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Series haematologica (1968)最新文献

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Inhibitors of platelet function in the prevention of arterial thrombosis. 血小板功能抑制剂在预防动脉血栓形成中的作用。
Series haematologica (1968) Pub Date : 1975-01-01
L A Harker
{"title":"Inhibitors of platelet function in the prevention of arterial thrombosis.","authors":"L A Harker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of platelet inhibiting drugs in the prevention of arterial thromboembolic occlusive disease demonstrates that only a few trials have been adequately designed to provide conclusive results. Dipyridamole is effective in preventing the thromboembolic complications of prosthetic heart valves and sulfinpyrazone reduces occlusive events in A-V silastic cannulae, while clofibrate is clearly ineffective in secondary prevention of myocardial infarction. No antiplatelet agent has yet been convincingly shown to exert any antithrombotic effect in venous thromboembolism, although the results with hydroxychloroquine deserve further study. Currently, only two antiplatelet drugs, dipyridamole and sulfinpyrazone are clearly proven clinically effective in reducing arterial thromboembolism. The promising results using ASA are under active study.</p>","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 3","pages":"105-24"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11980791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The platelet and coronary artery disease. 血小板和冠状动脉疾病。
Series haematologica (1968) Pub Date : 1975-01-01
M A Sahud
{"title":"The platelet and coronary artery disease.","authors":"M A Sahud","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 3","pages":"125-140"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11980792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New approaches to the therapy of chronic granulocytic leukemia. 慢性粒细胞白血病治疗的新途径。
Series haematologica (1968) Pub Date : 1975-01-01
A S Spiers
{"title":"New approaches to the therapy of chronic granulocytic leukemia.","authors":"A S Spiers","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 4","pages":"157-73"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11987749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneity of megakaryocytes and platelets. 巨核细胞和血小板的异质性。
Series haematologica (1968) Pub Date : 1975-01-01
D G Penington, K Streatfield
{"title":"Heterogeneity of megakaryocytes and platelets.","authors":"D G Penington,&nbsp;K Streatfield","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 1","pages":"22-48"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11270126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ultrastructure of the platelets in refractory anemia ("preleukemia") and myelomonocytic leukemia. 难治性贫血(“白血病前期”)和骨髓单核细胞白血病的血小板超微结构。
Series haematologica (1968) Pub Date : 1975-01-01
J E Maldonado
{"title":"The ultrastructure of the platelets in refractory anemia (\"preleukemia\") and myelomonocytic leukemia.","authors":"J E Maldonado","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have conducted extensive morphologic studies of the platelets in 16 patients with preleukemia or myelomonocytic leukemia. Although the degree and frequency of the changes varied in the different cases, it was evident that the platelets in these two pathologic states often were structurally abnormal. The abnormalities include changes in size (mainly giant forms), shape (frequent presence of round cells), and quantitative (particularly decreases) as well as qualitative changes in the platelet granules. Quite remarkable has been the finding of giant granules of irregular contour and heterogeneous composition, perhaps the result of fusion of several single granules. Other changes have included overabundance of the membranous systems of the platelet.</p>","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 1","pages":"101-25"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11270125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of two distinct membrane systems associated in giant complexes in pathological megakaryocytes. 病理巨核细胞中巨复合物相关的两种不同膜系统的发育。
Series haematologica (1968) Pub Date : 1975-01-01
J Breton-Gorius
{"title":"Development of two distinct membrane systems associated in giant complexes in pathological megakaryocytes.","authors":"J Breton-Gorius","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 1","pages":"49-67"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11270127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic myelogenous leukemia: a clinical and experimental evaluation of splenectomy and intensive chemotherapy. 慢性骨髓性白血病:脾切除术和强化化疗的临床和实验评价。
Series haematologica (1968) Pub Date : 1975-01-01
I Brodsky, K E Fuscaldo, S B Kahn, J F Conroy, C G Lamping
{"title":"Chronic myelogenous leukemia: a clinical and experimental evaluation of splenectomy and intensive chemotherapy.","authors":"I Brodsky,&nbsp;K E Fuscaldo,&nbsp;S B Kahn,&nbsp;J F Conroy,&nbsp;C G Lamping","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 4","pages":"143-56"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11987748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible mechanisms of pathogenesis and acute transformation in chronic myeloid leukemia. 慢性髓性白血病的可能发病机制和急性转化。
Series haematologica (1968) Pub Date : 1975-01-01
B Pedersen
{"title":"Possible mechanisms of pathogenesis and acute transformation in chronic myeloid leukemia.","authors":"B Pedersen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 4","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11987750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic myelocytic leukemia: cytogenetic findings and their relations to pathogenesis and clinic. 慢性髓细胞白血病:细胞遗传学发现及其与发病和临床的关系。
Series haematologica (1968) Pub Date : 1975-01-01
D K Hossfeld
{"title":"Chronic myelocytic leukemia: cytogenetic findings and their relations to pathogenesis and clinic.","authors":"D K Hossfeld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chromosome constitution of myeloid cells of 106 patients with chronic myelocytic leukemia (CML) was studied. Two thirds of the patients were in the chronic and one third in the blastic phase. Particular attention was paid to patients with a mixture of Ph1-positive and Ph1-negative metaphases, and those with additional chromosome anomalies. A statistical analysis of the additional anomalies observed during the chronic and the blastic phase waandom involvement of certain chromosome groups. Chromosomal findings in medullary and extramedullary tissues were compared; the results suggest an accumulation of cells with additional anomalies in extramedullary sites. Ph1-negative patients were shown to be older and to have a survival shorter than Ph1-positive patients. The medium survival time of patients in the blastic phase may be longer in those without additional chromosome anomalies. Apart from the chromosomal status, hemoglobin concentration, the number of platelets and the percentage of myeloblasts in the bone marrow had a definite influence on survival times.</p>","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 4","pages":"53-72"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12251585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some basic mechanisms in platelet physiology. 血小板生理学的一些基本机制。
Series haematologica (1968) Pub Date : 1975-01-01
E W Salzman
{"title":"Some basic mechanisms in platelet physiology.","authors":"E W Salzman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 3","pages":"38-49"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11980794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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