American Journal of Rhinology & Allergy最新文献

{"title":"Transcaruncular Approach With Orbital Protection for Resection of Sinonasal Lesions: How I do it.","authors":"Jakob L Fischer, Kelsey A Roelofs, Persiana S Saffari, Jeff D Suh, Daniel B Rootman, Robert A Goldberg, Jivianne T Lee","doi":"10.1177/19458924251364570","DOIUrl":"https://doi.org/10.1177/19458924251364570","url":null,"abstract":"<p><p>BackgroundMinimally invasive techniques for the resection of sinonasal masses have become increasingly important over the past few decades. Sinonasal disease involving the lamina papyracea remains difficult to manage given the risk of injury to critical orbital structures and hemorrhage from nearby vessels.ObjectiveDetail the transcaruncular approach with orbital protection for the resection of benign and malignant sinonasal pathologies.MethodsDescription of surgical technique and presentation of 2 representative cases that were successfully managed with this surgical technique.ResultsThe transcaruncular approach involves incising the lateral 1/3 of the caruncle in a vertical plane between the upper and lower puncta. Dissection is then carried through the retrocaruncular fascia posterior to Horner's muscle to the posterior lacrimal crest along the medial orbital wall. Dissection can then be performed in a subperiosteal or supraperiosteal plane with subsequent ligation of the anterior ethmoidal artery. Once dissected, a nylon sheet used for orbital reconstruction and colored orbital shield can then be placed to aid in protection and visualization or orbital contents during endonasal tumor resection.ConclusionThe transcaruncular approach with orbital protection provides intraoperative protection of the orbital contents, allowing for safer removal of the mass irrespective of integrity of the lamina papyracea.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251364570"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Serum Omentin-1 Level in Phenotypes of Chronic Rhinosinusitis.","authors":"Selin Dayısoylu, Tolga Ersözlü, Erdogan Gültekin, Aliye Celikkol","doi":"10.1177/19458924251363165","DOIUrl":"https://doi.org/10.1177/19458924251363165","url":null,"abstract":"<p><p>BackgroundChronic rhinosinusitis (CRS) is a common inflammatory condition of the paranasal sinuses and nasal mucosa. Despite significant advances in understanding its pathogenesis, CRS remains a complex condition to manage due to its heterogeneous nature. Identifying biomarkers could be beneficial in enhancing the diagnostic accuracy and guiding personalized treatment strategies for CRS patients.ObjectiveThis study aimed to evaluate Omentin-1 usage as a biomarker in CRS patients and to investigate its functionality. Serum Omentin-1 levels were evaluated in the phenotypes of CRS, which are CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP).MethodsA total of 90 participants, including CRSwNP (n = 30), CRSsNP (n = 30), and control group (n = 30) individuals, were included in the study. Symptom severity was scored using the Sino-Nasal Outcome Test-22 questionnaire, and disease severity was assessed radiologically with the Lund-Mackay scoring system. Venous blood samples were collected from all participants to evaluate serum Omentin-1 levels.ResultsMedian serum Omentin-1 levels were 124.511 ng/ml (CRSwNP), 131.889 ng/ml (CRSsNP), and 249.138 ng/ml (Control). A significant difference in serum Omentin-1 levels was found between CRSwNP, CRSsNP, and control groups (<i>P</i> = .005). Additionally, significant differences were observed between the CRSwNP group and the control group (<i>P</i> = .015), and between the CRSsNP group and the control group (<i>P</i> = .014). In the CRSwNP group, serum Omentin-1 levels were significantly higher in patients with a positive skin prick test (<i>P</i> = .006).ConclusionIn our study, Serum Omentin-1 levels were found to be significantly lower in CRS patients compared to the control group. Additionally, in the CRSwNP group, serum Omentin-1 levels were significantly higher in patients with a positive skin prick test compared to those with a negative skin prick test. These findings suggest that Omentin-1 could serve as a potential biomarker for differentiating CRS phenotypes, particularly in CRSwNP patients, and the insights gained from these findings may highlight the potential for future comprehensive studies.