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Research publications - Association for Research in Nervous and Mental Disease最新文献

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Glutamate receptors and excitotoxicity. 谷氨酸受体与兴奋毒性。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
G L Westbrook
{"title":"Glutamate receptors and excitotoxicity.","authors":"G L Westbrook","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The features of central glutamate synapses are well suited to the spectrum of functions these elements serve in brain function. However, receptor-mediated mechanisms are only one facet of phenomena such as excitotoxicity or long-term potentiation, which almost certainly involve other neuronal components, e.g., other transmitter systems, voltage-gated channels, and biochemical mechanisms as well as possibly astrocytes in some cases. Nonetheless the rapid pace of progress in this field reinforces not only the diversity and complexity of the CNS, but suggests that it is not overly optimistic to think that understanding of these mechanisms will soon have an impact on neurological and mental illness.</p>","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"35-50"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19366073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging strategies for the treatment of ischemic brain injury. 缺血性脑损伤治疗的新策略。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
M D Ginsberg
{"title":"Emerging strategies for the treatment of ischemic brain injury.","authors":"M D Ginsberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"207-37"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of excitotoxins in heredito-degenerative neurologic diseases. 兴奋毒素在遗传性退行性神经系统疾病中的作用。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
A B Young
{"title":"Role of excitotoxins in heredito-degenerative neurologic diseases.","authors":"A B Young","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In summary, EAA play an important role in neurodegenerative disorders simply by virtue of the pathways in brain that utilize EAA as neurotransmitters. Thus, the striatum, which is so strikingly affected in Huntington's disease, receives massive EAAergic input from all regions of the cerebral cortex and from the thalamus. In Parkinson's disease, some of the key pathways projecting into the substantia nigra pars compacta and to the subthalamic nucleus and basal ganglia output zones also use EAA as neurotransmitters. In Alzheimer's disease, the cerebral cortex and hippocampus are dependent on EAAergic neurotransmission for normal function. Drugs that manipulate these neurotransmitter inputs and outputs could be very helpful in the symptomatic relief of all these neurodegenerative disorders. In addition, there may be secondary excitotoxic effects of EAA on neuronal function in neurodegenerative disorders. Genetic abnormalities may render subsets of neurons more vulnerable to changes in ion concentration or energy demands and thus more susceptible to EAA-induced neurotoxicity. Although EAA themselves may not be the primary culprit in a disease, EAA-induced toxicity may cause significant damage as a secondary phenomenon. If so, the neuronal damage could potentially be attenuated by the use of EAA antagonists. Future research on these problems hold great promise.</p>","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"175-89"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19086664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ischemic penumbra in stroke: prospects for analysis by nuclear magnetic resonance spectroscopy. 脑卒中缺血性半暗带:核磁共振波谱分析的前景。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
J W Prichard
{"title":"The ischemic penumbra in stroke: prospects for analysis by nuclear magnetic resonance spectroscopy.","authors":"J W Prichard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"153-74"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current antisense nucleic acid strategies for manipulating neuronal and glial cells. 目前的反义核酸策略操纵神经元和神经胶质细胞。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
L F Eng
{"title":"Current antisense nucleic acid strategies for manipulating neuronal and glial cells.","authors":"L F Eng","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"293-310"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strokes involving gray matter: studies on in situ models of cerebral ischemia. 涉及灰质的中风:脑缺血原位模型的研究。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
W A Pulsinelli
{"title":"Strokes involving gray matter: studies on in situ models of cerebral ischemia.","authors":"W A Pulsinelli","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"107-20"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients. 利用人胎儿中脑组织替代帕金森病多巴胺缺陷的细胞:4例患者的初步结果
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
D E Redmond, R J Robbins, F Naftolin, K L Marek, T L Vollmer, C Leranth, R H Roth, L H Price, A Gjedde, B S Bunney
{"title":"Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients.","authors":"D E Redmond,&nbsp;R J Robbins,&nbsp;F Naftolin,&nbsp;K L Marek,&nbsp;T L Vollmer,&nbsp;C Leranth,&nbsp;R H Roth,&nbsp;L H Price,&nbsp;A Gjedde,&nbsp;B S Bunney","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"325-59"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracerebral transplantation: prospects for neuronal replacement in neurodegenerative diseases. 脑内移植:神经退行性疾病中神经元替代的前景。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
A Björklund
{"title":"Intracerebral transplantation: prospects for neuronal replacement in neurodegenerative diseases.","authors":"A Björklund","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"361-74"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19401542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The therapeutic window for methylprednisolone treatment of acute spinal cord injury: implications for cell injury mechanisms. 甲基强的松龙治疗急性脊髓损伤的治疗窗口期:细胞损伤机制的含义。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
W Young
{"title":"The therapeutic window for methylprednisolone treatment of acute spinal cord injury: implications for cell injury mechanisms.","authors":"W Young","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"191-206"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The design and appraisal of randomized clinical trials in cerebrovascular disease and CNS trauma. 脑血管疾病和中枢神经系统损伤随机临床试验的设计和评价。
Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1993-01-01
L M Brass
{"title":"The design and appraisal of randomized clinical trials in cerebrovascular disease and CNS trauma.","authors":"L M Brass","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"71 ","pages":"239-63"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19402376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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