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Glomerular deposits of rheumatoid factor in glomerulonephritis. 肾小球肾炎中类风湿因子的肾小球沉积。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
F Bartolomeo, A L'Abbate, C Martorano, V Misefari, A Caccamo, Q Maggiore
{"title":"Glomerular deposits of rheumatoid factor in glomerulonephritis.","authors":"F Bartolomeo,&nbsp;A L'Abbate,&nbsp;C Martorano,&nbsp;V Misefari,&nbsp;A Caccamo,&nbsp;Q Maggiore","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One hundred and forty-four kidney biopsy specimens with various forms of glomerulonephritis were studied to assess the presence of Rheumatoid Factor (RF) deposits. RF deposits were found in 21 specimens: six with acute post-streptococcal glomerulonephritis, two with crescentic glomerulonephritis, four with lupus nephritis, eight with essential mixed cryoglobulinaemia glomerulonephritis, and one with end-stage kidney disease. Blocking and elution studies carried out on specimens with essential mixed cryoglobulinaemia provided evidence that the RF deposits derive from circulating monoclonal RF. This data suggests that RF participates in the formation of glomerular immune deposits in several forms of immune complex mediated glomerulonephritis.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"686-91"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17409388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Berger's nephropathy: relationship between histological pattern, blood pressure and renin. 伯杰肾病:组织学类型、血压与肾素的关系。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
E Degli Esposti, P Zucchelli, C Chiarini, A Santoro, A Sturani, A Zuccalà, L Cagnoli, U Donini, M Mandreoli, S Pasquali
{"title":"Berger's nephropathy: relationship between histological pattern, blood pressure and renin.","authors":"E Degli Esposti,&nbsp;P Zucchelli,&nbsp;C Chiarini,&nbsp;A Santoro,&nbsp;A Sturani,&nbsp;A Zuccalà,&nbsp;L Cagnoli,&nbsp;U Donini,&nbsp;M Mandreoli,&nbsp;S Pasquali","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vascular damage (VD), glomerular sclerosis (GS), renin (PRA) and blood pressure were assessed in 50 patients with Berger's nephropathy. GS was present in 5/15 patients without VD and affected more than 15 per cent of glomeruli in seven patients with minimal VD. Nine out of 19 patients with GS were normotensive. VD was present in 35 patients: 16 were hypertensive and 19 normotensive. Therefore hypertension is not the only mechanism responsible for VD. In the seven normotensive patients with high PRA, GS was not present while VD was absent or minimal.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"696-700"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17409390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accumulation of silicone elastomer in regular dialysis. 常规透析中有机硅弹性体的积累。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
T Laohapand, E M Osman, A R Morley, M K Ward, D N Kerr
{"title":"Accumulation of silicone elastomer in regular dialysis.","authors":"T Laohapand,&nbsp;E M Osman,&nbsp;A R Morley,&nbsp;M K Ward,&nbsp;D N Kerr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A retrospective autopsy study of 78 patients treated by some form of dialysis for chronic renal failure in Newcastle 1964-1981 showed that: 1) Particles resembling silicone elastomer were present in 48 per cent of 61 patients haemodialysed with the use of silicone rubber pump inserts but in none of the 11 treated by haemodialysis with other pump inserts or of the six treated by peritoneal dialysis alone; 2) The prevalence of these particles and their density increased with time on haemodialysis; 3) There was little evidence of a tissue reaction to the particles and no association between their presence and histological evidence of liver disease; 4) There was a higher incidence of clinical and biochemical evidence of liver disease in patients with silicone deposits than in those without. Although there are other possible explanations for this higher incidence of hepatic dysfunction it would be safer to assume that silicone particle spallation is not innocuous.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"143-52"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17409771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperimmune immunoglobulin therapy for cytomegalovirus infections in renal transplant patients. 肾移植患者巨细胞病毒感染的超免疫免疫球蛋白治疗。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
C B Brown, A J Nicholls, N Edward, B Cuthbertson, P L Yap, D B McClelland
