Perspectives in nephrology and hypertension最新文献_第4页

Juvenile nephronophthisis and renal medullary cystic disease. 少年肾病和肾髓质囊性疾病。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

K D Gardner

引用次数: 0

Functional abnormalities in renal cystic diseases. 肾囊性疾病的功能异常。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

R A Defronzo, S O Thier

{"title":"Functional abnormalities in renal cystic diseases.","authors":"R A Defronzo, S O Thier","doi":"","DOIUrl":"","url":null,"abstract":"The functions of a kidney, whether normal or cystic, can be conceptualized in terms of anatomy (glomerulus, proximal tubule, loop of Henle, distal convolution, and collecting duct), activity (volume regulation, dilution and concentration, acid-base regulation, potassium excretion, transport of organic molecules, and calcium and phosphate excretion), and the integration of anatomic organization to meet functional demand. Our discussion of renal cystic disorders follows this conceptual outline. For discussions of normal renal physiology, the reader is referred to any one of several recent, excellent reviews (1-3). Systematic evaluation of renal function in cystic diseases of the kidney (medullary sponge kidney, medullary cystic disease, and polycystic kidney disease) has only rarely been performed. The available information suggests that the earliest detectable lesions consist primarily of tubular dysfunction. With time, however, significant reduction of glomerular filtration occurs and the resultant accumulation of uremic toxins dominates the clinical picture in polycystic and medullary cystic disease. Significant changes in glomerular function are unusual in medullary sponge kidney. This review represents an attempt to summarize the large body of literature that has accumulated on functional abnormalities in these disorders, and to point out those areas where further investigations are needed.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"4 ","pages":"65-81"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11229182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal involvement in leukemia and lymphoma. 白血病和淋巴瘤累及肾脏。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

W N Suki

引用次数: 0

Inherited biochemical defects affecting the kidney. 影响肾脏的遗传性生化缺陷。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

C T Caskey

{"title":"Inherited biochemical defects affecting the kidney.","authors":"C T Caskey","doi":"","DOIUrl":"","url":null,"abstract":"The identification of a disease entity as one that is the result of a heritable defect offers the physician an opportunity to intervene in a variety of ways. As emphasized, knowledge of the heritable pattern of a particular disease allows the physician an opportunity to counsel family members in personal disease risk and the offspring. Such genetic counseling results in a reduction of affected cases for many inherited diseases. There is every expectation that similar approaches would be effective for inherited renal diseases. The heritable diseases are a favored group for investigative purposes since these diseases result from a single gene defect no matter how plieotropic the effects of that defect. Thus the investigator is capable of constant probing with tools available for identifying that one event or component that lies at the basis of the disease. The emphasis of this chapter is on those inherited renal diseases for which we have reached a high level of understanding of this single defect. In many of these diseases a single enzyme is identified as deficient and is the presumed genetic defect. In others (cystinuria, RTA, and cystinosis) the precise biochemical answers appear close at hand. Thus a variety of therapeutic approaches to overcome either the gene defect or ill effects of the gene defect emerge for diseases involving the kidney and are listed in Table 7. For some of these diseases the new diagnostic technique of prenatal diagnosis can be used (Table 8). This genetic option provides couples at risk for bearing affected offspring with reduced risk. For a number of other diseases that are not identified by amniocentesis, this risk can be effectively lowered to acceptable levels by use of artificial insemination. Thus the inherited diseases of the kidney are amenable to medical intervention at a variety of levels. Such intervention can predictably lead to a lowering of both the incidence and consequences of these gene defects.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"3 ","pages":"255-74"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11963573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and pathophysiology of polycystic kidney disease in man. 人多囊肾病的临床特点及病理生理。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

G M Danovitch

引用次数: 0

Maternal uterine vascular lesions in the hypertensive complications of pregnancy. 妊娠高血压并发症中母体子宫血管病变的探讨。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

W B Robertson, I Brosens, G Dixon

{"title":"Maternal uterine vascular lesions in the hypertensive complications of pregnancy.","authors":"W B Robertson, I Brosens, G Dixon","doi":"","DOIUrl":"","url":null,"abstract":"To establich hemochorial placentation, the nonvillous trophoblast breaches the spiral arteries in the basal decidua and later migrates down the arteries as far as the parent radial arteries in the myometrium. Interactions between the endovascular trophoblast and the tissues of the maternal vessel wall (physiological changes) adapt these arteries to the uteroplacental arteries, and these large caliber vessels empty into the intervillous space. Loss of reactive musculoelastic vascular tissue results in a lowering of peripheral resistance, permitting a greatly increased blood flow into the intervillous space. In preeclamptic pregnancies, there is inhibition of the secondary endovascular trophoblast migration in the second trimester, so that the myometrial segments of the uteroplacental arteries remain as responseive musculoelastic arteries. With the onset of clinical preeclampsia, acute atherosis, a necrotizing arteriopathy, affects small muscular arteries in the placental bed and arterioles in the decidua vera. When essential hypertension is complicated by preeclampsia, the placental bed arteries show a combination of hyperplastic arteriosclerosis and acute atherosis. There is evidence that the establishment of hemochorial placentation requires controlled immunological reactions between fetal and maternal tissues and that an inappropriate immune response may be involved in the pathogenesis of the arteriopathy of preeclampsia.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"115-27"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12184648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selectivity of proteinuria during pregnancy assessed by different methods. 不同方法评价妊娠期蛋白尿的选择性。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

S M Wood, D Burnett, J Studd

引用次数: 0

Dietary sodium chloride in pregnant hypertensive patients: a preliminary report. 妊娠期高血压患者饮食中氯化钠:初步报告。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

L J Schewitz, G A Rodriguez, I L Voyevidka

引用次数: 0

Diabetes mellitus and the kidney. 糖尿病和肾脏。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01 DOI: 10.1142/9789812776990_0013

Tisher Cc, McCoy Rc