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Revista de farmacia e bioquimica da Universidade de Sao Paulo最新文献

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[Preparation and biological trials of antimalarial sulfa embonates]. [抗疟磺胺酯的制备和生物学试验]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-07-01
A Korolkovas, G N Yang, M Itaya, A U Krettli
{"title":"[Preparation and biological trials of antimalarial sulfa embonates].","authors":"A Korolkovas,&nbsp;G N Yang,&nbsp;M Itaya,&nbsp;A U Krettli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. Six of the seven embonates prepared showed activity against Plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine).</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 2","pages":"193-215"},"PeriodicalIF":0.0,"publicationDate":"1975-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11978888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Latentiation of naphthylazoderivatives by polymerarization]. [通过聚合的方法对萘杂化衍生物的影响]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-07-01
A Korolkovas, J Pellegrino, J R Romero, E J Goncalez
{"title":"[Latentiation of naphthylazoderivatives by polymerarization].","authors":"A Korolkovas,&nbsp;J Pellegrino,&nbsp;J R Romero,&nbsp;E J Goncalez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Five naphthylazoderivatives (of sulfadiazine, sulfamethazine, sulfathiazole, sulfamethoxazole, and sulfamonomethoxine) -- the first four displaying schistosomicidal activity -- were latentiated, in the form of polyamides of acrylic and methacrylic acids, by reacting those compounds with these polymers. In biological tests in mice experimentally infected by Schistosoma mansoni, the new nine compounds were found to be inactive. However, the original method of latentiation described in this paper has possibilities of wide application, owing to its favourable features: versatility of the reactive group of the polymer, lability of the bond (easily hydrolyzable) formed between drug and polymer, greater viability of reaction between the polyanhydride and the drug, and solubility in water of the polymers thus formed.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 2","pages":"217-25"},"PeriodicalIF":0.0,"publicationDate":"1975-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12408038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of irradiation and heat on the agglutination and mitogenic capacity of phytohemagglutinins]. 辐照和加热对植物血凝素凝集和有丝分裂能力的影响。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
J Mancini Filho, D M Vizeu, F M Lajolo
{"title":"[Effect of irradiation and heat on the agglutination and mitogenic capacity of phytohemagglutinins].","authors":"J Mancini Filho,&nbsp;D M Vizeu,&nbsp;F M Lajolo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors studied the effect of ionizing radiation on hemaglutinating and mitogenic activity of phytohemaglutinis (PHA) in solution. 10 Krad (electron beam) are needed for the destruction of 50% of the aglutinating capacity. The mitogenic effect is more resistent to irradiation (70 Krad for 50% inactivation) maybe because both effects are due to different molecules. Changes were also followed by electrophoresis in polyacrylamida. The resistence to irradiation showed to be exponential function of the concentration of PHA in solution.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"117-32"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Value of proteins of the flour of cheastnuts of Pará]. [帕尔<e:1>栗子面粉中蛋白质的价值]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
S M Zucas, E C Vasconcellos Silva, M I Fernandes
{"title":"[Value of proteins of the flour of cheastnuts of Pará].","authors":"S M Zucas,&nbsp;E C Vasconcellos Silva,&nbsp;M I Fernandes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors have made some chemical analysis of the deffated Brazil-nut flour. The average protein content was about 46% and aminogram showed that all the essential aminoacids were present in the protein, and a high concentration of total sulfur aminoacids was found. The chemical analysis also showed an utilization of about 54% for the Brazil-nut flour and 55% for the casein. However, the biological value of the casein prepared diet was higher than that prepared with Brazil-nut flour.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"133-43"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Identification of aminoacidopathies using thin layer chromatography of urine]. [尿薄层色谱法鉴定氨基酸病]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
A B Simonetti, A La Rocca Rossi