{"title":"Hyperimmune immunoglobulin therapy for cytomegalovirus infections in renal transplant patients.","authors":"C B Brown,&nbsp;A J Nicholls,&nbsp;N Edward,&nbsp;B Cuthbertson,&nbsp;P L Yap,&nbsp;D B McClelland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Eleven renal transplant patients with CMV infection have been treated by passive immunisation, one with high-titre anti-CMV plasma and 10 with fractionated hyperimmune anti-CMV immunoglobulin. All were pyrexial for at least seven days before treatment with typical clinical and laboratory features of CMV infection. Seven of the 11 patients treated showed a striking and sustained response within 24-48 hours of therapy, with lysis of fever, resolution of pneumonitis, a rise in white cell count and improvement in renal function and liver function tests.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"271-9"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17379877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological monitoring of viral infections in renal transplant recipients. 肾移植受者病毒感染的免疫学监测。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
B Brando, G Civati, C Grillo, G Busnach, G Colussi, M L Broggi, L Minetti
{"title":"Immunological monitoring of viral infections in renal transplant recipients.","authors":"B Brando,&nbsp;G Civati,&nbsp;C Grillo,&nbsp;G Busnach,&nbsp;G Colussi,&nbsp;M L Broggi,&nbsp;L Minetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twelve viral episodes occurred in 54 antilymphocyte globulin-treated renal transplant recipients (two primary cytomegalovirus, seven cytomegalovirus reactivations, one chickenpox, two influenza). In 11 of 12 cases the ratio between peripheral T4 and T8 subsets fell (from 1.698 to 0.986, p less than 0.01) due both to a reduction of T4+ and to an increase of T8+ cells. T10+ and 5/9 subsets also increased. Suppressor T-cell function, as measured by two simultaneous assays, was enhanced. In antibody-negative CMV patients the reversal of T4/T8 ratio preceded the appearance of specific IgM. T4/T8 ratios rapidly returned to normal in mild episodes, but remained reverted in symptomatic CMV patients for several months, despite a reduction in the immunosuppressive regimen. Symptomatic viral episodes displayed marked imbalances in T cell subset numbers and function, while in asymptomatic cases the changes were less evident.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"265-70"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17379979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of cadaveric renal allograft survival by thoracic duct drainage: relation with T-lymphocyte subset modifications assessed by flow-cytometry. 胸导管引流改善尸体移植肾存活:与流式细胞术评估的t淋巴细胞亚群改变的关系。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
M Laville, G Cordier, J Brochier, R Lefebvre, J P Revillard, J Traeger
{"title":"Improvement of cadaveric renal allograft survival by thoracic duct drainage: relation with T-lymphocyte subset modifications assessed by flow-cytometry.","authors":"M Laville,&nbsp;G Cordier,&nbsp;J Brochier,&nbsp;R Lefebvre,&nbsp;J P Revillard,&nbsp;J Traeger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thoracic duct drainage (TDD) with reinfusion of cell-free lymph was performed in 118 prospective recipients within four months before transplantation. TDD was unsuccessful in 27 patients (A); it yielded 1-19 X 10(9) lymphocytes in 25 cases (B) and 20-185 X -10(9) in 66 cases (C). The incidence of acute rejection episodes and the requirement for early post-transplant dialysis were lower in C than in A. Six patients were studied for T-lymphocyte subsets, using monoclonal antibodies from OKT series and a monomorphic and HLA-DR (BL2) raised in our laboratory. During TDD peripheral blood lymphocyte (PBL) counts decreased and the percentage of BL2 cells increased. Simultaneously, typical small PBL were replaced by large less differentiated cells slightly labelled by OKT3, some of them bearing both OKT4 and OKT8 markers. The larger the depletion, the earlier the emergence of immature T-cells. In lymph fluid, lymphocyte counts decreased later than in blood, the proportion of T8+ cells lacking Fc receptors increased with time. Changes in B patients were less than in C. These results support the hypothesis that T-cell subset modifications represent the main immunological change accounting for better allograft prognosis.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"488-94"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17288262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T-lymphocyte subsets in primary and secondary glomerulonephritis. 原发性和继发性肾小球肾炎的t淋巴细胞亚群。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
A Fornasieri, R Sinico, G Fiorini, D Goldaniga, G Colasanti, F Vendemia, A Gibelli, G D'Amico