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251363165"},"PeriodicalIF":2.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous Versus Aerosol Intranasal Corticosteroid Spray for Allergic Rhinitis: Systematic Review and Meta-Analysis.","authors":"Dylan A Levy, Ajibola B Bakare, Robert E Gurevich, Edward D McCoul","doi":"10.1177/19458924251360917","DOIUrl":"https://doi.org/10.1177/19458924251360917","url":null,"abstract":"<p><p><b>Background:</b> Allergic rhinitis (AR) affects millions of people worldwide, impacting quality of life and causing economic burden. Intranasal corticosteroids (INCs) are the mainstay treatment for AR, delivered via aerosol or aqueous sprays. <b>Objective:</b> This systematic review and meta-analysis investigate the comparative efficacy and safety of aerosol and aqueous delivery methods in AR treatment. <b>Methods:</b> Two independent reviewers searched 4 databases (Embrace, Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Web of Science) for English-language, prospective randomized controlled trial (RCT), comparing aqueous and aerosol INCs for AR treatment. Studies were excluded for specific reasons (wrong comparisons, full text unavailable, insufficient data for extraction, wrong patient population, incorrect route of administration (non-intranasal), unverifiable inclusion criteria). Primary outcomes were Total Nasal Symptom Score (TNSS) and subset scores; secondary outcome was adverse event (AEs). <b>Results:</b> No significant difference in overall TNSS was found between the delivery methods. However, aqueous sprays showed a slight edge in reducing specific symptoms like congestion, itching, sneezing, and rhinorrhea. AEs did not differ significantly. <b>Conclusion:</b> Our findings suggest no significant difference in efficacy or safety between aerosol and aqueous INCs for AR treatment. Patient preference should be a primary consideration when choosing a delivery method to optimize adherence and symptom control.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251360917"},"PeriodicalIF":2.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Limited Airflow in Olfactory Cleft and Impaired Olfactory Function: A Systematic Review.","authors":"Yajie Wei, Xincen Jiang, Yankun Li, Lina Chen, Dawei Wu","doi":"10.1177/19458924251360408","DOIUrl":"https://doi.org/10.1177/19458924251360408","url":null,"abstract":"<p><p><b>Objective:</b> This systematic review aims to evaluate and summarize the available literature on the relationship between olfactory cleft (OC) airflow and olfactory function in both healthy individuals and those with olfactory dysfunction. <b>Methods:</b> A systematic search was conducted in PubMed, Google Scholar, OVID, and Cochrane databases to identify studies on OC airflow and olfactory function. Studies were selected based on predefined inclusion criteria. <b>Results:</b> 12 studies were included. The average OC airflow rate and velocity of healthy people were strongly correlated with olfactory threshold (OT) and olfactory discrimination (OD), but weakly with olfactory identification (OI). The anatomical localization of nasal polyps (NP) significantly influenced nasal airflow patterns, with lesions situated in the pre-olfactory region or occupying the entire OC demonstrating complete obstruction of OC airflow and consequent impairment of olfactory recognition thresholds. In contrast, NP localized to the superior or middle meatus exerted minimal clinical impact on airflow parameters. Quantitative analysis revealed an inverse correlation between polyp volume and both OI scores and peak nasal inspiratory flow measurements. In patients with nasal septum deviation, the OT and OI scores were significantly lower on the affected side, though these parameters demonstrated improvement following septoplasty. Combined septoplasty with partial inferior turbinectomy improved the nasal airflow and olfaction, particularly the OD and OI scores. Patients with hypertrophic inferior turbinate due to chronic rhinitis had higher nasal resistance and lower OT, OD, and OI scores compared to healthy controls. There was a significant recovery in resistance, OT, OD, and OI scores postoperatively. Middle turbinate resection demonstrated efficacy in augmenting the olfactory flux and nasal airflow. Notably, superior turbinate lateralization in chronic rhinosinusitis with NP increased the cross-sectional area of OC and improved odor identification function. <b>Conclusion:</b> Impaired OC airflow was highly associated with olfactory dysfunction. Precise mapping through computational fluid dynamics of the airflow-olfaction axis not only enhances diagnostic accuracy but also informs targeted surgical interventions.