{"title":"[Identification of aminoacidopathies using thin layer chromatography of urine].","authors":"A B Simonetti,&nbsp;A La Rocca Rossi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aminoacidopathies, inborn errors of aminoacids metabolism, are rare pathological conditions that have mental retardation as secondarty cause. Using TLC with cellulose as adsorvent and using specific solvents and developer, we can obtain early diagnosis of a great number of those biochemical deviations. The authors based themselves in Ersser's publications to effect this research, now in its initial phase. The author's principal aim is to transform the semi-quantitative method into a quantitative one and to early diagnose the metabolic errors of aminoacids.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"161-72"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acid hydrolysis of mandioca]. [下颌骨的酸水解]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
A J Colombo, B Schneiderman, R Baruffaldi, R Nacco
{"title":"[Acid hydrolysis of mandioca].","authors":"A J Colombo,&nbsp;B Schneiderman,&nbsp;R Baruffaldi,&nbsp;R Nacco","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of time of hydrolysis, pression of the process, ratio of mass of flour and volume and concentration of the acid solution was studied in the hydrolytic processes for Cassava flour. The aim was to obtain fermentable sugars, and the results were submitted to variance analysis.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"75-90"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chemical study of rosemary of Campinas. II]. 迷迭香的化学研究。二)。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
J Muradian, P Carvalho Ferreira, R Braz Filho
{"title":"[Chemical study of rosemary of Campinas. II].","authors":"J Muradian,&nbsp;P Carvalho Ferreira,&nbsp;R Braz Filho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The flavone glycoside isolated from the leaves of Holocalyx glaziovii Taub. (syn. Holocalyx balansae Mich.) gave on hydrolysis kaempferol and rhamnose. The glycoside was identified by chemical, spectroscopic and chromatographic methods as kaempferol-3,7-dirhamnoside (kaempferitrin).</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"173-82"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthetic organic dyes in liquid solutions. Contribution to the study of their stability]. [液体合成有机染料。对其稳定性研究的贡献]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
J H Helou
{"title":"[Synthetic organic dyes in liquid solutions. Contribution to the study of their stability].","authors":"J H Helou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The A. studied the influence of storage conditions in regard to ten certified dyes contained in liquid pharmaceutical preparations: aqueous solution, simple and modified syrups and elixir, buffered at pH 2.0; 4.0; 6.0; 7.0 AND 8.0. The diffuse light is the most important factor in the alteration of colorants in liquid dosage forms. The room temperature had influence over the following dyes: amaranth, F.D. & C. Red n; degrees 1; F;D. & C. Blue n. degrees 2; F.D. & C. Red n. degrees 4 and F.D. & C. Violet n. degrees 1.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Influence of proles vegetable enzymes on meat]. [无产者蔬菜酶对肉类的影响]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
R Baruffaldi, A J Colombo, E M Fontinele, O H Ramos, T Bauch, A H Waszyk, R Schuch
{"title":"[Influence of proles vegetable enzymes on meat].","authors":"R Baruffaldi,&nbsp;A J Colombo,&nbsp;E M Fontinele,&nbsp;O H Ramos,&nbsp;T Bauch,&nbsp;A H Waszyk,&nbsp;R Schuch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies on the enzymatic digestion of food proteins are being carried out \"in vitro\" in order to prepare protein hydrolysates to be added to specific diet. The digested product is lyophilized to preserve its solubility characteristics.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Correlation between non-empirical electronic parameters and the therapeutic action of aminoacridine]. [非经验电子参数与氨基吖啶治疗作用的相关性]。
Revista de farmacia e bioquimica da Universidade de Sao Paulo Pub Date : 1975-01-01
A Korolkovas
{"title":"[Correlation between non-empirical electronic parameters and the therapeutic action of aminoacridine].","authors":"A Korolkovas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By using the omega technique of molecular orbital calculations, certain non-empirical electronic parameters (charge density, HOMO and LEMO) in acridine, five monoaminoacridines, and five diaminoacridines were determined. High correlations were found between: a) pKalpha and electron density at the ring nitrogen; b) pKalpha and LEMO; c) electron density at the ring nigrogen and bacteriostatic index; d) LEMO and bacteriostatic index. However, no good correlation was seen between HOMO and both pKalpha and bacteriostatic index. It was also found that LEMO values in acridines allow them to act as good electron acceptors in a charge-transfer process.</p>","PeriodicalId":76437,"journal":{"name":"Revista de farmacia e bioquimica da Universidade de Sao Paulo","volume":"13 1","pages":"47-62"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12404915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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