{"title":"T-lymphocyte subsets in primary and secondary glomerulonephritis.","authors":"A Fornasieri,&nbsp;R Sinico,&nbsp;G Fiorini,&nbsp;D Goldaniga,&nbsp;G Colasanti,&nbsp;F Vendemia,&nbsp;A Gibelli,&nbsp;G D'Amico","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T-lymphocyte subsets, using the monoclonal antibodies OKT3 (peripheral T-cells), OKT4 (helper/inducer T-cells) and OKT8 (suppressor/cytotoxic T-cells) were measured in peripheral blood from 110 patients with various forms of primary and secondary glomerulonephritis (GN) (Berger's disease, membranous GN, focal glomerulosclerosis, membranoproliferative GN, lupus nephritis and mixed essential cryoglobulinaemia with GN). We have found a significantly higher OKT4+/OKT8+ ratio in patients with Berger's disease and membranous GN and a rather low OKT4+/OKT8+ ratio in patients with lupus nephritis and mixed essential cryoglobulinaemia, due to a significant decrease in OKT4+ cells. Our results suggest an imbalance in immunoregulatory mechanisms in some forms of GN.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"635-41"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17288263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renovascular hypertension: easier diagnosis and treatment with intravenous renal arteriography and percutaneous transluminal dilatation. 肾血管性高血压:静脉肾动脉造影和经皮腔内扩张术更容易诊断和治疗。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
J P Cecile, A Fournier, J P Sorez, D Delambre, C Galy, P Fievet, A Remond
{"title":"Renovascular hypertension: easier diagnosis and treatment with intravenous renal arteriography and percutaneous transluminal dilatation.","authors":"J P Cecile,&nbsp;A Fournier,&nbsp;J P Sorez,&nbsp;D Delambre,&nbsp;C Galy,&nbsp;P Fievet,&nbsp;A Remond","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For the diagnosis of renovascular disease, the authors propose the use of intravenous arteriography with photographic subtraction as the method of choice and advise the use of pyelogram wash-out to assess the functional significance of the stenosis. Furthermore they report their experience with percutaneous transluminal dilatation in 41 patients (10 fibrotic--31 atherosclerotic renal artery stenoses) and suggest that this method is valid alternative to surgery specially in poor risk patients. A controlled trial of this method versus surgery needs however to be undertaken to define the respective roles of these treatments.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"749-55"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17288266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-thrombotic complications of PTFE grafts for haemodialysis. 聚四氟乙烯血液透析移植的非血栓性并发症。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01 DOI: 10.1007/978-94-009-6592-8_30
M. Slooff, P. Smits, D. Lichtendahl, G. van der Hem
{"title":"Non-thrombotic complications of PTFE grafts for haemodialysis.","authors":"M. Slooff, P. Smits, D. Lichtendahl, G. van der Hem","doi":"10.1007/978-94-009-6592-8_30","DOIUrl":"https://doi.org/10.1007/978-94-009-6592-8_30","url":null,"abstract":"","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"36 1","pages":"234-7"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51557575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Immunogenetics and immunopathology of human membranous glomerulonephritis. 人膜性肾小球肾炎的免疫遗传学和免疫病理学。
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01
B Laurent, F C Berthoux, J C Le Petit, G Genin, P Laurent, F Broutin, F Touraine, J L Touraine
{"title":"Immunogenetics and immunopathology of human membranous glomerulonephritis.","authors":"B Laurent,&nbsp;F C Berthoux,&nbsp;J C Le Petit,&nbsp;G Genin,&nbsp;P Laurent,&nbsp;F Broutin,&nbsp;F Touraine,&nbsp;J L Touraine","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In most of our membranous glomerulonephritis (MGN) patients, we have studied the HLA-A, B, DR phenotype, the clearance of anti-D rhesus coated 51Cr-labelled autologous erythrocytes, and T-lymphocyte subpopulations with monoclonal antibodies (OKT3, T4, T8). The frequency of B8 antigen in 28 patients with MGN (five cases associated with lupus excluded) is 57.14 per cent versus 14.42 per cent in controls (Pc = 0.0002). In 26 patients the frequency of DR3 antigen is 65.38 per cent versus 20.27 per cent in controls (Pc = 0.00008). The half-life of sensitised erythrocytes is respectively 35.36 +/- 8.50 minutes in nine controls and 67.05 +/- 69.64 min in 18 patients with MGN. The half-life is significantly prolonged in one-third of the patients at time of exacerbation. The peripheral blood T-lymphocyte subsets study showed a significant decrease of OKT3 and OKT4 positive cell subsets. T4/T8 ratio is high during exacerbation of disease and diminishes in remission. Our data are consistent with a latent subtle genetic immunodeficiency, only expressed during acute phases of the disease.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"629-34"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17470208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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