Research publications - Association for Research in Nervous and Mental Disease最新文献

Eating and its disorders. 饮食及其失调。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 2012-11-05 DOI: 10.1002/9781118328910

J. Fox, K. Goss

引用次数: 39

The SIV model of AIDS encephalopathy. Role of neurotropic viruses in diseases. 艾滋病脑病的SIV模型。嗜神经病毒在疾病中的作用。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

J E Clements, M G Anderson, M C Zink, S V Joag, O Narayan

引用次数: 0

Peripheral nerve disorders in HIV infection. Similarities and contrasts with CNS disorders. HIV感染的周围神经紊乱。与中枢神经系统疾病的异同。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

J W Griffin, S L Wesselingh, D E Griffin, J D Glass, J C McArthur

引用次数: 0

HIV, AIDS, and The Brain. Proceedings of the 72nd annual ARNMD meeting. New York, 1992. 艾滋病毒、艾滋病和大脑。第72届年会论文集。纽约，1992年。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

引用次数: 0

Laboratory basis of novel therapeutic strategies to prevent HIV-related neuronal injury. 预防hiv相关神经元损伤的新治疗策略的实验室基础。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

S A Lipton

引用次数: 0

HIV neurons and cytotoxic T lymphocytes. Concepts about the AIDS dementia complex and viral persistence. HIV神经元和细胞毒性T淋巴细胞。关于艾滋病痴呆复合体和病毒持久性的概念。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

M B Oldstone

引用次数: 0

Evaluation of the AIDS dementia complex in adults. 成人艾滋病痴呆复合体的评价。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

J J Sidtis

引用次数: 0

HIV-1-associated CNS disease in infants and children. 婴儿和儿童hiv -1相关中枢神经系统疾病

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

A L Belman

引用次数: 0

Cytokine circuits in brain. Implications for AIDS dementia complex. 大脑中的细胞因子回路。对艾滋病痴呆复合体的影响。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

E N Benveniste

{"title":"Cytokine circuits in brain. Implications for AIDS dementia complex.","authors":"E N Benveniste","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This chapter has summarized studies showing that cells of the immune system and glial cells of the CNS use many of the same cytokines as communication signals. Activated astrocytes and microglia are the principal sources of these cytokines in the CNS, although oligodendrocytes are capable of expressing IL-1 and TGF-beta. There is a complex circuitry of interactions mediated by cytokines, especially in the event of blood-brain barrier damage and lymphoid/mononuclear cell infiltration into the CNS. Infiltrating activated macrophages produce cytokines such as IL-1, TNF-alpha, and IL-6, which would trigger glial cells to produce their own cytokines. The activation of astrocytes and microglia to secrete proinflammatory cytokines such as IL-1, TNF-alpha, IL-6, and GM-CsF may contribute to the propagation of intracerebral immune and inflammatory responses initiated by immune cells, as well as enhancement of HIV-1 expression in the CNS. The cytokine cascades ongoing in the CNS could ultimately be suppressed due to the presence of immunosuppressive cytokines such as TGF-beta. Whether immune and inflammatory responses within the CNS are propagated or suppressed depends on a number of parameters, including (a) the activational status of these cells, (b) cytokine receptor levels on glial and immune cells, (c) the presence of cytokines with both immune-enhancing and immune-suppressing effects (IFN-gamma, IL-1, TNF-alpha, IL-6, TGF-beta, CsFs), (d) the concentration and location of these cytokines in the CNS, and (e) the temporal sequence in which a particular cell is exposed to numerous cytokines (see Fig. 1). The ultimate outcome of immunologic and inflammatory events in the CNS, as well as HIV expression, will be determined, in part, by an interplay of the above parameters.</p>","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"72 ","pages":"71-88"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19107807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophages and microglia in HIV-related CNS neuropathology. 巨噬细胞和小胶质细胞在hiv相关中枢神经系统病理中的作用。

Research publications - Association for Research in Nervous and Mental Disease Pub Date : 1994-01-01

D W Dickson, S C Lee, W Hatch, L A Mattiace, C F Brosnan, W D Lyman

引用次数: 0