that may be beneficial in protein-deficient or protein-intolerant subjects. First, they bring about an increase in the concentrations of essential amino acids in the blood at the expense of the concentrations of certain non-essential amino acids, notably alanine and glutamine. This effect is most readily demonstrated in children with congenital defects of the urea cycle enzymes, but can also be seen during daily therapy of adults with portal-systemic encephalopathy. Second, these compounds promote nitrogen balance through their suppressive effect on urea synthesis (an effect not attributable to re-utilization of ammonia derived from urease action in the gut). This action is demonstrable in obese subjects who are already conserving nitrogen maximally at the end of a prolonged fast and can also be shown in the first week of fasting when the branched-chain keto acids alone are administered. In both situations, improved nitrogen conservation persists long after the analogues are metabolized, suggesting enzyme adaptations. In chronic uremics, nitrogen balance can be maintained in some (but not all) patients on very low nitrogen intakes. Third, these mixtures may delay or reverse the progressive decline in glomerular filtration rate characteristic of chronic renal failure in some cases: thus, for example, 5 of 6 patients taken off chronic dialysis have maintained lower serum urea concentrations without evidence of protein malnutrition for periods of 2-24 months.</p>","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 19","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"1976-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12254894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Intestinal resorption of macromolecular proteins in animals and man].","authors":"J Seifert","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":"18 ","pages":"1-72"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11283387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relative rates of metabolism MCT, LCT and ethanol in man.","authors":"F L Iber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 17","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15633332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A non-caloric role for MCT and other lipids.","authors":"J J Kabara, A J Conley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76841,"journal":{"name":"Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa","volume":" 17","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15633328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}