American Journal of Rhinology & Allergy最新文献

{"title":"Synthetic Grafts to Prevent Nasal Septal Perforation After Bilateral Mucosal Tears During Septal Surgery.","authors":"Anthony P Di Ponio, Carl P Wilson, Robert H Deeb, John R Craig","doi":"10.1177/19458924251388802","DOIUrl":"https://doi.org/10.1177/19458924251388802","url":null,"abstract":"<p><p>BackgroundSeptoplasty is a common cause of nasal septal perforation (NSP), especially when bilateral apposing septal mucosal tears (BATs) occur intraoperatively. While prior studies have largely focused on NSP management once formed, there is limited evidence on how to prevent NSPs should BATs occur during septal surgery.ObjectiveThe purpose of this study was to assess the efficacy of intraseptal synthetic interposition graft (SIG) placement to prevent NSPs following BATs during septal surgery.MethodsA single-institution retrospective cohort study was conducted with adult patients who underwent septoplasty or septorhinoplasty by 2 surgeons. Patients who had BATs intraoperatively had SIGs placed between the septal flaps (cadaveric acellular dermal or porcine collagen grafts). Patients were monitored endoscopically for NSP development at a minimum of 2 months postoperatively.ResultsOf 1132 operative patients between January 2016 and July 2024, 50 patients (4.4%) experienced BATs and had SIGs placed intraoperatively. Of the 50 patients, the median age was 52.7 years, 72.0% were males, and the median follow-up duration was 4.8 months (range: 2.0-85.4). Regarding the SIGs placed, 54.0% were porcine collagen and 46.0% were cadaveric dermis. While 46/50 patients experienced complete mucosalization of their BATs (92.0%), 4 developed NSPs postoperatively (8.0%). Two NSPs occurred within 2 months postoperatively, and 2 were delayed after complete mucosalization. All NSPs occurred following porcine collagen grafts.ConclusionIntraseptal synthetic IP graft placement demonstrated 92% success in preventing NSPs following BATs during septal surgery. Future studies should explore the efficacy of different SIGs at preventing NSPs following BATs during septal surgery.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251388802"},"PeriodicalIF":2.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction Model for Recurrence After Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps.","authors":"Virat Kirtsreesakul, Paramee Thongsuksai, Nuttha Sanghan, Chakapan Promsopa","doi":"10.1177/19458924251389175","DOIUrl":"https://doi.org/10.1177/19458924251389175","url":null,"abstract":"<p><p>BackgroundRecurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) following endoscopic sinus surgery (ESS) is common, with reported rates varying considerably depending on follow-up duration. A clinically practical and reliable model for predicting long-term recurrence risk remains an unmet need.ObjectiveTo identify clinical predictors of recurrence and develop a prognostic model for estimating recurrence-free survival at 2, 5, 10, and 15 years after ESS.MethodsA retrospective, single-institution cohort study of 437 patients with CRSwNP who underwent ESS was analyzed for time-to-event recurrence. Candidate predictors, including age, sex, smoking status, asthma, NSAID hypersensitivity, symptom duration, blood eosinophil count (BEC), modified Lund-Kennedy (MLK) score, and Lund-Mackay (LM) score, were entered into a LASSO penalized Cox model for variable selection. A nomogram was constructed to estimate recurrence-free survival at predefined time points. Model performance was assessed using time-dependent area under the ROC curve (AUROC), Brier scores, calibration curves, internal validation via 1000 bootstrap resamples, and clinical utility through decision curve analysis (DCA).ResultsRecurrence occurred in 54.0% of patients. The LASSO-penalized Cox model identified age, NSAID hypersensitivity, asthma, symptom duration, BEC, MLK, and LM scores as significant predictors. The nomogram demonstrated strong discrimination, with AUROCs of 0.878, 0.870, 0.886, and 0.873 at 2, 5, 10, and 15 years post-ESS, respectively. Corresponding Brier scores were 0.150, 0.147, 0.135, and 0.138, indicating low prediction error. Internal validation confirmed the model's stability, with AUROCs of 0.873, 0.866, 0.879, and 0.864 at the same time points. Calibration plots showed good agreement between predicted and observed outcomes across all time horizons. DCA demonstrated greater net benefit compared to treat-all or treat-none strategies across the 0.1 to 0.9 threshold range.ConclusionThe nomogram developed using a LASSO-penalized Cox model offers a robust, well-calibrated, and clinically applicable tool for individualized long-term recurrence risk prediction in patients with CRSwNP following ESS.