American Journal of Rhinology & Allergy最新文献

{"title":"Association Between Ultra-Processed Food Intake and Sinusitis.","authors":"Anthony Thai, Noel F Ayoub","doi":"10.1177/19458924251404161","DOIUrl":"10.1177/19458924251404161","url":null,"abstract":"<p><p>BackgroundUltra-processed foods (UPF) are industrial formulations derived mostly from substances refined or extracted from foods. UPF intake has been linked to obesity, cardiovascular disease, and adult mortality, with recent studies demonstrating possible associations with asthma and allergy.ObjectiveWe investigate the association of UPF intake with self-reported sinusitis and other sinonasal symptoms.MethodsWe retrospectively reviewed 3 cycles of the National Health and Nutrition Examination Survey (NHANES), ranging from 2005 to 2014, which includes dietary and sinonasal symptom data on a large, representative sample of the US population. Individuals were divided into quartiles based on the percent of daily caloric intake consisting of Nova category 4 UPF. Multivariable logistic regression was performed to assess the association of UPF intake with sinonasal symptoms, adjusting for demographic data and medical comorbidities.ResultsAnd 10,068 individuals (mean age 54.2 years, 52.1% female) were studied. Compared to the lowest quartile of UPF intake, the highest quartile had a higher rate of asthma (16% vs 11%, <i>P</i> = .03), obesity (40% vs 30%, <i>P</i> < .001), smoking (51.6% vs 44.4%, <i>P</i> < .001), emphysema (2.9% vs 1.8%, <i>P</i> = .02), and food insecurity (26% vs 21%, <i>P</i> = .002). On multivariable regression, the highest quartile of UPF intake was associated with self-reported sinusitis (odds ratio [OR] = 1.54, 95% confidence interval [CI] 1.15-2.05, <i>P</i> = .007). UPF intake was also associated with xerostomia-related dysgeusia (OR 1.79, CI 1.15-2.80, <i>P</i> = .02) but not with other sinonasal symptoms, including hyposmia, allergies, hay fever, or nasal congestion from allergies.ConclusionUPF intake is significantly associated with self-reported sinusitis and xerostomia-related dysgeusia, although not with other sinonasal symptoms. Further studies are needed to elucidate the mechanism of this association.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"191-196"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Topical Levofloxacin Rinses on Chronic Rhinosinusitis.","authors":"Ali M Baird, Russell Whitehead, Vidit Talati, Grant S Owen, Romney Hansen, Peter Filip, Bobby A Tajudeen, Pete S Batra, Peter Papagiannopoulos","doi":"10.1177/19458924251408176","DOIUrl":"10.1177/19458924251408176","url":null,"abstract":"<p><p>BackgroundTreatment of postoperative exacerbations with topical antibiotics has grown in popularity due to their ability to administer a high local drug concentration to the sinuses and mitigate systemic side effects. Published literature on the efficacy of topical levofloxacin for treating CRS is scarce.ObjectivePatients who started levofloxacin 100 mg nasal rinses twice daily following functional endoscopic sinus surgery (FESS) were retrospectively identified. Data collected included rinse duration, bacterial cultures, Sino-Nasal Outcome Test-22 (SNOT-22) scores, Lund-Kennedy (LK) scores, and adverse effects. SNOT and LK scores were compared at 3 time points: pre-operative (<b>Baseline</b>), 3 month postoperative pre-rinse (<b>PostOp</b>), and at the completion of rinse therapy (<b>PostRinse</b>). Analysis of variance (ANOVA) and Wilcoxon rank sum tests were used for pairwise comparisons.ResultsOne hundred and thirty-three patients received levofloxacin rinses for a mean 8.4 ± 18.9 months. On pairwise comparison for LK scores, the difference between PostOp and PostRinse LK scores was -1.0 ± 1.7 (<i>P</i> <i><</i> <i>.</i>001). The change from Baseline to PostOp was -2.0 ± 2.8 (<i>P</i> <i><</i> <i>.</i>001) and the change from Baseline to PostRinse LK scores was -3.2 ± 2.8 (<i>P</i> <i><</i> <i>.</i>001). On pairwise comparison for SNOT scores, significant improvement was observed between Baseline and PostRinse scores (-19.4 ± 20.7, <i>P</i> <i>=</i> <i>.</i>001) but not between PostOp and PostRinse scores. There was one musculoskeletal adverse event noted.ConclusionTopical levofloxacin rinses afforded a possible benefit in endoscopic appearance of operated sinuses but less definitive benefit in symptom scores. Further, they were safely tolerated with one mild musculoskeletal adverse event.