American Journal of Rhinology & Allergy最新文献

{"title":"The Post Review Analysis: Enhancing My Practice, Anticipating the Future, and Maybe Some Validation.","authors":"Patricia G Johnson","doi":"10.1177/19458924261487657","DOIUrl":"https://doi.org/10.1177/19458924261487657","url":null,"abstract":"","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":"40 6","pages":"468-469"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Sensitization Status and Its Association With Severe Epiphora (Suspected Lacrimal Duct Obstruction): Insights From NHANES.","authors":"Hua Sun, Xin Shen, Rui Dong, Kegao Liu","doi":"10.1177/19458924261452420","DOIUrl":"10.1177/19458924261452420","url":null,"abstract":"<p><p>BackgroundLacrimal duct obstruction (LDO) is a prevalent cause of epiphora, traditionally attributed to involutional stenosis or infection. The role of systemic atopy in the pathogenesis of LDO remains unclear. This study aims to investigate the association between specific allergic sensitization and severe epiphora/suspected LDO using a nationally representative sample.MethodsThis cross-sectional study analyzed data from 5420 adults in the national health and nutrition examination survey (NHANES) ranging from 2005 to 2006. Severe epiphora, serving as a clinical proxy for suspected LDO, was defined by frequent tearing (ie, epiphora) in the absence of acute infection. Allergic sensitization was assessed via serum specific IgE (sIgE) to 19 aeroallergens and food allergens. Weighted logistic regression and restricted cubic splines (RCS) were used to evaluate associations.ResultsThe weighted prevalence of suspected LDO was 14.2%. Any allergic sensitization (sIgE ≥ 0.35 ku/l) was significantly associated with suspected LDO (OR 1.48, 95% CI 1.21-1.82). Specifically, sensitization to aeroallergens conferred a 56% increased risk, whereas food sensitization showed no significant association. A J-shaped nonlinear dose-response relationship was observed between total IgE levels and suspected LDO risk. Subgroup analyses revealed stronger associations in adults aged < 60 years.ConclusionSystemic allergic sensitization is an independent risk factor associated with severe epiphora/suspected LDO. Chronic mucosal inflammation driven by aeroallergens may compromise nasolacrimal patency. Anti-allergic management should be considered in patients with epiphora who exhibit signs of atopy.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"494-502"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Utilization in Patients With Chronic Rhinosinusitis With Nasal Polyps - Analysis of the Reg-ent Clinical Data Registry.","authors":"Christina H Fang, Denisa Ferastraoaru, Hyun Song, Richard V Smith, Patrick Colley, Nadeem A Akbar, Elizabeth A Borowiec","doi":"10.1177/19458924261498481","DOIUrl":"https://doi.org/10.1177/19458924261498481","url":null,"abstract":"<p><p>BackgroundPatients with chronic rhinosinusitis with nasal polyps (CRSwNP) who fail medical management are often offered endoscopic sinus surgery (ESS). Dupilumab is also used to treat patients with inadequately controlled CRSwNP.ObjectiveThis retrospective cohort study uses a national registry to examine the patterns in healthcare utilization in patients with CRSwNP.MethodsA review of the AAO-HNSF Reg-ent^SM data registry of CRSwNP patients who underwent ESS or received dupilumab from 2019 to 2025 was performed. The primary outcome of oral antibiotic and corticosteroid free-probability was summarized by Kaplan-Meier estimates and compared between dupilumab treatment and surgery by piecewise Cox proportional hazards model with follow-up time split at 6 months while adjusting for age, sex, ethnicity, race, history of asthma, and allergic rhinitis. Secondary outcomes include polyp recurrence/persistence and repeat imaging.Results12,944 patients were included. Kaplan-Meier analysis demonstrated the hazard ratio changing over time indicating lower relative hazard of post-intervention antibiotics/corticosteroid use early on among patients who were treated with dupilumab, but the relative hazard of the group increased over time. Antibiotic/corticosteroid use was lower among dupilumab treated patients compared to ESS patients (HR = 0.873; aHR = 0.740; p < 0.0001) in the first 6 months, but they demonstrated higher antibiotic/corticosteroid use thereafter (HR = 1.60, aHR = 1.279; p < 0.0012). There was an increased risk of nasal polyp recurrence/persistence in the dupilumab group during both time periods (aHR = 1.189 & 2.040 before and after 6 months, p < 0.0005 & 0.0001). During the first 6 months, the hazard of repeat imaging was higher among dupilumab patients compared to ESS patients (aHR = 2.098; p < 0.0001). After 6 months, the hazard among dupilumab patients was lower than the ESS patients (aHR = 0.409, p < 0.0001).ConclusionCRSwNP patients treated with dupilumab and ESS demonstrated variable healthcare utilization over time, highlighting the importance of patient selection and shared decision making when considering initiation of dupilumab therapy for CRSwNP.