Pharmakopsychiatrie, Neuro-Psychopharmakologie最新文献_第7页

[A comparative study of viloxazine and imipramine (author's transl)]. [维洛嗪与丙咪嗪的比较研究[作者译]。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-07-01 DOI: 10.1055/s-0028-1094626

L Floru, J Tegeler

引用次数: 6

Clinical profile and serum concentration of viloxazine as compared to amitriptyline. 维洛嗪与阿米替林的临床特征和血清浓度比较。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-07-01 DOI: 10.1055/s-0028-1094627

B Müller-Oerlinghausen, E Rüther

{"title":"Clinical profile and serum concentration of viloxazine as compared to amitriptyline.","authors":"B Müller-Oerlinghausen, E Rüther","doi":"10.1055/s-0028-1094627","DOIUrl":"https://doi.org/10.1055/s-0028-1094627","url":null,"abstract":"The antidepressive effect of viloxazine (300 mg/d) was investigated during three weeks in 41 patients with depressive syndromes requiring drug-treatment against amitriptyline (150 mg/d), using a controlled double-blind design. Viloxazine differs from amitriptyline by selective inhibition of norepinephrine re-uptake, whereas amitriptyline acts also on serotonin re-uptake. Psychopathological changes were documented by means of the Hamilton Depression Rating Scale, the Bf-S (v. Zerssen), the AMDP-System, and videotaped recordings. Besides routine clinical-chemical tests, the serum concentrations of viloxazine and partly of amitriptyline were determined. Repeated EEG-recordings were evaluated by spectral analysis. The number of global responders and non-responders -- defined according to the final HDRS-scores -- was equally distributed between the two drug-groups. The AMDP-evaluation suggests that viloxazin has a somewhat more marked and more rapid effect on symptoms of retardation, whereas amitriptyline acts predominantly on depressive mood, disturbances of sleep and vital feelings. The EEG-profile of both drugs was similar to the spectral changes seen under tricyclic antidepressants, through only the viloxazine-induced changes reached statistical significance on the 10th and 20th day, the variability of the EEG-recordings being greater in the amitriptyline group. The viloxazine blood levels showed a remarkably low inter- and intraindividual variance. Steady state was reached at day 5 at the latest. Amitriptyline serum concentrations still increased between the 10th and the 21st day. The average blood concentration of viloxazine was higher in the responder- than in the non-responder-group.","PeriodicalId":76325,"journal":{"name":"Pharmakopsychiatrie, Neuro-Psychopharmakologie","volume":"12 4","pages":"321-37"},"PeriodicalIF":0.0,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1094627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11594180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

[Incidence of anonymous medication before admission to the hospital (author's transl)]. [入院前匿名服药的发生率(提交人的翻译)]。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01 DOI: 10.1055/s-0028-1094623

O K Linde

引用次数: 0

Reversal of neuroleptic-induced stupor by procyclidin. Two case reports and their theoretical implications. 顺环素逆转抗精神病药诱导的昏迷。两个案例报告及其理论意义。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01

G Ungvári, B Pethö

引用次数: 0

[Clinico-physiological sleep- and hangover-spectra from pentobarbital, promazin and their combination, as reflected by self-ratings of young and elderly subjects (author's transl)]. [戊巴比妥、丙马嗪及其组合的临床生理睡眠和宿醉谱，反映在年轻和老年受试者的自我评定中(作者译)]。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01 DOI: 10.1055/s-0028-1094619

R Kohnen, G A Lienert, F I Schmidt

引用次数: 0

Central antiserotonin action of amitriptyline. 阿米替林的中枢抗血清素作用。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01 DOI: 10.1055/s-0028-1094622

J Maj, A Lewandowska, A Rawtów

引用次数: 53

Effects of piracetam on the incorporation of 32P into the phospholipids of neurons and glial cells isolated from rabbit cerebral cortex. 吡拉西坦对兔大脑皮层神经元和神经胶质细胞磷脂中32P掺入的影响。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01 DOI: 10.1055/s-0028-1094617