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"207-213"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145761898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle Turbinate Medialization With Absorbable Packing After Trans-sphenoidal Skull Base Surgery: Outcomes and Significance of a Simple Technique.","authors":"Mark T Liu, Joyce Lee, Matthew J Kabalan, Christopher R Roxbury, Raj Sindwani","doi":"10.1177/19458924251409273","DOIUrl":"10.1177/19458924251409273","url":null,"abstract":"<p><p>BackgroundMiddle turbinate (MT) medialization after endoscopic skull base surgery (ESBS) allows natural positioning of the turbinate, re-opening of the osteomeatal complex, and potential skull base protection from iatrogenic injury by endonasal device insertion. Our institution routinely preserves and medializes the MTs in ESBS by placing bioabsorbable nasal packing in both middle meatuses.ObjectiveThe goal of our study was to use postoperative endoscopic MT scoring to objectively assess the efficacy and durability of our simple technique, in which bioabsorbable nasal packing is placed in both middle meatuses to position the MTs against the septum, following trans-sphenoidal skull base surgery.MethodsA single-center retrospective review was performed of consecutive trans-sphenoidal ESBS patients from 2023 to 2024 to assess postoperative MT positioning. Patients with recorded postoperative nasal endoscopies more than 20 days after surgery were included. Recorded endoscopies were evaluated by 2 independent raters using 2 standardized MT scoring systems assessing station and apposition. An additional subgroup analysis was performed in patients with multiple postoperative endoscopies to assess effect of time on MT position.ResultsFifty patients (100 turbinates) scored by 2 raters were included for a total of 200 turbinate ratings. One hundred ninety-two turbinates (96%) had station assessed as 1+, signifying medialization, and 176 turbinates (88%) demonstrated direct apposition to the septum. Nasal endoscopies were analyzed 43.5 days (median) after surgery. Cohen's kappa coefficient was 0.90 for station and 0.63 for apposition, signifying substantial inter-rater reliability. Subgroup analysis demonstrated no significant effect of time on turbinate station or apposition.ConclusionsOur experience with bioabsorbable nasal packing in the middle meatus demonstrates that a simple technique can achieve durable MT medialization in many patients following ESBS. Optimizing MT positioning can improve postoperative sinus function and help protect against inadvertent skull base injuries in ESBS patients.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"214-221"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145852893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Adipose Mesenchymal Stem Cell-Derived Exosomes on the Th2/Treg Cells in Peripheral Blood of the Patients with Allergic Rhinitis and its Mechanism.","authors":"Feiyan Han, Xiaojie Xu, Ying Wang","doi":"10.1177/19458924251401732","DOIUrl":"10.1177/19458924251401732","url":null,"abstract":"<p><p>BackgroundAt present, there are many therapeutic regimens for allergic rhinitis (AR), but their therapeutic effects are not better. Therefore, it is a focus to find new therapeutic targets by exploring AR immune regulation.ObjectiveTo explore the possible mechanism that adipose mesenchymal stem cell-derived exosomes (AMSC-exos) regulate the balance of Th2/Treg cells by mTOR pathway in AR patients.MethodsThirty patients with AR and 30 patients with deviated nasal septum alone were selected as AR group and control group. From each patient, 10 ml of peripheral blood were collected for determining the levels of blood plasma IL-4 and TGF- β as well as protein levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389) in peripheral blood mononuclear cells (MCs) and the proportions of Th2 and Treg cells. And then MCs from AR patients were divided into two groups. One group was as AR cell group. Another group was co-cultured with AMSC-exos and served as AR cell + exos group. The levels of IL-4 and TGF- β in supernatant, the protein levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389) in MCs and the proportions of Th2 and Treg cells were also determined.ResultsThe levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389), the IL-4 level and the proportion of Th2 cells were significantly higher in the AR group than in the control group (all <i>P</i> < 0.05). However, the levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389), the IL-4 level and the proportion of Th2 cells were significantly lower in the AR cell + exos group than in the AR cell group (all <i>P</i> < 0.05).ConclusionsAMSC-exos may regulate the balance between Th2 and Treg cells by PI3K/AKT/mTOR/p70S6K pathways in vitro.