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Virchows Archiv. B, Cell pathology最新文献

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Ruthenium red binding to cell coat in neoplastic neurogenic cell lines in culture. 培养肿瘤神经源性细胞系中钌红与细胞外壳的结合。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899357
A Haugen
{"title":"Ruthenium red binding to cell coat in neoplastic neurogenic cell lines in culture.","authors":"A Haugen","doi":"10.1007/BF02899357","DOIUrl":"https://doi.org/10.1007/BF02899357","url":null,"abstract":"<p><p>The cell coat of cultivated fetal rat brain cells as well as malignant rat neurogenic cell lines in culture were studied by transmission electron microscopy with the ruthenium red staining technique. Some of the transformed cell lines demonstrated alteration in the bindng properties of ruthenium red to the cell surface. Otherwise no significant correlation between the visualized cell coat thickness and neoplastic transformation was noted.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"245-52"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effects of a single high dose of 55Fe in mice. 单次高剂量铁对小鼠的影响。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899363
J A Laissue, H Burlington, E P Cronkite, B Heldman, U Reincke
{"title":"Effects of a single high dose of 55Fe in mice.","authors":"J A Laissue,&nbsp;H Burlington,&nbsp;E P Cronkite,&nbsp;B Heldman,&nbsp;U Reincke","doi":"10.1007/BF02899363","DOIUrl":"https://doi.org/10.1007/BF02899363","url":null,"abstract":"","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"321-35"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
DNA distribution in biopsy specimens from human cervical carcinoma investigated by flow cytometry. 流式细胞术研究人宫颈癌活检标本DNA分布。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899364
A Jakobsen, P Bichel, A Sell
{"title":"DNA distribution in biopsy specimens from human cervical carcinoma investigated by flow cytometry.","authors":"A Jakobsen,&nbsp;P Bichel,&nbsp;A Sell","doi":"10.1007/BF02899364","DOIUrl":"https://doi.org/10.1007/BF02899364","url":null,"abstract":"<p><p>Flow cytometry was used for the investigation of the DNA distribution in biopsy specimens from 51 patients with cervical carcinoma. Portio biopsy specimens from 9 pregnant women and from 10 patients with cancer of the breast served as controls. The results demonstrate that most specimens from patients suffering from cervical carcinoma contain considerable cell populations with increased DNA as compared with controls. The possible clinical significance of these findings is discussed.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"337-42"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Acute fine structural changes in rat hepatocytes induced by a single large dose of 2-acetylaminofluorene. 单次大剂量2-乙酰氨基芴致大鼠肝细胞急性精细结构改变。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899362
B Flaks, W A Basley
{"title":"Acute fine structural changes in rat hepatocytes induced by a single large dose of 2-acetylaminofluorene.","authors":"B Flaks,&nbsp;W A Basley","doi":"10.1007/BF02899362","DOIUrl":"https://doi.org/10.1007/BF02899362","url":null,"abstract":"<p><p>Male rats were given a single intragastric dose of 2-acetylaminofluorene, 600 mg/kg body weight, killed at intervals up to 14 days after treatment, and their hepatic tissue examined by electron microscopy. The early cytoplasmic lesion produced in hepatocytes by lower doses, consisting of perinuclear glycogen pooling, peripheral displacement of organelles and pyknosis, was delayed for several days. Among the changes which appeared to be independent of this lesion were disorganization and decrease of the granular endoplasmic reticulum and abnormalities of the bile canaliculi. These changes were similar to those which are seen during chronic exposure to 2-AAF and other hepatocarcinogens and in hepatic cell tumours.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"309-20"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
[In vitro interactions between normal liver cells and cancer cells: an ultrastructural study (author's transl)]. [正常肝细胞和癌细胞的体外相互作用:一项超微结构研究]。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06
T K Leung, F Babai
{"title":"[In vitro interactions between normal liver cells and cancer cells: an ultrastructural study (author's transl)].","authors":"T K Leung,&nbsp;F Babai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"267-80"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11431656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shedding of peripheral cytoplasm - a mechanism of liver cell atrophy in human amyloidosis. 外周细胞质脱落——人淀粉样变性肝细胞萎缩的机制。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899356
U Pfeifer, K Aterman
{"title":"Shedding of peripheral cytoplasm - a mechanism of liver cell atrophy in human amyloidosis.","authors":"U Pfeifer,&nbsp;K Aterman","doi":"10.1007/BF02899356","DOIUrl":"https://doi.org/10.1007/BF02899356","url":null,"abstract":"<p><p>A liver biopsy specimen from a case of primary amyloidosis was investigated by electron microscopy. The cytoplasmic periphery of the hepatocytes showed degenerativechanges which are interpreted as indicating shedding of peripheral parts of the cytoplasm. Two main variants of this process could be discerned: 1) Protrusion and sequestration of hernia-like blebs of cytoplasm, and 2) shedding of vesicles derived from degenerated endoplasmic reticulum. In the latter case transient defects of the plasma membrane seem to be relevance. Endoplasmic reticulum and cytoplasmic ground substance appeared to be shed preferentially, whereas mitochondria are retained within the cell. As a consequence the fractional volume of the mitochondria in the cytoplasm of atrophic cells is markedly increased. Shedding of peripheral cytoplasm, therefore, seems to be an effective mechanism enabeling the cell to adapt the mass and the composition of its cytoplasm to an unfavourable environment.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"229-43"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
