{"title":"Long-term timolol and epinephrine in monkeys. I. Functional morphology of the ciliary processes.","authors":"E Lütjen-Drecoll, P L Kaufman, M Eichhorn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cynomolgus monkeys were treated twice daily in one eye with timolol 180 micrograms for 2.7, 6.0, or 7.4 months (2 monkeys for each period) or epinephrine 540-600 micrograms for 6.7 months (2 monkeys). Some ciliary processes in both eyes of all timolol-treated monkeys exhibited light and electron microscopic changes consistent with decreased secretion: narrowed stromal vessels with few fenestrations surrounded by a thickened fibre sheath; thickened PE basement membrane; few PE and NPE basolateral infoldings; flattened NPE with small mitochondria. Additionally, the NPE contained pigment granules and large phagolysosomes. The processes in both eyes of the epinephrine-treated monkeys exhibited one of two pictures: dilated stromal capillaries with numerous fenestrations; normal stroma, PE basement membrane and PE; numerous well-developed NPE basolateral infoldings and enlarged mitochondria; dilated stromal capillaries with ruptured fenestrations; ballooned protein-filled stroma; degenerated NPE. The first picture could be consistent with hypersecretion, the second with hyposecretion. Possible pathophysiological explanations and implications of these findings are discussed.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 2) ","pages":"180-95"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14592137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Higher control mechanisms of saccadic eye movements.","authors":"C Kennard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The higher control of saccadic eye movements depends on a complex interaction between a number of different neural centres. Inputs from the frontal eye field and superior colliculus both project to the brainstem and appear to provide parallel and interacting inputs. The former is more concerned with voluntary shifts of gaze, whereas the latter mediates involuntary reflexive gaze shifts to suddenly appearing visual stimuli. The basal ganglia through the substantia nigra, pars reticularis has direct inputs to the colliculus and appears to have a gating role. These concepts, derived from experimental studies on primates, are discussed in relation to clinical material.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 6) ","pages":"705-8"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14248011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ciliary surgery for glaucoma.","authors":"U Demeler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ciliary Body excision for the treatment of intractable glaucoma has been performed in 64 eyes (75 operations) between 1975 and 1985. The indications, intra-and postoperative complications and the results are presented. In the majority of the patients the indication for surgery was a secondary closed angle glaucoma with aphakia. All the eyes had been previously operated on at least three times, some having had as many as seven other antiglaucomatous procedures before the partial excision of the pars plicata of the ciliary body. The preoperative intraocular pressures pressures ranged from minimally 35 mm Hg to over 50 mm Hg. Intraoperative complications such as vitreous loss and vitreous haemorrhages from ciliary body vessels were reduced to a minimum by the use of a Fleiringa-ring, a paracentesis and an extensive cauterisation of the ciliary body tissue. The postoperative complication of scleral wound dehiscence was reduced by a double scleral wound closure. Postoperatively the intraocular pressure was reduced to a satisfactory level in nearly 80% of cases.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 2) ","pages":"242-5"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14589657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiation therapy for uveal melanomas involving the ciliary body.","authors":"D H Char","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty-four patients with medium (2) or large (32) uveal melanomas which involved the ciliary body (ciliary-choroidal, ciliary, and iris-ciliary) were treated with helium ion (29) or I-125 brachytherapy (5). Thirty-one of 34 eyes were retained after treatment. Most melanomas were too large for surgical removal with retention of the eye. Eyes containing very large tumours often had poor visual acuity after treatment.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 2) ","pages":"252-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14589658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P K Wishart, E S Sherrard, S Nagasubramanian, M G Kerr Muir, R A Hitchings
