Age and ageing最新文献

{"title":"3136 Improving patient and public involvement (PPI) in dementia research: building conditions for impact","authors":"N Morley, K Liabo, V Goodwin","doi":"10.1093/ageing/afaf133.080","DOIUrl":"https://doi.org/10.1093/ageing/afaf133.080","url":null,"abstract":"Introduction Dementia is a major challenge to healthy ageing, and research into dementia is essential. Including people with lived experience of dementia in research leads to higher-quality, more impactful outcomes. But successful engagement can be complex and routine involvement practices may not always be inclusive for people with living with dementia. This project aimed to highlight what is needed to improve public involvement in dementia research and support researchers in engaging those with lived experience. Method We collaborated with experts by experience (people living with Dementia) and dementia researchers to explore current PPI activities within NIHR-funded dementia research. Mixed method data collection included an online questionnaire and structured conversations, supplemented with web searches. Data was organised in MAXQDA and visually mapped in MindGenius, identifying patterns and gaps. Results A diverse group of 38 participants, including researchers, healthcare professionals, funding panellists, and experts by experience, contributed. They emphasised that dementia affects individuals uniquely and involvement should be tailored to individual’s abilities and preferences. They encouraged avoiding assumptions and a focus on positive change, particularly for underserved communities. Creative approaches were highlighted as effective for prompting discussions and enabling non-verbal individuals to express their experiences. Openness to learning from lived experiences and adaptability were key in shifting from task-oriented to relational approaches and deepen understanding. However, participants also identified that rigid funding processes, limited resources, and a lack of understanding of involvement can undermine these practices. They emphasised the need for funder guidelines, ethical working frameworks, and supportive spaces for shared learning. Conclusion Promoting good practice in Patient and Public Involvement for people with dementia is critical to enhancing both research and impact. This work seeks to highlight examples of relational approaches that foster co-learning and meaningful engagement, and addresses structural barriers, providing supportive frameworks to achieve impactful and inclusive dementia research.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccination and risk of dementia: a systematic review and meta-analysis.","authors":"Wen-Kang Yang,Shih-Chieh Shao,Chia-Chao Liu,Ching-Chi Chi","doi":"10.1093/ageing/afaf169","DOIUrl":"https://doi.org/10.1093/ageing/afaf169","url":null,"abstract":"BACKGROUNDThe association between influenza vaccination and a reduction in dementia was unclear with inconsistent evidence. We aimed to evaluate the association between influenza vaccination and dementia risk in the overall population and the high-risk populations for dementia, such as patients with chronic kidney syndrome (CKD), chronic obstruction pulmonary disease (COPD) and vascular disease.METHODSWe performed a systematic review and searched PubMed, Embase and CENTRAL from inception to 6 April 2025. The risk of bias was assessed using the Newcastle-Ottawa Scale. A random-effects model meta-analysis was executed.RESULTSWe included eight cohort studies with 9,938,696 subjects. Except for one study, the risk of bias of all other included studies was low. Influenza vaccination was associated with a reduced risk of incident dementia in high-risk populations for dementia, but not in the overall population (HR 0.93; 95% CI: 0.86-1.01). For high-risk populations, more than one dose of influenza vaccination showed an association with a lower risk of incident dementia (2-3 doses: HR 0.84; 95% CI: 0.76-0.92; ≥ 4 doses: HR 0.43; 95% CI: 0.38-0.48).CONCLUSIONInfluenza vaccination was associated with a decreasing risk of incident dementia in a dose-response manner.