American Journal of Respiratory Cell and Molecular Biology最新文献

{"title":"A Breath of Fresh Insight: Targeting CXCR4 in Early COPD.","authors":"Rebecca E Bignold, Jill R Johnson","doi":"10.1165/rcmb.2025-0235ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0235ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerandomilast - A Multifrontal Therapeutic Approach to Lung Fibrosis.","authors":"Daniel Kalina, Malgorzata Wygrecka","doi":"10.1165/rcmb.2025-0140ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0140ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair.","authors":"Irene H Heijink, Kingsley Okechukwu Nwozor, Tillie-Louise Hackett","doi":"10.1165/rcmb.2025-0165ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0165ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May Highlights/Papers by Junior Investigators/NIH News.","authors":"","doi":"10.1165/rcmb.72i5RedAlert","DOIUrl":"https://doi.org/10.1165/rcmb.72i5RedAlert","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":"72 5","pages":"iii-iv"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Developmental Step Along the 'Omics Journey.","authors":"James S Hagood","doi":"10.1165/rcmb.2024-0524ED","DOIUrl":"10.1165/rcmb.2024-0524ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":"464-465"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Start SPREADing the News: Biosensors Detect Ripples of Extracellular Signal-regulated Kinase Signaling in Airway Epithelial Cells.","authors":"Luis F Vilches, John D Dickinson","doi":"10.1165/rcmb.2024-0547ED","DOIUrl":"10.1165/rcmb.2024-0547ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":"469-471"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Mycobacterium tuberculosis</i> Induces Warburg Metabolism in Human Alveolar Macrophages: A Transcriptomic Analysis.","authors":"Kevin Brown, Aaron Walsh, Anjali Yennemadi, Seónadh O'Leary, Mary O'Sullivan, Parthiban Nadarajan, Sharee Basdeo, Gina Leisching, Joseph Keane","doi":"10.1165/rcmb.2024-0268LE","DOIUrl":"https://doi.org/10.1165/rcmb.2024-0268LE","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":"72 5","pages":"597-602"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in Chronic Obstructive Pulmonary Disease.","authors":"Yue Yang, Weiyu Shen, Zheming Zhang, Youai Dai, Zixiao Zhang, Tingting Liu, Jinyan Yu, Shulun Huang, Yu Ding, Rong You, Ziteng Wang, Yan Wu, Tao Bian","doi":"10.1165/rcmb.2023-0467OC","DOIUrl":"10.1165/rcmb.2023-0467OC","url":null,"abstract":"<p><p>GPX4 (glutathione peroxidase 4) has recently been reported to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). FSP1 (ferroptosis suppressor protein-1) is a protein that defends against ferroptosis in parallel with GPX4, but its role in the pathogenesis of COPD remains unexplored, and further research is needed. Normal and COPD lung tissues were obtained from lobectomy and lung transplant specimens, respectively. FSP1-overexpressing mice were established by monthly transfection with adenoassociated virus 9-FSP1 through modified intranasal administration. The expression of FSP1, GPX4, and PTGS2 (prostaglandin-endoperoxide synthase 2) was measured by Western blotting, immunohistochemistry and other methods. The correlation between FSP1 and ferroptosis and the role of FSP1 in COPD were explored by screening the expression of ferroptosis-related genes in a COPD cell model after the inhibition and overexpression of FSP1. We then explored the underlying mechanism of low FSP1 expression in patients with COPD <i>in vitro</i> by methylated RNA immunoprecipitation quantitative qPCR. We found that cigarette smoke exposure can lead to an increase in lipid peroxide production and ultimately ferroptosis, which is negatively regulated by FSP1 activity. FSP1 overexpression can prevent ferroptosis and alleviate emphysema. Next, we found that decreased FSP1 expression was caused by increased N6-methyladenosine modification of FSP1 mRNA. Moreover, the level of FSP1 decreased in a YTHDF2-dependent manner. These results indicate that METTL3-induced FSP1 mRNA methylation leading to low FSP1 expression is a potential therapeutic target for COPD.</p>","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":"551-562"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Mitochondrial <i>N</i>-Formyl Peptides Are Associated with Acute Respiratory Distress Syndrome after Cardiopulmonary Bypass and Regulate Endothelial Barrier through FPR2.","authors":"Peng Lu, Xiaopei Li, Jinqiang Wang, Xiangyu Li, Zihao Shen, Yuanpu Qi, Mingyu Chu, Xin Yao, Xiao Zhang, Yu Zheng, Faliang Zhan, Meijuan Song, Xiaowei Wang","doi":"10.1165/rcmb.2024-0076OC","DOIUrl":"10.1165/rcmb.2024-0076OC","url":null,"abstract":"<p><p>Cardiopulmonary bypass (CPB) increases the risk of acute respiratory distress syndrome (ARDS) because of endothelial cell (EC) barrier dysfunction. However, the specific role of mitochondrial <i>N</i>-formyl peptides (mtNFPs) in ARDS after CPB remains unexplored. Here, we investigated the differential expression of circulating mtNFPs in patients after CPB, focusing on the novel role of FPR2 (formyl-peptide receptor 2) in ECs. Concentrations of circulating mtNFPs were assessed using ELISA. Several mtNFPs (ND4 [nicotinamide adenine dinucleotide dehydrogenase subunit 4], ND5, ND6, and Cox1) were significantly upregulated in patients with ARDS at Day 1 after CPB compared with patients without ARDS. Higher concentrations of ND6 were correlated with worse ratios of arterial oxygen pressure to fraction of inspired oxygen (<i>r</i> = -0.2219; <i>P</i> < 0.0001) and cardiac troponin T (<i>r</i> = 2.107; <i>P</i> < 0.0001). Using patient-derived serum and a rat lung ischemia-reperfusion injury model, we observed a positive correlation between serum ND6 concentration and ARDS, which is also associated with EC barrier dysfunction. <i>In vitro</i> experiments, using transendothelial electric resistance measurements and fluorescence microscopy with FITC-labeled vascular endothelial cadherin, demonstrated that ND6 disrupts the EC barrier through FPR2. Furthermore, FPR2 controls the release of ND6 out of mitochondria and cytoplasm under hypoxia-reoxygenation. Activated FPR2 leads to the upregulation of NF-κB by inducing IκBα phosphorylation, promoting ICAM1 (intercellular cell adhesion molecule-1) and VCAM1 expression, thereby compromising EC barrier integrity. Circulating proinflammatory and barrier-disruptive mtNFPs, particularly ND6, are associated with ARDS in patients undergoing CPB. The novel ND6-FPR2 axis regulates inflammation and EC permeability through the NF-κB pathway.</p>","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":"533-550"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma.","authors":"Arun K Jannu, Raymond B Penn","doi":"10.1165/rcmb.2024-0521ED","DOIUrl":"10.1165/rcmb.2024-0521ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":"466-468"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}