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"183-190"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Exposure to Phenols and Parabens and Allergy-Related Outcomes.","authors":"Caishan Fang, Xiangjun Qi, Qinwei Fu, Shipeng Zhang, Xi Chen, Qinxiu Zhang","doi":"10.1177/19458924251408169","DOIUrl":"10.1177/19458924251408169","url":null,"abstract":"<p><p>BackgroundParabens and phenols (PAPs) are widely used in consumer and personal care products. Although prior studies suggest links between PAP exposure and allergic outcomes, evidence across adolescents and adults remains limited.ObjectiveTo investigate associations between urinary PAPs and allergy-related outcomes.MethodsWe conducted a cross-sectional analysis of NHANES 2005-2006. Eight urinary PAPs were considered; three with >33.3% values below the limit of detection were excluded. Allergic symptoms and sensitization were assessed based on participants' self-reported health conditions. Three survey-weighted generalized linear models (crude model: unadjusted; Model I: partially adjusted; Model II: fully adjusted) and weighted quantile sum regression were used to evaluate the associations between PAPs exposure and allergy-related outcomes in both adolescents and adults.ResultsAmong adolescents, higher triclosan (TCS) exposure was positively associated with allergic rhinitis, allergies, sinus infection, and sneezing; in the fully adjusted model, odds ratios (ORs) were 2.04 (95% CI: 1.18-3.54), 2.36 (1.25-4.47), 3.28 (1.36-7.91), and 2.12 (1.27-3.52), respectively. Higher TCS, methyl paraben (MPB), and propyl paraben (PPB) were associated with dust-mite sensitization, with ORs of 2.00 (1.16-3.45), 2.09 (1.05-4.17), and 3.87 (2.09-7.16). Among adults, MPB was positively associated with allergic rhinitis (OR = 1.95, 95% CI: 1.26-3.00) and sneezing (OR = 1.99, 1.27-3.10), and TCS was associated with hay fever (OR = 1.99, 1.22-3.23) and plant sensitization (OR = 1.40, 1.03-1.91). In mixture analyses, PAPs were positively associated with allergies (adjusted OR = 1.27, 95% CI: 1.07-1.51), sneezing (1.15, 1.00-1.33), and plant sensitization (1.21, 1.02-1.43) in adolescents, but no significant mixture associations were found in adults.ConclusionHigher levels of specific PAPs, particularly TCS, MPB, and PPB, and PAP mixtures were associated with increased risks of allergy-related outcomes in adolescents. In adults, TCS and MPB showed positive associations with multiple outcomes, whereas the overall PAP mixture was not statistically significant.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"197-206"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Nasoseptal-Lacrimal Fossa Distance as a Predictor of Endoscopic DCR Failure: A Retrospective Analysis.","authors":"Kalena Liu, Christopher Valentini, Kelsey Limage, Henry Moss, Ava Whitlark, Tiffany Cheng, Henry Bair, Charlotte Marous, Adam Flanders, Marc Rosen, Gurston Nyquist, Elina Toskala, Karine Shebaclo, Alison Watson, Mindy Rabinowitz","doi":"10.1177/19458924251410664","DOIUrl":"10.1177/19458924251410664","url":null,"abstract":"<p><p>BackgroundDacryocystorhinostomy (DCR) is a surgery performed for nasolacrimal duct obstruction (NLDO). A high septal deflection may limit surgical access, and if not corrected, contribute to an increase in DCR failure rates due to increased adhesion formation. We hypothesize that a narrower distance between the nasal septum (NS) and lacrimal fossa (LF) is associated with higher rates of DCR failure.ObjectiveTo evaluate whether a reduced nasal septum-lacrimal fossa (NS-LF) distance is associated with higher rates of endoscopic DCR (Endo DCR) failure and to determine a clinically relevant cutoff distance that may guide consideration for concomitant septoplasty.MethodsA single-institution retrospective chart review was performed for patients who received an endoscopic \"Endo\" DCR between July 2018 and July 2023. Data collected included demographics, septal deviation presence and laterality, NLDO laterality, and failure rates, where failure was defined as the need for a repeat ipsilateral DCR. The NS-LF distance was determined on preoperative computed tomography.ResultsA total of 521 patients were identified, with an average age of 60.3 years (SD = 16.47); 4.4% (n = 23) of patients experienced Endo DCR failure, requiring revision Endo DCR; 8.7% (n = 45) of patients underwent concomitant septoplasty with initial DCR. Patients who failed had a significantly shorter NS-LF distance (8.47 mm vs 9.25 mm, <i>P</i> = .028). Receiver operating characteristic curve analysis cutoff distance of 8.85 mm demonstrated a NS-LF distance ≥8.85 mm had a significantly lower failure rate compared to those with a distance <8.85 mm (2.6% vs 7.3%, <i>P</i> = .016). All revision DCRs were successful regardless of septoplasty status.ConclusionA NS-LF distance of <8.85 mm was significantly associated with Endo DCR failure, suggesting that concomitant septoplasty should be considered in these patients. Prospective studies and standardized preoperative imaging may improve surgical planning and outcomes in Endo DCR.