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251389175"},"PeriodicalIF":2.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxiredoxin 2 Alleviates Oxidative Stress-Induced Epithelial Remodeling in Chronic Rhinosinusitis with Nasal Polyps.","authors":"Ru Gao, Yu Chen, Honghui Liu, Maoyu Ye, Ling Chu, Tiansheng Wang","doi":"10.1177/19458924251386929","DOIUrl":"https://doi.org/10.1177/19458924251386929","url":null,"abstract":"<p><p>ObjectiveChronic rhinosinusitis with nasal polyp (CRSwNP) is a chronic inflammatory disease characterized by epithelial remodeling. This study aimed to investigate the role of peroxiredoxin 2 (PRDX2) in CRSwNP and its potential mechanisms.MethodsProteomics analysis was conducted on nasal tissues from CRSwNP patients and healthy controls. Top-rank differentially expressed proteins were validated by immunofluorescence (IF) staining and reverse transcription quantitative-polymerase chain reaction (RT-PCR). In vitro experiments validated the effects and regulatory mechanisms of PRDX2 on nasal epithelial remodeling.ResultsProteomics results revealed a disease-specific protein expression profile in CRSwNP polyp tissues, with DEGs primarily associated with oxidative stress. Our validation results demonstrated elevated reactive oxygen species (ROS) levels in CRSwNP with predominant accumulation in the nasal epithelium. Among these DEGs, PRDX2 was the most significantly downregulated, which was further confirmed by RT-PCR and IF. Moreover, PRDX2 was primarily expressed in nasal epithelial cells (NECs). RT-PCR results indicated that tissue PRDX2 expression was positively correlated with E-cadherin and negatively correlated with TGF-β1 and Vimentin expression in CRSwNP. In vitro experiments demonstrated that H₂O₂ stimulation promoted ROS and epithelial-mesenchymal transition (EMT) in NECs, while PRDX2 overexpression (OE) mitigated these effects. Furthermore, PRDX2 OE suppressed the H₂O₂-induced activation of the TGF-β1/SMAD signaling pathway, which plays a crucial role in regulating EMT in NECs.ConclusionOur findings suggest that the accumulation of ROS plays a critical role in the pathogenesis of CRSwNP. PRDX2 modulates ROS-induced epithelial remodeling, contributing to disease progression by activating the TGF-β1/Smad signaling pathway.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251386929"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Race and Ethnicity in Chronic Rhinosinusitis With Nasal Polyps: A Scoping Review.","authors":"Arthur W Wu, Mishek Thapa, Mahdi Alghezi, Eugene Oh, Hector A Perez, Dennis M Tang, Yi-Tsen Lin, Aria Jafari, Waleed M Abuzeid","doi":"10.1177/19458924251384391","DOIUrl":"https://doi.org/10.1177/19458924251384391","url":null,"abstract":"<p><p>BackgroundRace or ethnicity may influence chronic rhinosinusitis (CRS) endotype. Asian patients with CRS with nasal polyps (CRSwNP) may have increased Th1/Th17/mixed endotypes. However, there is a paucity of research concerning the endotype of non-Caucasian and non-Asian patients.ObjectiveThis review seeks to summarize literature as it pertains to associations between race or ethnicity and endotype with the goal highlighting knowledge gaps to guide future inquiry.MethodsSystematic scoping review methodology was used to summarize the current literature in accordance with PRISMA guidelines.ResultsOf the 8877 articles identified, 261 articles pertaining to race or ethnicity and endotype in CRSwNP were included. 163 studies with race or ethnicity-specific data involved Asian patients and demonstrated increased presence of Th1, Th17, and mixed endotypes, but also increasing prevalence of Th2 endotypes in multiple countries across Asia. There were 56 studies involving Caucasian patients demonstrating a predominance of Th2 endotypes though several recent studies also demonstrated that mixed inflammation may contribute to disease. There was a relative lack of literature involving other races and ethnicities, specifically: South Asian (<i>n</i> = 2), Middle Eastern (<i>n</i> = 9), African/African-American (<i>n</i> = 16), and Latino/Hispanic-American (<i>n</i> = 9). Allergic fungal rhinosinusitis appeared relatively prevalent in South Asian, Middle Eastern and African/African-American patients, though, relatively low numbers of studies and patients preclude definitive conclusions.ConclusionThis scoping review demonstrates that both race and ethnicity appear to play a role in affecting CRSwNP endotype. Additional research is necessary to investigate these factors, particularly in non-Caucasian and non-Asian patients.