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261498481"},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ramadan Fasting-Associated Improvement in Chronic Rhinosinusitis Symptoms.","authors":"Doğan Çakan, Harun Cansiz, Firat Tevetoglu, Haluk Çevik, Yavuz Beşli, Zeliha Kübra Çakan","doi":"10.1177/19458924261495213","DOIUrl":"https://doi.org/10.1177/19458924261495213","url":null,"abstract":"<p><p>BackgroundChronic rhinosinusitis (CRS) is a common disease that markedly impairs quality of life. Although Ramadan fasting (RF) has demonstrated influences on nasal physiology, its effects on sinonasal symptoms in CRS patients remain unclear.ObjectiveThis study aimed to investigate the symptom changes of patients with CRS during RF.MethodsThis prospective study included 42 male CRS patients and 42 healthy male individuals. Participants underwent nasal endoscopic evaluations, and their Lund-Kennedy scores were recorded. Sinonasal symptoms, including nasal congestion, nasal discharge, postnasal drip, olfactory disturbance, facial pain/pressure, headache, and overall symptoms, were assessed using a visual analog scale (VAS) on day 0, the first and last days of RF (days 1 and 30), and at the study's end (day 210). Participants' body weights were recorded on days 0 and 210, and the collected data were analyzed statistically.ResultsThe patients' scores were significantly higher than those of healthy individuals on all study days. Significant differences were observed in nasal congestion, nasal discharge, postnasal drip, olfactory disturbance, and overall symptoms at various study periods. On day 0, scores for nasal congestion, nasal discharge, and postnasal drip were significantly higher than on days 1 and 30. Olfactory disturbance and overall symptoms were also higher on day 0 compared to day 30. On day 210, nasal discharge and postnasal drip scores were significantly higher than on days 1 and 30, while nasal congestion, olfactory disturbance, and overall symptoms were higher than on day 30 (<i>p</i> < 0.05).ConclusionThis study demonstrated that RF was associated with temporary improvement in nasal congestion, nasal discharge, postnasal drip, olfactory disturbance, and overall sinonasal symptoms in CRS patients.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261495213"},"PeriodicalIF":2.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"High Response Rates and Predictors in Patients with CRSwNP Treated With Mepolizumab and Dupilumab: Results From a Prospective, Multicenter Cohort Study\".","authors":"","doi":"10.1177/19458924261457294","DOIUrl":"https://doi.org/10.1177/19458924261457294","url":null,"abstract":"","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261457294"},"PeriodicalIF":2.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and Purification of Staphylococcal Enterotoxin B and Detection of SEB-Specific IgG Antibodies in Allergic Children.","authors":"Huixin Gao, Yuqian Yan, Qingling Ma, Xiaolan Ai, Hao Zheng, Zhenwen Zhou, Yunfeng Liu","doi":"10.1177/19458924261493373","DOIUrl":"https://doi.org/10.1177/19458924261493373","url":null,"abstract":"<p><p>ObjectiveThis study aims to express and purify staphylococcal enterotoxin B (SEB) and to detect and analyze the levels of SEB-specific IgG antibodies in the serum of children with food or aeroallergen allergies using an enzyme-linked immunosorbent assay (ELISA).MethodsSEB protein was expressed and purified in a recombinant pET-28<i>α</i>(+)-SEB <i>E. coli</i> system. The purified SEB protein was used as an antigen to detect SEB-IgG antibody levels in the serum of 100 clinically confirmed cases of food-allergic and aeroallergen-allergic children, and the results were compared with those of 50 healthy children using ELISA.ResultsThe recombinant SEB protein, with a molecular weight of approximately 35 kDa, was successfully expressed and purified. ELISA results showed that the SEB-IgG antibody levels in the serum of food-allergic and aeroallergen-allergic children (OD450 values of 0.30 ± 0.03 and 0.31 ± 0.04, respectively) were significantly higher than those in the normal control group (0.24 ± 0.05, <i>P</i> < .05). However, there was no significant difference in SEB-IgG antibody levels between food-allergic children and aeroallergen-allergic children (<i>P</i> > .05). The positive rate of SEB-IgG antibodies was 68% in aeroallergen-allergic children and 56% in food-allergic children. SEB-IgG positivity increased with the number of allergens but was not correlated with the severity of the allergy.ConclusionThis study successfully expressed and purified SEB protein in a prokaryotic system. We found that SEB-IgG antibody levels were significantly higher in allergic children compared to healthy controls and were related to the number of allergens. These results suggest an association between SEB exposure and allergic diseases in the pediatric population, highlighting its potential role as an immunomodulator and laying a foundation for further mechanistic and clinical investigations.