Virchows Archiv. B, Cell pathology最新文献_第9页

The regeneration of the cells of the macula densa after subtotal nephrectomy in the rat. 大鼠肾大部切除后致密斑细胞的再生。

Virchows Archiv. B, Cell pathology Pub Date : 1978-05-19 DOI: 10.1007/BF02888999

W Romen, W D Heine, M Hollenz

引用次数: 1

The organization, composition and matrix of hepatocyte nuclei exposed to alpha-amanitin. 暴露于α -amanitin的肝细胞核的组织、组成和基质。

Virchows Archiv. B, Cell pathology Pub Date : 1978-05-19 DOI: 10.1007/BF02888994

K Brasch, G D Sinclair

{"title":"The organization, composition and matrix of hepatocyte nuclei exposed to alpha-amanitin.","authors":"K Brasch, G D Sinclair","doi":"10.1007/BF02888994","DOIUrl":"https://doi.org/10.1007/BF02888994","url":null,"abstract":"Alterations in the structure and molecular composition of avian hepatocyte nuclei were compared following administration in vivo of lethal and sub-lethal doses of alpha-amanitin. This toxin interferes with extranucleolar transcription by direct inhibition of RNA polymerase II activity. the resultant effects include: extensive condensation of chromatin, displacement of nucleoplasmic contents and fragmentation of nucleoli. Changes in nuclear morphology were quantitated by stereometry and related to variations in RNA and residual, non-histone proteins (NHP). Gross alterations in nuclear structure and depletion of RNA and NHP levels were of similar magnitude with both doses of amanitin. The effects were fully reversible, however, with a minimal dose but terminal with a lethal dose. DNA and histone protein levels remained unchanged at all stages. These results imply that the process of transciption may itself keep and/or maintain chromatin in a dispersed state, and that in the absence of transcription chromatin naturally condenses. Modification of nuclear proteins may be necessary only to maintain chromatin compacted permanently or for extended periods of time. A model of nuclear organization is proposed to incorporate these considerations and to identify the probable location of the nuclear matrix in situ.","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"27 3","pages":"193-204"},"PeriodicalIF":0.0,"publicationDate":"1978-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02888994","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11317617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Deviated formation of intestinal glycocalyx in human stomach cancer cells. Another type of signet ring cell. 人胃癌细胞肠糖萼的畸变形成。另一种类型的图章戒指细胞。

Virchows Archiv. B, Cell pathology Pub Date : 1978-05-19 DOI: 10.1007/BF02888996

S Tokumitsu, K Tokumitsu, H Nomura, T Takeuchi

{"title":"Deviated formation of intestinal glycocalyx in human stomach cancer cells. Another type of signet ring cell.","authors":"S Tokumitsu, K Tokumitsu, H Nomura, T Takeuchi","doi":"10.1007/BF02888996","DOIUrl":"https://doi.org/10.1007/BF02888996","url":null,"abstract":"The process of glycocalyx formation by the trilaminar membrane was investigated at the subcellular level by use of cultivated cancer cells derived from a human stomach adenocarcinoma. Glycocalyx was apparently synthesized on the characteristic trilaminar membrane of Golgi-derived vesicles which gave rise to cytoplasmic vacuoles which, in turn, fused to form an intracytoplasmic cyst. Characteristic microvilli similar to those of intestinal epithelium extended from the membrane lining the intracytoplasmic cyst. These ultrastructural features agree with earlier histochemical findings in suggesting intestinal metaplasia in the origin of the gastric tumor. The morphologic features of the cancer cells clearly indicated that glycoprotein is first synthesized in the Golgi complex and fully formed mucoprotein then emerges as membrane-bound glycocalyx in the vesicles budding from the Golgi stacks. The glycocalyx layer is an integral part of the external leaflet of the characteristic trilaminar membrane. Abundant deposits of glycocalyx in the intracytoplasmic cyst constituted the ultrastructural basis for a distinctive type of signet ring cell that differed from mucous signet ring cells derived from goblet cells.","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"27 3","pages":"217-27"},"PeriodicalIF":0.0,"publicationDate":"1978-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02888996","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11424071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Acute eosinophilic leukemia. An ultrastructural study. 急性嗜酸性粒细胞白血病。超微结构研究。