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251384391"},"PeriodicalIF":2.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent Risk Patterns of Upper Airway Inflammation in Autoimmune Diseases: A Nationwide Retrospective Analysis.","authors":"Jessan A Jishu, Cameron Galic, Abdelrahman Shata, Gabriel J Montclare, Hunter Leggett, Reyna Halalsheh, Manal S Fawzy, Eman A Toraih","doi":"10.1177/19458924251386200","DOIUrl":"https://doi.org/10.1177/19458924251386200","url":null,"abstract":"<p><p>ObjectivesWhile autoimmune diseases (ADs) are known for systemic inflammation, their specific association with upper airway inflammation (UAI) has not been extensively characterized. We aim to investigate the associations between various ADs and subsequent UAI development in a large, national cohort.MethodsThis retrospective cohort study utilized de-identified electronic health records from TriNetX, a national collaborative database. Adolescent and adult patients with a diagnosis of 1 or more ADs were identified. A 12 month washout period was implemented to exclude preexisting UAI. The primary outcome was the incidence of UAI (chronic rhinosinusitis, allergic rhinitis, nonallergic rhinitis, chronic laryngitis, obstructive sleep apnea) following AD diagnosis. Hazard ratios and relative risks (RRs) with 95% confidence intervals (CIs) were calculated.ResultsAfter propensity matching, 1 327 186 patients with ADs and 1 327 186 controls were included. Patients with ADs exhibited a significantly lower overall incidence of UAI compared to controls (9.11% vs 13.81%; RR 0.71, 95% CI 0.70-0.71). This reduced risk was notable for allergic rhinitis (RR 0.64, 95% CI 0.64-0.65) and chronic sinusitis (RR 0.88, 95% CI 0.87-0.89). Juvenile idiopathic arthritis and type 1 diabetes demonstrated the most pronounced reductions in UAI risk. However, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis were associated with a significantly increased risk of UAI.ConclusionMost ADs were associated with a reduced overall risk of subsequent UAI. However, certain vasculitides significantly increased UAI risk, highlighting disease-specific pathophysiological mechanisms. These findings suggest a complex interplay between systemic autoimmunity and localized airway inflammation, warranting further investigation into underlying mechanisms and the impact of AD treatments.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251386200"},"PeriodicalIF":2.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice Patterns and Outcomes of Dacryocystorhinostomy for Secondary Nasolacrimal Duct Obstruction.","authors":"Lily C Farrell, Piotr K Kopinski, Mohamad Rani Hassoun, Jeffrey P Graves, Janalee K Stokken, Andrea A Tooley, Elizabeth A Bradley, Lilly H Wagner","doi":"10.1177/19458924251386210","DOIUrl":"https://doi.org/10.1177/19458924251386210","url":null,"abstract":"<p><p>BackgroundSinonasal pathology, such as chronic inflammatory disease or neoplasm, can cause secondary nasolacrimal duct obstruction (sNLDO). There is a paucity of data on dacryocystorhinostomy (DCR) techniques and outcomes for NLDO secondary to known sinonasal pathologies.ObjectiveTo describe case characteristics, management, and surgical outcomes of sNLDO at a tertiary academic center.MethodsCharts of DCR cases with at least 3 months follow-up done at a single institution over a 5-year period (2018-2022) were reviewed. Patient and surgical characteristics were recorded and compared between secondary and primary NLDO groups. The primary outcome was early functional success of DCR, assessed by improvement or resolution of epiphora at 3 months.ResultsA total of 236 cases were included. Of those, 79 (33.5%) were classified as secondary NLDO associated with sinonasal pathology. Reasons for sNLDO were sinonasal cancer (46.8%), chronic inflammatory disease (24.1%), trauma (16.5%), or prior head and neck radiation (31.6%). When comparing primary acquired NLDO to sNLDO cases, DCR for sNLDO was more likely to be performed endoscopically (68.4% vs 31.8%, <i>P</i> < .01), by a multidisciplinary team of rhinologist and oculoplastic surgeon (70.9% vs 8.3%, <i>P</i> < .01), and required bilateral surgery (36.7% vs 5.7%, <i>P</i> < .01). The overall functional success rate was 79.7% for sNLDO compared to 87.9% for primary acquired NLDO (<i>P</i> < .01). Revision surgery for sNLDO, history of sinonasal malignancy, and radiation were associated with lower functional success rates (66.7%, 70.3%, and 68.0%, respectively). Canalicular pathology was more common in sNLDO cases (29.0% vs 8.3%, <i>P</i> < .01).ConclusionsSecondary NLDO was more commonly managed with an endoscopic approach by a multidisciplinary team. Revisions for sNLDO, as well as cases with a history of sinonasal malignancy and radiation, had a markedly lower success rate, and sNLDO was frequently associated with canalicular obstruction. These findings may facilitate surgical planning and patient counseling.