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261493373"},"PeriodicalIF":2.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancies Between SNOT-22 Questionnaire, Objective Assessments, and Histopathologic Findings in Chronic Rhinosinusitis With Nasal Polyps.","authors":"Elchanan Zloczower, Eitan Shavit, Nir Tsur, Raviv Allon, Yuval Cohen, Naama Ronel, Yael Shapira-Galitz, Meir Warman","doi":"10.1177/19458924261492820","DOIUrl":"https://doi.org/10.1177/19458924261492820","url":null,"abstract":"<p><p>BackgroundThe Sinonasal Outcome Test-22 (SNOT-22) is widely used to evaluate symptom burden in chronic rhinosinusitis with nasal polyps (CRSwNP), yet its relationship with objective disease measures, pathological features, and specific endotypes remains unclear.ObjectiveTo assess correlations between SNOT-22 scores, including subdomains, and clinical, radiologic, and histopathologic features in patients undergoing endoscopic sinus surgery (ESS) for CRSwNP.MethodsWe retrospectively reviewed records of 83 adult patients with CRSwNP treated with ESS at a single tertiary medical center between 2018 and 2024. All patients completed the SNOT-22 questionnaire and underwent preoperative computed tomography imaging. Nasal polyp scores (NPS), Lund-Mackay staging, and histopathologic characteristics were documented. Correlations between SNOT-22 domains and demographic, clinical, objective parameters, and histopathological findings were analyzed using appropriate statistical tests.ResultsThe mean preoperative SNOT-22 total score was 55.9 ± 23.5. No significant associations were observed between total SNOT-22 scores and Lund-Mackay staging, NPS, or clinical endotypes. Female sex correlated with higher rhinologic subdomain scores (<i>P</i> = .037). Higher NPS demonstrated an association with greater emotional burden (Pearson correlation coefficient = 0.249, <i>P</i> = .038). Among histopathologic features, tissue eosinophil count showed a nonsignificant trend toward higher emotional subdomain scores (<i>P</i> = .081). No other significant correlations were identified.ConclusionsIn this cohort, SNOT-22 scores and their subdomains showed limited correlation with objective measures of disease severity, radiologic burden, endotype classification, and histopathologic findings. These findings underscore the complex interplay between subjective symptom perception and objective disease markers in CRSwNP.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261492820"},"PeriodicalIF":2.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypropylene Microplastics Disrupt Epithelial Barrier Integrity and Viability in Human Airway Epithelial Cells.","authors":"Ji Hyun An, Hla Myat Mo Mo, Hye Ji Yang, Yong Min Kim","doi":"10.1177/19458924261488144","DOIUrl":"https://doi.org/10.1177/19458924261488144","url":null,"abstract":"<p><p>ObjectiveTo investigate the effects of polypropylene microplastics (PP-MPs) on the integrity and viability of upper airway epithelial cells and to elucidate the underlying mechanisms.MethodsHuman nasal primary epithelial cells and a human alveolar epithelial cell line A549 were exposed to PP-MPs. Intracellular reactive oxygen species (ROS) production, epithelial-mesenchymal transition (EMT) markers (N-cadherin, vimentin), and tight junction (TJ) proteins (ZO-1, E-cadherin, occludin) were analyzed. Activation of the TGF-β/p38 mitogen-activated protein kinase (MAPK) signaling pathway was evaluated. In addition, the effects of the ROS scavenger N-acetyl-L-cysteine (NAC) were assessed.ResultsPP-MP exposure significantly increased intracellular ROS production and induced EMT, as evidenced by upregulation of N-cadherin and vimentin, along with downregulation of TJ proteins, including ZO-1, E-cadherin, and occludin. These changes were associated with activation of the TGF-β/p38 MAPK signaling pathway. NAC treatment effectively reversed these effects, restoring epithelial barrier integrity.ConclusionPP-MPs induce EMT and impair epithelial barrier function through ROS-mediated activation of the TGF-β/p38 MAPK pathway. These findings highlight the potential respiratory health risks associated with MP exposure.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261488144"},"PeriodicalIF":2.