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251360408"},"PeriodicalIF":2.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Microplastic Inhalation on Allergic and Nonallergic Rhinitis.","authors":"Yesim Itmec, Aysegul Tuna, Ayse Fusun Kalpaklioglu, Ayse Baccioglu","doi":"10.1177/19458924251357135","DOIUrl":"https://doi.org/10.1177/19458924251357135","url":null,"abstract":"<p><p>BackgroundMicroplastics are increasingly prevalent in daily life. While their adverse effects on health are well-known, their specific role in rhinitis has not been fully established.ObjectiveIt is known that microplastics suspended in the air have toxic effects on cells through inhalation. The primary aim of this study was to investigate the presence of microplastics in nasal lavage samples from patients in both allergic rhinitis (AR) and nonallergic rhinitis (NAR) groups.MethodsDemographic data, allergy test results, respiratory function tests, mini-Rhinoconjunctivitis Quality of Life Questionnaire and Total Nasal Symptom Score of patients aged 18 to 65 years who applied to the allergy clinic were recorded. Nasal lavage fluid (NLF) samples were collected with physiological serum and placed in glass tubes for all cases. After the filtration process of the samples, microplastic counting was performed under a Stereomicroscope.ResultsA total of 90 subjects (AR: 30, NAR: 30, controls: 30), 64.4% females, within the mean age of 30.27 ± 10.53 years were investigated. Microplastic density in NLF was higher in all rhinitis patients (<i>n</i>: 60) with no difference between AR and NAR than controls (all rhinitis = 3.10 ± 1.00 particles/mL, AR = 3.23 ± 1.29 particles/mL, NAR = 2.97 ± 0.57 particles/mL, controls = 1.18 ± 0.52 particles/mL, <i>P</i> < .001). Microplastic density was higher in young subjects than in older ones (values are \"years; particles/mL\"; 18-30; 2.79 ± 1.22, 31-45; 2.18 ± 1.13, 46-60; 1.5 ± 1.09, <i>P</i> < .05). In logistic procedures, microplastic density of NLF (OR = 2.20, 95% CI [1.02 to 4.75], <i>P</i> = .04) determine the likelihood of sneezing.ConclusionsIn this study, regardless of allergy or nonallergy, higher microplastic density was found in NLF of rhinitis patients than healthy individuals. We also found quantifiable and noteworthy concentrations of microplastics in the nasal lavage of control group. These results support the idea that microplastics cause inflammation in the upper airways.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251357135"},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactic Acid Metabolism-Related Gene May Act as a Prognostic Predictor by FARS2 in Nasopharyngeal Carcinoma.","authors":"Wenxuan Huang, Huanfeng Zhu, Xiang Cao, Guannan Zou, Zixuan Wang, Dan Zong","doi":"10.1177/19458924251334856","DOIUrl":"10.1177/19458924251334856","url":null,"abstract":"<p><p>BackgroundThis study aimed to investigate the clinical value of lactic acid metabolism-related genes (LRGs) in nasopharyngeal carcinoma (NPC).MethodsClinical and genetic information was extracted from the TGCA and Gene Expression Omnibus databases. Consistency clustering was employed to identify NPC subpopulations. Immune infiltration was appraised using TIMER, ESTIMATE, and MCPCounter. Functional analysis was conducted to elucidate potential mechanisms. A prognostic risk model was successfully constructed using the LASSO algorithm and multivariate Cox regression analysis. Phenotypic experiments were conducted to validate the glycolysis and lactic acid metabolism.ResultsAccording to prognostically LRG genes, two clusters were identified and exhibited significant difference in immune landscape, which indicated variations in immune status. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis revealed that the differentially expressed genes were predominantly implicated in immune-related pathways. These findings suggested that the LRG-based risk model could successfully predict the prognosis of NPC patients. Moreover, the risk model retained its predictive potency by stratifying patients with sex and age, with lower risk score patients displaying improved prognosis. In the training cohort, the low-risk group showed significantly lower stromal score, immune score, and ESTIMATE score compared with the high-risk group. To further enhance the precision of prognostic predictions, we developed a nomogram that integrated the risk model with clinical features. In the training cohort, the established nomogram could accurately predict the prognosis of NPC patients. Mechanically, the knockdown of FARS2 in NPC cells resulted in altered glycolysis and lactification. Deregulated FARS2 led to the accumulation of metabolic intensity, which resulted in the disruption of lactic acid metabolism.ConclusionThese results highlighted the potential association between LRGs expression and immune dysfunction, which might contribute to adverse prognosis in NPC patients. This study represented a pioneering effort in exploring the prognostic value of LRGs in NPC.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"309-321"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Era of Comprehensive Rhinology Is Here.","authors":"Michael Platt","doi":"10.1177/19458924251345232","DOIUrl":"https://doi.org/10.1177/19458924251345232","url":null,"abstract":"","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":"39 4","pages":"256-258"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Topical Corticosteroid Irrigations on Sinonasal Wound Healing.","authors":"Jackson R Vuncannon, Khaled A Altartoor, Anastasia Kolousek, Ethan Roback, Andre J Burnham, Michael Koval, Prestina Smith-Davidson, Joshua M Levy","doi":"10.1177/19458924251334854","DOIUrl":"10.1177/19458924251334854","url":null,"abstract":"<p><p>BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease frequently requiring surgical intervention and the long-term use of topical corticosteroids to control patient symptoms. However, corticosteroids may delay postoperative recovery following sinus surgery by disrupting tissue inflammation, a key mediator of early wound healing. This study therefore seeks to assess the impact of topical corticosteroids on sinonasal epithelial healing following local injury.MethodsPrimary human nasal epithelial cells (HNECs) were collected from two patients with CRSwNP and differentiated at air-liquid interface (ALI). A linear scratch was introduced to each monolayer of differentiated HNECs, followed by apical treatment with or without budesonide (2 μg/mL) to simulate topical use. Live-cell imaging assessed time to wound closure. Epithelial barrier function was assessed with trans-epithelial electrical resistance (TEER) before the injury as a baseline, immediately post-injury, and at 12 and 24 hours.ResultsAll wounds closed within 19 hours. The average time to wound closure was 15.1 hours for CRSwNP HNECs exposed to budesonide and 12.3 hours for those exposed to control media. This difference was statistically significant (<i>P</i> = .0033) despite a relatively small cohort. TEER values universally increased following an initial drop from baseline induced by scratch injury. No statistically significant difference in TEER recovery was observed between groups.ConclusionWound closure was delayed in CRSwNP HNECs exposed to budesonide versus control; however, no wounds failed to close, and no difference was identified in the return of epithelial barrier function. Topical corticosteroids may be safely initiated 24 hours following ESS.