The effect of DL-2-bromopalmitate on the utilization of palmitic acid by rat granular pneumocytes. dl -2-溴铝酸酯对大鼠颗粒性肺细胞利用棕榈酸的影响。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899358
H O Heinemann, G G Pietra, M Wagner, M Minda
{"title":"The effect of DL-2-bromopalmitate on the utilization of palmitic acid by rat granular pneumocytes.","authors":"H O Heinemann,&nbsp;G G Pietra,&nbsp;M Wagner,&nbsp;M Minda","doi":"10.1007/BF02899358","DOIUrl":"https://doi.org/10.1007/BF02899358","url":null,"abstract":"<p><p>The effect of DL-2-bromopalmitate (BrPA), an analogue of palmitic acid (PA), on the utilization of this fatty acid by rat lungs was investigated by a combination of anatomic and biochemical methods. The experiments were performed in vitro on two types of preparations, isolated perfused lungs and lung slices. In the isolated lung preparation the substrate reached the lung via the capillaries, in lung slices via the alveolar epithelium. Electron microscope autoradiography showed that BrPA depressed uptake of PA by granular pneumocytes. Radioactivity recovered by tissue analysis and capture of CO2 established that PA oxidation and incorporation into phospholipids and triglycerides was depressed by BrPA. A close correlation was found between the reduction in radioactivity in phospholipids and the grain density over lamellar bodies. The study shows that BrPA reversibly interferes with the uptake and utilization of long chain fatty by granular pneumocytes. BrPA appears as a useful tool to study palmitate metabolism and surfactant production by the lung.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"253-65"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on cell surface conformation following injury. II. Scanning and transmission electron microscopy of cell surface changes following anoxic injury in Ehrlich ascites tumor cells. 损伤后细胞表面构象的研究。2埃利希腹水肿瘤细胞缺氧损伤后细胞表面变化的扫描电镜观察。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06
B F Trump, A Penttila, I K Berezesky
{"title":"Studies on cell surface conformation following injury. II. Scanning and transmission electron microscopy of cell surface changes following anoxic injury in Ehrlich ascites tumor cells.","authors":"B F Trump,&nbsp;A Penttila,&nbsp;I K Berezesky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Exposure of Ehrlich ascites tumor cells to anoxia resulted in rapid and characteristic conformational changes of cell surface topography. Combined scanning and transmission E/M studies revealed rapid alterations including simplification of the cell surface configuration with disappearance of microvilli which were replaced with formation of blebs and recesses at the cell periphery. These surface changes were accompanied by characteristic organelle alterations inside the cells which in this and other cellular systems have been shown to be reversible. Later, the cell surface topography became smoother and monotonic with small blebs and cribriform invaginations in addition to larger eruptions of the cell periphery. Combined transmission E/M studies revealed fragmentation of cellular membrane systems and lysis of organelles indicating the irreversible phase of anoxic injury. The rapid conformational surface changes encountered in Ehrlich ascites tumor cells following anoxia suggest the important role of the plasma membrane and its unfolding as a virtually instantaneous response of the cells to this injury.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"297-307"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell proliferation in epithelium of murine oral mucosa in vivo and in vitro. An autoradiographic study using tritiated thymidine. 小鼠口腔黏膜上皮细胞的体内外增殖。氚化胸腺嘧啶放射自显影研究。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899365
D A Luke
{"title":"Cell proliferation in epithelium of murine oral mucosa in vivo and in vitro. An autoradiographic study using tritiated thymidine.","authors":"D A Luke","doi":"10.1007/BF02899365","DOIUrl":"https://doi.org/10.1007/BF02899365","url":null,"abstract":"","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"343-9"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11325977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Intermediate filaments in hyaline material in alcoholic liver disease (Mallory bodies) and in cultured hepatoma cells. 酒精性肝病(马洛里体)和培养的肝癌细胞中透明物质中的中间纤维。
Virchows Archiv. B, Cell pathology Pub Date : 1979-02-06 DOI: 10.1007/BF02899367
I Virtanen, V P Lehto, P Kurki, A Miettinen, E Linder, S Stenman
{"title":"Intermediate filaments in hyaline material in alcoholic liver disease (Mallory bodies) and in cultured hepatoma cells.","authors":"I Virtanen,&nbsp;V P Lehto,&nbsp;P Kurki,&nbsp;A Miettinen,&nbsp;E Linder,&nbsp;S Stenman","doi":"10.1007/BF02899367","DOIUrl":"https://doi.org/10.1007/BF02899367","url":null,"abstract":"<p><p>Antibodies specific for cytoskeletal intermediate (10 nm) filaments reacted both with the hyaline deposits in alcoholic liver disease (Mallory bodies) and with perinuclear hyaline material of cultured hepatoma cells used as a model for hyaline formation in vitro. Our results suggest that disorganization and accumulation of intermediate filaments is an important step in the pathogenesis of alcoholic liver injury.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 4","pages":"363-7"},"PeriodicalIF":0.0,"publicationDate":"1979-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11305188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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