{"title":"对氯苯丙胺转化为3,4-二甲氧基苯丙胺的质谱证据。","authors":"A D Sherman, E M Gál","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Intraventricularly injected p-chloroamphetamine (p-CA) was actively metabolized to 3,4-dimethoxyamphetamine (3,4-DMA) in the rat brain. Time-course experiments with intraperitoneally injected p-CA confirmed that the presence of cerebral 3,4-DMA was not due to its \"one-pass\" entry from the peripheral organs. The identity of 3,4-DMA from brain tissue and urine was established by comparison to authentic 3,4-DMA. The synthetic and biological samples were isographic in all analytical systems. 3,4-DMA from biological samples was verified by mass spectrography.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 5-6","pages":"421-7"},"PeriodicalIF":0.0000,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mass-spectrographic evidence of the conversion of p-chloroamphetamine to 3,4-dimethoxyamphetamine.\",\"authors\":\"A D Sherman, E M Gál\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Intraventricularly injected p-chloroamphetamine (p-CA) was actively metabolized to 3,4-dimethoxyamphetamine (3,4-DMA) in the rat brain. Time-course experiments with intraperitoneally injected p-CA confirmed that the presence of cerebral 3,4-DMA was not due to its \\\"one-pass\\\" entry from the peripheral organs. The identity of 3,4-DMA from brain tissue and urine was established by comparison to authentic 3,4-DMA. The synthetic and biological samples were isographic in all analytical systems. 3,4-DMA from biological samples was verified by mass spectrography.</p>\",\"PeriodicalId\":76387,\"journal\":{\"name\":\"Psychopharmacology communications\",\"volume\":\"2 5-6\",\"pages\":\"421-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology communications","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mass-spectrographic evidence of the conversion of p-chloroamphetamine to 3,4-dimethoxyamphetamine.
Intraventricularly injected p-chloroamphetamine (p-CA) was actively metabolized to 3,4-dimethoxyamphetamine (3,4-DMA) in the rat brain. Time-course experiments with intraperitoneally injected p-CA confirmed that the presence of cerebral 3,4-DMA was not due to its "one-pass" entry from the peripheral organs. The identity of 3,4-DMA from brain tissue and urine was established by comparison to authentic 3,4-DMA. The synthetic and biological samples were isographic in all analytical systems. 3,4-DMA from biological samples was verified by mass spectrography.
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