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelve-Month Effectiveness of Dupilumab on Eosinophilic Otitis Media in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps: A Multicenter Observational Study.","authors":"Cosimo Galletti, Giovanna Stilo, Federico Sireci, Federica Giammona Indaco, Daniele Portelli, Maria Antonietta Barbieri, Silvia Frangipane, Giorgia Giunta, Riccardo Manzella, Maria Grazia Ferrisi, Angelo Immordino, Salvatore Maira, Antonino Maniaci, Francesco Ciodaro, Francesco Dispenza, Salvatore Cocuzza, Francesco Galletti, Salvatore Gallina, Ignazio La Mantia, Bruno Galletti","doi":"10.1177/19458924261480415","DOIUrl":"https://doi.org/10.1177/19458924261480415","url":null,"abstract":"<p><p>BackgroundEosinophilic otitis media (EOM) is a refractory type 2 inflammatory disease of the middle ear, frequently associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Conventional otologic treatments often provide incomplete or transient benefit. Because EOM and CRSwNP may share a type 2 inflammatory pathway involving the nasal, Eustachian tube, and middle-ear compartments, biologic therapy may offer benefit beyond sinonasal disease control. Long-term multicenter real-world data on dupilumab in patients with concomitant EOM and severe CRSwNP remain limited.ObjectiveTo evaluate the 12-month effectiveness of dupilumab on subjective and objective otologic outcomes in adults with EOM and severe CRSwNP.MethodsIn this multicenter observational cohort, 48 adults with severe CRSwNP and concomitant EOM, diagnosed according to Iino criteria, received dupilumab 300 mg every 2 weeks. Otologic outcomes included the Chronic Otitis Media Outcome Test 15 (COMOT-15; range 0-75) and tympanometry. Sinonasal outcomes, including Nasal Polyp Score, SNOT-22, and visual analog scale of nasal congestion, were secondary measures. Outcomes were evaluated at baseline, 6 months, and 12 months.ResultsDupilumab was associated with progressive improvement in EOM-related outcomes. Median COMOT-15 decreased from 49 at baseline to 20 at 6 months and 15 at 12 months (<i>P</i> < 0.0001). Tympanometry improved from 32 type B and 16 type C patterns at baseline to predominantly type A patterns at 12 months. Sinonasal outcomes also improved: median NPS decreased from 6 to 3 and 2, SNOT-22 from 68 to 28 and 22, and VAS nasal congestion from 8 to 2 and 1 at 6 and 12 months, respectively (all <i>P</i> < 0.0001). Peripheral eosinophil counts did not significantly decrease.ConclusionIn patients with severe CRSwNP and concomitant EOM, dupilumab was associated with sustained 12-month improvement in EOM-related quality of life and tympanometric patterns, supporting further investigation within a one-airway-one-ear type 2 framework.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261480415"},"PeriodicalIF":2.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"lncRNA DANCR Enhances Inflammatory Response in Allergic Rhinitis by Inhibiting miR-338-3p.","authors":"Jinkai Han, Bin Liu, Yang Wang, Ning Li","doi":"10.1177/19458924261484683","DOIUrl":"https://doi.org/10.1177/19458924261484683","url":null,"abstract":"<p><p>ObjectiveLong non-coding RNAs (lncRNAs) have been implicated in the development of allergic rhinitis (AR). This study aimed to examine the clinical importance and functional mechanism of lncRNA DANCR in AR.MethodsVolunteer participants, including healthy controls and those with AR, were recruited, with clinical information and serum samples being gathered. Expression of DANCR and miR-338-3p was quantified by qRT-PCR. An in vitro model of AR was established using IL-13-stimulated human nasal epithelial cells (HNECs), and modulation of target expression via molecular transfection was regulated. ELISA was used to measure IL-4, IL-5, eotaxin, and GM-CSF levels. Cell viability and apoptosis were assessed by CCK8 and flow cytometry, respectively. The interaction between DANCR and miR-338-3p was validated using a dual luciferase reporter system.ResultsSerum DANCR expression was significantly elevated in AR patients, showing high diagnostic accuracy (AUC = 0.878) with 82.05% sensitivity and 81.25% specificity. IL-13 stimulation increased DANCR in HNECs. IL-13 induction in HNECs led to an increase in inflammation, a decrease in cell viability, and modulation of apoptotic processes; however, silencing DANCR mitigated these IL-13-mediated effects. In AR and IL-13-induced HNECs, miR-338-3p was decreased, while DANCR functioned as its ceRNA. miR-338-3p silencing reversed the protective effects of DANCR downregulation.ConclusionIn this research, it was observed that elevated DANCR expression in AR was tightly linked to disease progression. Furthermore, it uncovered its mode of action in modulating inflammatory responses and cellular functions via miR-338-3p.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"19458924261484683"},"PeriodicalIF":2.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}