{"title":"From Protein Folding to Precision Therapy: SP-A in the Spotlight.","authors":"David R Ziehr, Raghu R Chivukula","doi":"10.1165/rcmb.2025-0366ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0366ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aartik Sarma, Xin Sun, Jennifer Sucre, Jason Hong, Lejla Medzikovic, Claudia V Jakubzick, Xin Li, Rachel L Zemans, Benjamin D Singer
{"title":"Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease.","authors":"Aartik Sarma, Xin Sun, Jennifer Sucre, Jason Hong, Lejla Medzikovic, Claudia V Jakubzick, Xin Li, Rachel L Zemans, Benjamin D Singer","doi":"10.1165/rcmb.2025-0092PS","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0092PS","url":null,"abstract":"<p><p>In this Perspective, we review the major themes from a Basic Science Core session at ATS 2024: Multi-omic and single-cell approaches for elucidating cellular biology and pathobiology of lung disease, with a focus on novel biology identified in human lungs. Recent advances have enabled researchers to study nucleic acids, proteins, and metabolites at single-cell resolution in the lung. These tools can be integrated with complementary methods to lead to new discoveries about lung function and develop treatments for respiratory diseases. We discuss the role of multicenter consortia in developing lung cell atlases and highlight the role of single-cell methods in identifying new respiratory cell types. We then review advances in several respiratory diseases that demonstrate the use of these tools to study lung development, injury, and repair. Lastly, we consider future directions for the field, including efforts to harmonize cell types across studies and to develop more robust analytical pipelines.</p>","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IFN It Isn't Broke, It May Still Be Driving Disease: Interferons as Mediators of Senescence in COPD.","authors":"Jenny P Nguyen, Maor Sauler","doi":"10.1165/rcmb.2025-0301ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0301ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noah J Smith, Rashika Joshi, Hitesh Deshmukh, Jerilyn Gray, Andrea D Edwards, Elham Shahreki, Brian M Varisco
{"title":"Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development.","authors":"Noah J Smith, Rashika Joshi, Hitesh Deshmukh, Jerilyn Gray, Andrea D Edwards, Elham Shahreki, Brian M Varisco","doi":"10.1165/rcmb.2024-0378LE","DOIUrl":"https://doi.org/10.1165/rcmb.2024-0378LE","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When Lipid Mediators Keep Lungs Whole: A Spontaneous, Female-Predominant Model of Emphysema.","authors":"Rene A Girard, Harry Karmouty-Quintana","doi":"10.1165/rcmb.2025-0349ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0349ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Scripts\" Don't Lie: Sex and Age Shape Blood Immune Gene Expression in Asthma.","authors":"Patricia Silveyra","doi":"10.1165/rcmb.2025-0371ED","DOIUrl":"https://doi.org/10.1165/rcmb.2025-0371ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unraveling the Molecular Complexity of Asthma: Insights from a Multicohort Transcriptome Study.","authors":"Heidi Makrinioti, Carlos A Camargo, Zhaozhong Zhu","doi":"10.1165/rcmb.2024-0497ED","DOIUrl":"10.1165/rcmb.2024-0497ED","url":null,"abstract":"","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":"73 1","pages":"6-8"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonja Oehmcke-Hecht, Praveen Vasudevan, Juliane Köhler, Claudia Maletzki, Stefan Mikkat, Robert David, Bernd Kreikemeyer
{"title":"Exploring Peripheral and Cardiac Immune Responses in a Pneumosepsis Mouse Model with Group A <i>Streptococcus</i>.","authors":"Sonja Oehmcke-Hecht, Praveen Vasudevan, Juliane Köhler, Claudia Maletzki, Stefan Mikkat, Robert David, Bernd Kreikemeyer","doi":"10.1165/rcmb.2024-0320OC","DOIUrl":"10.1165/rcmb.2024-0320OC","url":null,"abstract":"<p><p><i>Streptococcus pyogenes</i> (group A <i>Streptococcus</i> [GAS]) is a human pathogen that causes local and systemic infections of the skin and mucous membranes. However, GAS is also found asymptomatically in the nasopharynx of infants. GAS infections, including pharyngitis and invasive pneumosepsis, pose significant public health concerns. Streptokinase, a key virulence factor of GAS, activates human plasminogen, facilitating bacterial dissemination. Plasminogen, traditionally known for its role in fibrinolysis, may also modulate host immune responses. We therefore aim to investigate systemic and cardiac immune cell responses during pneumonia and pneumosepsis with GAS in a murine infection model. The interaction of streptokinase with human plasminogen is species specific, so the murine pneumosepsis model was developed in a transgenic mouse strain that produces human plasminogen. The data show a critical role of human plasminogen for GAS colonization and systemic spread via the nasopharynx. Because of pneumosepsis, blood immune cell profiles and plasma protein concentrations are significantly altered, indicating potential biomarkers for distinguishing local from systemic infection. In the hearts of animals with invasive infection, proinflammatory immune cells significantly increased and likely displaced resident healing macrophages. The established pneumosepsis model is useful to study the pathophysiological mechanisms underlying local and invasive pneumonia caused by GAS and to investigate new therapeutic options.</p>","PeriodicalId":7655,"journal":{"name":"American Journal of Respiratory Cell and Molecular Biology","volume":"73 1","pages":"49-59"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}