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"293-299"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Oral Corticosteroid Use Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis.","authors":"Justina Shafik, Kara Sangiuolo, Eden Sheinin, Juan Lin, Meryl B Kravitz, Elizabeth A Borowiec, Christina H Fang","doi":"10.1177/19458924251335075","DOIUrl":"10.1177/19458924251335075","url":null,"abstract":"<p><p>BackgroundPatients with chronic rhinosinusitis (CRS) refractory to medical management often require endoscopic sinus surgery (ESS). Oral corticosteroids (OCSs) are frequently prescribed postoperatively, but the evidence of their efficacy is limited.ObjectiveThe purpose of this study is to evaluate the efficacy of OCS use in patients with CRS following ESS.MethodsA systematic search was performed to identify studies examining the use of OCSs in patients undergoing ESS for CRS. The primary outcomes were sinonasal outcome test (SNOT) and Lund-Kennedy (LK) endoscopic scores. Secondary outcomes were visual analog scale (VAS) scores. Meta-analysis was conducted using a fixed effects model with a heterogeneity test via the I2 statistic.ResultsThe search yielded 1899 articles, and 22 were included in the qualitative analysis, 14 of which were randomized controlled trials with 793 total patients. OCS use differed based on type, dosage, and duration. Studies included in meta-analysis did not show a significant difference in SNOT (Standardized Mean Difference [SMD] -0.03, Confidence Interval [CI] -0.47-0.40, I2 0%), LK (SMD -0.20 CI -0.57-0.17 I2 58%), or VAS (SMD 0.19 CI -0.25-0.63 I2 54%) scores between steroid and non-steroid groups. Two studies that assessed OCSs in the allergic fungal rhinosinusitis (AFRS) subtype of CRS showed significant improvement in outcomes. Two additional studies examined OCS versus itraconazole in AFRS, with both groups showing improvement but neither one with greater significance.ConclusionThis study showed no significant difference in SNOT, LK, or VAS scores in patients with CRS who received OCSs following ESS. Given the limited number of studies in the analysis, further investigations are warranted before making recommendations.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"322-332"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Diabetes Mellitus and Allergic Diseases Sensitized by Different Allergens and the Potential Mechanism of Diabetes Mellitus Affecting Ovalbumin-Induced Allergic Rhinitis.","authors":"Gan Lu, Yan Wang, Huan Huang, Hong-Li Hua, Yang Xi, Shi-Ming Chen, Yong-Gang Kong, Yu Xu, Yu-Qin Deng, Ze-Zhang Tao","doi":"10.1177/19458924251332786","DOIUrl":"10.1177/19458924251332786","url":null,"abstract":"<p><p>ObjectiveTo investigate the association between diabetes mellitus (DM) and allergic diseases caused by different allergens and explore the mechanism of DM in allergic rhinitis (AR) induced by ovalbumin (OVA).MethodsWe established linear regression models to examine the correlation of specific immunoglobulin E (sIgE) and total immunoglobulin E (TIgE) with glycohemoglobin (A1c) and fasting plasma glucose (FPG) in individuals allergic to different allergens by retrospectively analyzing the 2005-2006 National Health and Nutrition Examination Survey database. Participants were classified into Allergy + DM and Allergy groups based on whether they had allergic disease and DM or only allergic disease. An AR mouse model was established using OVA. Mice were randomly assigned to the control, AR, diabetic (db), or db & AR group, with 6 mice in each group. The expression of GATA3, T-bet, and Foxp3 was detected using immunofluorescence and western blotting. Cytokines, FPG, A1c, and immunoglobulin in serum were detected using enzyme-linked immunosorbent assays.ResultsBased on the database, the TIgE and SIgE levels in participants with perennial allergies were lower in the Allergy + DM group than in the Allergy group, whereas those in participants with food allergies were higher in the Allergy + DM group than in the Allergy group. TIgE was negatively correlated with FPG or A1c in participants with perennial allergies and positively correlated with FPG and A1c in participants with egg allergy (among food allergens). In mice, AR symptoms, eosinophilic infiltration, and OVA-induced IgE levels were more serious in the db & AR group than in the AR group. TIgE was positively correlated with FPG, and interleukin-2 (IL-2) was negatively correlated with FPG; this was most pronounced in db & AR mice. The expression of T-bet and Foxp3 in mice was negatively associated with A1c.ConclusionsThe effect of DM on allergic diseases is related to the type of allergen. Decreased IL-2, T-bet, and Foxp3 levels resulting from elevated FPG and A1c levels may be involved in the association between OVA-induced AR and DM.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"271-283"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}