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American Journal of Respiratory Cell and Molecular Biology最新文献

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From Protein Folding to Precision Therapy: SP-A in the Spotlight. 从蛋白质折叠到精确治疗：SP-A在聚光灯下。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-23 DOI: 10.1165/rcmb.2025-0366ED
David R Ziehr, Raghu R Chivukula
{"title":"From Protein Folding to Precision Therapy: SP-A in the Spotlight.","authors":"David R Ziehr, Raghu R Chivukula","doi":"10.1165/rcmb.2025-0366ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0366ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptomics in T2-High Severe Asthmatics Treated with Biologics: Comparison Between Anti-IgE, Anti-IL-5 and Anti-IL-5R-Targeted Treatments. 生物制剂治疗t2高重症哮喘患者的转录组学研究：抗ige、抗il -5和抗il - 5r靶向治疗的比较
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-23 DOI: 10.1165/rcmb.2025-0188LE
Sara Gerday, Florence Schleich, Mare Sabbe, Catherine Moermans, Françoise Guissard, Carole Sanchez, Séverine Kenens, Virginie Paulus, Monique Henket, Fabrice Bureau, Christophe Desmet, Renaud Louis
{"title":"Transcriptomics in T2-High Severe Asthmatics Treated with Biologics: Comparison Between Anti-IgE, Anti-IL-5 and Anti-IL-5R-Targeted Treatments.","authors":"Sara Gerday, Florence Schleich, Mare Sabbe, Catherine Moermans, Françoise Guissard, Carole Sanchez, Séverine Kenens, Virginie Paulus, Monique Henket, Fabrice Bureau, Christophe Desmet, Renaud Louis","doi":"10.1165/rcmb.2025-0188LE","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0188LE","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease. 多组学和单细胞方法阐明肺部疾病的细胞生物学和病理生物学。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-23 DOI: 10.1165/rcmb.2025-0092PS
Aartik Sarma, Xin Sun, Jennifer Sucre, Jason Hong, Lejla Medzikovic, Claudia V Jakubzick, Xin Li, Rachel L Zemans, Benjamin D Singer
{"title":"Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease.","authors":"Aartik Sarma, Xin Sun, Jennifer Sucre, Jason Hong, Lejla Medzikovic, Claudia V Jakubzick, Xin Li, Rachel L Zemans, Benjamin D Singer","doi":"10.1165/rcmb.2025-0092PS","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0092PS","url":null,"abstract":"<p><p>In this Perspective, we review the major themes from a Basic Science Core session at ATS 2024: Multi-omic and single-cell approaches for elucidating cellular biology and pathobiology of lung disease, with a focus on novel biology identified in human lungs. Recent advances have enabled researchers to study nucleic acids, proteins, and metabolites at single-cell resolution in the lung. These tools can be integrated with complementary methods to lead to new discoveries about lung function and develop treatments for respiratory diseases. We discuss the role of multicenter consortia in developing lung cell atlases and highlight the role of single-cell methods in identifying new respiratory cell types. We then review advances in several respiratory diseases that demonstrate the use of these tools to study lung development, injury, and repair. Lastly, we consider future directions for the field, including efforts to harmonize cell types across studies and to develop more robust analytical pipelines.</p>","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IFN It Isn't Broke, It May Still Be Driving Disease: Interferons as Mediators of Senescence in COPD. 干扰素没有破坏，它可能仍然是疾病的驱动因素：干扰素作为慢性阻塞性肺病衰老的介质。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-09 DOI: 10.1165/rcmb.2025-0301ED
Jenny P Nguyen, Maor Sauler
{"title":"IFN It Isn't Broke, It May Still Be Driving Disease: Interferons as Mediators of Senescence in COPD.","authors":"Jenny P Nguyen, Maor Sauler","doi":"10.1165/rcmb.2025-0301ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0301ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development. 靶向CELA1改善肺泡发育受损小鼠高氧模型的分隔。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-09 DOI: 10.1165/rcmb.2024-0378LE
Noah J Smith, Rashika Joshi, Hitesh Deshmukh, Jerilyn Gray, Andrea D Edwards, Elham Shahreki, Brian M Varisco
{"title":"Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development.","authors":"Noah J Smith, Rashika Joshi, Hitesh Deshmukh, Jerilyn Gray, Andrea D Edwards, Elham Shahreki, Brian M Varisco","doi":"10.1165/rcmb.2024-0378LE","DOIUrl":"https://doi.org/10.1165/rcmb.2024-0378LE","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Lipid Mediators Keep Lungs Whole: A Spontaneous, Female-Predominant Model of Emphysema. 当脂质介质保持肺完整：自发性、女性为主的肺气肿模型。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-02 DOI: 10.1165/rcmb.2025-0349ED