H Woelk

{"title":"Effects of piracetam on the incorporation of 32P into the phospholipids of neurons and glial cells isolated from rabbit cerebral cortex.","authors":"H Woelk","doi":"10.1055/s-0028-1094617","DOIUrl":"https://doi.org/10.1055/s-0028-1094617","url":null,"abstract":"In the search for the biochemical basis of the action of Piracetam, the effects of this encephalotropic substance on the neuronal and glial phospholipid metabolism was investigated. Piracetam increases the incorporation of 32P into phosphatidylinositol and phosphatidyl choline of both glia and neuronal cell bodies (Figs. 1 and 2). When taking the important role of phosphatidylinositol in the processes of synaptic transmission and axonal conduction into consideration, the data obtained in the present work suggest that piracetam may stimulate excitatory neurons and may be involved in the process of synaptic transmission. The stimulatory effect of piracetam on the incorporation of 32P into phosphatidylinositol and phosphatidyl choline appears to be mediated by noerpinephrine or another neurotransmitter. Glial cells, isolated from the cerebral cortex of a rabbit, contained approximately one-third more phospholipids per uint protein than the neuronal cell bodies. The distribution and pattern of phospholipid relative to the total amount, was rather similar in both cell types. The incorporation of 32P into phosphatidylinositol and phosphatidyl choline was somewhat faster in neurons than in glial cells. Compared to glial cells the neuronal cell fraction had a higher phospholipid turnover.","PeriodicalId":76325,"journal":{"name":"Pharmakopsychiatrie, Neuro-Psychopharmakologie","volume":"12 3","pages":"251-6"},"PeriodicalIF":0.0,"publicationDate":"1979-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1094617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11688043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Effects of the synthetic analogue of methionine enkephalin FK 33-824 on psychotic symptoms. 蛋氨酸脑啡肽fk33 -824合成类似物对精神病症状的影响

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01 DOI: 10.1055/s-0028-1094621

N Nedopil, E Rüther

引用次数: 43

beta-Endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders. 精神分裂症和其他神经精神疾病患者脑脊液和血浆中的-内啡肽样免疫反应性

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-05-01 DOI: 10.1055/s-0028-1094620

H M Emrich, V Höllt, W Kissling, M Fischler, H Laspe, H Heinemann, D von Zerssen, A Herz

{"title":"beta-Endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders.","authors":"H M Emrich, V Höllt, W Kissling, M Fischler, H Laspe, H Heinemann, D von Zerssen, A Herz","doi":"10.1055/s-0028-1094620","DOIUrl":"https://doi.org/10.1055/s-0028-1094620","url":null,"abstract":"Measurements of beta-endorphin-like immunoreactivity have been performed in CSF and plasma of patients with schizophrenia and other neuropsychiatric disorders. The detection limit of the RIA was between 20--50 pg/ml (6--15 fmole/ml). In CSF the quantity of beta-endorphin-like immunoreactivity ranges up to 65 pg/ml. The data from schizophrenics and other neuropsychiatric patients show no obvious deviation from the results in a control group of medical patients with normal CSF findings. In plasma the immunoreactive beta-endorphin-like material ranges up to 250 pg/ml. There is only a small tendency to higher values in schizophrenic patients, if compared with different types of neuroses and affective and organic psychoses. In a second series of experiments also this tendency could not be reproduced. In 9 electroconvulsive treatments an increase of blood beta-endorphin-like immunoreactivity was observed 7 times. A possible endorphinergic mechanism in the mode of action of electroconvulsion is hypothesized.","PeriodicalId":76325,"journal":{"name":"Pharmakopsychiatrie, Neuro-Psychopharmakologie","volume":"12 3","pages":"269-76"},"PeriodicalIF":0.0,"publicationDate":"1979-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1094620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11688045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Latest advances in pharmaco-electroencephalography. Symposium in Basle/Switzerland, July 17-20, 1978. Part II. 药物脑电图的最新进展。1978年7月17日至20日在瑞士巴塞尔举行专题讨论会。第二部分。

Pharmakopsychiatrie, Neuro-Psychopharmakologie Pub Date : 1979-03-01

引用次数: 0