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"12 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting oral frailty indicators of late-life cognitive disorders and depression: a systematic review.","authors":"Vittorio Dibello,Vincenzo Solfrizzi,Madia Lozupone,Vincenzo Vertucci,Filippo Santarcangelo,Claudio Pace,Antonio Dibello,Antonio Daniele,Francesco Panza","doi":"10.1093/ageing/afaf182","DOIUrl":"https://doi.org/10.1093/ageing/afaf182","url":null,"abstract":"BACKGROUNDOral frailty is an age-related gradual loss of oral function together with a cognitive and physical function decline. Previous systematic reviews and meta-analyses examined the association of some oral frailty indicators with late-life cognitive and late-life depression (LLD). However, none of these studies investigated a large series of possible indicators and outcomes.OBJECTIVETo clarify the impact of oral frailty indicators on late-life cognitive disorders and LLD.DESIGNSystematic review.SUBJECTSSixty-three studies (56,520,662 subjects) with 11 oral frailty indicators in four categories: (i) oral health status deterioration, (ii) decline in oral motor skills, (iii) chewing, swallowing, and saliva disorders, and (iv) oral pain.METHODSFrom database inception to April 24, 2024, six different electronic databases were consulted by two independent researchers assessing the eligibility of 24,045 records against the inclusion criteria and found 63 studies fitting the eligibility requirements. The protocol was registered a priori with PROSPERO (CRD42021249428).RESULTSFour oral frailty indicators (number of remaining teeth, periodontal disease, difficulties in chewing, and difficulties in swallowing) were associated with late-life cognitive impairment/decline, mild cognitive impairment (MCI), dementia, and LLD. Among categories, oral health status deterioration and chewing, swallowing, and saliva disorders were associated with late-life cognitive impairment/decline, MCI, dementia, and LLD. Decline in oral motor skills was associated with late-life cognitive impairment/decline, while oral pain was related only to LLD.CONCLUSIONCertain oral frailty indicators may contribute to the development of late-life cognitive disorders and LLD.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"184 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MovingTogether: a randomised controlled trial of a mental-health-informed, digital health promotion intervention for older adults.","authors":"Chiara Mastrogiovanni, Simon Rosenbaum, Kim Delbaere, Anne Tiedemann, Scott Teasdale, Catherine Sherrington, Meghan Ambrens, Gülşah Kurt, Grace McKeon","doi":"10.1093/ageing/afaf190","DOIUrl":"10.1093/ageing/afaf190","url":null,"abstract":"<p><strong>Background: </strong>Physical activity and nutrition are modifiable risk factors associated with a range of mental health and psychosocial outcomes in older adults. This trial evaluated the efficacy of a multicomponent digital health promotion intervention in reducing levels of psychological distress among adults aged 60+ years.</p><p><strong>Methods: </strong>The MovingTogether intervention is a Facebook- and eHealth-delivered intervention, facilitated by allied health professionals, and incorporates healthy lifestyle education, tailored exercise guidance (including balance training), and social support. Participants (n = 80) aged 60+ years were randomly assigned to the intervention (n = 39) or waitlist control (n = 41) in a 1:1 ratio, treating household couples as one unit. The primary outcome was psychological distress and secondary outcomes included physical activity levels, social capital, concern about falling, loneliness, physical functioning, quality of life and physical activity enjoyment. Outcomes were measured at baseline, postintervention (Week 11) and at follow-up (Week 16) via self-report, online questionnaires. Linear mixed models and an intention-to-treat approach were applied to determine between-group differences. Adherence, retention and adverse events were also tracked, and participant experience interviews were evaluated through a directed qualitative content analysis.</p><p><strong>Results: </strong>The MovingTogether intervention significantly reduced psychological distress in the intervention group compared to the control postintervention, with a medium effect size [mean change between groups = 2.34, 95% confidence interval (CI) 0.25, 4.43, P = .03, Cohen's d = 0.59]. Change was maintained at follow-up (mean change between groups = 2.02, 95% CI: 0.27, 3.77, P = 0.03, Cohen's d = 0.31). No significant changes were found in secondary outcomes. Thirty-one (39%) participants dropped out of the study by the postprogramme point.</p><p><strong>Conclusion: </strong>The results suggest multicomponent digital health promotion interventions, combining lifestyle education, physical activity and social support, can improve the mental health of older adults. More research is needed to understand how to best utilise digital engagement strategies and improve retention in physical activity programmes for older adults.