Series haematologica (1968)最新文献

Chronic granulocytic leukemia--selective removal of immature granulocytic cells by leukapheresis. 慢性粒细胞白血病——通过白细胞分离术选择性去除未成熟的粒细胞。

Series haematologica (1968) Pub Date : 1975-01-01

J M Goldman, R M Lowenthal, N A Buskard, A S Spiers, K H Th'ng, D S Park

引用次数: 0

Static and functional morphology of the pathological platelets in primary myelofibrosis and myeloproliferative syndrome. 原发性骨髓纤维化和骨髓增生性综合征病理血小板的静态和功能形态。

Series haematologica (1968) Pub Date : 1975-01-01

A Hattori, K Koike, S Ito, M Matsuoka

{"title":"Static and functional morphology of the pathological platelets in primary myelofibrosis and myeloproliferative syndrome.","authors":"A Hattori, K Koike, S Ito, M Matsuoka","doi":"","DOIUrl":"","url":null,"abstract":"Native and functioning platelets in patients with primary myelofibrosis and myeloproliferative syndrome were examined by transmission electron microscopy. Among various types of ultrastructural abnormalities in the platelets, three features were emphasized: hypoplasia of the surface connecting system (SCS) with few orifices, hyperplasia of the dense tubular system, and considerable variety in numbers of granule. Morphological analysis was made on platelets of these patients and of normal subjects. Functional morphology of the abnormal platelets was examined in the aggregate samples either by ADP or collagen and the effluent blood from platelet retention test. The abnormal platelets were more or less indifferent from the aggregates and underwent only to a slight degree the changes observed in normal platelets. They frequently retained their native, round, smooth-surfaced form without pseudpod, and did not show the inward shift of organelles; furthermore, they retained more granules than did normal platelets. From these morphological findings we speculated that these ultrastructurally abnormal platelets had an impaired release reaction as a result of the dysfunction of SCS in passing released substances, of the inability of microfilaments to constrict in expelling these substances and sometimes because of a lack of granules as the sources.","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 1","pages":"126-50"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12308635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of platelets in hemostasis and thrombosis. 血小板在止血和血栓形成中的作用。

Series haematologica (1968) Pub Date : 1975-01-01

H J Day

{"title":"Role of platelets in hemostasis and thrombosis.","authors":"H J Day","doi":"","DOIUrl":"","url":null,"abstract":"Platelets are central to both normal hemostasis and abnormal thrombotic states along with the vessel wall, coagulation elements, and blood flow. The platelets play a pivotal role in the reaction that occurs after vessel injury, during which platelets first adhere to the vessel wall, undergo a release reaction and then aggregate, probably as a result of the materials released from platelets. These processes can be studied by a series of in vitro tests which form the basis of our knowledge of platelets in hemostasis. While the hemostatic plug is usually microscopic in size, this same plug (platelet thrombus) may contribute to the pathogenesis of several arterial diseases such as transient ischemic attacks, sudden blindness, sudden cardiac death and acute respiratory death syndrome. Careful microscopic examinations have shown that platelet aggregates may be found in the microcirculation which could affect vital structures such as the conduction system of the heart. Both anatomic and therapeutic evidence evidence suggests that platelets play a role in venous thrombosis. Recent evidence suggests increased levels of materials known to be released from platelets in patients with both arterial and venous thrombi along with increased platelet coagulant activities in patients with venous thrombosis.","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 3","pages":"23-37"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12410322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal platelet numbers. Pulmonary-platelet interactions. 血小板数正常。Pulmonary-platelet交互。

Series haematologica (1968) Pub Date : 1975-01-01

W H Crosby

引用次数: 0

Autosomal linkage in humans (methodology and results of computer analysis). 人类常染色体连锁(计算机分析的方法和结果)。

Series haematologica (1968) Pub Date : 1975-01-01

C T Falk, M E Walker, M D Martin, F H Allen

引用次数: 0

Structural-functional relationships in platelets in acute leukemia and related disorders. 急性白血病及相关疾病中血小板的结构-功能关系。

Series haematologica (1968) Pub Date : 1975-01-01

D H Cowan, R C Graham

{"title":"Structural-functional relationships in platelets in acute leukemia and related disorders.","authors":"D H Cowan, R C Graham","doi":"","DOIUrl":"","url":null,"abstract":"Platelet ultrastructure and adenine nucleotide metabolism were studied in acute leukemia in order to elucidate mechanisms for the functional defects of platelets in this clinical setting. A number of structural defects were observed: (1) giant platelets, (2) marked variability in the number and size of cytoplasmic granules, (3) dilatation of the open channel system, (4) cytoplasmic vacuolization, and (5) poorly delineated microtubular system. Metabolic defects included reduced cellular concentrations of ATP and ADP and selective reduction of the storage pool (non-metabolic) nucleotides. Stimulation of platelets was associated with delayed and incomplete granule migration, reduced degranulation, subnormal release of ATP and ADP, and poor platelet aggregate formation. The structural and metabolic defects observed indicate abnormalities exist in the contractile mechanism and the release reaction of platelets in acute leukemia which partly explain the functional defects reported previously. Platelets from patients with pre-leukemic states share some of the structural and metabolic defects seen in acute leukemia. The defects are less uniform consistent with a lesser degree of functional impairment than seen in acute leukemia. Studies of megakaryocytic ultrastructure suggest that the structural defects seen in acute leukemia and pre-leukemia may arise in the late stages of megakaryocyte maturation.","PeriodicalId":76538,"journal":{"name":"Series haematologica (1968)","volume":"8 1","pages":"68-100"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12236973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simultaneous study of bone marrow, spleen, and liver in chronic myeloid leukemia: evidence for differences in cell composition and karyotypes. 慢性髓性白血病患者骨髓、脾脏和肝脏的同时研究:细胞组成和核型差异的证据。

Series haematologica (1968) Pub Date : 1975-01-01

M Baccarani, A Zaccaria, A M Santucci, G P Bagnara, P Ricci, M Gobbi, D Ruggero, M A Brunelli, S Tura

引用次数: 0

Aspirin revisited. 阿司匹林再现。

Series haematologica (1968) Pub Date : 1975-01-01

R Rodvein, A R Cooke

引用次数: 0

Comparative cytogenetic studies of bone marrow and extramedullary tissues in chronic myeloid leukemia. 慢性髓性白血病骨髓和髓外组织的细胞遗传学比较研究。

Series haematologica (1968) Pub Date : 1975-01-01

F Mitelman