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"222-229"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-Sparing Effects of Biologics in Chronic Rhinosinusitis with Nasal Polyps: Systematic Review and A Meta-Analysis of Randomized Controlled Trials.","authors":"Ali M Alsudays, Yasser G Alarimah, Khaled A Almanea, Ahmad Alroqi","doi":"10.1177/19458924251414922","DOIUrl":"10.1177/19458924251414922","url":null,"abstract":"<p><p>BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) presents significant management challenges, largely due to reliance on systemic corticosteroids (SCS) for symptom control. Advances in biologic therapies targeting type 2 inflammation have shown promise in reducing polyp burden, improving symptoms, and decreasing the need for SCSs and surgery.ObjectiveThis systematic review and meta-analysis compare the steroid-sparing efficacy of biologics and safety with other biologics or standard care in CRSwNP. Key outcomes include reducing SCS Use and drug safety.MethodsWe searched PubMed, Embase, Cochrane Library, Scopus, and the Web of Science. We included randomized controlled trials (RCTs) comparing biologics versus placebo/standard care in adults with CRSwNP. The primary outcomes were SCS reduction and safety. Meta-analyses, which use a statistical method called random effects models, were employed.ResultsThis meta-analysis of seven RCTs (n = 3097) revealed that biologic therapies significantly reduce SCS use in CRSwNP patients (pooled proportion: 20.9%, 95% CI: 8.4%-37.0%), though with substantial heterogeneity (I² = 98.3%). Trial-level predictors included control-arm safety profiles (higher serious adverse events (SAEs) reduced treatment effects) [odds ratio (OR) 0.70]. In contrast, placebo-arm SAEs enhanced them [OR 1.81]) and sample size (larger trials showed diluted responses [OR 0.993 per patient]). These results highlight the role of trial design and baseline patient risk in determining the interest of the results. They further highlight the possibility for individualized strategies in terms of treatment and call for more in-depth studies with patient-level data to refine the steroid-sparing therapeutic strategy, providing an impetus for future work in this area.ConclusionsThe biologics, specifically dupilumab, represent a paradigm shift in treating CRSwNP, significantly decreasing the burden of SCS-their consistent safety and efficacy support integration into treatment algorithms for severe cases.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"245-256"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Response Rates and Predictors in Patients with CRSwNP Treated With Mepolizumab and Dupilumab: Results From a Prospective, Multicenter Cohort Study.","authors":"Mireia Golet, Paula Cruz Toro, Albert Llansana Ríos, Carlota González Lluch, Laura Pardo-Muñoz, Ignacio Clemente, Aina Brunet, Xavier Gonzalez-Compta","doi":"10.1177/19458924261431418","DOIUrl":"10.1177/19458924261431418","url":null,"abstract":"<p><p>BackgroundDupilumab and mepolizumab are effective add-on therapies for severe chronic rhinosinusitis with nasal polyps (CRSwNP). However, predictors of response and guidance on biologic selection remain limited. The aims were to identify baseline parameters associated with favorable response to dupilumab or mepolizumab at 6 and 12 months in severe CRSwNP and compare outcomes among treatments.MethodsWe conducted a multicenter, prospective, non-randomized, real-world cohort study across three tertiary hospitals in Spain. Patients with severe CRSwNP initiating dupilumab or mepolizumab were enrolled and followed at 6 and 12 months. Response was defined using EPOS/EUFOREA 2023 criteria, incorporating nasal polyp score (NPS), sinonasal outcome test (SNOT-22), total symptom score (TSS), olfaction (Sniffin' Sticks Smell Test), systemic corticosteroid need, and asthma control test. Patients were classified as excellent, good, poor, or non-responders based on criteria fulfilled.ResultsSixty-nine patients were included: 35 received dupilumab and 34 mepolizumab. Asthma was present in 86.8%, and 42.6% had aspirin-exacerbated respiratory disease. Both biologics improved SNOT-22, TSS and NPS at 6 and 12 months (<i>P</i> < .05), with comparable efficacy for most outcomes. Dupilumab showed superior improvement in olfaction (coefficient <i>B</i> [95% CI] mepolizumab vs dupilumab: -6.30 [-9.42; -3.19]). Overall, 84.2% of patients achieved a good/excellent response at 6 months and 89.6% at 12 months. Factors associated with better response included comorbid asthma and shorter time since last surgery.ConclusionsDupilumab and mepolizumab improved clinical outcomes in severe CRSwNP, with dupilumab offering greater benefit in olfaction. Asthma and surgical history may help predict response.