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is age associated with different vital signs in adults presenting to hospital with bacterial infection? A systematic review and meta-analysis.","authors":"Phoebe Tupper, Oliver Redfern, Charlotte H Harrison, Stephen Gerry, Christopher Biggs, Bethany Walker, Peter Watkinson","doi":"10.1093/ageing/afaf194","DOIUrl":"https://doi.org/10.1093/ageing/afaf194","url":null,"abstract":"<p><strong>Background: </strong>It has long been suspected that the vital sign abnormalities that accompany bacterial infection are subtle or absent in older adults. This review summarises the evidence for whether older adults present with different vital sign abnormalities to younger adults when hospitalised with bacterial infection.</p><p><strong>Methods: </strong>MEDLINE, EMBASE and CINAHL EBSCO were searched from inception to 19 December 2024 for English-language research articles of patients hospitalised with bacterial infection reporting age and admission vital signs. We used meta-regression to assess how vital signs vary with age. Where studies reported vital signs in multiple age groups, we undertook a meta-analysis in younger (<65) and older patients (≥65). Evidence quality was assessed using an adapted Quality Assessment of Diagnostic Accuracy Studies-2 tool.</p><p><strong>Results: </strong>Our search yielded 14 487 studies; 132 were included after screening. Older adults were less likely to be tachycardic (RR 0.82, 0.69 to 0.97, I2 = 86.5%) with a mean difference in heart rate of 5 bpm (-7 to -3 bpm, I2 = 88.3%). Older adults were less likely to be febrile (RR 0.89, 0.83 to 0.95, I2 = 85.9%) with a mean difference in temperature of 0.14°C (-0.26 to -0.02°C, I2 = 94.6%). Most (129/132) studies were at high risk of bias.</p><p><strong>Conclusions: </strong>Whilst differences in absolute values were small, there was consistency in the finding that older adults were less likely than younger adults to be tachycardic or febrile. As vital signs at presentation may prompt suspicion of infection, influencing investigations and treatment, special consideration for the possibility of infection in older patients with normal vital signs may be warranted.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of qigong on frailty in older cancer survivors: a randomised controlled trial.","authors":"Denise Shuk Ting Cheung, Wing Lok Chan, Pui Hing Chau, Inda Sung Soong, Wing Fai Yeung, Shing Fung Lee, Parco M Siu, Jean Woo, Doris Sau Fung Yu, Chia-Chin Lin","doi":"10.1093/ageing/afaf184","DOIUrl":"10.1093/ageing/afaf184","url":null,"abstract":"<p><strong>Background: </strong>Frailty predicts increased cancer recurrence and mortality among older cancer survivors. Qigong has been shown to improve physical and mental well-being, as well as inflammation, which are closely linked with frailty in the cancer population.</p><p><strong>Objective: </strong>This study aims to evaluate the effect of qigong on frailty among older cancer survivors.</p><p><strong>Design: </strong>An assessor-blind multi-centre randomised controlled trial.</p><p><strong>Methods: </strong>Post-treatment cancer survivors aged 65+ screened as pre-frail or frail based on the Fried frailty phenotype were recruited and randomised to an intervention (16-week qigong Baduanjin) or an active control group (16-week light flexibility exercise). The primary outcome was the reversal of frailty status. The secondary outcomes included physical frailty severity, multidimensional frailty severity, physical performance, psychological well-being and quality of life. Analysis was based on the intention-to-treat principle.</p><p><strong>Results: </strong>Two hundred twenty-six older cancer survivors were randomised, 113 to the qigong group and 113 to the light flexibility exercise group. At 16 weeks, the difference in the rates of frailty reversal in the qigong group (28.7%) and the light flexibility exercise group (22.5%) was insignificant (adjusted odds ratio = 1.39, 95% CI, 0.65 to 2.95). While both groups had significant improvement in physical frailty severity, physical performance, psychological well-being and quality of life, only the qigong group had significant improvement in multidimensional frailty severity. The group × time interaction was not significant.</p><p><strong>Conclusion: </strong>Qigong was not superior to an active control in its effect on improving frailty in older cancer survivors. Researchers should include routine care as control and examine the underlying mechanisms driving the change in frailty.