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251386210"},"PeriodicalIF":2.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Disparities in Management of Chronic Rhinosinusitis by Race and Ethnicity: An All of Us Research Program Study.","authors":"Christina Zhu, Wynne Zheng, Emily Clementi, Maeen Arslan, Christopher Guirguis, Daniel Spielman","doi":"10.1177/19458924251383016","DOIUrl":"https://doi.org/10.1177/19458924251383016","url":null,"abstract":"<p><p>ObjectiveTo evaluate disparities in the management of chronic rhinosinusitis (CRS) across racial, ethnic, and gender groups, focusing on treatment patterns and associated comorbidities.MethodsThis cross-sectional study analyzed data from 28,278 adults with CRS in the NIH All of Us Research Program between 2018 and 2022. Multivariable logistic regression was used to assess associations between demographic variables, associated comorbidities, and receipt of treatments including systemic steroids, leukotriene modifiers, antibiotics, biologics, and sinus surgery.ResultsBlack individuals had higher odds of receiving systemic steroids (OR: 1.59, <i>P</i> < .0001) and antibiotics (OR: 1.67, <i>P</i> < .0001), but were less likely to receive biologics (OR: 0.30, <i>P</i> = .051). Non-Hispanic individuals were more likely to receive systemic steroids (OR: 1.54, <i>P</i> < .001) and antibiotics (OR: 1.54, <i>P</i> = .0007), but were less likely to undergo sinus surgery (OR: 0.67, <i>P</i> = .016). Male sex was associated with reduced odds of receiving systemic steroids (OR: 0.86, <i>P</i> < .0001), leukotriene modifiers (OR: 0.81, <i>P</i> < .001), and antibiotics (OR: 0.91, <i>P</i> < .001) but increased odds of undergoing surgery (OR: 1.37, <i>P</i> < .0001). Presence of nasal polyps and comorbid asthma strongly predicted use of biologics (ORs: 4.39 and 13.83, respectively, <i>P</i> < .0001) and surgical intervention (ORs: 13.13 and 1.34, respectively, <i>P</i> < .0001).ConclusionSignificant racial, ethnic, and gender disparities exist in the treatment of CRS, independent of comorbidities. These findings highlight the need for equity-focused strategies to ensure timely access to advanced therapies and to address structural barriers that may influence treatment allocation.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251383016"},"PeriodicalIF":2.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Nasal Nerve Neurectomy With Mucosal Flap Coverage of the Sphenopalatine Foramen for Treatment of Allergic Rhinitis: 12-Month Outcomes After Treatment in a Prospective Cohort Study.","authors":"Linlu Wang, Huiyi Deng, Qintai Yang, Shuo Wu","doi":"10.1177/19458924251382757","DOIUrl":"https://doi.org/10.1177/19458924251382757","url":null,"abstract":"<p><p>ObjectivesPosterior nasal nerve (PNN) neurectomy is an effective surgical option for refractory allergic rhinitis (AR), but delayed massive hemorrhage remains a concern. This study aimed to evaluate whether preserving a mucosal flap to cover the sphenopalatine foramen (SPF) affects postoperative efficacy and complications.MethodsThis prospective cohort study included 61 patients with moderate-to-severe AR who underwent PNN neurectomy. Patients were divided into two groups based on whether a mucosal flap was preserved to cover the SPF. Outcomes included mucosal epithelialization time, incidence of delayed bleeding, Visual Analog Scale (VAS), reflective Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), nasal airway resistance (NAR), and inflammatory markers. Follow-up was conducted at 1, 3, 6, and 12 months postoperatively.ResultsNo significant differences were found between groups in baseline characteristics. Both groups showed significant improvements in VAS, rTNSS, RQLQ, and NAR, with sustained benefits up to 12 months. The With Mucosal Flap Preservation group had a significantly shorter epithelialization time (<i>P</i> < .001) and lower incidence of delayed bleeding (<i>P</i> = .046). Mediation analysis indicated that epithelialization time mediated the relationship between the surgical method and delayed bleeding (<i>P</i> = .046), while the direct effect was not significant (<i>P</i> = .748).ConclusionThis study shows that PNN neurectomy with mucosal flap preservation reduces the risk of delayed postoperative bleeding through the key mediating mechanism of accelerated mucosal epithelialization, while achieving comparable improvements in nasal symptom relief and quality of life compared to the procedure without mucosal flap preservation.