Rene A Girard, Harry Karmouty-Quintana
{"title":"When Lipid Mediators Keep Lungs Whole: A Spontaneous, Female-Predominant Model of Emphysema.","authors":"Rene A Girard, Harry Karmouty-Quintana","doi":"10.1165/rcmb.2025-0349ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0349ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Antiviral Effect of Linoleic Acid Against Rhinovirus Infection. 亚油酸对鼻病毒感染的抗病毒作用。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-02 DOI: 10.1165/rcmb.2024-0612LE
Taehyun Kim, Sungmin Moon, Juyeon Lee, Jae-Sung Nam, Youn Wook Chung, Hyun Seok Kim, Hyung-Ju Cho, Chang-Hoon Kim, Ji-Hwan Ryu
{"title":"An Antiviral Effect of Linoleic Acid Against Rhinovirus Infection.","authors":"Taehyun Kim, Sungmin Moon, Juyeon Lee, Jae-Sung Nam, Youn Wook Chung, Hyun Seok Kim, Hyung-Ju Cho, Chang-Hoon Kim, Ji-Hwan Ryu","doi":"10.1165/rcmb.2024-0612LE","DOIUrl":"https://doi.org/10.1165/rcmb.2024-0612LE","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Scripts" Don't Lie: Sex and Age Shape Blood Immune Gene Expression in Asthma. “剧本”不要撒谎：性别和年龄影响哮喘患者的血液免疫基因表达。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-02 DOI: 10.1165/rcmb.2025-0371ED
Patricia Silveyra
{"title":"\"Scripts\" Don't Lie: Sex and Age Shape Blood Immune Gene Expression in Asthma.","authors":"Patricia Silveyra","doi":"10.1165/rcmb.2025-0371ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0371ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the Molecular Complexity of Asthma: Insights from a Multicohort Transcriptome Study. 揭示哮喘的分子复杂性：来自多队列转录组研究的见解。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-01 DOI: 10.1165/rcmb.2024-0497ED
Heidi Makrinioti, Carlos A Camargo, Zhaozhong Zhu
{"title":"Unraveling the Molecular Complexity of Asthma: Insights from a Multicohort Transcriptome Study.","authors":"Heidi Makrinioti, Carlos A Camargo, Zhaozhong Zhu","doi":"10.1165/rcmb.2024-0497ED","DOIUrl":"10.1165/rcmb.2024-0497ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":"73 1","pages":"6-8"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Peripheral and Cardiac Immune Responses in a Pneumosepsis Mouse Model with Group A Streptococcus. a组链球菌感染的肺脓毒症小鼠模型外周和心脏免疫反应的研究。
IF 5.9 2区 医学
American Journal of Respiratory Cell and Molecular Biology Pub Date : 2025-07-01 DOI: 10.1165/rcmb.2024-0320OC
Sonja Oehmcke-Hecht, Praveen Vasudevan, Juliane Köhler, Claudia Maletzki, Stefan Mikkat, Robert David, Bernd Kreikemeyer
{"title":"Exploring Peripheral and Cardiac Immune Responses in a Pneumosepsis Mouse Model with Group A <i>Streptococcus</i>.","authors":"Sonja Oehmcke-Hecht, Praveen Vasudevan, Juliane Köhler, Claudia Maletzki, Stefan Mikkat, Robert David, Bernd Kreikemeyer","doi":"10.1165/rcmb.2024-0320OC","DOIUrl":"10.1165/rcmb.2024-0320OC","url":null,"abstract":"<p><p><i>Streptococcus pyogenes</i> (group A <i>Streptococcus</i> [GAS]) is a human pathogen that causes local and systemic infections of the skin and mucous membranes. However, GAS is also found asymptomatically in the nasopharynx of infants. GAS infections, including pharyngitis and invasive pneumosepsis, pose significant public health concerns. Streptokinase, a key virulence factor of GAS, activates human plasminogen, facilitating bacterial dissemination. Plasminogen, traditionally known for its role in fibrinolysis, may also modulate host immune responses. We therefore aim to investigate systemic and cardiac immune cell responses during pneumonia and pneumosepsis with GAS in a murine infection model. The interaction of streptokinase with human plasminogen is species specific, so the murine pneumosepsis model was developed in a transgenic mouse strain that produces human plasminogen. The data show a critical role of human plasminogen for GAS colonization and systemic spread via the nasopharynx. Because of pneumosepsis, blood immune cell profiles and plasma protein concentrations are significantly altered, indicating potential biomarkers for distinguishing local from systemic infection. In the hearts of animals with invasive infection, proinflammatory immune cells significantly increased and likely displaced resident healing macrophages. The established pneumosepsis model is useful to study the pathophysiological mechanisms underlying local and invasive pneumonia caused by GAS and to investigate new therapeutic options.</p>","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":"73 1","pages":"49-59"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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