Pharmakopsychiatrie, Neuro-Psychopharmakologie最新文献_第9页

Paroxysmal EEG activity and psychopathology during the treatment with clozapine. 氯氮平治疗期间发作性脑电图活动和精神病理。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-03-01 DOI: 10.1055/s-0028-1094608

M Koukkou, J Angst, D Zimmer

引用次数: 41

Vigilance and evaluation of psychotropic drug effects on EEG. 精神药物对脑电图影响的警惕性及评价。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-03-01 DOI: 10.1055/s-0028-1094604

D Bente

引用次数: 61

Statistical problems in the analysis of comparative pharmaco-EEG trials. 比较药物-脑电图试验分析中的统计问题。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-03-01 DOI: 10.1055/s-0028-1094614

K Abt

引用次数: 3

Is a man, a man, a man? (or: is an EEG, an EEG, an EEG?) some remarks on the homogeneity of "normal subjects". 一个男人，一个男人，一个男人?(或者:脑电图，脑电图，脑电图?)一些关于“正常受试者”同质性的评论。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094596

L Goldstein

引用次数: 3

HZI systems for EEG parametrization and classification of psychotropic drugs. 脑电参数化与精神药物分类的HZI系统。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094590

T M Itil, D M Shapiro, W M Herrmann, W Schulz, V Morgan

引用次数: 39

Evaluation of pharmacodynamic properties of psychotropic drugs: quanitative EEG, psychometric and blood level investigations in normals and patients. 精神药物药效学性质的评价:正常人和病人的定量脑电图、心理测量和血液水平调查。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094593

B Saletu, J Grünberger

{"title":"Evaluation of pharmacodynamic properties of psychotropic drugs: quanitative EEG, psychometric and blood level investigations in normals and patients.","authors":"B Saletu, J Grünberger","doi":"10.1055/s-0028-1094593","DOIUrl":"https://doi.org/10.1055/s-0028-1094593","url":null,"abstract":"Quantitative EEG analyses in combination with certain statistical procedures may be utilized in order to classify psychotropic drugs and to determine their cerebral bioavailability. Psychometric tests including evaluation of attention, concentration, psychomotor activity, critical flicker frequency, reaction time, Archimedean spiral, mood and affectivity, may add valuable information about a drug's psychotropic and pharmacodynamic properties. As was seen in studies involving a new pyridodiazepine, short-term drug effects in the EEG of normals are predictive of EEG and clinical effects in patients. Pharmaco-EEG profiles of lopirazepam were found similar in normals and alcoholic patients with an anxiety syndrom as far as the type of changes was concerned, although some quantitative differences were observed. As previously described, quantitative EEG changes during treatment were correlated with clinical improvement or deterioration. Moreover, there is some evidence that single dose effects in the EEG of patients may eventually be utilized to predict therapeutic outcome with a certain drug. Finally, relationships between blood level, quantitative EEG and psychometric changes after administration of phentermine and oxazepam are described and discussed.","PeriodicalId":76325,"journal":{"name":"Pharmakopsychiatrie, Neuro-Psychopharmakologie","volume":"12 1","pages":"45-58"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1094593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11624279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

EEG and other effects of naltrexone and heroin in man. 纳曲酮和海洛因对人体的脑电图和其他影响。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094597

J Volavka, B James, D Reker, A Mallya, D Cho, J Pevnick

引用次数: 36

Development of a classification rule for four clinical therapeutic psychotropic drug classes with EEG power-spectrum variables of human volunteers. 基于志愿者脑电功率谱变量的四种临床治疗性精神药物分类规则的建立。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094591

W M Herrmann, K Fichte, T M Itil, S Kubicki

{"title":"Development of a classification rule for four clinical therapeutic psychotropic drug classes with EEG power-spectrum variables of human volunteers.","authors":"W M Herrmann, K Fichte, T M Itil, S Kubicki","doi":"10.1055/s-0028-1094591","DOIUrl":"https://doi.org/10.1055/s-0028-1094591","url":null,"abstract":"An objective rule for the classification of psychotropic substances has been developed. Classification is based on data from five basic studies simultaneously designed and performed and involving 75 healthy volunteers who ingested 20 different psychotropic drugs and 5 placebos in single oral dosages. Each volunteer took one psychostimulant, one antidepressant, one neuroleptic, one minor tranquilizer and one placebo in a double-blind Latin square cross-over design. The variables were 6 frequency bands, based on power spectrum estimates and determined by factor analysis, plus total power in the 1.5-30.0 Hz range. An objective classification rule was established by multi-group (5 groups) linear discriminant analysis. Reclassification of the substances by the new rule yielded correct results for 17 out of 20 psychotropic drugs and 4 out of 5 placebos. Of placebos from various studies not used for the establishment of the classification rule, 7/9 were classified correctly. The validity of the rule for other classes of substances will have to be verified in independent studies.","PeriodicalId":76325,"journal":{"name":"Pharmakopsychiatrie, Neuro-Psychopharmakologie","volume":"12 1","pages":"20-34"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1094591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11625434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Drug-induced EEG changes studied on two-dimensional rectangular coordinates using principal component analysis. 利用主成分分析方法研究了二维直角坐标下药物致脑电变化。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094594

M Saito

引用次数: 1

CNS effects of the antihistamines diphenhydramine and terfenadine (RMI 9918). 抗组胺药苯海拉明和特非那定对中枢神经系统的影响(RMI 9918)。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094592

M Fink, P Irwin

引用次数: 43