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term clinical outcomes of delirium after hospital discharge: a systematic review and meta-analysis.","authors":"Yonas Tesfaye, Courtney R Davis, Melissa J Hull, Danielle Greaves, James du Preez, Sally Johns, Alice Bourke, Hannah A D Keage","doi":"10.1093/ageing/afaf188","DOIUrl":"10.1093/ageing/afaf188","url":null,"abstract":"<p><strong>Background: </strong>Delirium has been linked to adverse health outcomes. There has not been a comprehensive attempt to synthesise these outcomes.</p><p><strong>Objective: </strong>To synthesise evidence comparing post-discharge clinical outcomes in individuals who experienced delirium in hospital compared to those who did not.</p><p><strong>Methods: </strong>A systematic electronic search was conducted in Medline, Embase, CINAHL, PsycINFO and Cochrane databases. Random-effects models were used to assess effect size differences between those who experienced delirium and those who did not: odds ratios (OR) for categorical outcomes and Hedges' g for continuous outcomes. Analyses were conducted for each outcome relative to ≤6 months, >6-12 months, 12+ months and collapsed across time post-discharge.</p><p><strong>Results: </strong>Data were synthesised from 253 studies representing 29 814 participants who experienced delirium and 107 583 participants who did not experience delirium. The mean (SD) age of participants was 76.0 (9.3) years. Collapsed over follow-up period, results included, those who experienced delirium in hospital showed higher objective cognitive decline (OR = 1.58, P < .001), greater subjective cognitive impairment (OR = 2.11, P = .041), greater functional decline (g = -0.43, P = .001), lower quality of life (g = -0.44, P < .001), higher burden of poor mental health (OR = 1.69, P < .001), increased risk of dementia (OR = 5.37, P < .001), higher likelihood of institutionalisation (OR = 2.80, P < .001), greater rates of hospital readmission (OR = 1.70, P < .001) and increased mortality (OR = 2.55, P < .001) post-hospital discharge compared to those who did not experience delirium in hospital. Time-specific analyses did not reveal any consistent patterns of effects.</p><p><strong>Conclusions: </strong>Older adults who experience delirium in hospital demonstrate significantly worse long-term clinical outcomes compared to those who do not.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can laboratory test-based frailty indices contribute to frailty screening in emergency departments?","authors":"Hugh Logan Ellis, Liam Dunnell, Julie Whitney, Cara Jennings, Dan Wilson, Jane Tippett, James Teo, Zina Ibrahim, Kenneth Rockwood","doi":"10.1093/ageing/afaf192","DOIUrl":"10.1093/ageing/afaf192","url":null,"abstract":"<p><strong>Background: </strong>Laboratory-based frailty indices (FI-Labs) offer potential adjuncts and alternatives to clinical assessments. Still, their optimal configuration and construct validity compared with nurse-assessed Clinical Frailty Scale (CFS) scores remain unclear.</p><p><strong>Methods: </strong>In this retrospective cohort study, we evaluated five FI-Lab configurations against nurse-assessed CFS scores using data from 74 493 emergency department visits. We examined their association with clinical outcomes and assessed measurement reliability using mixed effects models.</p><p><strong>Results: </strong>While nurse assessments demonstrated superior outcome discrimination (c-statistic 0.726 for 90-day mortality versus 0.718 for best FI-Lab), automated FI-Lab measures showed significantly greater between-visit reliability [intraclass correlation coefficient (ICC) = 0.51-0.76 versus 0.37 for nurse CFS]. The drug-adjusted FI-Lab demonstrated highest reliability (ICC = 0.76) but weaker age associations (β = 0.002, P = .08) compared to other configurations (β = 0.006-0.013, P < .001). In complex models adjusting for illness severity, nurse CFS scores showed stronger mortality associations (HR 1.55, 95% CI 1.45-1.66 per standard deviation) compared to FI-Lab configurations (HR range 1.19-1.29). Notably, all frailty measures showed effect sizes comparable to age (HR range 1.37-1.55 per SD).</p><p><strong>Conclusions: </strong>Automated FI-Lab measures offer a reliability advantage over nurse-assessed CFS scores despite slightly lower predictive validity for mortality. Their comparable effect sizes to age suggest these automated measures capture clinically meaningful patient characteristics. This trade-off between reliability and predictive validity suggests that integrated approaches combining automated screening with targeted clinical assessment may provide optimal frailty identification in emergency settings.