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251382757"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Dental Intervention and Disease on Acute Invasive Fungal Rhinosinusitis Severity and Outcomes.","authors":"Jakob L Fischer, Nikitha Kosaraju, Katherine M Lucarelli, Connie M Sears, Jivianne T Lee, Daniel M Beswick, Daniel B Rootman, Marilene B Wang, Jeffrey D Suh","doi":"10.1177/19458924251382514","DOIUrl":"https://doi.org/10.1177/19458924251382514","url":null,"abstract":"<p><p>BackgroundAcute invasive fungal rhinosinusitis (AIFRS) is an aggressive and often fatal disease process that principally impacts immunocompromised patients. Maxillary dental trauma and infections have been associated with the development of maxillary sinus fungal balls, but the role of dental procedures/trauma in the pathogenesis of AIFRS remains poorly defined.ObjectiveThis study seeks to review a single-institutional experience with AIFRS and examine the association between dental events and AIFRS severity and outcomes.MethodsRetrospective review of 95 consecutive patients with biopsy-proven AIFRS treated at a tertiary institution between 2010 and 2024. Demographic information, comorbidities, disease course and outcomes were evaluated. The primary objective was to evaluate the impact of antecedent dental events on AIFRS morbidity and mortality. Secondary objectives included evaluating variability in demographic factors, comorbidities, and extent of disease.ResultsEleven patients with an antecedent dental event within 2 weeks of AIFRS diagnosis were identified for a rate of 11.6%. Dental AIFRS patients were more likely to be African American (<i>P</i> = .003) and more likely to have diabetes mellitus as their underlying immunodeficiency (<i>P</i> = .03) than non-dental AIFRS patients. Patients with dental-related AIFRS were more likely to present with invasion of the orbit (OR 6.0, 95% CI 1.2-29.5) and nasal floor (OR 4.2, 95% CI 1.1-17.1) than non-dental AIFRS patients. There was no difference in mortality between dental and non-dental AIFRS (36.4% vs 52.4%, <i>P</i> = .31).ConclusionMore investigation is necessary to further evaluate the association between dental events and the development of AIFRS. In our cohort, 11.6% of patients experienced AIFRS within 2 weeks of a dental event and these patients tended to present with higher rates of orbital involvement without a resultant increase in mortality.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251382514"},"PeriodicalIF":2.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Previous Temporary Nasolacrimal Stent Implantation on Endoscopic Dacryocystostomy.","authors":"Linjuan Wu, Xinyu Li, Guangming Zhou, Wencan Wu, Wentao Yan, Bo Yu","doi":"10.1177/19458924251382085","DOIUrl":"https://doi.org/10.1177/19458924251382085","url":null,"abstract":"<p><p>AimsWe compared the outcomes of endoscopic dacryocystorhinostomy (En-DCR) in patients with chronic dacryocystitis (CD), with or without previous temporary nasolacrimal stent implantation (TNLSI), then explored whether previous TNLSI influenced postoperative outcomes.MethodsThis retrospective study included consecutive patients with CD and previous TNLSI who underwent En-DCR (group A) between September 2019 and May 2022, and an age- and sex-matched control group of patients with CD who had not undergone previous implantation (group B). Lacrimal sac parameters were measured by computed tomography-dacryocystography, and surgical findings were recorded during surgeries. The surgical success rates were compared between the two groups at 12 months after surgery.ResultsThere were 53 patients in group A and 106 patients in group B. In group A, the mean horizontal, sagittal, and vertical lengths were 4.94 ± 1.30 mm, 4.88 ± 1.17 mm, and 7.85 ± 2.03 mm; in group B, these three lengths were 6.16 ± 1.25 mm, 5.97 ± 1.20 mm, and 10.00 ± 2.18 mm, respectively. All three parameters were significantly smaller in group A than in group B. Scar formation in the sac was observed in all patients in group A; it was not present in group B. At 12 months after surgery, the anatomical and functional success rates were 75.47% (40/53) and 71.70% (39/53), respectively, in group A; they were 93.40% (99/106) and 91.51% (97/106) in group B. The success rates were significantly higher in group B than in group A.ConclusionPrevious TNLSI may reduce lacrimal sac parameters and cause scar formation, thereby reducing the likelihood of success after En-DCR.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924251382085"},"PeriodicalIF":2.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}