Virchows Archiv. B, Cell pathology Pub Date : 1978-05-19 DOI: 10.1007/BF02888998

A Anteunis, A A Audebert, M Krulik, J Debray, R Robineaux

引用次数: 8

Epidermal chalones and squamous cell carcinomas. The growth inhibitory effects of aqueous epidermal extracts (G1 and G2 chalones) on the epidermis and on a transplantable keratinizing carcinoman in nude mice. 表皮醌和鳞状细胞癌。表皮水提物(G1和G2 chalones)对裸鼠表皮和可移植角化癌细胞的生长抑制作用。

Virchows Archiv. B, Cell pathology Pub Date : 1978-05-19

O H Iversen

{"title":"Epidermal chalones and squamous cell carcinomas. The growth inhibitory effects of aqueous epidermal extracts (G1 and G2 chalones) on the epidermis and on a transplantable keratinizing carcinoman in nude mice.","authors":"O H Iversen","doi":"","DOIUrl":"","url":null,"abstract":"Balb/c/nu nude mice that had been transplanted with a moderately differentiated squamous cell carcinoma were injected i.p. with different doses of epidermal chalone, and control animals were injected with saline. The labelling indices (H3TdR) and the mitotic rate (stathmokinetic method with vinblastine sulphate) were determined. In the untreated animals, both the labelling index and the mitotic rate of the tumor were considerably higher than in the epidermis, and the rate of cell birth was almost twice that of the epidermis. Higher doses of chalone were needed to reduce the labelling index for the tumour than for the epidermis, and there was generally a less pronounced dose/response relationship in the tumours than in the epidermis. The same was true of the mitotic rate but here the results were not as obvious as for the labelling index. A possible explanation of the results may be that the tumour cells are less sensitive than epidermal cells to the injected chalones, or that reduced vascularization of the transplanted tumour may lead to reduced access of chalone, or that tumour necrosis may pay a role. However, it is evident that the tumour cells react less than the epidermis to both the G1 and the G2 chalone, and thus the findings of this study do not provide any evidence against the theory that epidermoid transplanted tumours are less sensitive to epidermal chalones than normal tissue of the same histogenetic origin.","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"27 3","pages":"229-35"},"PeriodicalIF":0.0,"publicationDate":"1978-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11368458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural changes of human sural nerves in the neuropathy induced by intrauterine methylmercury poisoning (so-called fetal Minamata disease). 宫内甲基汞中毒(所谓胎儿水俣病)所致神经病变中人腓肠神经的超微结构变化

Virchows Archiv. B, Cell pathology Pub Date : 1978-03-29 DOI: 10.1007/BF02888989

T Takeuchi, K Eto, S Oyanag, H Miyajima

引用次数: 31

A light and electron microscopic study on complete dissociation of rat ascites hepatoma cells under activation of neutral protease and calcium depletion. 中性蛋白酶激活和钙缺失对大鼠腹水肝癌细胞完全解离的光镜和电镜研究。

Virchows Archiv. B, Cell pathology Pub Date : 1978-03-29 DOI: 10.1007/BF02888991

H Katsuya, Y Ishimaru, M Koono, H Hayashi

引用次数: 5

Fucosidosis and I-cell disease: a fine structural and silver-staining study of abnormal inclusion bodies in small-intestinal cells. 聚焦病和i细胞病:小肠细胞异常包涵体的精细结构和银染色研究。

Virchows Archiv. B, Cell pathology Pub Date : 1978-03-29

L A Ginsel, P H Cambier, Daems WTh