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.","authors":"Ryota Matsuzawa, Koutatsu Nagai, Takara Mori, Masaaki Onishi, Shotaro Tsuji, Kana Hashimoto, Kayoko Tamaki, Yosuke Wada, Hiroshi Kusunoki, Yasuyuki Nagasawa, Ken Shinmura","doi":"10.1093/ageing/afaf185","DOIUrl":"https://doi.org/10.1093/ageing/afaf185","url":null,"abstract":"<p><strong>Background: </strong>Identifying individuals at risk of sarcopenia incidence or progression remains challenging. Serum creatinine- and cystatin C-derived indices are objective markers of muscle metabolism; however, their predictive value for sarcopenia progression remains uncertain. This study evaluated the association between a creatinine- and cystatin C-derived index, the total body muscle mass index (TBMM) and sarcopenia incidence or progression in community-dwelling older adults.</p><p><strong>Methods: </strong>This prospective cohort study included 671 older adults (median age 72 [IQR 68-76] years; 35.0% male). Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia criteria. Participants were stratified by sex-specific tertiles of TBMM. The outcome was defined as incident or progressive sarcopenia, with progression defined as the development of severe sarcopenia in those affected at baseline. Cox proportional hazards regression models and time-dependent receiver operating characteristic curve analyses were used to assess the associations.</p><p><strong>Results: </strong>During follow-up, 7.5% of participants experienced sarcopenia incidence or progression. Higher TBMM tertiles were significantly associated with a lower risk, with adjusted hazard ratios of 0.18 (95% confidence interval [CI]: 0.07-0.42; P < .001) and 0.15 (95% CI: 0.06-0.40; P < .001) for Tertiles 2 and 3, respectively, compared with Tertile 1. Incorporating TBMM into predictive models improved discrimination (area under the curve increased from 0.771 to 0.856, P = .01).</p><p><strong>Conclusions: </strong>TBMM is a strong predictor of sarcopenia incidence and progression in community-dwelling older adults. Given its accessibility and accuracy, TBMM may serve as a valuable tool for early risk stratification and timely interventions in clinical practice.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"James Lind Alliance Priority Setting Partnership in co-existing dementia and hearing conditions: a research agenda defined by people with lived experience and healthcare professionals.","authors":"Eithne Heffernan, Sian Calvert, Tom Dening, Emma E Broome, Ruth Spriggs, Nahid Ahmad, Natalie Lerigo-Smith, Helen Henshaw","doi":"10.1093/ageing/afaf191","DOIUrl":"10.1093/ageing/afaf191","url":null,"abstract":"<p><strong>Background: </strong>Dementia and hearing conditions are both major public health concerns. Most people living with dementia also live with hearing conditions (e.g. hearing loss, tinnitus, vestibular disorders). Furthermore, hearing loss may be a risk factor for dementia. There is a critical need for research to explain the association between dementia and hearing conditions and to optimise assessments and treatments for this co-morbidity.</p><p><strong>Objective: </strong>This James Lind Alliance (JLA) Priority Setting Partnership (PSP) aimed to develop an agenda for research about dementia and hearing conditions by systematically identifying unanswered research questions that are prioritised by people living with these conditions and professionals from healthcare and social care.</p><p><strong>Methods: </strong>Participants were people living with hearing conditions and/or dementia, supporters (e.g. carers, relatives), clinicians, and social care professionals. A survey (N = 404) gathered 47 research questions proposed by participants. An evidence-checking process confirmed that these questions were unanswered. A second survey (N = 560) produced a shortlist of 16 questions. At a final workshop (N = 19), the top 10 questions were prioritised.</p><p><strong>Results: </strong>The prioritised research questions spanned diverse topics, including training for clinicians about this co-morbidity, routine health checks that incorporate hearing and cognition, dementia risk reduction strategies for people living with hearing loss, and potential mechanisms underlying the link between hearing loss and dementia.</p><p><strong>Conclusion: </strong>This novel JLA PSP was the first to identify research priorities for two different, yet co-morbid, health conditions. It has important implications for researchers, funders, commissioners, and clinicians, particularly those working with older adults who have multiple long-term conditions.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}