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Psychopharmacology communications最新文献

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Conditioning of discriminable stimuli produced by morphine. 吗啡产生的可辨别的刺激的条件作用。
Psychopharmacology communications Pub Date : 1976-01-01
S Miksic, N Smith, H Lal
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引用次数: 0
Mass-spectrographic evidence of the conversion of p-chloroamphetamine to 3,4-dimethoxyamphetamine. 对氯苯丙胺转化为3,4-二甲氧基苯丙胺的质谱证据。
Psychopharmacology communications Pub Date : 1976-01-01
A D Sherman, E M Gál
{"title":"Mass-spectrographic evidence of the conversion of p-chloroamphetamine to 3,4-dimethoxyamphetamine.","authors":"A D Sherman,&nbsp;E M Gál","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intraventricularly injected p-chloroamphetamine (p-CA) was actively metabolized to 3,4-dimethoxyamphetamine (3,4-DMA) in the rat brain. Time-course experiments with intraperitoneally injected p-CA confirmed that the presence of cerebral 3,4-DMA was not due to its \"one-pass\" entry from the peripheral organs. The identity of 3,4-DMA from brain tissue and urine was established by comparison to authentic 3,4-DMA. The synthetic and biological samples were isographic in all analytical systems. 3,4-DMA from biological samples was verified by mass spectrography.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 5-6","pages":"421-7"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12206671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discriminative properties of narcotic antagonists. 麻醉拮抗剂的鉴别性质。
Psychopharmacology communications Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-3090-5_4
S. Holtzman, H. Shannon, G. J. Schaefer
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引用次数: 30
Discriminative properties of narcotic antagonists. 麻醉拮抗剂的鉴别性质。
Psychopharmacology communications Pub Date : 1976-01-01
S G Holtzman, H E Shannon, G J Schaefer
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引用次数: 0
Enhancement of morphine-withdrawal and apomorphine-induced aggression by clonidine. 可乐定增强吗啡戒断和阿吗啡诱导的攻击行为。
Psychopharmacology communications Pub Date : 1976-01-01
G Gianutsos, M D Hynes, H Lal
{"title":"Enhancement of morphine-withdrawal and apomorphine-induced aggression by clonidine.","authors":"G Gianutsos,&nbsp;M D Hynes,&nbsp;H Lal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clonidine, a proposed alpha-noradrenergic receptor stimulant, intensifies the aggression occuring during morphine-withdrawal or following the administration of apomorphine. The possibility of a noradrenergic/dopaminergic interaction in drug-induced aggression is discussed.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 2","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12170639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive effect of 5-hydroxytryptophan and p-chloro-phenylalanine in preventing audiogenic seizures in inbred mice. 5-羟色氨酸和对氯苯丙氨酸预防自交系小鼠听原性癫痫发作的加性作用。
Psychopharmacology communications Pub Date : 1976-01-01
G J Alexander, L M Kopeloff
{"title":"Additive effect of 5-hydroxytryptophan and p-chloro-phenylalanine in preventing audiogenic seizures in inbred mice.","authors":"G J Alexander,&nbsp;L M Kopeloff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Convulsive responsiveness of O'Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin precursor, 5-hydroxytryptophan, or serotonin depletor, p-chlorophenylalanine. Neither agent exerted any antagonistic or synergistic action on the effect of the other. Upon sequential administration, their effects were additive. There was no indication that the increase in brain serotonin due to administration of its direct precursor interfered with the protective effect of p-chlorophenylalanine against seizures. Neither was there evidence that p-chlorophenylalanine-induced interruption of biosynthesis which led to severe depletion of brain serotonin affected the protective action of 5-hydroxytryptophan.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 5-6","pages":"379-90"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11358981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression of REM sleep in cats by nisoxetine, a potential antidepressant drug. 一种潜在的抗抑郁药物尼索西汀对猫快速眼动睡眠的抑制作用。
Psychopharmacology communications Pub Date : 1976-01-01
I H Slater, G T Jones, R A Moore
{"title":"Depression of REM sleep in cats by nisoxetine, a potential antidepressant drug.","authors":"I H Slater,&nbsp;G T Jones,&nbsp;R A Moore","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nisoxetine, a potent and specific inhibitor of norepinephrine uptake, suppressed REM sleep in cats. Oral doses as small as 0.1 mg/kg were effective during the first 2 1/2 hours of a recording session; 0.25 mg/kg, for 5 hours. The amount of slow wave sleep increased in cats that received 0.1-1.0 mg/kg of nisoxetine. These changes in sleep pattern resemble those reported after treatment with somewhat higher doses of tricylic antidepressants.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 3","pages":"181-8"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11403208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure-activity relationships among desmethyl derivatives of neuroleptics and antidepressants for substrate specificty to indolethylamine N-methyltransferase from rabbit lung. 抗精神病药和抗抑郁药去甲基衍生物对兔肺吲哚乙胺n -甲基转移酶底物特异性的构效关系
Psychopharmacology communications Pub Date : 1976-01-01
N Narasimhachari, R L Lin
{"title":"Structure-activity relationships among desmethyl derivatives of neuroleptics and antidepressants for substrate specificty to indolethylamine N-methyltransferase from rabbit lung.","authors":"N Narasimhachari,&nbsp;R L Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Desmethylperazine (norperazine) and desmethylprochlorperazine (norprochlorperazine), like nor1- and nor2chlorpromazine, are excellent substrates for indolethylamine N-methyltransferase (NMT) and also inhibit the formation of dimethyltryptamine (DMT) from N-methyl-tryptamine (NMT). Nortriptyline and protriptyline, antidepressant compounds which like NMT contain a secondary amino group, also serve as substrates for INMT but lack in inhibitory effect on DMT formation.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 1","pages":"27-38"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11233398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discriminable effects of benzodiazepines. 苯二氮卓类药物的明显影响。
Psychopharmacology communications Pub Date : 1976-01-01
D A Overton
{"title":"Discriminable effects of benzodiazepines.","authors":"D A Overton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a shock-escape T-maze task, rats rapidly discriminated diazepam, flurazepam and chloridazepoxide from no drug. The discriminable effects of these benzodiazepines were not completely interchangeable with those of barbiturate anesthetics. The dose-response curve for diazepam asymptoted over the range 15 to 100 mg/kg, ip whereas dose-response curves for flurazepam and chloridazepoxide were more linear.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 4","pages":"339-43"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11234611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discriminable stimuli produced by alcohol and other CNS depressants. 酒精和其他中枢神经系统抑制剂产生的可辨别的刺激。
Psychopharmacology communications Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-3090-5_5
H. Barry, E. C. Krimmer
{"title":"Discriminable stimuli produced by alcohol and other CNS depressants.","authors":"H. Barry, E. C. Krimmer","doi":"10.1007/978-1-4684-3090-5_5","DOIUrl":"https://doi.org/10.1007/978-1-4684-3090-5_5","url":null,"abstract":"","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"87 1","pages":"323-6"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51016877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
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