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261431418"},"PeriodicalIF":2.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Microplastic Inhalation on Allergic and Nonallergic Rhinitis.","authors":"Yesim Itmec, Aysegul Tuna, Ayse Fusun Kalpaklioglu, Ayse Baccioglu","doi":"10.1177/19458924251357135","DOIUrl":"10.1177/19458924251357135","url":null,"abstract":"<p><p>BackgroundMicroplastics are increasingly prevalent in daily life. While their adverse effects on health are well-known, their specific role in rhinitis has not been fully established.ObjectiveIt is known that microplastics suspended in the air have toxic effects on cells through inhalation. The primary aim of this study was to investigate the presence of microplastics in nasal lavage samples from patients in both allergic rhinitis (AR) and nonallergic rhinitis (NAR) groups.MethodsDemographic data, allergy test results, respiratory function tests, mini-Rhinoconjunctivitis Quality of Life Questionnaire and Total Nasal Symptom Score of patients aged 18 to 65 years who applied to the allergy clinic were recorded. Nasal lavage fluid (NLF) samples were collected with physiological serum and placed in glass tubes for all cases. After the filtration process of the samples, microplastic counting was performed under a Stereomicroscope.ResultsA total of 90 subjects (AR: 30, NAR: 30, controls: 30), 64.4% females, within the mean age of 30.27 ± 10.53 years were investigated. Microplastic density in NLF was higher in all rhinitis patients (<i>n</i>: 60) with no difference between AR and NAR than controls (all rhinitis = 3.10 ± 1.00 particles/mL, AR = 3.23 ± 1.29 particles/mL, NAR = 2.97 ± 0.57 particles/mL, controls = 1.18 ± 0.52 particles/mL, <i>P</i> < .001). Microplastic density was higher in young subjects than in older ones (values are \"years; particles/mL\"; 18-30; 2.79 ± 1.22, 31-45; 2.18 ± 1.13, 46-60; 1.5 ± 1.09, <i>P</i> < .05). In logistic procedures, microplastic density of NLF (OR = 2.20, 95% CI [1.02 to 4.75], <i>P</i> = .04) determine the likelihood of sneezing.ConclusionsIn this study, regardless of allergy or nonallergy, higher microplastic density was found in NLF of rhinitis patients than healthy individuals. We also found quantifiable and noteworthy concentrations of microplastics in the nasal lavage of control group. These results support the idea that microplastics cause inflammation in the upper airways.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"98-104"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of the Questionnaire of Olfactory Disorders-Negative Statements in Age-Related Olfactory Dysfunction.","authors":"Alexander Duffy, Zachary M Soler, Kristina A LaPointe, Rod J Schlosser","doi":"10.1177/19458924251382100","DOIUrl":"10.1177/19458924251382100","url":null,"abstract":"<p><p>BackgroundOlfactory dysfunction (OD) is both under-recognized and underdiagnosed in aging adults. Prior studies in chronic rhinosinusitis have demonstrated a correlation between the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) and psychophysical olfactory testing, indicating potential utility for screening in this group. This study examined the correlation between QOD-NS scores, psychophysical function, and olfactory-associated patient-reported outcome measures (PROMs) in a novel, aging population. Additionally, we examined the potential utility of the QOD-NS as a screening instrument in this population.MethodsProspective cohort study in which healthy, adult volunteers completed the QOD-NS, olfaction-related visual analog scale (VAS) questions, Sniffin' Sticks (TDI), De Jong Giervald Loneliness Scale, UCLA loneliness survey (UCLA), and the Patient Health Questionnaire-9 (PHQ9).ResultsTwo-hundred and twenty-eight adults with mean age 50.3 ± 17.7 years were included. Subjects ≥50 years old had higher prevalences of hyposmia (58.3% vs 19.8%, P < 0.001) and anosmia (9.1% vs 3.1%, P < 0.001), and had worse QOD-NS and VAS (P < 0.001 for both). Aging subjects had significant correlations between QOD-NS and TDI (r = -0.386, p < 0.001), all VAS scores (P < 0.001), PHQ9 (r = 0.283, P = 0.001). Receiver operating characteristic curve demonstrated a QOD-NS of 8.0 as the optimal cutoff for a Youden's index of 0.23 for detection of dysosmia in aging patients.ConclusionsThe QOD-NS has significant, although weak correlation with psychophysical testing and psychosocial PROMs in aging subjects. However, a low Youden Index suggests limited potential of the QOD-NS as an OD screening tool in this population.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"105-111"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13191185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}