{"title":"Corneal endothelial changes following short pulsed laser iridotomy and surgical iridectomy.","authors":"P K Wishart, E S Sherrard, S Nagasubramanian, M G Kerr Muir, R A Hitchings","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pre- and post-operative endothelial specular photo-microscopy was performed on 46 eyes of 29 patients who had been randomly assigned to iridotomy with the Nd:YAG or the dye laser, or to surgical peripheral iridectomy for the relief of pupil block glaucoma. Localised damage to the endothelium was observed in two eyes following Nd:YAG laser iridotomy and in one eye following dye laser iridotomy. No endothelial changes were recognised after surgical peripheral iridectomy. Central corneal endothelial cell densities remained unchanged following all procedures.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 5) ","pages":"541-8"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14589663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fluorescein angiography in carotid disease.","authors":"N J Sarkies, J S Shilling, R W Russell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty four cases in whom occlusive disease of the carotid artery was proven by digital subtraction angiography or direct carotid arteriography were studied. In five cases venous stasis retinopathy was evident ophthalmoscopically. Fluorescein angiography was abnormal in 19 cases. The abnormalities found were microaneurysms (16 cases); slow arteriovenous transit time (8 cases); macular oedema (8 cases); leakage from the arterioles (3 cases); disc new vessels (4 cases). The differences between this retinopathy and diabetic retinopathy are discussed.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 4) ","pages":"489-93"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14590126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The treatment of diabetic maculopathy by argon laser photocoagulation.","authors":"R H Grey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Argon Laser photocoagulation was undertaken in 153 eyes of 112 patients with diabetic maculopathy. Morphological resolution of maculopathy was achieved in 88 per cent of cases. Exudative maculopathy responded well but had a high recurrence rate, whereas oedematous maculopathy had a moderate failure rate and few recurrences. Insulin or non-insulin dependency did not appear to influence the outcome. Poor visual results were found mainly in those eyes associated with poor initial acuity, failure of treatment or post-laser complications.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 4) ","pages":"424-9"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14590265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L M Davies, M F Drummond, E G Woodward, R J Buckley
{"title":"A cost-effectiveness comparison of the intraocular lens and the contact lens in aphakia.","authors":"L M Davies, M F Drummond, E G Woodward, R J Buckley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is currently interest in the effectiveness and cost of the intraocular lens as compared with other methods of correcting aphakia following cataract extraction. We have undertaken a retrospective review of patients undergoing cataract surgery by the extracapsular method at Moorfields Eye Hospital during the period January 1982 to July 1983. From the total population we selected at random two groups of patients, having their aphakia corrected either by means of a contact lens or an intraocular implant. Patients under the age of 60 years and those with complicating illnesses were excluded from the study. Using case notes, we followed the sample patients from the time of referral until one year after the operation, and recorded a number of clinical and economic variables such as waiting time for operation, length of inpatient stay, incidence of per- and post-operative complications, number of follow-up visits, final visual acuity and (for the contact lens patients) waiting time for lens issue and average daily wearing time. We found that the visual acuities obtained, and the total costs to society, were similar for the two groups.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 3) ","pages":"304-13"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14590508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N H Joseph, M B Sherwood, G Trantas, R A Hitchings, L Lattimer
{"title":"A one-piece drainage system for glaucoma surgery.","authors":"N H Joseph, M B Sherwood, G Trantas, R A Hitchings, L Lattimer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A one-piece system for aqueous humour drainage consists of a tube, with a pressure gradient limiting valve, physically continuous with and not able to be divided by scar tissue from a large surface area silicone object. Results in the first 19 consecutive eyes operated on at Moorfields Eye Hospital using this device show average intraocular pressures below 18 mmHg at one, 2, 3, 6 and 9 months post-operation. Further study of this device seems appropriate.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 6) ","pages":"657-64"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14602373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optic disc swelling in sympathetic ophthalmitis and Harada's disease.","authors":"C M Lane, C A Jones, A C Bird","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In sympathetic ophthalmitis and Harada's disease the fundus appearance is characterised by pale areas of elevated retina associated with a diffuse choroidal abnormality on fluorescein angiography. Optic disc swelling, though constant, is rarely prominent. Four patients, one with sympathetic ophthalmitis and three with Harada's disease, are described, in whom optic disc swelling with visual loss was the predominent sign at one stage of the disease.</p>","PeriodicalId":76757,"journal":{"name":"Transactions of the ophthalmological societies of the United Kingdom","volume":"105 ( Pt 6) ","pages":"667-73"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14623028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}